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公开(公告)号：US20110190330A1
公开(公告)日：2011-08-04
申请号：US13119951
申请日：2009-10-13
申请人： Sean P. Brown , Paul Dransfield , Xiaohui Du , Zice Fu , Jonathan Houze , XianYun Jiao , Sujen Lai , An-Rong Li , Jiwen Liu , Zhihua Ma , Julio C. Medina , Vatee Pattaropong , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang , Ming Yu , Liusheng Zhu
发明人： Sean P. Brown , Paul Dransfield , Xiaohui Du , Zice Fu , Jonathan Houze , XianYun Jiao , Sujen Lai , An-Rong Li , Jiwen Liu , Zhihua Ma , Julio C. Medina , Vatee Pattaropong , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang , Ming Yu , Liusheng Zhu
IPC分类号： A61K31/4418 , C07C69/757 , C07C62/34 , C07D213/64 , C07D249/08 , C07D311/96 , C07D217/24 , C07D231/12 , A61K31/216 , A61K31/192 , A61K31/4196 , A61K31/352 , A61K31/415 , A61K31/426 , A61P3/10
CPC分类号： C07C62/34 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07D213/643 , C07D217/24 , C07D253/065 , C07D277/22 , C07D311/04 , C07D401/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula IA, IB, I′A or I′B: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译： 本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。 这些化合物具有通式IA，IB，I'A或I'B：其中本文提供变量的定义。 本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。
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公开(公告)号：US08748462B2
公开(公告)日：2014-06-10
申请号：US13119951
申请日：2009-10-13
申请人： Sean P. Brown , Paul Dransfield , Xiaohui Du , Zice Fu , Jonathan Houze , XianYun Jiao , Sujen Lai , An-Rong Li , Jiwen Liu , Zhihua Ma , Julio C. Medina , Vatee Pattaropong , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang , Ming Yu , Liusheng Zhu
发明人： Sean P. Brown , Paul Dransfield , Xiaohui Du , Zice Fu , Jonathan Houze , XianYun Jiao , Sujen Lai , An-Rong Li , Jiwen Liu , Zhihua Ma , Julio C. Medina , Vatee Pattaropong , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang , Ming Yu , Liusheng Zhu
IPC分类号： A61K31/19 , C07C69/76 , C07D211/72 , C07D211/84 , C07D213/62 , A61K31/44
CPC分类号： C07C62/34 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07D213/643 , C07D217/24 , C07D253/065 , C07D277/22 , C07D311/04 , C07D401/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula IA, IB, I′A or I′B: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译： 本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。 这些化合物具有通式IA，IB，I'A或I'B：其中本文提供变量的定义。 本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。
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公开(公告)号：US08030354B2
公开(公告)日：2011-10-04
申请号：US12287036
申请日：2008-10-03
申请人： Sean P. Brown , Qiong Cao , Paul John Dransfield , Xiaohui Du , Zice Fu , Jonathan Houze , Xian Yun Jiao , Yong-Jae Kim , Todd J. Kohn , SuJen Lai , An-Rong Li , Daniel Lin , Jiwen Liu , Jian Luo , Julio C. Medina , Jeffrey D. Reagan , Vatee Pattaropong , Margrit Schwarz , Wang Shen , Yongli Su , Gayathri Swaminath , Marc Vimolratana , Yingcai Wang , Yumei Xiong , Li Yang , Ming Yu , Jie Zhang , Liusheng Zhu
发明人： Sean P. Brown , Qiong Cao , Paul John Dransfield , Xiaohui Du , Zice Fu , Jonathan Houze , Xian Yun Jiao , Yong-Jae Kim , Todd J. Kohn , SuJen Lai , An-Rong Li , Daniel Lin , Jiwen Liu , Jian Luo , Julio C. Medina , Jeffrey D. Reagan , Vatee Pattaropong , Margrit Schwarz , Wang Shen , Yongli Su , Gayathri Swaminath , Marc Vimolratana , Yingcai Wang , Yumei Xiong , Li Yang , Ming Yu , Jie Zhang , Liusheng Zhu
IPC分类号： A61K31/192 , C07C53/134
CPC分类号： C07C323/62 , C07C59/68 , C07C59/72 , C07C217/54 , C07C217/62 , C07C317/22 , C07C323/19 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D213/64 , C07D309/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译： 本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。 这些化合物具有通式I：其中本文提供变量的定义。 本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。
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公开(公告)号：US20090137561A1
公开(公告)日：2009-05-28
申请号：US12287036
申请日：2008-10-03
申请人： Sean P. Brown , Qiong Cao , Paul John Dransfield , Xiaohui Du , Jonathan Houze , Xian Yun Jiao , Yong-Jae Kim , Todd J. Kohn , SuJen Lai , An-Rong Li , Daniel Lin , Jian Luo , Julio C. Medina , Jeffrey D. Reagan , Vatee Pattaropong , Margrit Schwarz , Wang Shen , Yongli Su , Gayathri Swaminath , Marc Vimolratana , Xiang Wang , Yumei Xiong , Li Yang , Ming Yu , Jie Zhang , Liusheng Zhu
发明人： Sean P. Brown , Qiong Cao , Paul John Dransfield , Xiaohui Du , Jonathan Houze , Xian Yun Jiao , Yong-Jae Kim , Todd J. Kohn , SuJen Lai , An-Rong Li , Daniel Lin , Jian Luo , Julio C. Medina , Jeffrey D. Reagan , Vatee Pattaropong , Margrit Schwarz , Wang Shen , Yongli Su , Gayathri Swaminath , Marc Vimolratana , Xiang Wang , Yumei Xiong , Li Yang , Ming Yu , Jie Zhang , Liusheng Zhu
IPC分类号： C07C59/48 , A61K31/192 , A61K31/235 , C07C69/76 , C07D309/00 , A61K31/351 , C07D211/20 , A61K31/445 , A61K31/44 , A61K31/55 , C07D223/04 , A61P7/00
CPC分类号： C07C323/62 , C07C59/68 , C07C59/72 , C07C217/54 , C07C217/62 , C07C317/22 , C07C323/19 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D213/64 , C07D309/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
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5.发明授权公开(公告)号：US08450522B2
公开(公告)日：2013-05-28
申请号：US12863578
申请日：2009-03-04
申请人： Sean P. Brown , Paul J. Dransfield , Jonathan Houze , Todd J. Kohn , Jiwen Liu , Julio Medina , Vatee Pattaropong , Wang Shen , Marc Vimolratana , Yingcai Wang , Ming Yu , Liusheng Zhu
发明人： Sean P. Brown , Paul J. Dransfield , Jonathan Houze , Todd J. Kohn , Jiwen Liu , Julio Medina , Vatee Pattaropong , Wang Shen , Marc Vimolratana , Yingcai Wang , Ming Yu , Liusheng Zhu
IPC分类号： C07C63/00 , A61K31/185
CPC分类号： C07C59/72
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I or the general formula III: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译： 本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。 这些化合物具有通式I或通式III：其中本文提供变量的定义。 本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。
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6.发明申请公开(公告)号：US20100298367A1
公开(公告)日：2010-11-25
申请号：US12863578
申请日：2009-03-04
申请人： Sean P. Brown , Paul J. Dransfield , Jonathan Houze , Todd J. Kohn , Jiwen Liu , Julio Medina , Vatee Pattaropong , Wang Shen , Marc Vimolratana , Yingcai Wang , Ming Yu , Liusheng Zhu
发明人： Sean P. Brown , Paul J. Dransfield , Jonathan Houze , Todd J. Kohn , Jiwen Liu , Julio Medina , Vatee Pattaropong , Wang Shen , Marc Vimolratana , Yingcai Wang , Ming Yu , Liusheng Zhu
IPC分类号： A61K31/216 , A61K31/44 , A61K31/192 , C07D213/63 , C07D213/55 , C07C69/007 , C07C59/62 , A61P9/12 , A61P3/10 , A61P35/04 , A61P13/12 , A61P3/00 , A61P3/06 , A61P9/10 , A61P9/00
CPC分类号： C07C59/72
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I or the general formula III: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译： 本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。 这些化合物具有通式I或通式III：其中本文提供变量的定义。 本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。
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公开(公告)号：US07687526B2
公开(公告)日：2010-03-30
申请号：US11900014
申请日：2007-09-06
申请人： Sean P. Brown , Paul Dransfield , Jonathan B. Houze , Jinqian Liu , Jiwen Liu , Zhihua Ma , Julio C. Medina , Vatee Pattaropong , Michael J. Schmitt , Rajiv Sharma , Yingcai Wang
发明人： Sean P. Brown , Paul Dransfield , Jonathan B. Houze , Jinqian Liu , Jiwen Liu , Zhihua Ma , Julio C. Medina , Vatee Pattaropong , Michael J. Schmitt , Rajiv Sharma , Yingcai Wang
IPC分类号： A61K31/4192 , A61K31/192 , C07D249/04 , C07C59/13
CPC分类号： C07D233/64 , C07C51/09 , C07C51/367 , C07C51/47 , C07C235/34 , C07C2602/10 , C07D207/327 , C07D213/55 , C07D231/12 , C07D239/26 , C07D249/10 , C07D257/04 , C07D261/08 , C07D263/32 , C07D277/587 , C07D285/12 , C07D333/24 , C07C59/72
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables and A are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译： 本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。 这些化合物具有通式I：其中本文提供变量和A的定义。 本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。
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公开(公告)号：US20100137323A1
公开(公告)日：2010-06-03
申请号：US12696770
申请日：2010-01-29
申请人： Sean P. Brown , Paul Dransfield , Jonathan B. Houze , Jinqian Liu , Jiwen Liu , Zhihua Ma , Julio C. Medina , Vatee Pattaropong , Michael J. Schmitt , Rajiv Sharma , Yingcai Wang
发明人： Sean P. Brown , Paul Dransfield , Jonathan B. Houze , Jinqian Liu , Jiwen Liu , Zhihua Ma , Julio C. Medina , Vatee Pattaropong , Michael J. Schmitt , Rajiv Sharma , Yingcai Wang
IPC分类号： A61K31/498 , A61K31/505 , A61K31/4409 , A61K31/433 , A61K31/42 , A61K31/421 , A61K31/4196 , A61K31/4164 , C07D239/26 , C07D213/55 , C07D285/12 , C07D263/32 , C07D249/08 , C07D233/64
CPC分类号： C07D233/64 , C07C51/09 , C07C51/367 , C07C51/47 , C07C235/34 , C07C2602/10 , C07D207/327 , C07D213/55 , C07D231/12 , C07D239/26 , C07D249/10 , C07D257/04 , C07D261/08 , C07D263/32 , C07D277/587 , C07D285/12 , C07D333/24 , C07C59/72
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables Q, L1, , L2,M, X, L3, and A are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译： 本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。 这些化合物具有通式I：其中本文提供了变量Q，L1，，L2，M，X，L3和A的定义。 本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。
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公开(公告)号：US20080119511A1
公开(公告)日：2008-05-22
申请号：US11900014
申请日：2007-09-06
申请人： Sean P. Brown , Paul Dransfield , Jonathan B. Houze , Jinqian Liu , Jiwen Liu , Zhihua Ma , Julio C. Medina , Vatee Pattaropong , Michael J. Schmitt , Rajiv Sharma , Yingcai Wang
发明人： Sean P. Brown , Paul Dransfield , Jonathan B. Houze , Jinqian Liu , Jiwen Liu , Zhihua Ma , Julio C. Medina , Vatee Pattaropong , Michael J. Schmitt , Rajiv Sharma , Yingcai Wang
IPC分类号： A61K31/47 , A61K31/192 , C07D319/14 , A61K31/335
CPC分类号： C07D233/64 , C07C51/09 , C07C51/367 , C07C51/47 , C07C235/34 , C07C2602/10 , C07D207/327 , C07D213/55 , C07D231/12 , C07D239/26 , C07D249/10 , C07D257/04 , C07D261/08 , C07D263/32 , C07D277/587 , C07D285/12 , C07D333/24 , C07C59/72
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables and A are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译： 本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。 这些化合物具有通式I：其中本文提供变量和A的定义。 本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。
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公开(公告)号：US07572934B2
公开(公告)日：2009-08-11
申请号：US12082645
申请日：2008-04-10
申请人： Sean P. Brown , Paul Dransfield , Zice Fu , Jonathan Houze , Xian Yun Jiao , Todd J. Kohn , Vatee Pattaropong , Marc Vimolratana , Michael J. Schmitt
发明人： Sean P. Brown , Paul Dransfield , Zice Fu , Jonathan Houze , Xian Yun Jiao , Todd J. Kohn , Vatee Pattaropong , Marc Vimolratana , Michael J. Schmitt
IPC分类号： C07C63/33 , C07C335/00 , A01N43/40 , A01N37/10
CPC分类号： C07C59/68 , C07C59/72 , C07D261/08
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译： 本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。 这些化合物具有通式I：其中本文提供变量的定义。 本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。
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