公开(公告)号：US20090281051A1

公开(公告)日：2009-11-12

申请号：US12490737

申请日：2009-06-24

申请人： Seiichiro OGAWA ,  Yoshiyuki Suzuki ,  Eiji Nanba ,  Junichiro Matsuda ,  Kousaku Ohno

发明人： Seiichiro OGAWA ,  Yoshiyuki Suzuki ,  Eiji Nanba ,  Junichiro Matsuda ,  Kousaku Ohno

IPC分类号： A61K31/70

CPC分类号： C07C215/44 ,  C07C271/24 ,  C07C2601/16 ,  C07F7/1804

摘要： A carba-sugar amine derivative represented by the following formula (1) or (2) is used as the active ingredient of a β-galactosidase inhibitor or a glycolipid metabolic disorder treating agent. Wherein each of R1 and R2 independently represents H, an alkyl group, an acyl group, an aryl group or an aralkyl group, with the proviso that both are not H at the same time, and each of R3, R4, R5 and R6 independently represents a hydroxyl group or hydroxyl group having a substituent.Also, R7 represents an alkyl group, and each of R8, R9, R10 and R11 independently represents a hydroxyl group or a hydroxyl group having a substituent.

摘要翻译： 作为β-半乳糖苷酶抑制剂或糖脂代谢紊乱处理剂的活性成分，使用下述式（1）或（2）表示的卡巴糖胺衍生物。 其中，R 1和R 2各自独立地表示H，烷基，酰基，芳基或芳烷基，条件是两者不同时为H，R3，R4，R5和R6各自独立地为 表示具有取代基的羟基或羟基。 此外，R 7表示烷基，R 8，R 9，R 10和R 11各自独立地表示羟基或具有取代基的羟基。

公开(公告)号：US07790773B2

公开(公告)日：2010-09-07

申请号：US10793857

申请日：2004-03-08

申请人： Seiichiro Ogawa ,  Yoshiyuki Suzuki ,  Eiji Nanba ,  Junichiro Matsuda ,  Kousaku Ohno

发明人： Seiichiro Ogawa ,  Yoshiyuki Suzuki ,  Eiji Nanba ,  Junichiro Matsuda ,  Kousaku Ohno

IPC分类号： A61K31/133 ,  C07C211/40 ,  C07C215/44

CPC分类号： C07C215/44 ,  C07C271/24 ,  C07C2601/16 ,  C07F7/1804

摘要： A carba-sugar amine derivative represented by the following formula (1) or (2) is used as the active ingredient of a β-galactosidase inhibitor or a glycolipid metabolic disorder treating agent. Wherein each of R1 and R2 independently represents H, an alkyl group, an acyl group, an aryl group or an aralkyl group, with the proviso that both are not H at the same time, and each of R3, R4, R5 and R6 independently represents a hydroxyl group or hydroxyl group having a substituent.Also, R7 represents an alkyl group, and each of R8, R9, R10 and R11 independently represents a hydroxyl group or a hydroxyl group having a substituent.

摘要翻译： 使用由下式（1）或（2）表示的卡巴糖胺衍生物作为β-半乳糖苷酶抑制剂或糖脂代谢紊乱处理剂的活性成分。 其中，R 1和R 2各自独立地表示H，烷基，酰基，芳基或芳烷基，条件是两者不同时为H，R3，R4，R5和R6各自独立地为 表示具有取代基的羟基或羟基。 此外，R 7表示烷基，R 8，R 9，R 10和R 11各自独立地表示羟基或具有取代基的羟基。

公开(公告)号：US08211945B2

公开(公告)日：2012-07-03

申请号：US12490737

申请日：2009-06-24

申请人： Seiichiro Ogawa ,  Yoshiyuki Suzuki ,  Eiji Nanba ,  Junichiro Matsuda ,  Kousaku Ohno

发明人： Seiichiro Ogawa ,  Yoshiyuki Suzuki ,  Eiji Nanba ,  Junichiro Matsuda ,  Kousaku Ohno

IPC分类号： A61K31/133 ,  C07C211/40 ,  C07C215/44

CPC分类号： C07C215/44 ,  C07C271/24 ,  C07C2601/16 ,  C07F7/1804

摘要： Methods for stabilizing β-galactosidase, stabilizing β-glucocerebrosidase, treating a glycolipid metabolic disorder caused by mutation of β-galactosidase gene, treating a glycolipid metabolic disorder caused by mutation of β-glucocerebrosidase gene, regenerating the activity of β-galactosidase, regenerating the activity of β-glucosidase, treating GM1 gangliosidosis, Morquio-B or Krabbe's disease, and treating Gaucher's disease, include administering a carba-sugar amine derivative represented by the following formula (1) or (2):

摘要翻译： 治疗由半乳糖苷酶基因突变引起的糖脂代谢紊乱，治疗糖基代谢紊乱引起的糖脂代谢紊乱，再生bgr-半乳糖苷酶活性的方法， 再生γ葡糖苷酶的活性，治疗GM1神经节苷脂症，莫奎奥-B或克拉伯氏病，以及治疗戈谢病，包括给予由下式（1）或（2）表示的卡巴糖胺衍生物：

公开(公告)号：US06577022B2

公开(公告)日：2003-06-10

申请号：US10101869

申请日：2002-03-21

申请人： Kim Houng Joong ,  Kazuo Tahara ,  Kou Ajima ,  Koki Ueta ,  Toshiyuki Innami ,  Noriaki Hino ,  Taizo Miyazaki ,  Tomoyuki Hanyu ,  Kousaku Ohno

发明人： Kim Houng Joong ,  Kazuo Tahara ,  Kou Ajima ,  Koki Ueta ,  Toshiyuki Innami ,  Noriaki Hino ,  Taizo Miyazaki ,  Tomoyuki Hanyu ,  Kousaku Ohno

IPC分类号： H02P904

CPC分类号： B60K6/26 ,  B60K6/485 ,  B60K6/54 ,  B60L11/12 ,  H02K16/02 ,  H02K21/029 ,  Y02T10/6226 ,  Y02T10/641 ,  Y02T10/7005 ,  Y02T10/7077 ,  Y10S903/903 ,  Y10S903/906 ,  Y10S903/917

摘要： A hybrid drive type vehicle having a permanent magnet type synchronous motor can provide high torque characteristics in low revolution speed range of the engine and high power generation characteristics at high revolution speed range of the engine. The hybrid drive type vehicle includes an electric rotary machine being formed with a stator and a rotor. A field magnet of the rotor include a first field magnet and a second field magnet. The first and second field magnets are opposing with a magnetic pole of the stator and having a mechanism for varying a phase of a magnetic pole resulting from combination of the first and second field magnets relative to the magnetic pole of the first field magnet depending upon direction of a torque of the rotor.

公开(公告)号：US20120220420A1

公开(公告)日：2012-08-30

申请号：US13498935

申请日：2010-10-07

申请人： Kousaku Ohno ,  Hidetoshi Satake

发明人： Kousaku Ohno ,  Hidetoshi Satake

IPC分类号： B60W10/02

CPC分类号： F16D48/06 ,  B60K6/48 ,  B60W10/02 ,  B60W10/06 ,  B60W30/18127 ,  B60W30/18136 ,  E02F9/2075 ,  E02F9/2079 ,  F16D2500/50825 ,  F16D2500/5085 ,  F16D2500/70424 ,  Y02T10/6221 ,  Y10T477/26

摘要： [Object]Motorization of a running gear of a construction machine traveling on wheels is realized without enormous increases in vehicle-body dimensions and costs.[Solution Means]A wheeled excavator 41 includes travel wheels 10, 11 installed in a vehicle body, an engine 3, a running motor-generator 15, an inverter 21 and a battery 22 which are electrically connected to the motor-generator 15, a hydraulic pump 4 driven by the engine, and a power transmission mechanism which transmits power among the engine 3, the wheels 10, 11, the running motor-generator 15, and the hydraulic pump 4. A clutch 23 which connects and disconnects the power transmission between the engine 3 and the wheels 10, 11 is provided in the power transmission mechanism. In a required area on the vehicle body, a clutch switching means is mounted for switching the clutch 23 to a disengaged state during a level road run and to an engaged state during a downhill run.

摘要翻译： 实现了车轮行驶的施工机械的行走装置的机动化，而车体尺寸和成本却没有大的增加。 [解决方案]轮式挖掘机41包括安装在车体中的行驶轮10,11，电连接到电动发电机15的发动机3，行驶电动发电机15，逆变器21和电池22， 由发动机驱动的液压泵4以及在发动机3，车轮10,11，行驶电动发电机15和液压泵4之间传递动力的动力传递机构。连接和断开动力传递的离合器23 发动机3和车轮10,11之间设置有动力传递机构。 在车体的所需区域中，安装有离合器切换装置，用于在下坡行驶期间将离合器23切换到分离状态，并且在下坡行驶期间接合到接合状态。

公开(公告)号：US20080029355A1

公开(公告)日：2008-02-07

申请号：US11629977

申请日：2004-06-21

申请人： Yoshinari Kawahara ,  Kousaku Ohno ,  Atsushi Yokoyama ,  Mitsuhide Sasaki

发明人： Yoshinari Kawahara ,  Kousaku Ohno ,  Atsushi Yokoyama ,  Mitsuhide Sasaki

IPC分类号： F16D55/225 ,  B60T7/00

CPC分类号： B60T13/741 ,  B60T8/00 ,  B60T8/24

摘要： An electrically operated brake device in which braking force differences between electrically operated brakes are reduced to prevent unstable vehicle traveling during braking. Motors 13 of electrically operated brakes are returned to standard positions during the stop of a vehicle and the motor 13 of each of the brakes is driven for a predetermined amount, pressing a brake pad 17 against a disc rotor 18 to produce a braking force. An electric current value of each motor 13 in the above operation is measured and differences between the values are calculated. Electric current of each motor is increased or decreased so that there is no current difference between the motors 13. Based on a drive amount of each motor in this operation, standard positions of the motors are determined and updated. Repeating the above operations reduces braking force differences between the brakes.

摘要翻译： 一种电动制动装置，其中电动制动器之间的制动力差异减小，以防止在制动期间车辆行驶不稳定。 电动制动器的电动机13在车辆停止期间返回到标准位置，并且每个制动器的电动机13被驱动预定量，将制动衬块17压靠在盘转子18上以产生制动力。 测量上述操作中的每个电机13的电流值，并计算这些值之间的差值。 每个电动机的电流增加或减小，使得电动机13之间没有电流差。 基于该操作中的每个电动机的驱动量，确定和更新电动机的标准位置。 重复上述操作可减少制动器之间的制动力差异。

公开(公告)号：US06462430B1

公开(公告)日：2002-10-08

申请号：US09654081

申请日：2000-09-01

申请人： Kim Houng Joong ,  Kazuo Tahara ,  Kou Ajima ,  Koki Ueta ,  Toshiyuki Innami ,  Noriaki Hino ,  Taizo Miyazaki ,  Tomoyuki Hanyu ,  Kousaku Ohno

发明人： Kim Houng Joong ,  Kazuo Tahara ,  Kou Ajima ,  Koki Ueta ,  Toshiyuki Innami ,  Noriaki Hino ,  Taizo Miyazaki ,  Tomoyuki Hanyu ,  Kousaku Ohno

IPC分类号： H02P904

CPC分类号： B60K6/26 ,  B60K6/485 ,  B60K6/54 ,  B60L11/12 ,  H02K16/02 ,  H02K21/029 ,  Y02T10/6226 ,  Y02T10/641 ,  Y02T10/7005 ,  Y02T10/7077 ,  Y10S903/903 ,  Y10S903/906 ,  Y10S903/917

摘要： A hybrid drive type vehicle having a permanent magnet type synchronous motor can provide high torque characteristics in low revolution speed range of the engine and high power generation characteristics at high revolution speed range of the engine. The hybrid drive type vehicle includes an electric rotary machine being formed with a stator and a rotor. A field magnet of the rotor include a first field magnet and a second field magnet. The first and second field magnets are opposing with a magnetic pole of the stator and having a mechanism for varying a phase of a magnetic pole resulting from combination of the first and second field magnets relative to the magnetic pole of the first field magnet depending upon direction of a torque of the rotor.

公开(公告)号：US07445091B2

公开(公告)日：2008-11-04

申请号：US11629977

申请日：2004-06-21

申请人： Yoshinari Kawahara ,  Kousaku Ohno ,  Atsushi Yokoyama ,  Mitsuhide Sasaki

发明人： Yoshinari Kawahara ,  Kousaku Ohno ,  Atsushi Yokoyama ,  Mitsuhide Sasaki

IPC分类号： F16D55/08

CPC分类号： B60T13/741 ,  B60T8/00 ,  B60T8/24

摘要： An electrically operated brake device in which braking force differences between electrically operated brakes are reduced to prevent unstable vehicle traveling during braking.Motors 13 of electrically operated brakes are returned to standard positions during the stop of a vehicle and the motor 13 of each of the brakes is driven for a predetermined amount, pressing a brake pad 17 against a disc rotor 18 to produce a braking force.An electric current value of each motor 13 in the above operation is measured and differences between the values are calculated. Electric current of each motor is increased or decreased so that there is no current difference between the motors 13. Based on a drive amount of each motor in this operation, standard positions of the motors are determined and updated. Repeating the above operations reduces braking force differences between the brakes.

摘要翻译： 一种电动制动装置，其中电动制动器之间的制动力差异减小，以防止在制动期间车辆行驶不稳定。 电动制动器的电动机13在车辆停止期间返回到标准位置，并且每个制动器的电动机13被驱动预定量，将制动衬块17压靠在盘转子18上以产生制动力。 测量上述操作中的每个电机13的电流值，并计算这些值之间的差值。 每个电动机的电流增加或减小，使得电动机13之间没有电流差。 基于该操作中的每个电动机的驱动量，确定和更新电动机的标准位置。 重复上述操作可减少制动器之间的制动力差异。

公开(公告)号：US20060117886A1

公开(公告)日：2006-06-08

申请号：US11105433

申请日：2005-04-14

申请人： Kousaku Ohno ,  Kensuke Shoji

发明人： Kousaku Ohno ,  Kensuke Shoji

IPC分类号： F16H1/14

CPC分类号： F16H1/06 ,  F16H57/12 ,  F16H2057/128 ,  Y10T74/19688

摘要： In a parallel shaft-type of conical-geared transmission apparatus, a conical pinion is fitted to a first rotation shaft, and a second rotation shaft is arranged in parallel to this first rotation shaft. A conical wheel meshing with the conical pinion is fitted to the second rotation shaft. The pinion and the wheel are substantially equal in cone angle. A supporting device supports the first rotation shaft to be movable in the axial direction. A pressing device applies thrust in the axial direction of the first rotation shaft. A load bearing body to bear the thrust applied by the pressing device and to allow the first rotation shaft to be displaced in the radial direction is provided at an end of the first rotation shaft.

摘要翻译： 在平行轴式的锥齿轮传动装置中，锥形小齿轮装配到第一旋转轴上，并且第二旋转轴平行于该第一旋转轴布置。 与锥形小齿轮啮合的锥形轮装配到第二旋转轴上。 小齿轮和车轮的锥角基本相等。 支撑装置支撑第一旋转轴以沿轴向移动。 按压装置在第一旋转轴的轴向施加推力。 在第一旋转轴的端部设置承受由加压装置施加的推力并允许第一旋转轴沿径向移位的承载体。

公开(公告)号：US6051613A

公开(公告)日：2000-04-18

申请号：US2928

申请日：1998-01-05

申请人： Kousaku Ohno ,  Jin-emon Konishi ,  Seishi Suehiro

发明人： Kousaku Ohno ,  Jin-emon Konishi ,  Seishi Suehiro

IPC分类号： A61K9/08 ,  A61K35/12 ,  A61K35/36 ,  A61P3/00 ,  A61P31/04 ,  A61P43/00

CPC分类号： A61K35/36 ,  A61K35/76 ,  C12N2710/24133 ,  Y10S514/921 ,  Y10T428/12028 ,  Y10T428/12063 ,  Y10T428/1209 ,  Y10T428/12097 ,  Y10T428/12104 ,  Y10T428/12132 ,  Y10T428/12167 ,  Y10T428/12181 ,  Y10T428/12188 ,  Y10T428/12194 ,  Y10T428/12201 ,  Y10T428/12208 ,  Y10T428/31928 ,  Y10T428/3196

摘要： A pharmaceutical composition containing an extract from inflammatory tissue inoculated with vaccinia virus may be used to suppress the death of cells caused by endotoxin, and suppress excessive production of nitrogen monoxide induced by endotoxin. The extract may also be used to relieve hypotension induced by endotoxin. In sepsis and other serious bacterial infectious diseases, endotoxin (an intracellular toxin) is produced and a shock symptom is induced by its action. The extract, having an excellent inhibitory action toward endotoxin-induced toxicity, is quite useful for the treatment or the prevention of endotoxin-induced shock symptoms, sepsis and various symptoms accompanied thereby. In addition, the extract has an inhibitory action towards abnormal nitrogen monoxide production during the diseased state and, therefore, it is also useful as a therapeutic and preventive agent for diseases wherein an excessive nitrogen monoxide production occurs, such as acute hypotension.

摘要翻译： 可以使用含有用痘苗病毒接种的炎性组织的提取物的药物组合物来抑制由内毒素引起的细胞死亡，并抑制由内毒素引起的一氧化氮的过量产生。 提取物也可用于缓解由内毒素引起的低血压。 在败血症和其他严重的细菌感染性疾病中，产生内毒素（细胞内毒素），并通过其作用诱发休克症状。 对内毒素诱导的毒性具有优异的抑制作用的提取物对于治疗或预防内毒素诱导的休克症状，败血症和伴随的各种症状是非常有用的。 此外，提取物对患病状态下的异常一氧化一氮生成具有抑制作用，因此也可用作急性低血压等过量的一氧化氮生成的疾病的治疗和预防剂。