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公开(公告)号：US08575350B2
公开(公告)日：2013-11-05
申请号：US13230519
申请日：2011-09-12
IPC分类号： C07D211/78
CPC分类号： C07D213/803 , C07D213/807
摘要： Disclosed herein cost effective and ecofriendly large scale process for producing pyridine carboxylic acid with high purity and yield at industrial scale.
摘要翻译： 本文公开了在工业规模下以高纯度和产率生产吡啶羧酸的成本有效和环保的大规模方法。
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公开(公告)号：US08952170B2
公开(公告)日：2015-02-10
申请号：US14112018
申请日：2012-04-14
IPC分类号： C07D213/82 , B01J23/34 , C07D213/81 , B01J23/86
CPC分类号： C07D213/82 , B01J23/34 , B01J23/864 , B01J23/866 , C07D213/81 , Y02P20/582
摘要： An improved catalytic process for the production of pyridine carboxylic acid amides, by catalytic hydration reaction of pyridine nitriles with solid heterogeneous catalyst wherein the process involve effective utilization and recycling of the catalytic components, and reactants.
摘要翻译： 通过吡啶腈与固体多相催化剂的催化水合反应制备吡啶羧酸酰胺的改进的催化方法，其中该方法涉及催化组分和反应物的有效利用和再循环。
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公开(公告)号：US20140081029A1
公开(公告)日：2014-03-20
申请号：US14112018
申请日：2012-04-14
IPC分类号： C07D213/82 , B01J23/34 , B01J23/86 , C07D213/81
CPC分类号： C07D213/82 , B01J23/34 , B01J23/864 , B01J23/866 , C07D213/81 , Y02P20/582
摘要： An improved catalytic process for the production of pyridine carboxylic acid amides, by catalytic hydration reaction of pyridine nitriles with solid heterogeneous catalyst wherein the process involve effective utilization and recycling of the catalytic components, and reactants.
摘要翻译： 通过吡啶腈与固体多相催化剂的催化水合反应制备吡啶羧酸酰胺的改进的催化方法，其中该方法涉及催化组分和反应物的有效利用和再循环。
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4.发明申请公开(公告)号：US20100041894A1
公开(公告)日：2010-02-18
申请号：US12441042
申请日：2006-11-17
IPC分类号： C07D213/06
CPC分类号： C07D213/06
摘要： Disclosed herein is a process for recovery of pyridine and/or its derivatives from their aqueous mass and/or manufacturing reaction mass by liquid-liquid extraction employing an environmentally non-hazardous organic solvent. The process further comprising effective recovering and recycle of solvents from the aqueous phase and the other waste obtained during the process.
摘要翻译： 本文公开了一种通过使用环境无害有机溶剂的液 - 液萃取从其水性物质和/或制备反应物质中回收吡啶和/或其衍生物的方法。 该方法还包括有效地从水相中回收和循环溶剂和在该过程中获得的其它废物。
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公开(公告)号：US06939972B2
公开(公告)日：2005-09-06
申请号：US10407773
申请日：2003-04-04
IPC分类号： C07D213/74 , C07D213/02
CPC分类号： C07D213/74
摘要： An improved process for producing 4-dimethyl amino pyridine is provided. The process comprises quaternizing pyridine with a suitable quaternizing agent in the presence of organic solvent, isolating the resulting salt and aminating the salt, N-[4-pyridyl] pyridinium chloride hydrochloride, with N,N-dimethyl formamide. The resultant reaction mass is hydrolysed in the presence of a base, extracted with an aromatic solvent and distilled under vacuum to produce 4-dimethyl amino pyridine.
摘要翻译： 提供了一种改进的制备4-二甲基氨基吡啶的方法。 该方法包括在有机溶剂存在下用合适的季铵化剂季铵化吡啶，分离得到的盐，并用N，N-二甲基甲酰胺胺化盐，N- [4-吡啶基]吡啶鎓氯化物盐酸盐。 所得反应物质在碱的存在下水解，用芳族溶剂萃取并在真空下蒸馏以产生4-二甲基氨基吡啶。
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公开(公告)号：US08057643B2
公开(公告)日：2011-11-15
申请号：US12441042
申请日：2006-11-17
IPC分类号： B01D3/34 , C07D213/06
CPC分类号： C07D213/06
摘要： A process recovers of pyridine and/or its derivatives from their aqueous mass and/or manufacturing reaction mass by liquid-liquid extraction employing an alkyl acetate. The process further involves effective recovering and recycling of solvents from the aqueous phase and other waste obtained during the process.
摘要翻译： 通过使用乙酸烷基酯的液 - 液萃取从其水性物质和/或制备反应物质中回收吡啶和/或其衍生物。 该方法还涉及有效地从水相中回收和再循环溶剂和在该过程中获得的其它废物。
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7.发明授权公开(公告)号：US07745631B2
公开(公告)日：2010-06-29
申请号：US11547407
申请日：2004-06-17
IPC分类号： C07D213/02
CPC分类号： C07D213/80 , C07D213/85
摘要： The invention discloses an improved process for producing an intermediate to produce large quantity of 2-(Phenyl methyl thio)-3-pyridine carboxylic acid. The process comprises reacting 2-chloro-3-cyanopyridine with benzyl mercaptan in presence of a base and an aprotic solvent. The resulting intermediate 2-(phenyl methyl thio)-3-cyanopyridine is hydrolyzed in presence of a base in an autoclave and isolated under acidic condition to get the desired product.
摘要翻译： 本发明公开了一种生产大量2-（苯基甲基硫代）-3-吡啶羧酸的中间体的改进方法。 该方法包括在碱和非质子溶剂的存在下使2-氯-3-氰基吡啶与苯甲硫醇反应。 得到的中间体2-（苯基甲基硫代）-3-氰基吡啶在高压釜中碱存在下水解，在酸性条件下分离得到所需产物。
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8.发明申请公开(公告)号：US20080139817A1
公开(公告)日：2008-06-12
申请号：US11547407
申请日：2004-06-17
IPC分类号： C07D211/04
CPC分类号： C07D213/80 , C07D213/85
摘要： The invention discloses an improved process for producing an intermediate to produce large quantity of 2-(Phenyl methyl thio)-3-pyridine carboxylic acid. The process comprises reacting 2-chloro-3-cyanopyridine with benzyl mercaptan in presence of a base and an aprotic solvent. The resulting intermediate 2-(phenyl methyl thio)-3-cyanopyridine is hydrolyzed in presence of a base in an autoclave and isolated under acidic condition to get the desired product.
摘要翻译： 本发明公开了一种生产大量2-（苯基甲基硫代）-3-吡啶羧酸的中间体的改进方法。 该方法包括在碱和非质子溶剂的存在下使2-氯-3-氰基吡啶与苯甲硫醇反应。 得到的中间体2-（苯基甲基硫代）-3-氰基吡啶在高压釜中碱存在下水解，在酸性条件下分离得到所需产物。
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公开(公告)号：US09233955B2
公开(公告)日：2016-01-12
申请号：US13983521
申请日：2012-01-24
申请人： Deepak Bansal , Himanchal Mishra , Shailendr Kumar Dubey , Alka Srivastava Choudhary , Dharam Vir , Ashutosh Agarwal
发明人： Deepak Bansal , Himanchal Mishra , Shailendr Kumar Dubey , Alka Srivastava Choudhary , Dharam Vir , Ashutosh Agarwal
IPC分类号： C07D413/10 , C07D413/14
CPC分类号： C07D413/10 , C07D413/14
摘要： The present invention relates to an improved process for the preparation of azilsartan or its esters or salts thereof. Specifically, the invention provides a method for the preparation of highly pure methyl 1-[[2′-(4,5-dihydro-5-oxo-4H-1,2,4-oxa-diazol-3-yl)biphenyl-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylate an intermediate compound of formula (4) for azilsartan medoxomil with reduced content of desethyl impurity. The invention also involves the use of highly pure methyl 1-[[2′-(4,5-dihydro-5-oxo-4H-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylate in the preparation of azilsartan or its esters or salts thereof, preferably medoxomil with reduced content of desethyl impurity.
摘要翻译： 本发明涉及制备吖唑烷或其酯或其盐的改进方法。 具体地说，本发明提供了制备高纯度1 - [[2' - （4,5-二氢-5-氧代-4H-1,2,4-氧杂 - 二唑-3-基）联苯基] 吡啶-4-基]甲基] -2-乙氧基-1H-苯并咪唑-7-羧酸甲酯，其中式（4）的中间体化合物用于脱乙基杂质含量较低的吖唑烷酮。 本发明还涉及使用高纯度的1 - [[2' - （4,5-二氢-5-氧代-4H-1,2,4-恶二唑-3-基）联苯-4-基]甲基] -2-乙氧基-1H-苯并咪唑-7-羧酸乙酯制备吖唑烷或其酯或其盐，优选含有脱乙基杂质含量的内酯。
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公开(公告)号：US07365204B2
公开(公告)日：2008-04-29
申请号：US10806061
申请日：2004-03-22
申请人： Rajiv Kumar , Praphulla Narahar Joshi , Gopal Moreshwar Chaphekar , Prashant Suresh Niphadkar , Ashutosh Agarwal , Pradeep Kumar Verma , Kumar Samir Singh
发明人： Rajiv Kumar , Praphulla Narahar Joshi , Gopal Moreshwar Chaphekar , Prashant Suresh Niphadkar , Ashutosh Agarwal , Pradeep Kumar Verma , Kumar Samir Singh
IPC分类号： C07D213/08 , C07D213/12
CPC分类号： C07D213/08 , B01J29/89 , B01J2229/12 , B01J2229/32 , C07D213/10
摘要： An process for the preparation of pyridine and/or picolines is disclosed. The process comprises contacting a mixture of carbonyl compound with ammonia in the presence of surface-passivated titanium-silicate catalyst in gas phase at a temperature ranging between 300-500° C., at gas space velocity in the range of 300 to 3000 h−1 and at a pressure ranging between 1 to 10 atmosphere, condensing and separating the products by conventional methods and if desired, further purifying the product using well known conventional methods.
摘要翻译： 公开了制备吡啶和/或吡啶甲酸的方法。 该方法包括在表面钝化的钛硅酸盐催化剂存在下，在300-300℃的温度范围内，在300-500℃的温度范围内，使羰基化合物与氨的混合物在气相中接触， SUP> -1，并且在1至10个大气压的范围内，通过常规方法冷凝和分离产物，如果需要，使用公知的常规方法进一步纯化产物。
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