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23 条记录 (耗时 0.014 秒)

    Process For The Preparation Of Azilsartan Medoxomil
    3.
    发明申请
    Process For The Preparation Of Azilsartan Medoxomil 有权
    阿齐沙坦酯的制备方法

    公开(公告)号：US20130317230A1

    公开(公告)日：2013-11-28

    申请号：US13983521

    申请日：2012-01-24

    申请人： Deepak Bansal ,  Himanchal Mishra ,  Shailendr Kumar Dubey ,  Alka Srivastava Choudhary ,  Dharam Vir ,  Ashutosh Agarwal

    发明人： Deepak Bansal ,  Himanchal Mishra ,  Shailendr Kumar Dubey ,  Alka Srivastava Choudhary ,  Dharam Vir ,  Ashutosh Agarwal

    IPC分类号： C07D413/10

    CPC分类号： C07D413/10 ,  C07D413/14

    摘要： The present invention relates to an improved process for the preparation of azilsartan or its esters or salts thereof. Specifically, the invention provides a method for the preparation of highly pure methyl 1-[[2′-(4,5-dihydro-5-oxo-4H-1,2,4-oxa-diazol-3-yl)biphenyl-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylate an intermediate compound of formula (4) for azilsartan medoxomil with reduced content of desethyl impurity. The invention also involves the use of highly pure methyl 1-[[2′-(4,5-dihydro-5-oxo-4H-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylate in the preparation of azilsartan or its esters or salts thereof, preferably medoxomil with reduced content of desethyl impurity.

    摘要翻译： 本发明涉及制备吖唑烷或其酯或其盐的改进方法。 具体地说，本发明提供了制备高纯度1 - [[2' - （4,5-二氢-5-氧代-4H-1,2,4-氧杂 - 二唑-3-基）联苯基] 吡啶-4-基]甲基] -2-乙氧基-1H-苯并咪唑-7-羧酸甲酯，其中式（4）的中间体化合物用于脱乙基杂质含量较低的吖唑烷酮。 本发明还涉及使用高纯度的1 - [[2' - （4,5-二氢-5-氧代-4H-1,2,4-恶二唑-3-基）联苯-4-基]甲基] -2-乙氧基-1H-苯并咪唑-7-羧酸乙酯制备吖唑烷或其酯或其盐，优选含有脱乙基杂质含量的内酯。

    Process for producing 4-dimethyl amino pyridine (4-DMAP)
    6.
    发明授权
    Process for producing 4-dimethyl amino pyridine (4-DMAP) 失效
    制备4-二甲基氨基吡啶（4-DMAP）的方法

    公开(公告)号：US06939972B2

    公开(公告)日：2005-09-06

    申请号：US10407773

    申请日：2003-04-04

    申请人： Mahendra Kumar ,  Shailendra Kumar Singh ,  Ashutosh Agarwal

    发明人： Mahendra Kumar ,  Shailendra Kumar Singh ,  Ashutosh Agarwal

    IPC分类号： C07D213/74 ,  C07D213/02

    CPC分类号： C07D213/74

    摘要： An improved process for producing 4-dimethyl amino pyridine is provided. The process comprises quaternizing pyridine with a suitable quaternizing agent in the presence of organic solvent, isolating the resulting salt and aminating the salt, N-[4-pyridyl] pyridinium chloride hydrochloride, with N,N-dimethyl formamide. The resultant reaction mass is hydrolysed in the presence of a base, extracted with an aromatic solvent and distilled under vacuum to produce 4-dimethyl amino pyridine.

    摘要翻译： 提供了一种改进的制备4-二甲基氨基吡啶的方法。 该方法包括在有机溶剂存在下用合适的季铵化剂季铵化吡啶，分离得到的盐，并用N，N-二甲基甲酰胺胺化盐，N- [4-吡啶基]吡啶鎓氯化物盐酸盐。 所得反应物质在碱的存在下水解，用芳族溶剂萃取并在真空下蒸馏以产生4-二甲基氨基吡啶。

    Catalytic process for production of pyridine and picolines
    7.
    发明申请
    Catalytic process for production of pyridine and picolines 审中-公开
    用于生产吡啶和吡啶甲酸的催化方法

    公开(公告)号：US20050131235A1

    公开(公告)日：2005-06-16

    申请号：US10731440

    申请日：2003-12-10

    申请人： Ashutosh Agarwal ,  Pradeep Verma ,  Kumar Singh ,  Praphulla Joshi ,  Gopal Chaphekar ,  Prashant Niphadkar ,  Rajiv Kumar

    发明人： Ashutosh Agarwal ,  Pradeep Verma ,  Kumar Singh ,  Praphulla Joshi ,  Gopal Chaphekar ,  Prashant Niphadkar ,  Rajiv Kumar

    IPC分类号： C07D213/10 ,  C07D213/08 ,  C07D213/14

    CPC分类号： C07D213/10

    摘要： The present invention relates to a single step new catalytic process for the production of pyridine and picolines from a mixture of carbonyl compound and ammonia in the presence of zeolite catalyst with MFI topology containing Si and Zr and/or Sn as zeolite constituents in gas phase. The catalyst is preferably loaded with other metal ions such as lead, nickel, thallium or their mixture for increased yield. Present invention provides the novel use of above mentioned zeolite catalysts for the production of picolines for the first time, with improved yield of desired products picolines.

    摘要翻译： 本发明涉及在气相中含有Si和Zr和/或Sn作为沸石成分的MFI拓扑结构的沸石催化剂存在下由羰基化合物和氨的混合物制备吡啶和吡啶类的单步新催化方法。 催化剂优选负载其它金属离子如铅，镍，铊或它们的混合物以提高产率。 本发明提供了上述沸石催化剂首次用于生产吡啶甲酸的新颖应用，并提高了所需产物吡啶的产率。

    Process for the preparation of azilsartan medoxomil
    8.
    发明授权
    Process for the preparation of azilsartan medoxomil 有权
    制备吖唑烷酯的方法

    公开(公告)号：US09233955B2

    公开(公告)日：2016-01-12

    申请号：US13983521

    申请日：2012-01-24

    申请人： Deepak Bansal ,  Himanchal Mishra ,  Shailendr Kumar Dubey ,  Alka Srivastava Choudhary ,  Dharam Vir ,  Ashutosh Agarwal

    发明人： Deepak Bansal ,  Himanchal Mishra ,  Shailendr Kumar Dubey ,  Alka Srivastava Choudhary ,  Dharam Vir ,  Ashutosh Agarwal

    IPC分类号： C07D413/10 ,  C07D413/14

    CPC分类号： C07D413/10 ,  C07D413/14

    摘要： The present invention relates to an improved process for the preparation of azilsartan or its esters or salts thereof. Specifically, the invention provides a method for the preparation of highly pure methyl 1-[[2′-(4,5-dihydro-5-oxo-4H-1,2,4-oxa-diazol-3-yl)biphenyl-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylate an intermediate compound of formula (4) for azilsartan medoxomil with reduced content of desethyl impurity. The invention also involves the use of highly pure methyl 1-[[2′-(4,5-dihydro-5-oxo-4H-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylate in the preparation of azilsartan or its esters or salts thereof, preferably medoxomil with reduced content of desethyl impurity.

    摘要翻译： 本发明涉及制备吖唑烷或其酯或其盐的改进方法。 具体地说，本发明提供了制备高纯度1 - [[2' - （4,5-二氢-5-氧代-4H-1,2,4-氧杂 - 二唑-3-基）联苯基] 吡啶-4-基]甲基] -2-乙氧基-1H-苯并咪唑-7-羧酸甲酯，其中式（4）的中间体化合物用于脱乙基杂质含量较低的吖唑烷酮。 本发明还涉及使用高纯度的1 - [[2' - （4,5-二氢-5-氧代-4H-1,2,4-恶二唑-3-基）联苯-4-基]甲基] -2-乙氧基-1H-苯并咪唑-7-羧酸乙酯制备吖唑烷或其酯或其盐，优选含有脱乙基杂质含量的内酯。