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1.发明授权Ionic molecular conjugates of N-acylated derivatives of poly(2-amino-2-deoxy-D-glucose) and polypeptides 失效聚（2-氨基-2-脱氧-D-葡萄糖）N-酰化衍生物和多肽的离子分子共轭物公开(公告)号：US06794364B2
公开(公告)日：2004-09-21
申请号：US10251018
申请日：2002-09-20
申请人： Shalaby W. Shalaby , Steven A. Jackson , Francis X. Ignatious , Jacques-Pierre Moreau , Ruth M. Russell
发明人： Shalaby W. Shalaby , Steven A. Jackson , Francis X. Ignatious , Jacques-Pierre Moreau , Ruth M. Russell
IPC分类号： A61K3800
CPC分类号： C08B37/003 , A61K38/31 , A61K47/61 , C08L5/08 , C08L2666/02
摘要： A copolymer comprising an N-acylated derivative, and a composition comprising said copolymer and a polypeptide, said polypeptide comprising at least one effective ionogenic amine, wherein at least 50 percent, by weight, of said polypeptide present in said composition is ionically bound to said polymer.
摘要翻译： 包含N-酰化衍生物的共聚物和包含所述共聚物和多肽的组合物，所述多肽包含至少一种有效的离子型胺，其中存在于所述组合物中的所述多肽的至少50重量％离子地结合到所述 聚合物。
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公开(公告)号：US07005420B2
公开(公告)日：2006-02-28
申请号：US10900220
申请日：2004-07-27
申请人： Shalaby W. Shalaby , Ruth M. Russell , Jacques-Pierre Moreau , Steven A. Jackson , Francis X. Ignatious
发明人： Shalaby W. Shalaby , Ruth M. Russell , Jacques-Pierre Moreau , Steven A. Jackson , Francis X. Ignatious
IPC分类号： A61K38/00
CPC分类号： C08B37/003 , A61K38/31 , A61K47/61 , C08L5/08 , C08L2666/02
摘要： A copolymer comprising an N-acylated derivative, and a composition comprising said copolymer and a polypeptide, said polypeptide comprising at least one effective ionogenic amine, wherein at least 50 percent, by weight, of said polypeptide present in said composition is ionically bound to said polymer.
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3.发明授权Ionic molecular conjugates of N-acylated derivatives of poly(2-amino-2-deoxy-D-glucose) and polypeptides 失效聚（2-氨基-2-脱氧-D-葡萄糖）N-酰化衍生物和多肽的离子分子共轭物公开(公告)号：US06479457B2
公开(公告)日：2002-11-12
申请号：US09169423
申请日：1998-10-09
申请人： Shalaby W. Shalaby , Steven A. Jackson , Francis X. Ignatious , Jacques-Pierre Moreau , Ruth M. Russell
发明人： Shalaby W. Shalaby , Steven A. Jackson , Francis X. Ignatious , Jacques-Pierre Moreau , Ruth M. Russell
IPC分类号： A61K3812
CPC分类号： C08B37/003 , A61K38/31 , A61K47/61 , C08L5/08 , C08L2666/02
摘要： A copolymer comprising an N-acylated derivative, and a composition comprising said copolymer and a polypeptide, said polypeptide comprising at least one effective ionogenic amine, wherein at least 50 percent, by weight, of said polypeptide present in said composition is ionically bound to said polymer.
摘要翻译： 包含N-酰化衍生物的共聚物和包含所述共聚物和多肽的组合物，所述多肽包含至少一种有效的离子型胺，其中存在于所述组合物中的所述多肽的至少50重量％离子地结合到所述 聚合物。
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4.发明授权Ionic molecular conjugates of N-acylated derivatives of poly(2-amino-2-deoxy-D-glucose) and polypeptides 失效聚（2-氨基-2-脱氧-D-葡萄糖）N-酰化衍生物和多肽的离子分子共轭物
公开(公告)号：US5665702A
公开(公告)日：1997-09-09
申请号：US468947
申请日：1995-06-06
IPC分类号： C07H5/04 , A61K38/04 , A61K38/14 , A61K38/31 , A61K47/48 , A61P35/00 , C07D407/14 , C07H5/06 , C07H13/02 , C07H17/04 , C07K9/00 , C08B37/00 , C08B37/08 , C08L5/00 , A61K38/12
CPC分类号： C08B37/003 , A61K38/31
摘要： A copolymer comprising an N-acylated derivative, and a composition comprising said copolymer and a polypeptide, said polypeptide comprising at least one effective ionogenic amine, wherein at least 50 percent, by weight, of said polypeptide present in said composition is ionically bound to said polymer.
摘要翻译： 包含N-酰化衍生物的共聚物和包含所述共聚物和多肽的组合物，所述多肽包含至少一种有效的离子型胺，其中存在于所述组合物中的所述多肽的至少50重量％离子地结合到所述 聚合物。
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5.发明授权Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides 失效生物降解聚酯和生物活性多肽的离子分子共轭物
公开(公告)号：US5863985A
公开(公告)日：1999-01-26
申请号：US867308
申请日：1997-06-02
IPC分类号： A61K38/00 , C07K14/655 , A61K9/16 , A61K9/52 , A61K37/02
CPC分类号： C07K14/655 , A61K38/00 , Y10S514/80 , Y10S514/806 , Y10S514/807 , Y10S514/808 , Y10S514/809
摘要： Disclosed is a sustained release pharmaceutical composition. The composition includes a polyester containing a free COOH group ionically conjugated with a bioactive polypeptide comprising at least one effective ionogenic amine, wherein at least 50% by weight of the polypeptide present in the composition is ionically conjugated to the polyester.
摘要翻译： 公开了缓释药物组合物。 所述组合物包括含有游离COOH基团的聚酯，所述游离COOH基团与包含至少一种有效的离子型胺的生物活性多肽离子地缀合，其中所述组合物中存在的多肽的至少50重量％与所述聚酯离子共轭。
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6.发明授权Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides 失效生物降解聚酯和生物活性多肽的离子分子共轭物
公开(公告)号：US5672659A
公开(公告)日：1997-09-30
申请号：US464735
申请日：1995-06-29
CPC分类号： A61K47/482 , A61K47/48284 , C07K7/23 , A61K38/00 , Y10S514/80 , Y10S514/806 , Y10S514/807 , Y10S514/808 , Y10S514/809 , Y10S514/963
摘要： A composition including a polyester containing one or more free COOH groups ionically conjugated with a bioactive polypeptide comprising at least one effective ionogenic amine, wherein the polyester contains a member selected from the group of L-lactic acid, D-lactic acid, DL-lactic acid, .epsilon.-caprolactone, p-dioxanone, .epsilon.-caprolic acid, alkylene oxalate, cycloalkylene oxalate, alkylene succinate, .beta.-hydroxybutyrate, substituted or unsubstituted trimethylene carbonate, 1,5-dioxopan-2-one, 1,4-dioxepan-2-one, glycolide, glycolic acid, L-lactide, D-lactide, DL-lactide, meso-lactide, and any optically active isomers, racemates or copolymers thereof, and at least 50%, by weight, of the polypeptide present in the composition is ionically conjugated to said polyester.
摘要翻译： PCT No.PCT / US94 / 00148 Sec。 371日期：1995年6月29日 102（e）日期1995年6月29日PCT 1994年1月5日PCT PCT。 出版物WO94 / 15587 日期1994年7月21日包含含有一种或多种游离COOH基团的组合物的组合物，所述游离COOH基团与包含至少一种有效的离子型胺的生物活性多肽离子地缀合，其中所述聚酯包含选自L-乳酸，D-乳酸 酸，DL-乳酸，ε-己内酯，对二恶烷酮，ε-己内酯，草酸亚烷基酯，草酸亚环烷基酯，琥珀酸亚烷基酯，β-羟基丁酸酯，取代或未取代的三亚甲基碳酸亚乙酯，1,5-二氧杂戊-2-酮，1 ，4-二氧杂环庚烷-2-酮，乙交酯，乙醇酸，L-丙交酯，D-丙交酯，DL-丙交酯，内消旋丙交酯及其任何光学活性异构体，外消旋体或其共聚物，和至少50重量％ 存在于组合物中的多肽与所述聚酯离子共轭。
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公开(公告)号：US5821221A
公开(公告)日：1998-10-13
申请号：US929363
申请日：1997-09-09
IPC分类号： C07H5/04 , A61K38/04 , A61K38/14 , A61K38/31 , A61K47/48 , A61P35/00 , C07D407/14 , C07H5/06 , C07H13/02 , C07H17/04 , C07K9/00 , C08B37/00 , C08B37/08 , C08L5/00 , A61K38/00
CPC分类号： C08B37/003 , A61K38/31
摘要： A copolymer comprising an N-acylated derivative, and a composition comprising said copolymer and a polypeptide, said polypeptide comprising at least one effective ionogenic amine, wherein at least 50 percent, by weight, of said polypeptide present in said composition is ionically bound to said polymer.
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8.发明授权Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides 失效生物降解聚酯和生物活性多肽的离子分子共轭物公开(公告)号：US06867181B1
公开(公告)日：2005-03-15
申请号：US09890013
申请日：2000-01-26
CPC分类号： C08G63/64 , A61K47/593 , C07K14/655 , C08G63/08 , Y10S514/80 , Y10S514/806 , Y10S514/807 , Y10S514/808 , Y10S514/809
摘要： A method of spherifying a sustained release ionic conjugate which contains a free carboxyl group-containing polymer and a free amino group-containing drug which are ionically bonded to each other.
摘要翻译： 一种使包含游离含羧基的聚合物和游离氨基的药物彼此离子键合的持续释放离子缀合物的球化方法。
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9.发明授权Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides 失效生物降解聚酯和生物活性多肽的离子分子共轭物公开(公告)号：US06221958B1
公开(公告)日：2001-04-24
申请号：US09237405
申请日：1999-01-26
IPC分类号： A61K916
CPC分类号： C07K7/23 , A61K38/00 , A61K47/593 , C07K14/655 , C08G63/06 , C08G63/08 , C08G63/64 , Y10S514/80 , Y10S514/806 , Y10S514/807 , Y10S514/808 , Y10S514/809
摘要： Disclosed is a sustained release pharmaceutical composition. The composition includes a polyester containing a free COOH group ionically conjugated with a bioactive polypeptide comprising at least one effective ionogenic amine, wherein at least 50% by weight of the polypeptide present in the composition is ionically conjugated to the polyester.
摘要翻译： 公开了缓释药物组合物。 所述组合物包括含有游离COOH基团的聚酯，所述游离COOH基团与包含至少一种有效的离子型胺的生物活性多肽离子地缀合，其中所述组合物中存在的多肽的至少50重量％与所述聚酯离子共轭。
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公开(公告)号：US20100279922A1
公开(公告)日：2010-11-04
申请号：US11988533
申请日：2006-07-10
IPC分类号： A61K38/12 , C07K7/54 , A61P29/00 , A61P19/02 , A61P3/04 , A61P35/00 , A61P9/00 , A61P11/06 , A61P17/06 , A61P17/02 , A61P17/10 , A61P25/22 , A61P25/24 , A61P37/06 , A61P5/00 , A61P15/00 , A61P25/32
CPC分类号： C07K7/06 , A61K38/00 , C07K7/08 , C07K14/665
摘要： The present invention is directed to compounds according to formula, (R2R3)-A1-c(A2-A3-A4-A5-A6-A7-A8-A9)-A10-R1, and pharmaceutically-acceptable salts thereof that act as ligands for one or more of the melanocortin receptors, to methods of using such compounds to treat mammals and to pharmaceutical compositions comprising said compounds.
摘要翻译： 本发明涉及下式的化合物：（R2R3）-A1-c（A2-A3-A4-A5-A6-A7-A8-A9）-A10-R1及其药物上可接受的盐作为配体 对于一种或多种黑皮质素受体，使用这些化合物治疗哺乳动物的方法和包含所述化合物的药物组合物。
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