公开(公告)号：US20230151408A1

公开(公告)日：2023-05-18

申请号：US17580176

申请日：2022-01-20

Applicant: Shanghai Tianma Micro-Electronics Co., Ltd.

Inventor： Baiquan LIN ,  Kerui XI ,  Kaidi ZHANG ,  Wei LI ,  Yunfei BAI ,  Ping SU ,  Junting OUYANG

IPC: C12Q1/6825 ,  G01N27/414

CPC classification number: C12Q1/6825 ,  G01N27/4145

Abstract: A gene sequencing structure, a gene sequencing device and a gene sequencing method are provided. The gene sequencing structure includes a substrate, a thin-film transistor array layer located on the substrate and including thin-film transistors that include a first electrode, and a second electrode; an ion-sensitive layer located on a side of the semiconductor layer away from the substrate; a micro-hole layer located on a side of the ion-sensitive layer away from the substrate, including a through-hole passing through the micro-hole layer, at least partially overlapping the semiconductor layer, and used for receiving a to-be-tested single-stranded nucleic acid inside; a conductive structure, located on a side of the layer away from the substrate and electrically connected to the first electrode or the second electrode; and a detection chip, located on a side of the conductive structure away from the substrate and electrically connected to the conductive structure.

公开(公告)号：US20200306750A1

公开(公告)日：2020-10-01

申请号：US16438796

申请日：2019-06-12

Applicant: Shanghai Tianma Micro-Electronics Co.,Ltd.

Inventor： Baiquan LIN ,  Kerui XI ,  Junting OUYANG ,  Jinyu LI ,  Xiaohe LI

IPC: B01L3/00 ,  B01F13/00

Abstract: An electrowetting panel includes a base substrate; an electrode array layer, including a plurality of electrodes arranged into an array; an insulating hydrophobic layer; a microfluidic channel layer located on the base substrate. Each electrode of the plurality of electrodes is connected to a driving circuit, and a droplet can move along a first direction by applying an electric voltage on each electrode. The insulating hydrophobic layer is located on the electrode array layer, and the microfluidic channel layer is located on the insulating hydrophobic layer. The electrodes includes a plurality of driving electrodes and a plurality of detecting electrodes. Along the first direction, a number N of the driving electrodes is located between every two adjacent detecting electrodes, where N is a natural number. The electrowetting panel also includes a detecting chip electrically connected to the detecting electrodes.

公开(公告)号：US20240165616A1

公开(公告)日：2024-05-23

申请号：US17758359

申请日：2021-06-30

Applicant: Shanghai Tianma Micro-Electronics Co., Ltd.

Inventor： Baiquan LIN ,  Kerui XI ,  Yunfei BAI ,  Wei LI ,  Dengming LEI ,  Zhen LIU ,  Zhenyu JIA ,  Junting OUYANG

IPC: B01L3/00

CPC classification number: B01L3/50273 ,  B01L2200/10 ,  B01L2300/0645 ,  B01L2400/0427

Abstract: Provided is a microfluidic chip. The microfluidic chip includes a first substrate and a second substrate disposed opposite to each other and drive electrodes, first sensing electrodes and second sensing electrodes disposed on a side of the first substrate. A microfluidic channel is formed between the first substrate and the second substrate and configured to accommodate at least one droplet. Different drive voltage signals are applied to adjacent drive electrodes, so as to drive the at least one droplet to move. Detection signals are applied to the first sensing electrodes and the second sensing electrodes, and a position of the at least one droplet is determined according to a change in capacitance between one first sensing electrode and an electrode corresponding thereto and a change in capacitance between one second sensing electrode and an electrode corresponding thereto when the at least one droplet flows by.

公开(公告)号：US20240165610A1

公开(公告)日：2024-05-23

申请号：US17758357

申请日：2021-07-19

Applicant: Shanghai Tianma Micro-Electronics Co., Ltd.

Inventor： Baiquan LIN ,  Kerui XI ,  Ping SU ,  Linzhi WANG ,  Yian ZHOU ,  Feng QIN ,  Junting OUYANG

IPC: B01L3/00

CPC classification number: B01L3/502715 ,  B01L2300/0645 ,  B01L2400/0427

Abstract: Provided is a microfluidic chip. The microfluidic chip includes a first substrate and a second substrate disposed opposite to each other, a microfluidic channel formed between the first substrate and the second substrate and configured to accommodate at least one droplet, drive electrodes arranged in an array and sensing electrodes disposed on a side of the first substrate. Each sensing electrode includes at least one first branch electrode and at least one second branch electrode. The first branch electrode extends along a first direction, and the second branch electrode extends along a second direction. Different drive voltage signals are applied to adjacent drive electrodes to drive the droplet to move. Detection signals are applied to the sensing electrodes, and a position of the droplet is determined according to a change in capacitance between one sensing electrode and an electrode corresponding thereto when the droplet flows by.