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    FLUORESCENCE DETECTION SYSTEM
    5.
    发明申请
    FLUORESCENCE DETECTION SYSTEM 审中-公开
    荧光检测系统

    公开(公告)号：US20090234225A1

    公开(公告)日：2009-09-17

    申请号：US12352408

    申请日：2009-01-12

    申请人： Edward W. Martin ,  Ronald X. Xu ,  Duxin Sun ,  Stephen P. Povoski ,  Joseph Pierre Heremans ,  Robert Lee ,  Vish V. Subramaniam ,  Claudia Turro

    发明人： Edward W. Martin ,  Ronald X. Xu ,  Duxin Sun ,  Stephen P. Povoski ,  Joseph Pierre Heremans ,  Robert Lee ,  Vish V. Subramaniam ,  Claudia Turro

    IPC分类号： A61B6/00 ,  A61K49/00

    CPC分类号： G01N21/6456 ,  G01N21/6428 ,  G01N33/57469 ,  G01N33/582

    摘要： Exemplary embodiments include systems, methods, and compositions for the intra-operative detection of target tissue. At least one embodiment includes a fluorescence detection instrument that may be used for intra-operative detection of a fluorescent targeting agent, its binding site, and its interaction within cancer tissues. An exemplary embodiment is highly sensitive to the local deposition of fluorescence agents even at a low concentration. In at least one embodiment, the system includes a handheld navigation instrument that is usable to excite, detect, and report the fluorescent deposition of the targeting agent in real-time. In alternative embodiments, the system includes a wearable unit to excite, detect, and visually report the fluorescent deposition of the targeting agent to the user. The wearable unit includes eyewear that allow the user to perform image-guided surgery based on the near real-time fluorescence detection of the fluorescent targeting agent.

    摘要翻译： 示例性实施方案包括用于目标组织的术中检测的系统，方法和组合物。 至少一个实施方案包括可用于术中检测荧光靶向剂，其结合位点及其在癌组织内的相互作用的荧光检测仪器。 一个示例性实施方案即使在低浓度下也对荧光剂的局部沉积高度敏感。 在至少一个实施例中，该系统包括可用于实时地激发，检测和报告靶向剂的荧光沉积的手持式导航仪器。 在替代实施例中，系统包括可佩戴单元，以激发，检测和视觉报告目标剂对用户的荧光沉积。 可穿戴单元包括允许用户基于荧光靶向剂的近实时荧光检测来执行图像引导手术的眼镜。

    Solid dosage formulation containing a Factor Xa inhibitor and method
    6.
    发明申请
    Solid dosage formulation containing a Factor Xa inhibitor and method 审中-公开
    含有因子Xa抑制剂和方法的固体剂量制剂

    公开(公告)号：US20050059719A1

    公开(公告)日：2005-03-17

    申请号：US10924043

    申请日：2004-08-23

    申请人： Sherif Badawy ,  Munir Hussain ,  Duxin Sun

    发明人： Sherif Badawy ,  Munir Hussain ,  Duxin Sun

    IPC分类号： A61K9/20 ,  A61K31/42

    CPC分类号： A61K9/2054 ,  A61K31/42

    摘要： An oral solid dosage formulation is provided which contains a Factor Xa inhibitor for which oral bioavailability is not reduced by co-administration of antacids, H2 antagonists and proton pump inhibitors. Such solid dosage formulation includes the Factor Xa inhibitor of the structure, a pharmaceutically acceptable carrier, and an acid component, such as tartaric acid, whereby upon ingestion of the oral solid dosage formulation, the acid component increases solubility of the Factor Xa inhibitor in the local environment of the dissolving solid dosage formulation resulting in an otherwise lower degree of supersaturation of the Factor Xa inhibitor in such environment, than if the acid were not present. The result is that precipitation of the Factor Xa inhibitor in the form of its insoluble free base is minimized during dissolution of the Factor Xa inhibitor thereby increasing its oral bioavailability. A method for enhancing bioavailability of the Factor Xa inhibitor is also provided wherein an acid such as tartaric acid is incorporated with the solid dosage pharmaceutical carrier for the Factor Xa inhibitor.

    摘要翻译： 提供口服固体剂量制剂，其含有通过共同给予抗酸剂，H 2拮抗剂和质子泵抑制剂而不降低口服生物利用度的因子Xa抑制剂。 这种固体剂量制剂包括结构的因子Xa抑制剂，药学上可接受的载体和酸组分，例如酒石酸，由此，在摄取口服固体剂量制剂后，酸组分增加因子Xa抑制剂在 溶解固体剂量制剂的局部环境导致因素Xa抑制剂在这种环境中的过饱和程度低于不存在酸的情况。 结果是在因子Xa抑制剂的溶解过程中，其不溶性游离碱形式的因子Xa抑制剂的沉淀被最小化，从而增加其口服生物利用度。 还提供了用于提高因子Xa抑制剂的生物利用度的方法，其中将诸如酒石酸的酸与用于因子Xa抑制剂的固体剂量药物载体结合。

    ELECTROMAGNETIC SYSTEM AND METHOD
    7.
    发明申请
    ELECTROMAGNETIC SYSTEM AND METHOD 审中-公开
    电磁系统与方法

    公开(公告)号：US20120035457A1

    公开(公告)日：2012-02-09

    申请号：US13210293

    申请日：2011-08-15

    申请人： Vishwanath Subramaniam ,  Joseph West ,  Jennifer McFerran Brock ,  Emily Sequin ,  Duxin Sun ,  Peng Zou

    发明人： Vishwanath Subramaniam ,  Joseph West ,  Jennifer McFerran Brock ,  Emily Sequin ,  Duxin Sun ,  Peng Zou

    IPC分类号： A61B5/053 ,  A61B5/05 ,  A61N2/02

    CPC分类号： A61B5/05 ,  A61B5/415 ,  A61B5/418

    摘要： Differences of electromagnetic (EM) properties between healthy and cancerous tissues allow detection of abnormal conditions occurring in a tissue of an animal, for example, intra-operative cancer detection. By using a time-varying EM field, electrical eddy currents are generated in the tissue sample, and assessed using phase-sensitive detection. In some aspects, a change in phase shift between the voltage in a receiver coil and the voltage in a driver coil provide a direct and immediate indication of differences in EM properties of specimens.

    摘要翻译： 健康和癌组织之间的电磁（EM）特性的差异允许检测动物组织中发生的异常状况，例如手术前癌症检测。 通过使用时变EM场，在组织样品中产生电涡流，并使用相敏检测进行评估。 在一些方面，接收器线圈中的电压和驱动器线圈中的电压之间的相移的变化提供了样品的EM性质的差异的直接和即时的指示。