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公开(公告)号：US20070225206A1
公开(公告)日：2007-09-27
申请号：US11573711
申请日：2005-08-12
申请人： Shari Ling , Lorah Perlee , Velizar Tchernev , Serguei Lejnine , Dhavalkumar Patel , Luigi Ferrucci , Ming Zhan
发明人： Shari Ling , Lorah Perlee , Velizar Tchernev , Serguei Lejnine , Dhavalkumar Patel , Luigi Ferrucci , Ming Zhan
IPC分类号： G01N33/68
CPC分类号： G01N33/54366 , C12Q1/6883 , C12Q2600/112 , C12Q2600/158 , G01N33/6887 , G01N33/6893 , G01N2800/105
摘要： Methods are provided for evaluating osteoarthritis (OA), for example for diagnosing OA, to confirm a diagnosis of OA, to assess or prognose progression of OA, determining the severity of a subject who has OA, and determining a subject's risk of developing OA in the future, as are arrays and kits that can be used to practice the methods. In particular examples, the method includes determining an amount of activity (such as an amount of protein present or an amount of expression) of OA risk-related molecules, such as soluble vascular adhesion protein 1 (sVAP-1) or interleukin-15 (IL-15). Also provided are methods of identifying one or more compounds that alter the activity of an OA-related molecule, thereby identifying potential anti-osteoarthritis drugs.
摘要翻译： 提供了用于评价骨关节炎（OA）的方法，例如用于诊断OA，确认OA的诊断，评估或预测OA的进展，确定具有OA的受试者的严重程度，以及确定受试者发生OA的风险 未来，以及可用于实践方法的数组和工具包。 在具体实例中，该方法包括确定OA风险相关分子（例如可溶性血管粘附蛋白1（sVAP-1））或白细胞介素-15（活性）的活性量（例如存在的蛋白质的量或表达量） IL-15）。 还提供了鉴定一种或多种改变OA相关分子的活性的化合物的方法，从而鉴定潜在的抗骨关节炎药物。
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公开(公告)号：US20060204986A1
公开(公告)日：2006-09-14
申请号：US11353025
申请日：2006-02-14
申请人： Barton Haynes , Dhavalkumar Patel , Munir Alam , Hua-Xin Liao
发明人： Barton Haynes , Dhavalkumar Patel , Munir Alam , Hua-Xin Liao
CPC分类号： C07K16/1063 , A61K39/12 , A61K39/21 , A61K47/646 , A61K47/6841 , A61K2039/505 , C07K14/005 , C07K2317/76 , C12N2710/24143 , C12N2740/16122 , C12N2740/16134 , Y10S530/826
摘要： The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralize a wide spectrum of HIV primary isolates. The invention also relates to a method of inducing anti-HIV antibodies using same.
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公开(公告)号：US08609268B2
公开(公告)日：2013-12-17
申请号：US13329086
申请日：2011-12-16
申请人： Jason D. Fuhr , Kem M. Obasih , Richard Mark De Keuster , Robert J. Mack , Gary P. Houchin-Miller , Dhavalkumar Patel
发明人： Jason D. Fuhr , Kem M. Obasih , Richard Mark De Keuster , Robert J. Mack , Gary P. Houchin-Miller , Dhavalkumar Patel
CPC分类号： H01M10/613 , H01M2/1077 , H01M2/12 , H01M2/1252 , H01M10/0525 , H01M10/615 , H01M10/625 , H01M10/643 , H01M10/647 , H01M10/653 , H01M10/6551 , H01M10/6554 , H01M10/6556 , H01M10/6563 , H01M10/6565 , H01M10/6567
摘要： A battery module includes a plurality of electrochemical cells and a structure including an upper portion configured to support a bottom portion of each of the plurality of electrochemical cells and a lower portion coupled to the upper portion. The lower portion includes a thermal management feature having at least one passage provided therein. The passage is configured for a thermal management fluid to pass therethrough to provide thermal management to the electrochemical cells of the battery module.
摘要翻译： 电池模块包括多个电化学电池和包括被配置为支撑多个电化学电池单元中的每一个的底部的上部的结构和联接到上部的下部。 下部包括具有设置在其中的至少一个通道的热管理特征。 通道构造成用于热管理流体通过，从而为电池模块的电化学电池提供热管理。
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公开(公告)号：US20120148889A1
公开(公告)日：2012-06-14
申请号：US13329086
申请日：2011-12-16
申请人： Jason D. Fuhr , Kem M. Obasih , Richard Mark De Keuster , Robert J. Mack , Gary P. Houchin-Miller , Dhavalkumar Patel
发明人： Jason D. Fuhr , Kem M. Obasih , Richard Mark De Keuster , Robert J. Mack , Gary P. Houchin-Miller , Dhavalkumar Patel
CPC分类号： H01M10/613 , H01M2/1077 , H01M2/12 , H01M2/1252 , H01M10/0525 , H01M10/615 , H01M10/625 , H01M10/643 , H01M10/647 , H01M10/653 , H01M10/6551 , H01M10/6554 , H01M10/6556 , H01M10/6563 , H01M10/6565 , H01M10/6567
摘要： A battery module includes a plurality of electrochemical cells and a structure including an upper portion configured to support a bottom portion of each of the plurality of electrochemical cells and a lower portion coupled to the upper portion. The lower portion includes a thermal management feature having at least one passage provided therein. The passage is configured for a thermal management fluid to pass therethrough to provide thermal management to the electrochemical cells of the battery module
摘要翻译： 电池模块包括多个电化学电池和包括被配置为支撑多个电化学电池单元中的每一个的底部的上部的结构和联接到上部的下部。 下部包括具有设置在其中的至少一个通道的热管理特征。 通道构造成用于热管理流体通过，从而为电池模块的电化学电池提供热管理
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公开(公告)号：US20080254482A1
公开(公告)日：2008-10-16
申请号：US11944254
申请日：2007-11-21
IPC分类号： G01N33/564
CPC分类号： G01N33/564 , G01N2800/102 , G01N2800/104
摘要： Provided herein are novel panels of biomarkers for the diagnosis of autoimmune diseases, and methods and kits for detecting these biomarkers in samples of individuals suspected of having an autoimmune disease. Also provided are methods of monitoring the progression of an autoimmune disease and methods of monitoring the efficacy and side effects of a treatment for an autoimmune disease.
摘要翻译： 本文提供了用于诊断自身免疫疾病的生物标志物的新颖小组，以及用于在疑似患有自身免疫疾病的个体的样品中检测这些生物标志物的方法和试剂盒。 还提供了监测自身免疫疾病进展的方法以及监测自身免疫疾病治疗的功效和副作用的方法。
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公开(公告)号：US5968768A
公开(公告)日：1999-10-19
申请号：US432016
申请日：1995-05-01
IPC分类号： G01N33/53 , A61K38/00 , A61P37/06 , C07K14/705 , C07K14/725 , C07K16/28 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/00 , C12R1/91
CPC分类号： C07K14/70503 , C07K16/2803 , A61K38/00 , C07K2319/30
摘要： The present invention relates to an isolated nucleic acid molecule having a sequence that encodes a CD6 ligand present on the surface of thymic epithelial cells, monocytes, activated T cells and a variety of other cell types. The invention further relates to a construct containing the nucleic acid molecule and to a host cell comprising same. Further, the invention relates to a method of producing a CD6 ligand.
摘要翻译： 本发明涉及具有编码存在于胸腺上皮细胞，单核细胞，活化的T细胞和多种其他细胞类型的表面上的CD6配体的序列的分离的核酸分子。 本发明还涉及包含核酸分子的构建体和包含该核酸分子的宿主细胞。 此外，本发明涉及一种制备CD6配体的方法。
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公开(公告)号：US5578468A
公开(公告)日：1996-11-26
申请号：US113646
申请日：1993-08-31
IPC分类号： C12N15/863 , C12N15/10 , C12N1/21 , C12N5/10 , C12N15/11
CPC分类号： C12N15/86 , C12N2710/24143
摘要： The present invention relates to a method of effecting site-specific cleavage of RNA and to an element and a factor responsible for such cleavage.
摘要翻译： 本发明涉及实现RNA和元件的位点特异性切割以及造成这种切割的因素的方法。
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公开(公告)号：US20120004130A1
公开(公告)日：2012-01-05
申请号：US13153262
申请日：2011-06-03
IPC分类号： C40B30/04 , C40B40/10 , G01N33/566
CPC分类号： G01N33/564 , G01N2800/102 , G01N2800/104
摘要： Provided herein are novel panels of biomarkers for the diagnosis of autoimmune diseases, and methods and kits for detecting these biomarkers in samples of individuals suspected of having an autoimmune disease. Also provided are methods of monitoring the progression of an autoimmune disease and methods of monitoring the efficacy and side effects of a treatment for an autoimmune disease.
摘要翻译： 本文提供了用于诊断自身免疫疾病的生物标志物的新颖小组，以及用于在疑似患有自身免疫疾病的个体的样品中检测这些生物标志物的方法和试剂盒。 还提供了监测自身免疫疾病进展的方法以及监测自身免疫疾病治疗的功效和副作用的方法。
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公开(公告)号：US5723437A
公开(公告)日：1998-03-03
申请号：US333350
申请日：1994-11-02
IPC分类号： G01N33/53 , A61K38/00 , C07K14/705 , C07K16/28 , C12N5/06 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/02 , C12R1/91 , G01N33/566 , A61K38/17 , C07K14/435
CPC分类号： C07K16/2803 , C07K14/705 , A61K38/00 , C07K2319/00 , C07K2319/30
摘要： The present invention relates, in general, to CD6 and, in particular, to a CD6 ligand present on the surface of thymic epithelial cells, monocytes, activated T cells and a variety of other cells types. The invention further relates to methods of inhibiting the interaction of CD6 and the CD6 ligand, and to the methods of screening componunds for their ability to inhibit that interaction.
摘要翻译： 本发明一般涉及CD6，特别是涉及存在于胸腺上皮细胞，单核细胞，活化的T细胞和多种其他细胞类型的表面上的CD6配体。 本发明还涉及抑制CD6和CD6配体相互作用的方法，以及筛选组分抑制该相互作用的能力的方法。
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