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48 条记录 (耗时 0.075 秒)

    O-linked glycosylation of peptides
    1.
    发明申请
    O-linked glycosylation of peptides 有权
    肽的O-连接糖基化

    公开(公告)号：US20090169509A1

    公开(公告)日：2009-07-02

    申请号：US10585385

    申请日：2005-01-10

    申请人： Shawn DeFrees ,  David A. Zopf ,  Zhi-Guang Wang ,  Henrik Clausen

    发明人： Shawn DeFrees ,  David A. Zopf ,  Zhi-Guang Wang ,  Henrik Clausen

    IPC分类号： A61K38/21 ,  C07K7/00 ,  C07K14/00 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06 ,  C12P21/02 ,  A61K38/16

    CPC分类号： A61K38/193 ,  C07K1/1077 ,  C07K9/00 ,  C07K9/001 ,  C07K14/535

    摘要： The present invention provides polypeptides that include an O-linked glycosylation site that is not present in the wild-type peptide. The polypeptides of the invention include glycoconjugates in which a species such as a water-soluble polymer, a therapeutic agent of a biomolecule is covalently linked through an intact O-linked glycosyl residue to the polypeptide. Also provided are methods of making the peptides of the invention and methods, pharmaceutical compositions containing the peptides and methods of treating, ameliorating or preventing diseased in mammals by administering an amount of a peptide of the invention sufficient to achieve the desired response.

    摘要翻译： 本发明提供了包含在野生型肽中不存在的O-连接的糖基化位点的多肽。 本发明的多肽包括糖缀合物，其中诸如水溶性聚合物的物质，生物分子的治疗剂通过完整的O连接的糖基残基与多肽共价连接。 还提供了制备本发明的肽和方法的方法，含有肽的药物组合物和通过施用足够达到所需反应的量的本发明的肽来治疗，改善或预防哺乳动物患病的方法。

    O-linked glycosylation of peptides
    2.
    发明授权
    O-linked glycosylation of peptides 有权
    肽的O-连接糖基化

    公开(公告)号：US07338933B2

    公开(公告)日：2008-03-04

    申请号：US11033365

    申请日：2005-01-10

    申请人： Shawn DeFrees ,  David A. Zopf ,  Zhi-Guang Wang ,  Henrik Clausen

    发明人： Shawn DeFrees ,  David A. Zopf ,  Zhi-Guang Wang ,  Henrik Clausen

    IPC分类号： A61K38/16 ,  A61K38/00

    CPC分类号： A61K38/193 ,  C07K1/1077 ,  C07K9/00 ,  C07K9/001 ,  C07K14/535

    摘要： The present invention provides polypeptides that include an O-linked glycosylation site that is not present in the wild-type peptide. The polypeptides of the invention include glycoconjugates in which a species such as a water-soluble polymer, a therapeutic agent of a biomolecule is covalently linked through an intact O-linked glycosyl residue to the polypeptide. Also provided are methods of making the peptides of the invention and methods, pharmaceutical compositions containing the peptides and methods of treating, ameliorating or preventing diseased in mammals by administering an amount of a peptide of the invention sufficient to achieve the desired response.

    摘要翻译： 本发明提供了包含在野生型肽中不存在的O-连接的糖基化位点的多肽。 本发明的多肽包括糖缀合物，其中诸如水溶性聚合物的物质，生物分子的治疗剂通过完整O-连接的糖基残基与多肽共价连接。 还提供了制备本发明的肽和方法的方法，含有肽的药物组合物和通过施用足够达到所需反应的量的本发明的肽来治疗，改善或预防哺乳动物患病的方法。

    PURIFICATION OF PEPTIDE CONJUGATES BY HYDROPHOBIC INTERACTION CHROMATOGRAPHY
    4.
    发明申请
    PURIFICATION OF PEPTIDE CONJUGATES BY HYDROPHOBIC INTERACTION CHROMATOGRAPHY 审中-公开
    通过疏水相互作用色谱法纯化肽结合

    公开(公告)号：US20120016105A1

    公开(公告)日：2012-01-19

    申请号：US13186726

    申请日：2011-07-20

    申请人： Shawn DeFrees ,  David A. Zopf ,  Zhi-Guang Wang ,  Henrik Clausen

    发明人： Shawn DeFrees ,  David A. Zopf ,  Zhi-Guang Wang ,  Henrik Clausen

    IPC分类号： C07K1/20 ,  C07K14/755

    CPC分类号： A61K38/193 ,  C07K1/1077 ,  C07K9/00 ,  C07K9/001 ,  C07K14/535

    摘要： The present invention provides polypeptides that include an O-linked glycosylation site that is not present in the wild-type peptide. The polypeptides of the invention include glycoconjugates in which a species such as a water-soluble polymer, a therapeutic agent of a biomolecule is covalently linked through an intact O-linked glycosyl residue to the polypeptide. Also provided are methods of making a glycoconjugate, methods of isolating a glycoconjugate from a reaction mixture, pharmaceutical compositions containing a glycoconjugate, and methods of treating, ameliorating or preventing diseased in mammals by administering an amount of a glycoconjugate sufficient to achieve the desired response.

    摘要翻译： 本发明提供了包含在野生型肽中不存在的O-连接的糖基化位点的多肽。 本发明的多肽包括糖缀合物，其中诸如水溶性聚合物的物质，生物分子的治疗剂通过完整O-连接的糖基残基与多肽共价连接。 还提供了制备糖缀合物的方法，从反应混合物中分离糖缀合物的方法，含有糖缀合物的药物组合物，以及通过施用足以达到所需反应的量的糖缀合物来治疗，改善或预防哺乳动物患病的方法。

    O-LINKED GLYCOSYLATION OF PEPTIDES
    5.
    发明申请
    O-LINKED GLYCOSYLATION OF PEPTIDES 审中-公开
    肽连接的糖蛋白

    公开(公告)号：US20080242846A1

    公开(公告)日：2008-10-02

    申请号：US11843588

    申请日：2007-08-22

    申请人： Shawn DeFrees ,  David A. Zopf ,  Zhi-Guang Wang ,  Henrik Clausen

    发明人： Shawn DeFrees ,  David A. Zopf ,  Zhi-Guang Wang ,  Henrik Clausen

    IPC分类号： C07K14/00 ,  C07K1/00

    CPC分类号： A61K38/193 ,  C07K1/1077 ,  C07K9/00 ,  C07K9/001 ,  C07K14/535

    摘要： The present invention provides polypeptides that include an O-linked glycosylation site that is not present in the wild-type peptide. The polypeptides of the invention include glycoconjugates in which a species such as a water-soluble polymer, a therapeutic agent of a biomolecule is covalently linked through an intact O-linked glycosyl residue to the polypeptide. Also provided are methods of making the peptides of the invention and methods, pharmaceutical compositions containing the peptides and methods of treating, ameliorating or preventing diseased in mammals by administering an amount of a peptide of the invention sufficient to achieve the desired response.

    摘要翻译： 本发明提供了包含在野生型肽中不存在的O-连接的糖基化位点的多肽。 本发明的多肽包括糖缀合物，其中诸如水溶性聚合物的物质，生物分子的治疗剂通过完整O-连接的糖基残基与多肽共价连接。 还提供了制备本发明的肽和方法的方法，含有肽的药物组合物和通过施用足够达到所需反应的量的本发明的肽来治疗，改善或预防哺乳动物患病的方法。

    Glycopegylated granulocyte colony stimulating factor
    6.
    发明授权
    Glycopegylated granulocyte colony stimulating factor 有权
    糖基化的粒细胞集落刺激因子

    公开(公告)号：US07956032B2

    公开(公告)日：2011-06-07

    申请号：US11166404

    申请日：2005-06-23

    申请人： Shawn DeFrees ,  David A. Zopf ,  Zhi-Guang Wang ,  Caryn Bowe

    发明人： Shawn DeFrees ,  David A. Zopf ,  Zhi-Guang Wang ,  Caryn Bowe

    IPC分类号： A61K38/31

    CPC分类号： A61K38/193

    摘要： The present invention provides conjugates between Granulocyte Colony Stimulating Factor and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.

    摘要翻译： 本发明提供粒细胞集落刺激因子和PEG部分之间的缀合物。 缀合物经由完整的糖基连接基团连接，该基团介于并共价连接到肽和修饰基团之间。 通过糖基转移酶的作用，缀合物由糖基化和未糖基化的肽形成。 糖基转移酶将修饰的糖部分连接到肽上的氨基酸或糖基残基上。 还提供了包括缀合物的药物制剂。 缀合物的制备方法也在本发明的范围内。

    Glycopegylated interferon α
    9.
    发明授权
    Glycopegylated interferon α 有权
    糖基化干扰素α

    公开(公告)号：US08268967B2

    公开(公告)日：2012-09-18

    申请号：US11659942

    申请日：2005-09-12

    申请人： Shawn DeFrees ,  David A. Zopf ,  Henrik Clausen ,  Ruye Xing

    发明人： Shawn DeFrees ,  David A. Zopf ,  Henrik Clausen ,  Ruye Xing

    IPC分类号： C07K14/56 ,  A61K38/21

    CPC分类号： A61K38/212 ,  A61K47/60 ,  Y02A50/463 ,  Y02A50/473

    摘要： The present invention provides IFN-α conjugates including IFN-α peptides and modifying groups such as PEG moieties. The IFN-α peptide and modifying group are linked via an intact glycosyl linking group interposed between and covalently attached to the IFN-α peptide and the modifying group. The IFN-α conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar onto an amino acid or a glycosyl residue on the IFN-α peptide. Also provided are methods for preparing the IFN-α conjugates, methods for treating various disease conditions with the IFN-α conjugates, and pharmaceutical formulations including the IFN-α conjugates.

    摘要翻译： 本发明提供IFN-α缀合物，包括IFN-α肽和修饰基团例如PEG部分。 IFN-α肽和修饰基团通过介于IFN-α肽和修饰基团之间并共价连接的完整糖基连接基团连接。 通过糖基转移酶的作用由糖基化肽形成IFN-α缀合物。 糖基转移酶将修饰的糖连接到IFN-α肽上的氨基酸或糖基残基上。 还提供了制备IFN-α缀合物的方法，用IFN-α缀合物治疗各种疾病状况的方法，以及包括IFN-α缀合物的药物制剂。

    Glycopegylated Interferon Alpha
    10.
    发明申请
    Glycopegylated Interferon Alpha 有权
    糖基化干扰素α

    公开(公告)号：US20090028822A1

    公开(公告)日：2009-01-29

    申请号：US11659942

    申请日：2005-09-12

    申请人： Shawn DeFrees ,  David A. Zopf ,  Henrik Clausen ,  Ruye Xing

    发明人： Shawn DeFrees ,  David A. Zopf ,  Henrik Clausen ,  Ruye Xing

    IPC分类号： A61K38/21 ,  C07K14/56 ,  C12P21/00 ,  A61P35/00 ,  A61P31/00

    CPC分类号： A61K38/212 ,  A61K47/60 ,  Y02A50/463 ,  Y02A50/473

    摘要： The present invention provides IFN-α conjugates including IFN-α peptides and modifying groups such as PEG moieties. The IFN-α peptide and modifying group are linked via an intact glycosyl linking group interposed between and covalently attached to the IFN-α peptide and the modifying group. The IFN-α conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar onto an amino acid or a glycosyl residue on the IFN-α peptide. Also provided are methods for preparing the IFN-α conjugates, methods for treating various disease conditions with the IFN-α conjugates, and pharmaceutical formulations including the IFN-α conjugates.

    摘要翻译： 本发明提供IFN-α缀合物，包括IFN-α肽和修饰基团例如PEG部分。 IFN-α肽和修饰基团通过介于IFN-α肽和修饰基团之间并共价连接的完整糖基连接基团连接。 通过糖基转移酶的作用由糖基化肽形成IFN-α缀合物。 糖基转移酶将修饰的糖连接到IFN-α肽上的氨基酸或糖基残基上。 还提供了用于制备IFN-α缀合物的方法，用IFN-α缀合物治疗各种疾病状况的方法，以及包括IFN-α缀合物的药物制剂。