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公开(公告)号：US06716424B1
公开(公告)日：2004-04-06
申请号：US09485320
申请日：2000-02-08
申请人： Shigeto Uchiyama , Tomomi Ueno , Megumi Kumemura , Kiyoko Imaizumi , Kyosuke Masaki , Seiichi Shimizu
发明人： Shigeto Uchiyama , Tomomi Ueno , Megumi Kumemura , Kiyoko Imaizumi , Kyosuke Masaki , Seiichi Shimizu
IPC分类号： A01N1300
CPC分类号： C12R1/46 , A23C9/1236 , A23C9/1315 , A23C11/106 , A23L2/52 , A23L21/15 , A23L29/065 , A23L33/105 , A23L33/11 , A23L33/135 , A23L33/185 , A61K31/35 , A61K35/74 , A61K35/744 , A61K36/48 , C12P17/06 , C12R1/01 , A61K2300/00
摘要： This invention provides a composition comprising a daidzein-containing substrate and a strain of micro-organism capable of metabolizing daidzein to equol as essential ingredients. This composition is effective in the prevention and alleviation of unidentified clinical syndrome inclusive of menopausal syndrome in middle-aged to elderly woman for which no effective means of prevention or alleviation has heretofore been available.
摘要翻译： 本发明提供一种组合物，其包含含有黄豆苷原的底物和能够将黄豆苷原代谢为雌马酚作为必需成分的微生物菌株。 这种组合物在预防和缓解包括更年期综合征在内的中老年妇女不明的临床综合征方面是有效的，迄今尚无有效的预防或减轻手段。
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公开(公告)号：US07939060B2
公开(公告)日：2011-05-10
申请号：US11971458
申请日：2008-01-09
申请人： Shigeto Uchiyama , Tomomi Ueno , Megumi Kumemura , Kiyoko Imaizumi , Kyosuke Masaki , Seiichi Shimizu
发明人： Shigeto Uchiyama , Tomomi Ueno , Megumi Kumemura , Kiyoko Imaizumi , Kyosuke Masaki , Seiichi Shimizu
CPC分类号： C12R1/46 , A23C9/1236 , A23C9/1315 , A23C11/106 , A23L2/52 , A23L21/15 , A23L29/065 , A23L33/105 , A23L33/11 , A23L33/135 , A23L33/185 , A61K31/35 , A61K35/74 , A61K35/744 , A61K36/48 , C12P17/06 , C12R1/01 , A61K2300/00
摘要： This invention provides a composition comprising a daidzein-containing substrate and a strain of micro-organism capable of metabolizing daidzein to equol as essential ingredients. This composition is effective in the prevention and alleviation of unidentified clinical syndrome inclusive of menopausal syndrome in middle-aged to elderly women for which no effective means of prevention or alleviation has heretofore been available.
摘要翻译： 本发明提供一种组合物，其包含含有黄豆苷原的底物和能够将黄豆苷原代谢为雌马酚作为必需成分的微生物菌株。 该组合物有效预防和缓解了中老年妇女不明身份的临床综合征，包括绝经期综合征，迄今尚无有效的预防或减轻手段。
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公开(公告)号：US20080131412A1
公开(公告)日：2008-06-05
申请号：US11971458
申请日：2008-01-09
申请人： Shigeto Uchiyama , Tomomi Ueno , Megumi Kumemura , Kiyoko Imaizumi , Kyosuke Masaki , Seiichi Shimizu
发明人： Shigeto Uchiyama , Tomomi Ueno , Megumi Kumemura , Kiyoko Imaizumi , Kyosuke Masaki , Seiichi Shimizu
CPC分类号： C12R1/46 , A23C9/1236 , A23C9/1315 , A23C11/106 , A23L2/52 , A23L21/15 , A23L29/065 , A23L33/105 , A23L33/11 , A23L33/135 , A23L33/185 , A61K31/35 , A61K35/74 , A61K35/744 , A61K36/48 , C12P17/06 , C12R1/01 , A61K2300/00
摘要： This invention provides a composition comprising a daidzein-containing substrate and a strain of micro-organism capable of metabolizing daidzein to equol as essential ingredients. This composition is effective in the prevention and alleviation of unidentified clinical syndrome inclusive of menopausal syndrome in middle-aged to elderly women for which no effective means of prevention or alleviation has heretofore been available.
摘要翻译： 本发明提供一种组合物，其包含含有黄豆苷原的底物和能够将黄豆苷原代谢为雌马酚作为必需成分的微生物菌株。 该组合物有效预防和缓解了中老年妇女不明身份的临床综合征，包括绝经期综合征，迄今尚无有效的预防或减轻手段。
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4.发明授权公开(公告)号：US07345089B2
公开(公告)日：2008-03-18
申请号：US10752674
申请日：2004-01-08
申请人： Shigeto Uchiyama , Tomomi Ueno , Megumi Kumemura , Kiyoko Imaizumi , Kyosuke Masaki , Seiichi Shimizu
发明人： Shigeto Uchiyama , Tomomi Ueno , Megumi Kumemura , Kiyoko Imaizumi , Kyosuke Masaki , Seiichi Shimizu
CPC分类号： C12R1/46 , A23C9/1236 , A23C9/1315 , A23C11/106 , A23L2/52 , A23L21/15 , A23L29/065 , A23L33/105 , A23L33/11 , A23L33/135 , A23L33/185 , A61K31/35 , A61K35/74 , A61K35/744 , A61K36/48 , C12P17/06 , C12R1/01 , A61K2300/00
摘要： This invention provides a composition comprising a daidzein-containing substrate and a strain of micro-organism capable of metabolizing daidzein to equol as essential ingredients. This composition is effective in the prevention and alleviation of unidentified clinical syndrome inclusive of menopausal syndrome in middle-aged to elderly women for which no effective means of prevention or alleviation has heretofore been available.
摘要翻译： 本发明提供一种组合物，其包含含有黄豆苷原的底物和能够将黄豆苷原代谢为雌马酚作为必需成分的微生物菌株。 该组合物有效预防和缓解了中老年妇女不明身份的临床综合征，包括绝经期综合征，迄今尚无有效的预防或减轻手段。
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5.发明申请公开(公告)号：US20110189134A1
公开(公告)日：2011-08-04
申请号：US13119353
申请日：2009-09-18
申请人： Yoshikazu Isono , Hisako Mori , Tomomi Ueno , Rieko Endo , Megumi Kumemura , Yasuhiro Abiru , Shigeto Uchiyama
发明人： Yoshikazu Isono , Hisako Mori , Tomomi Ueno , Rieko Endo , Megumi Kumemura , Yasuhiro Abiru , Shigeto Uchiyama
CPC分类号： C12P17/06 , A23C9/1236 , A23C9/1315 , A23C11/106 , A23L11/09 , A23L29/065 , A23L33/135 , A23Y2240/00 , C07D311/60
摘要： An object of the present invention is to provide a fermented product containing equol-producing microorganisms in the state of living cells by which equol production ability is maintained.When producing a fermented material by using an equol-producing microorganism, with soybean powder or soybean milk as raw materials, (1) preparing a mother starter by fermentation under anaerobic conditions by using an equol-producing microorganism in the presence of a daidzein species at pH 5.0 or higher, (2) preparing a bulk starter by fermentation under anaerobic conditions by using said mother starter in the presence of a daidzein species at pH 5.0 or higher, and (3) preparing a fermented material by fermentation by using said bulk starter in a medium containing soybean powder or soybean milk, enables production of a fermented material containing microorganisms in the state of living cells in which the equol production ability is maintained.
摘要翻译： 本发明的目的在于提供含有维生素生产能力的活细胞状态下的产生雌马酚的微生物的发酵产物。 当使用牛尿酚产生微生物生产发酵物质时，以大豆粉或豆浆为原料，（1）通过在黄豆苷原物质存在下，使用牛尿酚产生微生物在厌氧条件下发酵来制备母体起始物 pH5.0以上，（2）通过在pH5.0以上的黄豆苷原物质的存在下使用所述母体起始剂在厌氧条件下发酵制备散装起动机，以及（3）通过使用所述批量起动机发酵制备发酵物质 在含有大豆粉末或豆浆的培养基中，能够生产维持雌马酚生产能力的活细胞状态的含有微生物的发酵物质。
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6.发明授权Fermentation product containing equol-producing microorganism having maintained equol-producing ability, and method for producing same 有权维持雌马酚产生能力的含有雌马酚产生微生物的发酵产物及其制造方法公开(公告)号：US09101159B2
公开(公告)日：2015-08-11
申请号：US13119353
申请日：2009-09-18
申请人： Yoshikazu Isono , Hisako Mori , Tomomi Ueno , Rieko Endo , Megumi Kumemura , Yasuhiro Abiru , Shigeto Uchiyama
发明人： Yoshikazu Isono , Hisako Mori , Tomomi Ueno , Rieko Endo , Megumi Kumemura , Yasuhiro Abiru , Shigeto Uchiyama
CPC分类号： C12P17/06 , A23C9/1236 , A23C9/1315 , A23C11/106 , A23L11/09 , A23L29/065 , A23L33/135 , A23Y2240/00 , C07D311/60
摘要： An object of the present invention is to provide a fermented product containing equol-producing microorganisms in the state of living cells by which equol production ability is maintained.When producing a fermented material by using an equol-producing microorganism, with soybean powder or soybean milk as raw materials, (1) preparing a mother starter by fermentation under anaerobic conditions by using an equol-producing microorganism in the presence of a daidzein species at pH 5.0 or higher, (2) preparing a bulk starter by fermentation under anaerobic conditions by using said mother starter in the presence of a daidzein species at pH 5.0 or higher, and (3) preparing a fermented material by fermentation by using said bulk starter in a medium containing soybean powder or soybean milk, enables production of a fermented material containing microorganisms in the state of living cells in which the equol production ability is maintained.
摘要翻译： 本发明的目的在于提供含有维生素生产能力的活细胞状态下的产生雌马酚的微生物的发酵产物。 当使用牛尿酚产生微生物生产发酵物质时，以大豆粉或豆浆为原料，（1）通过在黄豆苷原物质存在下，使用牛尿酚产生微生物在厌氧条件下发酵来制备母发酵剂 pH5.0以上，（2）通过在pH5.0以上的黄豆苷原物质的存在下使用所述母体起始剂在厌氧条件下发酵制备散装起动机，以及（3）通过使用所述批量起动机发酵制备发酵物质 在含有大豆粉或豆浆的培养基中，能够生产维持雌马酚生产能力的活细胞状态的含有微生物的发酵物质。
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7.发明申请公开(公告)号：US20120277302A1
公开(公告)日：2012-11-01
申请号：US13549568
申请日：2012-07-16
申请人： Hiroyuki Kimura , Takeshi Yamauchi , Tomomi Ueno , Toshimi Suzuki , Kentaro Tadano , Ikutaro Sato , Shigeto Uchiyama , Masahiro Oono , Masatoshi Mizuno
发明人： Hiroyuki Kimura , Takeshi Yamauchi , Tomomi Ueno , Toshimi Suzuki , Kentaro Tadano , Ikutaro Sato , Shigeto Uchiyama , Masahiro Oono , Masatoshi Mizuno
IPC分类号： A61K31/352 , A61K8/49
CPC分类号： A23L11/09 , A23L33/105 , A23V2002/00 , A61K8/498 , A61K8/97 , A61K2800/85 , A61Q19/00 , A61Q19/02 , A61Q19/10 , A23V2250/21172 , A23V2250/5488 , A23V2200/3262
摘要： An object of the invention is to provide an equol-containing fermented soybean hypocotyl material that is useful for foods, pharmaceutical preparations, cosmetic products, etc.The equol-containing fermented soybean hypocotyl material of the invention is obtained by fermenting soybean hypocotyls using at least one microorganism having an equol-producing ability by utilizing at least one daidzein compound selected from the group consisting of diadzein glycosides, daidzein, and dihydrodaidzein.
摘要翻译： 本发明的目的是提供可用于食品，药物制剂，化妆品等的含雌马酚的发酵大豆下胚轴材料。本发明的含雌马酚的发酵大豆下胚轴材料通过使用至少发酵大豆胚轴来获得 一种通过利用至少一种选自二甙糖苷，黄豆苷元和二氢黄豆苷元的黄豆苷元化合物具有雌马酚产生能力的微生物。
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公开(公告)号：US20060148045A1
公开(公告)日：2006-07-06
申请号：US10562687
申请日：2004-06-29
申请人： Shigeto Uchiyama , Tomomi Ueno , Toshimi Suzuki
发明人： Shigeto Uchiyama , Tomomi Ueno , Toshimi Suzuki
IPC分类号： C12P17/06
CPC分类号： A61K35/747 , A23C9/123 , A23C11/106 , A23L33/135 , A23Y2220/00 , A61K35/744 , C12P17/06 , C12R1/46
摘要： The present invention provides an equol-producing lactic acid bacteria-containing composition comprising, as an essential component thereof, a lactic acid bacterial strain belonging to the genus Lactococcus having an ability to utilize at least one daidzein compound selected from the group consisting of daidzein glycosides, daidzein, and dihydrodaidzein to produce equol. Such a composition is effective for the prevention and alleviation of malaise inclusive of climacteric disturbance in middle-aged and elderly women for which no effective prophylactic method or alleviating means has heretofore been available.
摘要翻译： 本发明提供一种产生雌马酚的含乳酸菌的组合物，其含有属于乳球菌属的乳酸菌株，其具有使用至少一种选自黄豆苷元苷的黄豆苷元化合物作为必需成分， ，黄豆苷元和二氢黄豆苷元产生雌马酚。 这样的组合物对于预防和缓解包括中年和老年妇女更年期障碍的不适，其中迄今为止没有有效的预防方法或缓解方法是有效的。
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公开(公告)号：US08765445B2
公开(公告)日：2014-07-01
申请号：US10562687
申请日：2004-06-29
申请人： Shigeto Uchiyama , Tomomi Ueno , Toshimi Suzuki
发明人： Shigeto Uchiyama , Tomomi Ueno , Toshimi Suzuki
IPC分类号： C12N1/20
CPC分类号： A61K35/747 , A23C9/123 , A23C11/106 , A23L33/135 , A23Y2220/00 , A61K35/744 , C12P17/06 , C12R1/46
摘要： The present invention provides an equol-producing lactic acid bacteria-containing composition comprising, as an essential component thereof, a lactic acid bacterial strain belonging to the genus Lactococcus having an ability to utilize at least one daidzein compound selected from the group consisting of daidzein glycosides, daidzein, and dihydrodaidzein to produce equol.Such a composition is effective for the prevention and alleviation of malaise inclusive of climacteric disturbance in middle-aged and elderly women for which no effective prophylactic method or alleviating means has heretofore been available.
摘要翻译： 本发明提供一种产生雌马酚的含乳酸菌的组合物，其含有属于乳球菌属的乳酸菌株，其具有使用至少一种选自黄豆苷元苷的黄豆苷元化合物作为必需成分， ，黄豆苷元和二氢黄豆苷元产生雌马酚。 这样的组合物对于预防和缓解包括中年和老年妇女更年期障碍的不适，其中迄今尚无有效的预防方法或缓解方法是有效的。
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10.发明授权公开(公告)号：US09386786B2
公开(公告)日：2016-07-12
申请号：US13549686
申请日：2012-07-16
申请人： Hiroyuki Kimura , Takeshi Yamauchi , Tomomi Ueno , Toshimi Suzuki , Kentaro Tadano , Ikutaro Sato , Shigeto Uchiyama , Masahiro Oono , Masatoshi Mizuno
发明人： Hiroyuki Kimura , Takeshi Yamauchi , Tomomi Ueno , Toshimi Suzuki , Kentaro Tadano , Ikutaro Sato , Shigeto Uchiyama , Masahiro Oono , Masatoshi Mizuno
CPC分类号： A23L11/09 , A23L33/105 , A23V2002/00 , A61K8/498 , A61K8/97 , A61K2800/85 , A61Q19/00 , A61Q19/02 , A61Q19/10 , A23V2250/21172 , A23V2250/5488 , A23V2200/3262
摘要： An object of the invention is to provide an equol-containing fermented soybean hypocotyl material that is useful for foods, pharmaceutical preparations, cosmetic products, etc.The equol-containing fermented soybean hypocotyl material of the invention is obtained by fermenting soybean hypocotyls using at least one microorganism having an equol-producing ability by utilizing at least one daidzein compound selected from the group consisting of diadzein glycosides, daidzein, and dihydrodaidzein.
摘要翻译： 本发明的目的是提供可用于食品，药物制剂，化妆品等的含雌马酚的发酵大豆下胚轴材料。本发明的含雌马酚的发酵大豆下胚轴材料通过使用至少发酵大豆胚轴来获得 一种通过利用至少一种选自二甙糖苷，黄豆苷元和二氢黄豆苷元的黄豆苷元化合物具有雌马酚产生能力的微生物。
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