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公开(公告)号:US08466259B2
公开(公告)日:2013-06-18
申请号:US12702567
申请日:2010-02-09
申请人: Shih-Jen Liu , Hsueh-Hung Liu , Chih-Hsiang Leng , Hsin-Wei Chen , Yan Chak Kwok , Pele Choi-Sing Chong
发明人: Shih-Jen Liu , Hsueh-Hung Liu , Chih-Hsiang Leng , Hsin-Wei Chen , Yan Chak Kwok , Pele Choi-Sing Chong
CPC分类号: C07K14/195 , C07K14/22 , C12P21/02
摘要: Disclosed are lipopeptides or lipoproteins, related compositions, and related methods.
摘要翻译: 公开了脂肽或脂蛋白,相关组合物和相关方法。
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公开(公告)号:US20100166785A1
公开(公告)日:2010-07-01
申请号:US12702567
申请日:2010-02-09
申请人: Shih-Jen Liu , Hsueh-Hung Liu , Chih-Hsiang Leng , Hsin-Wei Chen , Yan Chak Kwok , Pele Choi-Sing Chong
发明人: Shih-Jen Liu , Hsueh-Hung Liu , Chih-Hsiang Leng , Hsin-Wei Chen , Yan Chak Kwok , Pele Choi-Sing Chong
IPC分类号: A61K39/00 , A61K38/16 , A61K38/10 , A61K38/08 , A61K38/07 , A61K38/06 , A61K38/05 , A61P31/00 , A61P35/00 , C07C69/00 , C12P21/00
CPC分类号: C07K14/195 , C07K14/22 , C12P21/02
摘要: Disclosed are lipopeptides or lipoproteins, related compositions, and related methods.
摘要翻译: 公开了脂肽或脂蛋白,相关组合物和相关方法。
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公开(公告)号:US08658767B2
公开(公告)日:2014-02-25
申请号:US13296617
申请日:2011-11-15
申请人: Chih-Hsiang Leng , Chi-Ling Tseng , Hsueh-Hung Liu , Shih-Jen Liu , Hsin-Wei Chen , Pele Choi-Sing Chong
发明人: Chih-Hsiang Leng , Chi-Ling Tseng , Hsueh-Hung Liu , Shih-Jen Liu , Hsin-Wei Chen , Pele Choi-Sing Chong
CPC分类号: A61K39/12 , A61K2039/572 , A61K2039/6018 , A61K2039/70 , C07K14/005 , C12N2710/20022 , C12N2710/20034 , C12P21/02
摘要: This invention relates to, inter alia, an isolated lipidated polypeptide including a lipid moiety at the N-terminus and a plurality of epitopes, and methods of making and using the polypeptide.
摘要翻译: 本发明尤其涉及包含N-末端的脂质部分和多个表位的分离的脂化多肽,以及制备和使用该多肽的方法。
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公开(公告)号:US20120121628A1
公开(公告)日:2012-05-17
申请号:US13296617
申请日:2011-11-15
申请人: Chih-Hsiang Leng , Chi-Ling Tseng , Hsueh-Hung Liu , Shih-Jen Liu , Hsin-Wei Chen , Pele Choi-Sing Chong
发明人: Chih-Hsiang Leng , Chi-Ling Tseng , Hsueh-Hung Liu , Shih-Jen Liu , Hsin-Wei Chen , Pele Choi-Sing Chong
IPC分类号: A61K39/12 , A61P37/04 , C12P21/02 , C07K14/025 , A61P31/20
CPC分类号: A61K39/12 , A61K2039/572 , A61K2039/6018 , A61K2039/70 , C07K14/005 , C12N2710/20022 , C12N2710/20034 , C12P21/02
摘要: This invention relates to, inter alia, an isolated lipidated polypeptide including a lipid moiety at the N-terminus and a plurality of epitopes, and methods of making and using the polypeptide.
摘要翻译: 本发明尤其涉及包含N-末端的脂质部分和多个表位的分离的脂化多肽,以及制备和使用该多肽的方法。
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5.
公开(公告)号:US20100322953A1
公开(公告)日:2010-12-23
申请号:US12820264
申请日:2010-06-22
CPC分类号: C07K14/4748 , A61K38/00 , A61K39/0011 , A61K39/12 , A61K2039/55516 , A61K2039/585 , A61K2039/6018 , C07K14/005 , C07K2319/915 , C12N7/00 , C12N2710/20022 , C12N2710/20034
摘要: Disclosed are polypeptides and fusion proteins. Also disclosed are related immunotherapeutic compositions and methods.
摘要翻译: 披露的是多肽和融合蛋白。 还公开了相关的免疫治疗组合物和方法。
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公开(公告)号:US08287880B2
公开(公告)日:2012-10-16
申请号:US12787539
申请日:2010-05-26
IPC分类号: A61K39/295 , A61K39/12
CPC分类号: C07K14/005 , A61K39/12 , A61K2039/55516 , A61K2039/6068 , A61K2039/6075 , C07K2319/00 , C12N2770/24122 , C12N2770/24134 , Y02A50/386
摘要: Disclosed are immunogenic composition, fusion proteins, and related methods for inducing immune response to dengue virus infection.
摘要翻译: 公开了免疫原性组合物,融合蛋白和用于诱导对登革热病毒感染的免疫应答的相关方法。
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公开(公告)号:US08771990B2
公开(公告)日:2014-07-08
申请号:US13296558
申请日:2011-11-15
CPC分类号: C12P21/02 , C07K2319/90
摘要: A method of producing a recombinant lipidated polypeptide in E. coli. The method includes providing an E. coli host cell adapted to express a recombinant lipidated polypeptide; and culturing the E. coli host cell in a minimal medium under conditions that allow expression of the polypeptide in lipidated form.
摘要翻译: 一种在大肠杆菌中产生重组脂质化多肽的方法。 该方法包括提供适于表达重组脂质化多肽的大肠杆菌宿主细胞; 并在允许以脂质化形式表达多肽的条件下在基本培养基中培养大肠杆菌宿主细胞。
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8.USE OF OUTER MEMBRANE PORIN K36 PROTEIN (OMPK36) IN TREATMENT/PREVENTION/DIAGNOSIS OF ENTEROBACTERIACEAE INFECTION 审中-公开
标题翻译: 使用外膜蛋白K36蛋白(OMPK36)治疗/预防/诊断肠杆菌感染公开(公告)号:US20130251748A1
公开(公告)日:2013-09-26
申请号:US13545492
申请日:2012-07-10
申请人: Leung-Kei Siu , Feng-Yee Chang , Yung-Chung Lin , Chang-Phone Fung , Yip-Mei Liu , Jiun-Han Chen , Yu-Kuo Tsai , Pele Choi-Sing Chong , Chih-Hsiang Leng , Shih-Jen Liu , Hsin-Wei Chen
发明人: Leung-Kei Siu , Feng-Yee Chang , Yung-Chung Lin , Chang-Phone Fung , Yip-Mei Liu , Jiun-Han Chen , Yu-Kuo Tsai , Pele Choi-Sing Chong , Chih-Hsiang Leng , Shih-Jen Liu , Hsin-Wei Chen
IPC分类号: A61K39/108 , A61P31/04 , G01N21/76 , A61K39/112 , G01N33/569 , G01N21/64
CPC分类号: G01N33/56916 , A61K39/0266 , A61K2039/545 , A61K2039/55566 , G01N2333/245 , G01N2333/255 , G01N2333/26 , Y02A50/484 , Y02A50/59
摘要: The present invention relates a method for vaccinating a mammal to produce an antibody against Enterobacteriaceae infection caused by Klebsiella pneumoniae, Salmonella typhi, or E. coli in central nervous system and/or peripheral blood circulation, which comprises administering an effective amount of an OmpK36/homologues or its derivatives to the mammal.
摘要翻译: 本发明涉及一种疫苗接种哺乳动物以产生针对中枢神经系统和/或外周血循环中由肺炎克雷伯杆菌,伤寒沙门氏菌或大肠杆菌引起的肠杆菌科感染的抗体的方法,其包括给予有效量的OmpK36 / 同源物或其衍生物给哺乳动物。
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公开(公告)号:US08426163B2
公开(公告)日:2013-04-23
申请号:US12329026
申请日:2008-12-05
IPC分类号: C12P21/06
CPC分类号: C12P21/02 , C07K14/195
摘要: Production of a lipidated protein in an E. coli strain adapted to membrane protein expression.
摘要翻译: 在适于膜蛋白表达的大肠杆菌菌株中生产脂质化蛋白。
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10.Immunogenic Peptides of Tumor Associated Antigen L6 and Uses Thereof in Cancer Therapy 有权
标题翻译: 肿瘤相关抗原L6及其用途的免疫原性肽在癌症治疗中的应用公开(公告)号:US20110038894A1
公开(公告)日:2011-02-17
申请号:US12846092
申请日:2010-07-29
IPC分类号: A61K39/00 , C07K14/47 , C07K7/08 , C07K7/06 , C07K5/10 , C07K5/08 , A61P35/00 , C07H21/04 , C07K16/30
CPC分类号: A61K39/0011 , A61K2039/53 , A61K2039/55566
摘要: An immunopeptide containing a T cell epitope from the tumor associated antigen L6 (TAL6) and a nucleic acid encoding the immunopeptide. The immunopeptide and its encoding nucleic acid can be used as a component of an immune composition for enhancing immune response against cancer cells that express TAL6.
摘要翻译: 含有来自肿瘤相关抗原L6(TAL6)的T细胞表位的免疫肽和编码免疫肽的核酸。 免疫肽及其编码核酸可用作免疫组合物的组分,用于增强对表达TAL6的癌细胞的免疫应答。
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