Multi-phase emulsions based on amphiphilic block copolymers
    5.
    发明授权
    Multi-phase emulsions based on amphiphilic block copolymers 有权
    基于两亲性嵌段共聚物的多相乳液

    公开(公告)号:US08444993B2

    公开(公告)日:2013-05-21

    申请号:US13604610

    申请日:2012-09-05

    摘要: A method for enhancing a body's response to an immunogen is disclosed. The method comprises immunizing a subject in need thereof a vaccine composition in a water-in-oil (W/O/W) emulsion that comprises (a) an antigen; and (b) an adjuvant composition in a W/O/W emulsion. The adjuvant composition comprises: (i) a continuous aqueous phase comprising H2O; (ii) an oil phase comprising oil dispersed in the continuous aqueous phase, comprising an internal aqueous phase comprising H2O, being dispersed in the oil phase; and a physiologically acceptable lipophilic emulsifier selected from the group consisting of mannide monooleate and sorbitan esters, stabilizing the interface between the inner aqueous phase and the oil phase to form a water-in-oil (W/O) emulsion; and (iii) poly(ethylene glycol)-block-poly(lactide-co-ε-caprolactone), stabilizing the interface between the oil phase and the continuous aqueous phase.

    摘要翻译: 公开了增强人体对免疫原反应的方法。 该方法包括在有需要的受试者中免疫包含(a)抗原的油包水(W / O / W)乳剂中的疫苗组合物; 和(b)W / O / W乳剂中的佐剂组合物。 佐剂组合物包含:(i)包含H 2 O的连续水相; (ii)包含分散在连续水相中的油的油相,包含分散在油相中的包含H 2 O的内部水相; 和选自甘露苷单油酸酯和脱水山梨糖醇酯的生理上可接受的亲脂性乳化剂,稳定内部水相和油相之间的界面以形成油包水(W / O)乳液; 和(iii)聚(乙二醇) - 嵌段 - 聚(丙交酯 - 共 - 己内酯),稳定油相和连续水相之间的界面。