公开(公告)号：US5492924A

公开(公告)日：1996-02-20

申请号：US126361

申请日：1993-09-24

申请人： Shimon Gatt ,  Arie Dagan ,  Rene Santus ,  Jean-Claude Maziere ,  J. Donald Chapman ,  Edward L. Engelhardt

发明人： Shimon Gatt ,  Arie Dagan ,  Rene Santus ,  Jean-Claude Maziere ,  J. Donald Chapman ,  Edward L. Engelhardt

IPC分类号： A61K31/40 ,  A61K41/00 ,  A61K49/00 ,  A61K51/04 ,  C07D487/22

CPC分类号： A61K51/0485 ,  A61K31/40 ,  A61K41/0071 ,  A61K49/0036 ,  C07D487/22 ,  A61K2123/00

摘要： Phorbine derivatives having high potency and light absorptivity in the 650 to 780 nanometer range are useful in cancer diagnosis and therapy, especially photodynamic therapy.

摘要翻译： 在650至780纳米范围内具有高效能和光吸收性的菲啡宾衍生物可用于癌症诊断和治疗，特别是光动力疗法。

公开(公告)号：US5300508A

公开(公告)日：1994-04-05

申请号：US809515

申请日：1992-01-31

申请人： Alain Valla ,  Michel Giraud ,  Marc Bazin ,  Rene Santus

发明人： Alain Valla ,  Michel Giraud ,  Marc Bazin ,  Rene Santus

IPC分类号： A61K8/49 ,  A61K8/64 ,  A61Q19/00 ,  A61Q19/08 ,  C07D207/32 ,  C07D207/327 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D473/34 ,  A61K31/40 ,  A61K7/00

CPC分类号： C07D473/34 ,  A61K8/19 ,  A61K8/4913 ,  A61K8/64 ,  A61Q19/00 ,  C07D207/327 ,  C07D403/04 ,  A61K2800/58 ,  A61Q19/08

摘要： A method for intercepting an activated species of dioxygen by administering an N-substituted pyrrole derivative having the formula: ##STR1## in which: R is an amino acid derivative, a non-protein peptide, an amino sugar processing a free primary amino group, a purine bases which is substituted, at position 9 by alkyl groups, or a pyrimidine bases possessing a free primary amino group, wherein the pyrimidine bases are substituted by at least one SH group; R.sub.1 represents one or more substituents, identical or different and are a hydrogen, an alkyl radical containing from 1 to 6 carbon atoms, a primary amino radical, a secondary amino radical NHB, or a tertiary amino radical--N(B,B'), wherein B and B', identical or different represent an alkyl group of 1 to 6 carbon atoms, a SH or SB radical, wherein B is defined above, a --CH.sub.2 OH, --CH(B)OH, --C(B,B')OH radical or the corresponding esters and ethers, a cyclic radical of 3 to 6 carbon atoms or an oxygen, nitrogen or sulfur containing heterocycle such as furan, pyrrole or thiophene, or their salts with metal ions or amine complexes, esters of formula --COOR.sub.2, wherein R.sub.2 is an alkyl radical of 1 to 3 carbon atoms, amides of the formula COR.sub.3 wherein R.sub.3 is a primary, secondary and/or tertiary amine and wherein R.sub.3 is a secondary or tertiary amine said primary or tertiary amine is substituted by an alkyl group or alcohol of 1 to 4 carbon atoms or their complexes with physiologically acceptable salts wherein said N-substituted pyrrole derivatives are racemates or are optically active isomers, with the proviso that R.sub.1 is not hydrogen when R is a derivative selected from the group consisting of glycine, leucine, phenylalanine, tyrosine, serine and glutamic acid.