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1.发明申请Pharmaceutical composition containing 2,2-dichloro-12-(4-chlorophenyl)-dodecanoic acid 审中-公开含有2,2-二氯-12-（4-氯苯基） - 十二烷酸的药物组合物公开(公告)号：US20060051410A1
公开(公告)日：2006-03-09
申请号：US10500463
申请日：2003-01-15
CPC分类号： A61K31/192 , A61K9/2054 , A61K9/4866 , A61K2300/00
摘要： A highly stable pharmaceutical composition which comprises a mixture comprising a substance selected from the group consisting of 2,2-dichloro-12-(4-chlorophenyl)-dodecanoic acid, salts thereof, and esters thereof, and croscarmellose sodium.
摘要翻译： 一种高度稳定的药物组合物，其包含包含选自2,2-二氯-12-（4-氯苯基） - 十二烷酸及其盐及其酯的物质和交联羧甲基纤维素钠的混合物。
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公开(公告)号：US06753330B2
公开(公告)日：2004-06-22
申请号：US10414008
申请日：2003-04-16
IPC分类号： A61K3150
CPC分类号： A61K9/1652 , A61K9/146 , A61K9/1641 , A61K9/2077 , A61K31/50
摘要： The invention provides a solid dispersion composition containing 2-benzyl-5-(4-chlorophenyl)-6-[4-(methylthio)phenyl]-2H-pyridazin-3-one, hydroxypropylmethyl cellulose, and polyoxyethylene polyoxypropylene glycol. The solid dispersion composition of the present invention exhibits the excellent dissolvability of 2-benzyl-5-(4-chlorophenyl)-6-[4-(methylthio)phenyl]-2H-pyridazin-3-one in water, and enables this compound to be constant sequentially and thereby improve absorbability in blood.
摘要翻译： 本发明提供了含有2-苄基-5-（4-氯苯基）-6- [4-（甲硫基）苯基] -2H-哒嗪-3-酮，羟丙基甲基纤维素和聚氧乙烯聚氧丙烯二醇的固体分散体组合物。 本发明的固体分散体组合物表现出2-苄基-5-（4-氯苯基）-6- [4-（甲硫基）苯基] -2H-哒嗪-3-酮在水中的优异的溶解性，使该化合物 依次保持恒定，从而提高血液中的吸收性。
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3.发明授权公开(公告)号：US07537341B2
公开(公告)日：2009-05-26
申请号：US12048095
申请日：2008-03-13
申请人： Noriko Saito , Akio Kobayashi , Hiroyuki Kawashima
发明人： Noriko Saito , Akio Kobayashi , Hiroyuki Kawashima
CPC分类号： G02B26/06 , A61B3/1015 , A61B3/14 , G02B26/0825
摘要： A wavefront aberration compensating apparatus, which includes: a deformable mirror having electrodes and a thin-film mirror; an optical system provided with the deformable mirror and including an object; a wavefront sensor which measures a wavefront aberration of a light flux; and a controller configured to: calculate a first voltage value applied to each of the electrodes, on the basis of differences between application points on the thin-film mirror and target points both corresponding to the electrodes respectively; determine a superposition amplitude value of each expansion mode according to a polynomial of wavefront aberration, and calculate a second voltage value applied to each of the electrodes by using voltage templates previously stored, such that the wavefront aberration obtained by the wavefront sensor becomes a desired aberration; determine the voltage value applied to each of the electrodes, by mainly using the second voltage value in an initial stage of compensation of the configuration of the thin-film mirror and by mainly using the first voltage value in an end stage of the compensation; and repeat the compensation on the basis of the determined voltage value, such that the wavefront aberration of the light flux is suppressed.
摘要翻译： 一种波前像差补偿装置，包括：具有电极和薄膜反射镜的可变形反射镜; 设置有可变形反射镜并包括物体的光学系统; 测量光通量的波前像差的波前传感器; 以及控制器，其被配置为：基于薄膜反射镜上的应用点和分别对应于电极的目标点之间的差异来计算施加到每个电极的第一电压值; 根据波前像差的多项式确定每个扩展模式的叠加振幅值，并且通过使用预先存储的电压模板来计算施加到每个电极的第二电压值，使得由波前传感器获得的波前像差成为期望的像差 ; 通过在补偿薄膜反射镜的构造的初始阶段主要使用第二电压值，并且主要在补偿的最后阶段使用第一电压值来确定施加到每个电极的电压值; 并根据确定的电压值重复补偿，从而抑制光通量的波前像差。
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4.发明授权公开(公告)号：US07520613B2
公开(公告)日：2009-04-21
申请号：US12047946
申请日：2008-03-13
申请人： Noriko Saito , Akio Kobayashi , Hiroyuki Kawashima
发明人： Noriko Saito , Akio Kobayashi , Hiroyuki Kawashima
CPC分类号： G02B26/06 , A61B3/1015 , A61B3/12
摘要： A wavefront aberration compensating apparatus, including: a deformable mirror which compensates a wavefront aberration of a light flux and includes electrodes, and a thin-film mirror which changes a configuration thereof in accordance with a voltage value applied to each of the electrodes; an optical system provided with the deformable mirror and including an object subjected to aberration compensation; a wavefront sensor which measures the wavefront aberration of the light flux; a memory which stores therein a voltage template provided for each expansion mode according to a polynomial of wavefront aberration, as a voltage alignment data for the electrodes which induces the corresponding expansion mode; and a controller configured to determine a superposition amplitude value of each of the expansion modes and calculate the voltage value applied to each of the electrodes by using the voltage templates stored such that the wavefront aberration obtained by the wavefront sensor becomes a desired aberration, and to repeat compensation of the configuration of the thin-film mirror on the basis of the calculated voltage value, such that the wavefront aberration of the light flux measured by the wavefront sensor is suppressed.
摘要翻译： 一种波前像差补偿装置，包括：可变形反射镜，其补偿光束的波前像差并包括电极;以及薄膜反射镜，其根据施加到每个电极的电压值改变其配置; 设置有可变形反射镜并包括经受像差补偿的物体的光学系统; 测量光通量波前像差的波前传感器; 存储器，其中存储根据波前像差的多项式为每个扩展模式提供的电压模板作为引起相应扩展模式的电极的电压对准数据; 以及控制器，被配置为确定每个扩展模式的叠加振幅值，并且通过使用存储的电压模板来计算施加到每个电极的电压值，使得由波前传感器获得的波前像差成为期望的像差，并且 基于计算出的电压值重复补偿薄膜反射镜的结构，从而抑制由波前传感器测量的光通量的波前像差。
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公开(公告)号：US20080239528A1
公开(公告)日：2008-10-02
申请号：US12032871
申请日：2008-02-18
申请人： Kei Masunishi , Akihiro Koga , Ryo Furukawa , Tetsuya Kugimiya , Akio Kobayashi , Hiroyuki Kawashima
发明人： Kei Masunishi , Akihiro Koga , Ryo Furukawa , Tetsuya Kugimiya , Akio Kobayashi , Hiroyuki Kawashima
IPC分类号： G02B26/00
CPC分类号： G02B26/0825
摘要： It is made possible to provide a deformable mirror apparatus which is deformable to a complicated shape (high-order shape). A deformable mirror apparatus includes: a substrate; a plurality of electrodes provided on the substrate; a spacer fixed above the substrate, having a first opening passing through from a first face of the spacer facing to the substrate to a second face of the spacer facing opposite from the first face, surrounding the electrodes, and having a step on the second face; a drive part including a membrane part disposed so as to cover the step of the spacer and so as to be opposed to the electrodes, a casing part having an opening at a bottom face of which the membrane part is exposed and supporting the membrane part, and a reflection film provided on the membrane part; and a voltage generator configured to generate predetermined voltage patterns on the electrodes, respectively.
摘要翻译： 可以提供可变形为复杂形状（高阶形状）的可变形反射镜装置。 可变形反射镜装置包括：基板; 设置在所述基板上的多个电极; 固定在所述基板上方的间隔件，具有第一开口，所述第一开口从所述间隔件的面向所述基板的第一面穿过所述间隔件的与所述第一面相反的第二面，所述第二面围绕所述电极，并且在所述第二面上具有台阶 ; 驱动部，其具有设置成覆盖所述间隔件的台阶并且与所述电极相对的膜部;壳体部，其在所述膜部露出并支撑所述膜部的底面具有开口部， 以及设置在所述膜部上的反射膜; 以及电压发生器，其被配置为分别在所述电极上产生预定的电压图案。
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公开(公告)号：US20080225228A1
公开(公告)日：2008-09-18
申请号：US12047946
申请日：2008-03-13
申请人： Noriko Saito , Akio Kobayashi , Hiroyuki Kawashima
发明人： Noriko Saito , Akio Kobayashi , Hiroyuki Kawashima
CPC分类号： G02B26/06 , A61B3/1015 , A61B3/12
摘要： A wavefront aberration compensating apparatus, including: a deformable mirror which compensates a wavefront aberration of a light flux and includes electrodes, and a thin-film mirror which changes a configuration thereof in accordance with a voltage value applied to each of the electrodes; an optical system provided with the deformable mirror and including an object subjected to aberration compensation; a wavefront sensor which measures the wavefront aberration of the light flux; a memory which stores therein a voltage template provided for each expansion mode according to a polynomial of wavefront aberration, as a voltage alignment data for the electrodes which induces the corresponding expansion mode; and a controller configured to determine a superposition amplitude value of each of the expansion modes and calculate the voltage value applied to each of the electrodes by using the voltage templates stored such that the wavefront aberration obtained by the wavefront sensor becomes a desired aberration, and to repeat compensation of the configuration of the thin-film mirror on the basis of the calculated voltage value, such that the wavefront aberration of the light flux measured by the wavefront sensor is suppressed.
摘要翻译： 一种波前像差补偿装置，包括：可变形反射镜，其补偿光束的波前像差并包括电极;以及薄膜反射镜，其根据施加到每个电极的电压值改变其结构; 设置有可变形反射镜并包括经受像差补偿的物体的光学系统; 测量光通量波前像差的波前传感器; 存储器，其中存储根据波前像差的多项式为每个扩展模式提供的电压模板作为引起相应扩展模式的电极的电压对准数据; 以及控制器，被配置为确定每个扩展模式的叠加振幅值，并且通过使用存储的电压模板来计算施加到每个电极的电压值，使得由波前传感器获得的波前像差成为期望的像差，并且 基于计算出的电压值重复补偿薄膜反射镜的结构，从而抑制由波前传感器测量的光通量的波前像差。
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公开(公告)号：US20080158508A1
公开(公告)日：2008-07-03
申请号：US12005275
申请日：2007-12-27
IPC分类号： A61B3/14
CPC分类号： A61B3/14
摘要： An ophthalmologic apparatus includes an imaging system that illuminates a retina of an eye, and images the retina of the eye based on reflective luminous flux from the retina, an aberration measurement part that measures optical aberration of the eye, an aberration compensation device disposed in the imaging system to compensate the optical aberration of the eye based on a signal from the aberration measurement part, a first focusing device disposed in an optical path of the imaging system to perform focusing of the image of the retina of the eye according to a refractive property of the eye, and a second focusing device disposed in the optical path of the imaging system to compensate infinitesimal spherical aberration generated by the aberration compensation device after adjustment by the first focusing device.
摘要翻译： 眼科装置包括：照射眼睛的视网膜的成像系统，并且基于来自视网膜的反射光束对眼睛的视网膜进行成像，测量眼睛的光学像差的像差测量部，设置在眼睛中的像差补偿装置 成像系统，用于基于来自像差测量部分的信号补偿眼睛的光学像差;第一聚焦装置，其设置在成像系统的光路中，以根据折射特性进行眼睛的视网膜的图像的聚焦; 以及设置在成像系统的光路中的第二聚焦装置，以补偿由第一聚焦装置调节之后由像差补偿装置产生的无穷小的球面像差。
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公开(公告)号：US4882162A
公开(公告)日：1989-11-21
申请号：US242085
申请日：1988-09-08
申请人： Yoshito Ikada , Shokyu Gen , Shigeo Ohi , Yosuke Urabe , Hiroyuki Kawashima
发明人： Yoshito Ikada , Shokyu Gen , Shigeo Ohi , Yosuke Urabe , Hiroyuki Kawashima
IPC分类号： A61L27/00 , A61F2/10 , A61F13/00 , A61L15/16 , A61L27/18 , A61L27/58 , A61L27/60 , A61L15/04
CPC分类号： A61L27/60 , A61F2/105 , A61L27/18 , A61L27/58 , A61F2013/00157 , A61F2013/00221 , A61F2013/00259 , A61F2013/00263
摘要： An artificial skin or bandage is formed from an elastomeric layer which is surfaced by a fibrous wound contacting layer which is first formed into a fabric and subsequently degraded by heat hydrolysis or other degradative treatment into a form which could no longer be formed into a fabric but which forms an ideal bioabsorbable wound contact surface in which damage to the newly formed, fragile epidermus is minimized.
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公开(公告)号：US4139180A
公开(公告)日：1979-02-13
申请号：US766021
申请日：1977-02-07
CPC分类号： B66C19/00 , B63B9/00 , B63C5/02 , Y10T29/49751
摘要： The present invention relates to an apparatus for breaking up a large construction such as a large ship, and comprises a transporter movable in straddling relation to a construction to be broken up, a frame body supported by said transporter and movable in vertical direction, a circulating rail mounted on said frame body, a rail mounted independently in the beam direction of the transporter on said frame, a suspension transporting device movable on said circulating rail and a device having a cutter means movable on said independently mounted rail.Said cutter is also constructed such that an operation room is provided at the forward end of an arm, which is movable three-dimensionally, through a rotary device, and on said operation room a guide rail is projected and said guide rail is supported for up and down rocking motion and rotary motion around a fulcrum located near the operation room and in turn a cutter is movably supported on said guide rail.The present invention particularly permits to safely breaking up a large ship floating on the sea and transport broken up objects to given locations. Ships are composed of assemblies constructed three-dimensionally from steel plates and shape steel etc., but according to the cutting means of the present invention, such assemblies can be cut off three-dimensionally.
摘要翻译： 本发明涉及一种用于拆卸诸如大型船舶的大型结构的装置，并且包括可与被分解的构造跨接的运动装置，由所述运送装置支撑并可在垂直方向上运动的框架体，循环 轨道安装在所述框架体上，独立于所述框架上的所述运送器的梁方向安装的轨道，可在所述循环轨道上移动的悬挂输送装置和具有可在所述独立安装的轨道上移动的切割装置的装置。
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10.发明授权Solid-state imaging device, method for manufacturing solid-state imaging device, method for manufacturing solid-state imaging element, and semiconductor device 有权固态成像装置，固态成像装置的制造方法，固体摄像元件的制造方法以及半导体装置公开(公告)号：US08786055B2
公开(公告)日：2014-07-22
申请号：US12948029
申请日：2010-11-17
申请人： Hiroyuki Kawashima
发明人： Hiroyuki Kawashima
IPC分类号： H01L23/544
CPC分类号： H01L27/14601 , H01L27/14603 , H01L27/14621 , H01L27/14627 , H01L27/14645 , H01L27/14683 , H01L2924/0002 , H01L2924/00
摘要： A solid-state imaging device includes a semiconductor substrate configured to include a solid-state imaging element that is provided with a photoelectric conversion region, and a scribe line region that is provided along a periphery of the solid-state imaging element, a wiring layer that is formed to be layered on the semiconductor substrate, a support substrate that is formed to be layered on the wiring layer, and a groove that is provided between a blade region in the scribe line region and the solid-state imaging element, in the semiconductor substrate and penetrates through the semiconductor substrate.
摘要翻译： 固态成像装置包括：半导体基板，被配置为包括设置有光电转换区域的固态成像元件和沿着固态成像元件的周边设置的划线区域;布线层 其形成为层叠在半导体基板上，形成为层叠在布线层上的支撑基板和设置在划线区域中的叶片区域与固态成像元件之间的槽，在 半导体衬底并穿透半导体衬底。
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