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    Process for producing porous composite materials
    2.
    发明授权
    Process for producing porous composite materials 有权
    生产多孔复合材料的方法

    公开(公告)号：US07163965B2

    公开(公告)日：2007-01-16

    申请号：US10492300

    申请日：2002-05-01

    申请人： Shinichi Sotome ,  Toshimasa Uemura ,  Junzo Tanaka ,  Masanori Kikuchi ,  Kenichi Shinomiya ,  Soichiro Itoh ,  Tetsuya Tateishi

    发明人： Shinichi Sotome ,  Toshimasa Uemura ,  Junzo Tanaka ,  Masanori Kikuchi ,  Kenichi Shinomiya ,  Soichiro Itoh ,  Tetsuya Tateishi

    IPC分类号： A61L27/00 ,  A61L27/52

    CPC分类号： A61L27/56 ,  A61L27/46 ,  C08L89/06

    摘要： This invention relates to a process for producing porous and composite materials comprising steps of: freezing a complex containing at least one calcium salt selected from calcium carbonate, calcium phosphate, and hydroxyapatite and collagen, at least a part of which is gelatinized; and then lyophilizing the resultant. The porous and composite materials obtained by the method of the present invention have large pore diameters, high porosities, and adequate mechanical strengths and biodegradability. Thus, they are suitable for implants such as bone fillers, drug carriers for sustained-release, and the like.

    摘要翻译： 本发明涉及一种生产多孔和复合材料的方法，包括以下步骤：冷冻含有至少一种选自碳酸钙，磷酸钙和羟基磷灰石的钙盐的复合物和至少部分胶凝的胶原蛋白; 然后将所得物冷冻干燥。 通过本发明的方法获得的多孔和复合材料具有大的孔径，高孔隙率和足够的机械强度和生物降解性。 因此，它们适用于诸如骨填料，持续释放的药物载体等植入物。

    Materials sustainedly releasing drug in vivo
    5.
    发明申请
    Materials sustainedly releasing drug in vivo 审中-公开
    材料在体内持续释放药物

    公开(公告)号：US20050031698A1

    公开(公告)日：2005-02-10

    申请号：US10487706

    申请日：2002-08-14

    申请人： Shinichi Sotome ,  Toshimasa Uemura ,  Masanori Kikuchi ,  Kenichi Shinomiya ,  Junzo Tanaka

    发明人： Shinichi Sotome ,  Toshimasa Uemura ,  Masanori Kikuchi ,  Kenichi Shinomiya ,  Junzo Tanaka

    IPC分类号： A61K9/48 ,  A61K38/18 ,  A61K38/39 ,  A61K45/00 ,  A61K47/04 ,  A61K47/36 ,  A61K47/42 ,  A61K47/46 ,  A61K47/48 ,  A61K9/14

    CPC分类号： B82Y5/00 ,  A61K38/1825 ,  A61K38/39 ,  A61K47/548 ,  A61K47/6435 ,  A61K47/6921 ,  A61K47/6929

    摘要： Disclosed is a material for sustained chemical-release in vivo, which comprises a hydroxyapatite/collagen (HAp/Col) nanocomposite formed as a coprecipitate, and a chemical consisting at least one of a drug and a bioactive substance including a growth factor and a DNA enzyme. The hydroxyapatite (HAp) has a specific surface area in the range of 50 to 300 m2/g. The hydroxyapatite (HAp) and the collagen (Col) are combined in such a manner that the crystals of the hydroxyapatite (HAp) are oriented in the C-axis direction around the fibers of the collagen (Col). The chemical is carried on the surface of the hydroxyapatite (HAp), the surface of the collagen (Col) and in a hydrated water of the hydroxyapatite (HAp) and the collagen (Col). The sustained chemical-release material can be prepared in the form of a bioabsorbable capsule, or in the form of allowing in vivo administration by injection and in-vivo gelation after said administration.

    摘要翻译： 公开了一种用于体内持续化学释放的材料，其包含形成为共沉淀物的羟基磷灰石/胶原（HAp / Col）纳米复合物，以及包含生物因子和DNA的药物和生物活性物质中的至少一种的化学物质 酶。 羟基磷灰石（HAp）的比表面积为50〜300m 2 / g。 将羟基磷灰石（HAp）和胶原（Col）以使得羟基磷灰石（HAp）的晶体在胶原（Col）的纤维周围的C轴方向取向的方式组合。 该化学物质载于羟基磷灰石（HAp）的表面，胶原蛋白（Col）的表面和羟基磷灰石（HAp）和胶原（Col））的水合水中。 持续的化学释放材料可以以生物可吸收胶囊的形式制备，或以所述给药后允许通过注射和体内凝胶化的体内施用的形式。

    Artificial pyramid
    6.
    发明授权
    Artificial pyramid 有权
    人造金字塔

    公开(公告)号：US06887272B2

    公开(公告)日：2005-05-03

    申请号：US10468010

    申请日：2002-02-20

    申请人： Kenichi Shinomiya ,  Soichiro Itoh ,  Junzo Tanaka ,  Masanori Kikuchi

    发明人： Kenichi Shinomiya ,  Soichiro Itoh ,  Junzo Tanaka ,  Masanori Kikuchi

    IPC分类号： A61L27/00 ,  A61B17/80 ,  A61F2/44 ,  A61L27/46 ,  A61L27/58 ,  A61F2/28 ,  A61F13/00

    CPC分类号： A61L27/56 ,  A61B17/80 ,  A61F2/44 ,  A61L27/46 ,  A61L2430/38 ,  C08L89/06

    摘要： Disclosed is an artificial vertebra having a bone-marrow regenerating function, comprising a hydroxyapatite (HAp)/collagen (Col) composite body formed by pressure-dehydrating a coprecipitate of hydroxyapatite and collagen to have a nanocomposite structure in which HAp particles are conjugated along a Col fiber while aligned each of the c-axes of the HAp particles along the Col fiber. The HAp/Col composite body is formed with a perforated aperture for allowing a blood vessel and an osteogenic cell to intrude thereinto. The present invention also provides a biodecomposable/bioabsorbable support for fixing an artificial vertebra, comprising a polylactic acid plate prepared by injection-molding molten polylactic acid and then extrusion-molding the injection-molded polylactic acid in such a manner that it is draw-oriented in a uniaxial direction. The plate has four corner regions each formed with a screw hole for fixing the plate to vertebral bodies.

    摘要翻译： 公开了一种具有骨髓再生功能的人造椎骨，其包含羟磷灰石（HAp）/胶原（Col）复合体，其通过将羟基磷灰石和胶原的共沉淀物进行压力脱水而形成，以具有纳米复合结构，其中HAp颗粒沿着 Col纤维同时沿着Col纤维排列HAp颗粒的每个c轴。 HAp / Col复合体形成有穿孔，用于允许血管和成骨细胞侵入其中。 本发明还提供了一种用于固定人造椎骨的生物可组合/生物吸收性支撑体，其包括通过注射熔融聚乳酸制备的聚乳酸板，然后以注射成型聚乳酸的方式使其成为拉伸取向 在单轴方向。 该板具有四个拐角区域，每个角部区域形成有用于将板固定到椎体的螺钉孔。

    Porous composite containing calcium phosphate and process for producing the same
    9.
    发明申请
    Porous composite containing calcium phosphate and process for producing the same 有权
    含磷酸钙的多孔复合材料及其制备方法

    公开(公告)号：US20060292350A1

    公开(公告)日：2006-12-28

    申请号：US10558245

    申请日：2004-05-26

    申请人： Katsumi Kawamura ,  Takehiko Nakajima ,  Daisuke Shoji ,  Junzo Tanaka ,  Masanori Kikuchi ,  Toshiyuki Ikoma

    发明人： Katsumi Kawamura ,  Takehiko Nakajima ,  Daisuke Shoji ,  Junzo Tanaka ,  Masanori Kikuchi ,  Toshiyuki Ikoma

    IPC分类号： B32B3/00

    CPC分类号： A61L27/56 ,  A61L27/12 ,  A61L27/425 ,  Y10T428/24752

    摘要： A porous composite comprising a porous layer containing a calcium phosphate ceramic, and a dense layer formed on part of the porous layer and having a smaller average pore size than that of the porous layer. The porous composite can be produced by (1) introducing a slurry containing a calcium phosphate ceramic/collagen composite and collagen into a molding die having a high thermal conductivity, (2) rapidly freezing and drying the slurry in the molding die, to form a porous body comprising a porous layer and a dense layer formed on the porous layer, (3) cross-linking collagen in the porous body, and (4) removing the dense layer except for a portion thereof on a surface coming into contact with a soft tissue when implanted in a human body, so that the porous layer is exposed.

    摘要翻译： 一种多孔复合体，其包含含有磷酸钙陶瓷的多孔层，以及形成在所述多孔层的一部分上并且具有比所述多孔层的平均孔径更小的致密层。 多孔复合材料可以通过（1）将含有磷酸钙陶瓷/胶原复合材料和胶原的浆料引入到具有高导热性的成型模具中，（2）快速冷冻并干燥成型模具中的浆料，从而形成 多孔体包括多孔层和形成在多孔层上的致密层，（3）在多孔体中交联胶原，以及（4）在与柔软接触的表面上去除除了其一部分之外的致密层 植入人体时的组织，使得多孔层被暴露。

    Organic/inorganic composite biomaterials and process for producing the same
    10.
    发明授权
    Organic/inorganic composite biomaterials and process for producing the same 有权
    有机/无机复合生物材料及其制备方法

    公开(公告)号：US08168151B2

    公开(公告)日：2012-05-01

    申请号：US10492937

    申请日：2002-09-19

    申请人： Junzo Tanaka ,  Masanori Kikuchi ,  Noriichi Ito ,  Yoshinobu Mandai

    发明人： Junzo Tanaka ,  Masanori Kikuchi ,  Noriichi Ito ,  Yoshinobu Mandai

    IPC分类号： C01B15/16 ,  C01B25/26 ,  B05D3/00 ,  A61L27/32 ,  A61K6/033

    CPC分类号： A61L27/46 ,  Y10S623/919 ,  C08L89/06

    摘要： This invention provides organic/inorganic composite biomaterials constituted by composites of hydroxyapatite and collagen and having an average fiber length of 60 μm or longer, and a process for producing the same in which the calcium ion and phosphate ion concentrations in the reaction vessel are optimized through regulation of the concentration of a starting material and the flow rate. The organic/inorganic composite biomaterials have mechanical strength and a biodegradation rate suitable for artificial bones through the introduction of crosslinking therein.

    摘要翻译： 本发明提供由羟基磷灰石和胶原复合材料构成的平均纤维长度为60μm以上的有机/无机复合生物材料及其制造方法，其中反应容器中的钙离子和磷酸根离子浓度通过 原料浓度的调节和流速。 有机/无机复合生物材料通过在其中引入交联而具有机械强度和适于人造骨的生物降解速率。