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公开(公告)号：US07851187B2
公开(公告)日：2010-12-14
申请号：US11942873
申请日：2007-11-20
CPC分类号： C12N9/1014 , C12P13/06 , C12Y201/02001
摘要： The present invention provides a new method for producing serine derivatives and their optically-activated derivatives in a convenient manner. In the presence of an enzyme, an L-α-amino acid of formula (I): (in the formula (I), R1 is a hydrocarbon group) is reacted with an aldehyde of formula (II): (in the formula (II), R2 is a hydrocarbon) to produce an L-serine derivative of formula (III). .
摘要翻译： 本发明提供了以方便的方式制备丝氨酸衍生物及其光活性衍生物的新方法。 在酶的存在下，式（I）:(式（I）中的R 1为烃基）的式（I）的L-α-氨基酸与式（II）的醛反应：（在式 II），R 2为烃），得到式（III）的L-丝氨酸衍生物。 。
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公开(公告)号：US20090170171A1
公开(公告)日：2009-07-02
申请号：US11942873
申请日：2007-11-20
CPC分类号： C12N9/1014 , C12P13/06 , C12Y201/02001
摘要： The present invention provides a new method for producing serine derivatives and their optically-activated derivatives in a convenient manner. In the presence of an enzyme, an L-α-amino acid of formula (I): (in the formula (I), R1 is a hydrocarbon group) is reacted with an aldehyde of formula (II): (in the formula (II), R2 is a hydrocarbon) to produce an L-serine derivative of formula (III).
摘要翻译： 本发明提供了以方便的方式制备丝氨酸衍生物及其光活性衍生物的新方法。 在酶的存在下，式（I）:(式（I）中的R 1为烃基）的式（I）的L-α-氨基酸与式（II）的醛反应：（在式 II），R 2为烃），得到式（III）的L-丝氨酸衍生物。
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公开(公告)号：US20060263861A1
公开(公告)日：2006-11-23
申请号：US11419522
申请日：2006-05-22
CPC分类号： C12P13/04 , C12N9/1014
摘要： A method for producing β-hydroxy amino acid and its optically-active isomer is provided. The β-hydroxy amino acid is produced by reacting a predetermined D-α-amino acid and 5,10-methylene tetrahydrofolic acid in the presence of an enzyme derived from a microorganism belonging to the genera Paracoccus, Aminobacter, or Ensifer.
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公开(公告)号：US07745182B2
公开(公告)日：2010-06-29
申请号：US12345922
申请日：2008-12-30
CPC分类号： C12P13/04 , C12N9/1014
摘要： A method for producing β-hydroxy amino acid and its optically-active isomer is provided. The β-hydroxy amino acid is produced by reacting a predetermined D-α-amino acid and 5,10-methylene tetrahydrofolic acid in the presence of an enzyme derived from a microorganism belonging to the genera Paracoccus, Aminobacter, or Ensifer.
摘要翻译： 提供了一种生产β-羟基氨基酸及其光学活性异构体的方法。 β-羟基氨基酸通过使预定的D-α-氨基酸和5,10-亚甲基四氢叶酸在衍生自属于副球菌属，氨基杆菌属或Ensifer属的微生物的酶存在下反应来制备。
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公开(公告)号：US07556947B2
公开(公告)日：2009-07-07
申请号：US12345887
申请日：2008-12-30
CPC分类号： C12P13/04 , C12N9/1014
摘要： A method for producing β-hydroxy amino acid and its optically-active isomer is provided. The β-hydroxy amino acid is produced by reacting a predetermined D-α-amino acid and 5,10-methylene tetrahydrofolic acid in the presence of an enzyme derived from a microorganism belonging to the genera Paracoccus, Aminobacter, or Ensifer.
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6.发明申请公开(公告)号：US20090112019A1
公开(公告)日：2009-04-30
申请号：US12345922
申请日：2008-12-30
IPC分类号： C07C227/16
CPC分类号： C12P13/04 , C12N9/1014
摘要： A method for producing β-hydroxy amino acid and its optically-active isomer is provided. The β-hydroxy amino acid is produced by reacting a predetermined D-α-amino acid and 5,10-methylene tetrahydrofolic acid in the presence of an enzyme derived from a microorganism belonging to the genera Paracoccus, Aminobacter, or Ensifer.
摘要翻译： 提供了生产β-羟基氨基酸及其光学活性异构体的方法。 β羟基氨基酸是通过使预定的D-α-氨基酸和5,10-亚甲基四氢叶酸在衍生自属于副球菌属，氨基杆菌属或Ensifer属的微生物的酶存在下反应生成的。
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公开(公告)号：US20090111150A1
公开(公告)日：2009-04-30
申请号：US12345887
申请日：2008-12-30
IPC分类号： C12P13/04
CPC分类号： C12P13/04 , C12N9/1014
摘要： A method for producing β-hydroxy amino acid and its optically-active isomer is provided. The β-hydroxy amino acid is produced by reacting a predetermined D-α-amino acid and 5,10-methylene tetrahydrofolic acid in the presence of an enzyme derived from a microorganism belonging to the genera Paracoccus, Aminobacter, or Ensifer.
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公开(公告)号：US07507559B2
公开(公告)日：2009-03-24
申请号：US11419522
申请日：2006-05-22
CPC分类号： C12P13/04 , C12N9/1014
摘要： A method for producing β-hydroxy amino acid and its optically-active isomer is provided. The β-hydroxy amino acid is produced by reacting a predetermined D-α-amino acid and 5,10-methylene tetrahydrofolic acid in the presence of an enzyme derived from a microorganism belonging to the genera Paracoccus, Aminobacter, or Ensifer.
摘要翻译： 提供了生产β-羟基氨基酸及其光学活性异构体的方法。 β羟基氨基酸是通过使预定的D-α-氨基酸和5,10-亚甲基四氢叶酸在衍生自属于副球菌属，氨基杆菌属或Ensifer属的微生物的酶存在下反应生成的。
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公开(公告)号：US08372607B2
公开(公告)日：2013-02-12
申请号：US12836984
申请日：2010-07-15
申请人： Shinji Kuroda , Masakazu Sugiyama , Kunihiko Watanabe , Shunichi Suzuki , Kenzo Yokozeki , Tatsuki Kashiwagi
发明人： Shinji Kuroda , Masakazu Sugiyama , Kunihiko Watanabe , Shunichi Suzuki , Kenzo Yokozeki , Tatsuki Kashiwagi
CPC分类号： C12N9/1029 , C12P13/04
摘要： The present invention describes a method for generating a serine derivative and an optically active isomer thereof by a convenient technique, and an enzyme and the like useful in the method. In the presence of the following protein (A) and/or (B) having an enzymatic activity, an α-amino acid is reacted with an aldehyde to form a serine derivative: (A) a protein comprising the amino acid sequence of SEQ ID NO:5, and (B) a protein comprising an amino acid sequence of SEQ ID NO: 5, but which includes substitution, deletion, insertion and addition of one or more amino acids and is able to catalyze the reaction to form the serine derivative.
摘要翻译： 本发明描述了通过方便的技术产生丝氨酸衍生物和光学活性异构体的方法，以及在该方法中有用的酶等。 在具有酶活性的下列蛋白质（A）和/或（B）的存在下，α-氨基酸与醛反应形成丝氨酸衍生物：（A）包含SEQ ID NO：1的氨基酸序列的蛋白质 （B）包含SEQ ID NO：5的氨基酸序列但包括取代，缺失，插入和加入一个或多个氨基酸的蛋白质，并且能够催化该反应以形成丝氨酸衍生物 。
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10.发明申请公开(公告)号：US20100317068A1
公开(公告)日：2010-12-16
申请号：US12836984
申请日：2010-07-15
申请人： Shinji Kuroda , Masakazu Sugiyama , Kunihiko Watanabe , Shunichi Suzuki , Kenzo Yokozeki , Tatsuki Kashiwagi
发明人： Shinji Kuroda , Masakazu Sugiyama , Kunihiko Watanabe , Shunichi Suzuki , Kenzo Yokozeki , Tatsuki Kashiwagi
CPC分类号： C12N9/1029 , C12P13/04
摘要： The present invention describes a method for generating a serine derivative and an optically active isomer thereof by a convenient technique, and an enzyme and the like useful in the method. In the presence of the following protein (A) and/or (B) having an enzymatic activity, an α-amino acid is reacted with an aldehyde to form a serine derivative: (A) a protein comprising the amino acid sequence of SEQ ID NO:5, and (B) a protein comprising an amino acid sequence of SEQ ID NO: 5, but which includes substitution, deletion, insertion and addition of one or more amino acids and is able to catalyze the reaction to form the serine derivative.
摘要翻译： 本发明描述了通过方便的技术产生丝氨酸衍生物和光学活性异构体的方法，以及在该方法中有用的酶等。 在具有酶活性的下列蛋白质（A）和/或（B）的存在下，α-氨基酸与醛反应形成丝氨酸衍生物：（A）包含SEQ ID NO：1的氨基酸序列的蛋白质 （B）包含SEQ ID NO：5的氨基酸序列但包括取代，缺失，插入和加入一个或多个氨基酸的蛋白质，并且能够催化该反应以形成丝氨酸衍生物 。
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