公开(公告)号：US08791159B2

公开(公告)日：2014-07-29

申请号：US12879158

申请日：2010-09-10

申请人： Shinji Nakade ,  Hirotaka Mizuno ,  Takeji Ono ,  Masashi Minami ,  Hiroshi Saga ,  Hiroshi Hagiya ,  Takaki Komiya ,  Hiromu Habashita ,  Haruto Kurata ,  Kazuhiro Ohtsuki ,  Kensuke Kusumi

发明人： Shinji Nakade ,  Hirotaka Mizuno ,  Takeji Ono ,  Masashi Minami ,  Hiroshi Saga ,  Hiroshi Hagiya ,  Takaki Komiya ,  Hiromu Habashita ,  Haruto Kurata ,  Kazuhiro Ohtsuki ,  Kensuke Kusumi

IPC分类号： C07C227/36 ,  A61K31/235 ,  A61K31/197

CPC分类号： C07C229/36 ,  A61K31/197 ,  A61K31/198 ,  A61K31/397 ,  A61K31/401 ,  A61K31/44 ,  A61K31/445 ,  A61K45/06 ,  C07C229/14 ,  C07C229/22 ,  C07C229/34 ,  C07C233/47 ,  C07C255/16 ,  C07C255/41 ,  C07C271/22 ,  C07C323/12 ,  C07D205/04 ,  C07D207/16 ,  C07D211/62 ,  C07D211/70 ,  C07D217/04

摘要： A compound having an ability to bind to an SIP receptor and represented by formula (I), a salt thereof, a solvate thereof or a prodrug thereof is useful for prevention and/or treatment of rejection of transplantation, graft-versus-host disease, autoimmune disease, allergic disease and the like: wherein ring A is a cyclic group; ring B is a cyclic group which may have substituent(s); X is a spacer having 1 to 8 atoms in its main chain, etc.; Y is a spacer having 1 to 10 atoms in its main chain, etc.; n is 0 or 1, wherein when n is 0, m is 1 and R1 is a hydrogen atom or a substituent, and wherein when n is 1, m is 0 or an integer of 1 to 7 and R1 is a substituent, and wherein m is 2 or more, R1s are the same or different.

摘要翻译： 具有结合SIP受体并由式（I）表示的能力的化合物，其盐，其溶剂合物或其前药可用于预防和/或治疗移植排斥反应，移植物抗宿主病， 自身免疫性疾病，过敏性疾病等：其中环A为环状基团; 环B是可以具有取代基的环状基团; X是其主链中具有1至8个原子的间隔基等; Y是其主链中具有1至10个原子的间隔物等; n为0或1，其中当n为0时，m为1，R 1为氢原子或取代基，n为1时，m为0或1〜7的整数，R 1为取代基，其中， m为2以上，R 1相同或不同。

公开(公告)号：US07825109B2

公开(公告)日：2010-11-02

申请号：US10569831

申请日：2004-08-27

申请人： Shinji Nakade ,  Hirotaka Mizuno ,  Takeji Ono ,  Masashi Minami ,  Hiroshi Saga ,  Hiroshi Hagiya ,  Takaki Komiya ,  Hiromu Habashita ,  Haruto Kurata ,  Kazuhiro Ohtsuki ,  Kensuke Kusumi

发明人： Shinji Nakade ,  Hirotaka Mizuno ,  Takeji Ono ,  Masashi Minami ,  Hiroshi Saga ,  Hiroshi Hagiya ,  Takaki Komiya ,  Hiromu Habashita ,  Haruto Kurata ,  Kazuhiro Ohtsuki ,  Kensuke Kusumi

IPC分类号： C07D205/00 ,  A61K31/397

CPC分类号： C07D205/04 ,  C07C229/14 ,  C07C229/22 ,  C07C229/36 ,  C07C233/47 ,  C07C255/16 ,  C07C255/41 ,  C07C271/22 ,  C07C323/12 ,  C07C2601/08 ,  C07C2601/14 ,  C07D211/70 ,  C07D217/04

摘要： A compound having an ability to bind to an S1P receptor (particularly EDG-6, preferably EDG-1 and EDG-6), for example, the compound represented by formula (I) of the present invention, a salt thereof, a solvate thereof or a prodrug thereof is useful for prevention and/or treatment of rejection of transplantation, graft-versus-host disease, autoimmune disease, allergic disease and the like. wherein ring A is a cyclic group; ring B is a cyclic group which may have substituent(s); X is a spacer having 1 to 8 atoms in its main chain, etc.; Y is a spacer having 1 to 10 atoms in its main chain, etc.; n is 0 or 1, wherein when n is 0, m is 1 and R1 is a hydrogen atom or a substituent, and wherein when n is 1, m is 0 or an integer of 1 to 7 and R1 is a substituent, and wherein m is 2 or more, R1s are the same or different.

摘要翻译： 具有与S1P受体（特别是EDG-6，优选EDG-1和EDG-6）结合的能力的化合物，例如本发明的式（I）表示的化合物，其盐，其溶剂合物 或其前药可用于预防和/或治疗移植排斥反应，移植物抗宿主病，自身免疫性疾病，过敏性疾病等。 其中环A是环状基团; 环B是可以具有取代基的环状基团; X是其主链中具有1至8个原子的间隔物等; Y是其主链中具有1至10个原子的间隔物等; n为0或1，其中当n为0时，m为1，R 1为氢原子或取代基，n为1时，m为0或1〜7的整数，R 1为取代基，其中， m为2以上，R 1相同或不同。

公开(公告)号：US20110020324A1

公开(公告)日：2011-01-27

申请号：US12879158

申请日：2010-09-10

申请人： Shinji NAKADE ,  Hirotaka Mizuno ,  Takeji Ono ,  Masashi Minami ,  Hiroshi Saga ,  Hiroshi Hagiya ,  Takaki Komiya ,  Hiromu Habashita ,  Haruto Kurata ,  Kazuhiro Ohtsuki ,  Kensuke Kusumi

发明人： Shinji NAKADE ,  Hirotaka Mizuno ,  Takeji Ono ,  Masashi Minami ,  Hiroshi Saga ,  Hiroshi Hagiya ,  Takaki Komiya ,  Hiromu Habashita ,  Haruto Kurata ,  Kazuhiro Ohtsuki ,  Kensuke Kusumi

IPC分类号： A61K31/197 ,  C07C229/36 ,  A61K31/198 ,  C07C229/34 ,  C07D207/16 ,  A61K31/401 ,  A61K31/40 ,  C07D211/60 ,  A61K31/445 ,  C07D211/62 ,  C07D205/04 ,  A61K31/397 ,  A61K31/24 ,  A61P37/06 ,  A61P37/08 ,  A61K31/56 ,  A61K39/395

CPC分类号： C07C229/36 ,  A61K31/197 ,  A61K31/198 ,  A61K31/397 ,  A61K31/401 ,  A61K31/44 ,  A61K31/445 ,  A61K45/06 ,  C07C229/14 ,  C07C229/22 ,  C07C229/34 ,  C07C233/47 ,  C07C255/16 ,  C07C255/41 ,  C07C271/22 ,  C07C323/12 ,  C07D205/04 ,  C07D207/16 ,  C07D211/62 ,  C07D211/70 ,  C07D217/04

摘要： A compound having an ability to bind to an S1P receptor (particularly EDG-6, preferably EDG-1 and EDG-6), for example, the compound represented by formula (I) of the present invention, a salt thereof, a solvate thereof or a prodrug thereof is useful for prevention and/or treatment of rejection of transplantation, graft-versus-host disease, autoimmune disease, allergic disease and the like. wherein ring A is a cyclic group; ring B is a cyclic group which may have substituent(s); X is a spacer having 1 to 8 atoms in its main chain, etc.; Y is a spacer having 1 to 10 atoms in its main chain, etc.; n is 0 or 1, wherein when n is 0, m is 1 and R1 is a hydrogen atom or a substituent, and wherein when n is 1, m is 0 or an integer of 1 to 7 and R1 is a substituent, and wherein m is 2 or more, R1s are the same or different.

摘要翻译： 具有与S1P受体（特别是EDG-6，优选EDG-1和EDG-6）结合的能力的化合物，例如本发明的式（I）表示的化合物，其盐，其溶剂合物 或其前药可用于预防和/或治疗移植排斥反应，移植物抗宿主病，自身免疫性疾病，过敏性疾病等。 其中环A是环状基团; 环B是可以具有取代基的环状基团; X是其主链中具有1至8个原子的间隔物等; Y是其主链中具有1至10个原子的间隔物等; n为0或1，其中当n为0时，m为1，R 1为氢原子或取代基，n为1时，m为0或1〜7的整数，R 1为取代基，其中， m为2以上，R 1相同或不同。

公开(公告)号：US20070167425A1

公开(公告)日：2007-07-19

申请号：US10569831

申请日：2004-08-27

申请人： Shinji Nakade ,  Hirotaka Mizuno ,  Takeji Ono ,  Masashi Minami ,  Hiroshi Saga ,  Hiroshi Hagiya ,  Takaki Komiya ,  Hiromu Habashita ,  Haruto Kurata ,  Kazuhiro Ohtsuki ,  Kensuke Kusumi

发明人： Shinji Nakade ,  Hirotaka Mizuno ,  Takeji Ono ,  Masashi Minami ,  Hiroshi Saga ,  Hiroshi Hagiya ,  Takaki Komiya ,  Hiromu Habashita ,  Haruto Kurata ,  Kazuhiro Ohtsuki ,  Kensuke Kusumi

IPC分类号： A61K31/445 ,  A61K31/405 ,  A61K31/197 ,  A61K31/397 ,  A61K31/198

CPC分类号： C07D205/04 ,  C07C229/14 ,  C07C229/22 ,  C07C229/36 ,  C07C233/47 ,  C07C255/16 ,  C07C255/41 ,  C07C271/22 ,  C07C323/12 ,  C07C2601/08 ,  C07C2601/14 ,  C07D211/70 ,  C07D217/04

摘要： A compound having an ability to bind to an S1P receptor (particularly EDG-6, preferably EDG-1 and EDG-6), for example, the compound represented by formula (I) of the present invention, a salt thereof, a solvate thereof or a prodrug thereof is useful for prevention and/or treatment of rejection of transplantation, graft-versus-host disease, autoimmune disease, allergic disease and the like. wherein ring A is a cyclic group; ring B is a cyclic group which may have substituent(s); X is a spacer having 1 to 8 atoms in its main chain, etc.; Y is a spacer having 1 to 10 atoms in its main chain, etc.; n is 0 or 1, wherein when n is 0, m is 1 and R1 is a hydrogen atom or a substituent, and wherein when n is 1, m is 0 or an integer of 1 to 7 and R1 is a substituent, and wherein m is 2 or more, R1s are the same or different.

摘要翻译： 具有与S 1 P受体（特别是EDG-6，优选EDG-1和EDG-6）结合的能力的化合物，例如本发明的式（I）表示的化合物，其盐， 其溶剂合物或其前药可用于预防和/或治疗移植排斥反应，移植物抗宿主病，自身免疫性疾病，过敏性疾病等。 其中环A是环状基团; 环B是可以具有取代基的环状基团; X是其主链中具有1至8个原子的间隔物等; Y是其主链中具有1至10个原子的间隔物等; n为0或1，其中当n为0时，m为1，R 1为氢原子或取代基，n为1时，m为0或1〜7的整数 R 1是取代基，m是2以上，R 1相同或不同。

公开(公告)号：US06855543B1

公开(公告)日：2005-02-15

申请号：US09446634

申请日：1998-06-23

申请人： Hiroshi Hagiya ,  Masashi Minami ,  Hisao Tajima

发明人： Hiroshi Hagiya ,  Masashi Minami ,  Hisao Tajima

IPC分类号： A61K38/00 ,  A61K48/00 ,  C07K14/39 ,  C07K14/705 ,  C12N15/63

CPC分类号： C07K14/70567 ,  A61K38/00 ,  A61K48/00 ,  C07K14/39 ,  C07K14/70578

摘要： A plasmid DNA comprising a novel reporter gene DNA; a transformant transformed with the above plasmid DNA and a DNA encoding a known effector protein; a therapeutic agent for a cancer or an autoimmune disease, comprising both of the above DNAs as active ingredients; and a method for detecting a ligand of an intracellular receptor, comprising using the above transformant.

摘要翻译： 包含新型报道基因DNA的质粒DNA; 用上述质粒DNA转化的转化体和编码已知效应子蛋白的DNA; 用于癌症或自身免疫性疾病的治疗剂，包括上述两种DNA作为活性成分; 以及检测细胞内受体的配体的方法，包括使用上述转化体。

公开(公告)号：US20050158775A1

公开(公告)日：2005-07-21

申请号：US11023449

申请日：2004-12-29

申请人： Hiroshi Hagiya ,  Masashi Minami ,  Hisao Tajima

发明人： Hiroshi Hagiya ,  Masashi Minami ,  Hisao Tajima

IPC分类号： A61K38/00 ,  A61K48/00 ,  C07K14/39 ,  C07K14/705 ,  C12Q1/68 ,  C12N5/06

CPC分类号： C07K14/70567 ,  A61K38/00 ,  A61K48/00 ,  C07K14/39 ,  C07K14/70578

摘要： A plasmid DNA comprising a novel reporter gene DNA; a transformant transformed with the above plasmid DNA and a DNA encoding a known effector protein; a therapeutic agent for a cancer or an autoimmune disease, comprising both of the above DNAs as active ingredients; and a method for detecting a ligand of an intracellular receptor, comprising using the above transformant.

摘要翻译： 包含新型报道基因DNA的质粒DNA; 用上述质粒DNA转化的转化体和编码已知效应子蛋白的DNA; 用于癌症或自身免疫性疾病的治疗剂，包括上述两种DNA作为活性成分; 以及检测细胞内受体的配体的方法，包括使用上述转化体。

公开(公告)号：US4047228A

公开(公告)日：1977-09-06

申请号：US604119

申请日：1975-08-13

申请人： Tohmi Yagishita ,  Hiroshi Hagiya

发明人： Tohmi Yagishita ,  Hiroshi Hagiya

IPC分类号： H04N1/40 ,  H04N1/17 ,  H04N1/413 ,  H04N1/415 ,  H04N7/12

CPC分类号： H04N1/415

摘要： The present invention provides a receiving system, for a facsimile system wherein when a large portion of a scanning line of an original pattern consists of only black (or only white), that portion is not transmitted in order to reduce the transmission time. The received facsimile signal has three families, synchronizing signals, group weight indicator signals and picture signals. The present receiver comprises: a means receiving said synchronizing signal for discriminating said synchronizing signal; a means receiving said group weight indicator signals following said synchronizing signal, for storing said group weight indicator signals in a temporary memory; a means reading said group weight indicator signals from said temporary memory for deciphering the signals thus read, prior to recording said picture signals on a recording paper; a means performing predetermined addition on a selective address register, based on the result of said deciphering; a means immediately distributing and applying picture signals to selected recording elements in accordance with addressing by said selective address register; a means recording said picture signals on a recording paper, and; a means performing auxiliary scanning during a period for receiving said synchronizing signal and said group weight indicator signals.

摘要翻译： 本发明提供了一种用于传真系统的接收系统，其中当原始图案的扫描线的大部分仅由黑色（或仅白色）组成时，该部分不被传输以便减少传输时间。 接收到的传真信号有三个系列，同步信号，组重量指示信号和图像信号。 本接收机包括：接收所述同步信号以识别所述同步信号的装置; 接收所述同步信号之后的所述组重量指示符信号的装置，用于将所述组重量指示符信号存储在临时存储器中; 在将所述图像信号记录在记录纸上之前，读取来自所述临时存储器的所述组重量指示信号的装置，用于对所读出的信号进行解密; 基于所述解密的结果，在选择性地址寄存器上执行预定加法的装置; 根据所述选择性地址寄存器的寻址立即将图像信号分配并应用于所选记录元件的装置; 在记录纸上记录所述图像信号的装置， 在用于接收所述同步信号和所述组重量指示符信号的时段期间执行辅助扫描的装置。