公开(公告)号：US5183882A

公开(公告)日：1993-02-02

申请号：US656824

申请日：1991-02-19

申请人： Shinji Sakata ,  Takanori Miyashita ,  Kazuhiko Kondo ,  Atsushi Sakai ,  Toshiyuki Shibata ,  Takayuki Ogawa

发明人： Shinji Sakata ,  Takanori Miyashita ,  Kazuhiko Kondo ,  Atsushi Sakai ,  Toshiyuki Shibata ,  Takayuki Ogawa

IPC分类号： A61K9/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7052 ,  A61K31/7064 ,  A61K31/7068 ,  A61K47/12 ,  A61K47/26 ,  A61P31/12 ,  A61P35/00 ,  C07H19/06

CPC分类号： C07H19/06 ,  A61K47/12 ,  A61K47/26 ,  A61K9/0019

摘要： Novel stable, non-hygroscopic 2'-deoxy-2'-methylidenecytidine dihydrate and its methods for production, and compositions with improved solubility containing same and saccharide(s).

公开(公告)号：US5412089A

公开(公告)日：1995-05-02

申请号：US959267

申请日：1992-10-09

申请人： Shinji Sakata ,  Takanori Miyashita ,  Kazuhiko Kondo

发明人： Shinji Sakata ,  Takanori Miyashita ,  Kazuhiko Kondo

IPC分类号： A61K9/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7052 ,  A61K31/7064 ,  A61K31/7068 ,  A61K47/12 ,  A61K47/26 ,  A61P31/12 ,  A61P35/00 ,  C07H19/06

CPC分类号： C07H19/06 ,  A61K47/12 ,  A61K47/26 ,  A61K9/0019

摘要： Novel stable, non-hygroscopic 2'-deoxy-2'-methylidenecytidine dihydrate and its methods for production, and compositions with improved solubility containing same and saccharide(s).

摘要翻译： 新型稳定的，非吸湿性的2'-脱氧-2'-亚甲基联嘧啶二水合物及其制备方法，以及含有相同糖和糖的溶解度改善的组合物。

公开(公告)号：US5696097A

公开(公告)日：1997-12-09

申请号：US525606

申请日：1995-09-15

申请人： Akira Matsuda ,  Takuma Sasaki ,  Satoshi Shutou ,  Akihiro Fujii ,  Takashi Ono ,  Shinji Sakata ,  Takanori Miyashita

发明人： Akira Matsuda ,  Takuma Sasaki ,  Satoshi Shutou ,  Akihiro Fujii ,  Takashi Ono ,  Shinji Sakata ,  Takanori Miyashita

IPC分类号： C07H19/10 ,  A61K31/70 ,  C07H19/207

CPC分类号： C07H19/10

摘要： Novel 2'-methylidenenucleotide compounds of the formula (I) ##STR1## wherein R is a hydrogen or a halogen, R.sup.1 and R.sup.2 are the same or different and each is a fatty acid residue or a hydrocarbon residue, and R.sup.3 and R.sup.4 are the same or different and each is a hydrogen, a halogen or an alkyl; salts thereof; methods for production thereof; and pharmaceutical use thereof. The compounds and salts thereof show an excellent antitumor effect in mammals. More specifically, they show a remarkable activity of inhibiting growth of mouse tumors, cultured human tumor cells, and human tumors transplanted to nude mice, and are useful for the treatment and prevention of recurrence of lung cancer, gastrointestinal cancer, breast cancer, cervical cancer, gynecological cancer, urinological cancer, leukemia, melanoma, lymphogenous metastatic tumor and the like in mammals. They are also useful as antitumor agents since they have an increased bioavailability and low toxicity. In addition, they have the effects of maintaining and enhancing their activities.

摘要翻译： PCT No.PCT / JP94 / 00427 Sec。 371 1995年9月15日第 102（e）日期1995年9月15日PCT 1994年3月16日PCT公布。 第WO94 / 21659号公报 日期1994年9月29日新颖的式（I）的2'-亚甲基二核苷酸化合物其中R是氢或卤素，R 1和R 2相同或不同，各自为脂肪酸残基或烃 残基，R 3和R 4相同或不同，各自为氢，卤素或烷基; 的盐; 生产方法; 及其药物用途。 其化合物和盐在哺乳动物中表现出优异的抗肿瘤效果。 更具体地说，它们显示了抑制小鼠肿瘤，培养的人肿瘤细胞和移植到裸鼠的人肿瘤生长的显着活性，并且可用于治疗和预防肺癌，胃肠癌，乳腺癌，宫颈癌的复发 ，妇科癌症，尿毒症，白血病，黑素瘤，淋巴瘤转移瘤等。 它们也可用作抗肿瘤剂，因为它们具有增加的生物利用度和低毒性。 此外，它们还具有维护和增强活动的效果。

公开(公告)号：US5459254A

公开(公告)日：1995-10-17

申请号：US149943

申请日：1993-11-10

申请人： Toyofumi Yamaguchi ,  Takanori Miyashita ,  Shinji Sakata ,  Toichi Abiru ,  Akira Matsuda ,  Tohru Ueda ,  Kentaro Kogi

发明人： Toyofumi Yamaguchi ,  Takanori Miyashita ,  Shinji Sakata ,  Toichi Abiru ,  Akira Matsuda ,  Tohru Ueda ,  Kentaro Kogi

IPC分类号： C07H19/16 ,  C07H19/067

CPC分类号： C07H19/16 ,  Y02P20/55

摘要： The present invention relates to a novel compound represented by the following formula [I] which is useful as a synthetic intermediate of a 2-alkynyladenosine.The present invention also relates to a process for producing the compound and a process for producing a 2-alkynyladenosine [IV] by way of the compound.Further, the present invention relates to a 2-alkynyladenosine derivative represented by the following formula [V] having excellent storage stability and, to a method of storing the 2-alkynyladenosine in the form of that derivative. ##STR1## [I] A=a leaving group, [II] A=NH.sub.2,[V] A=NHR.sup.4,wherein R.sup.1 through R.sup.4 represent a hydrogen atom or a protective group, and n denotes an integer of 1 to 15, provided that R.sup.1 through R.sup.4 do not represent a hydrogen atom simultaneously.

摘要翻译： 本发明涉及可用作2-炔基腺苷合成中间体的下式[I]表示的新型化合物。 本发明还涉及该化合物的制备方法和通过该化合物制备2-炔基腺苷[Ⅳ]的方法。 此外，本发明涉及具有优异的储存稳定性的由下式[V]表示的2-炔基腺苷衍生物，以及以该衍生物的形式存储2-炔基腺苷的方法。 [I] A =离去基团，[II] A = NH 2，[V] A = NHR 4，其中R 1至R 4表示氢原子或保护基，n表示1至15的整数， R1至R4同时不表示氢原子。

公开(公告)号：US5026835A

公开(公告)日：1991-06-25

申请号：US447512

申请日：1989-12-07

申请人： Tohru Ueda ,  Takuma Sasaki ,  Akira Matsuda ,  Takanori Miyashita ,  Shinji Sakata ,  Keiji Yamagami ,  Akihiro Fujii

发明人： Tohru Ueda ,  Takuma Sasaki ,  Akira Matsuda ,  Takanori Miyashita ,  Shinji Sakata ,  Keiji Yamagami ,  Akihiro Fujii

IPC分类号： C07H19/06

CPC分类号： C07H19/06

摘要： Pyrimidine 2'-deoxy-2'-methylidene nucleoside compounds: ##STR1## wherein R.sup.1 represents amino, hydroxy, silylamino, silyloxy, acylamino or acyloxy; R.sup.2 represents hydrogen, halogen, a lower alkyl, a lower alkenyl, a lower alkynyl or haloalkyl; R.sup.3 and R.sup.4 represent the same or different hydrogen, silyl, acyl or aminoacyl, or a pharmaceutically acceptable salt or hydrate thereof, except that R.sup.1 is amino or hydroxy, and both of R.sup.3 and R.sup.4 are hydrogen.Said compounds possess excellent antitumor and antiviral activities, thus providing novel anticancer and antiviral agent.

公开(公告)号：US07590792B2

公开(公告)日：2009-09-15

申请号：US11515751

申请日：2006-09-06

申请人： Masumi Yamaga ,  Takanori Miyashita ,  Koichi Katou

发明人： Masumi Yamaga ,  Takanori Miyashita ,  Koichi Katou

IPC分类号： G06F12/00 ,  G06F13/00 ,  G06F13/28 ,  G06F12/08

CPC分类号： G06F12/0864

摘要： It is done to read information containing an address of a memory at which a cache miss is generated, from a cache memory. The numbers of cache misses generated at each cache miss generated address contained in the information are totalized. The cache miss generated addresses whose generated cache miss numbers are totalized are sectionalized by each of the sets. Further, the address group whose numbers of cache miss generated are consistent or close is extracted from a plurality of cache miss generated addresses divided as addresses in the same set.

摘要翻译： 完成从高速缓冲存储器读取包含生成高速缓存未命中的存储器地址的信息。 在信息中包含的每个高速缓存未生成地址处生成的高速缓存未命中的数量被合计。 高速缓存未命中产生的地址，其生成的高速缓存未命中数字被累加，由每组组成。 此外，从分配为同一集合中的地址的多个高速缓存未命中生成的地址中提取出生成的高速缓存未命中数一致或关闭的地址组。

公开(公告)号：US5189027A

公开(公告)日：1993-02-23

申请号：US799071

申请日：1991-11-27

申请人： Takanori Miyashita ,  Toichi Abiru ,  Yohko Watanabe ,  Toyofumi Yamaguchi ,  Akira Matsuda

发明人： Takanori Miyashita ,  Toichi Abiru ,  Yohko Watanabe ,  Toyofumi Yamaguchi ,  Akira Matsuda

IPC分类号： C07H19/16

CPC分类号： C07H19/16 ,  Y02P20/55

摘要： Disclosed herein are a novel 2-substituted adenosine derivative having the following formula [I] ##STR1## wherein R represents a hydrogen atom or a hydroxyl group, m is an integer of 2 to 7, n is 0 or an integer of 1 to 3, and R.sup.1, R.sup.2 and R.sup.3, which may be the same or different, each independently represent a hydrogen atom, a hydroxy protective group or a phosphoric acid residue, and salts thereof.The above compounds are excellent in a circulation ameliorating effect such as a vasodepressor activity, and have high selectivity for A.sub.2 receptors, but cause less undesirable side effects such as a suppresssive effect on the heart. They are therefore effective when used in pharmaceutical compositions for circulatory diseases.

公开(公告)号：US20070055809A1

公开(公告)日：2007-03-08

申请号：US11515751

申请日：2006-09-06

申请人： Masumi Yamaga ,  Takanori Miyashita ,  Koichi Katou

发明人： Masumi Yamaga ,  Takanori Miyashita ,  Koichi Katou

IPC分类号： G06F12/08

CPC分类号： G06F12/0864

摘要： It is done to read information containing an address of a memory at which a cache miss is generated, from a cache memory. The numbers of cache misses generated at each cache miss generated address contained in the information are totalized. The cache miss generated addresses whose generated cache miss numbers are totalized are sectionalized by each of the sets. Further, the address group whose numbers of cache miss generated are consistent or close is extracted from a plurality of cache miss generated addresses divided as addresses in the same set.

摘要翻译： 完成从高速缓冲存储器读取包含生成高速缓存未命中的存储器地址的信息。 在信息中包含的每个高速缓存未生成地址处生成的高速缓存未命中的数量被合计。 高速缓存未命中产生的地址，其生成的高速缓存未命中数字被累加，由每组组成。 此外，从分配为同一集合中的地址的多个高速缓存未命中生成的地址中提取出生成的高速缓存未命中数一致或关闭的地址组。

公开(公告)号：US06617444B1

公开(公告)日：2003-09-09

申请号：US09700728

申请日：2000-11-30

申请人： Kenya Mori ,  Takanori Miyashita ,  Hideaki Maeda ,  Hiroshi Sato ,  Yutaka Noda

发明人： Kenya Mori ,  Takanori Miyashita ,  Hideaki Maeda ,  Hiroshi Sato ,  Yutaka Noda

IPC分类号： C07H1910

CPC分类号： C07H21/00 ,  C07H1/06

摘要： The present invention is directed to crystals of P1-(2′-deoxycytidine 5′-)P4-(uridine 5′-)tetraphosphate (dCP4U) or a salt thereof and to a process for producing the crystals. The present invention also provides a process for producing dCP4U involving reacting uridine 5′-monophosphate (UMP), 2′-deoxycytidine 5′-monophosphate (dCMP), diphenyl phosphorochloridate (DPC), and pyrophosphate (PPi). The crystals of dCP4U obtained through the process according to the present invention have high purity and high stability and no hygroscopicity as compared with a freeze-dried product, and thereby serve as a useful raw material for preparing a pharmaceutical. The process for producing dCP4U according to the present invention permits use of inexpensive UMP as a raw material and realizes high yield. Thus, the process is suitable for large-scale synthesis of dCP4U.

摘要翻译： 本发明涉及P1-（2'-脱氧胞苷5' - ）P4-（尿苷5' - ）四磷酸（dCP4U）或其盐的晶体和晶体的制造方法。 本发明还提供一种生产dCP4U的方法，其涉及使尿苷5'-单磷酸（UMP），2'-脱氧胞苷5'-单磷酸（dCMP），二苯基氯代磷酸酯（DPC）和焦磷酸酯（PPi）反应。 通过本发明的方法获得的dCP4U的结晶与冷冻干燥产物相比具有高纯度和高稳定性和无吸湿性，从而用作制备药物的有用原料。 根据本发明的制备dCP4U的方法允许使用廉价的UMP作为原料，并且实现高产率。 因此，该方法适用于大规模合成dCP4U。

公开(公告)号：US08213522B2

公开(公告)日：2012-07-03

申请号：US12271199

申请日：2008-11-14

申请人： Takanori Miyashita ,  Shuichi Takayama ,  Hiroki Tatsumoto

发明人： Takanori Miyashita ,  Shuichi Takayama ,  Hiroki Tatsumoto

IPC分类号： H04N7/12

CPC分类号： H04N5/04 ,  H04H20/18 ,  H04H20/22 ,  H04H40/18 ,  H04N5/4401 ,  H04N5/455 ,  H04N21/2365 ,  H04N21/4305 ,  H04N21/4307 ,  H04N21/4347

摘要： The digital broadcast receiving apparatus according to the present invention includes: a first decoding unit which decodes video data of a first digital broadcast and outputs first video data that is decoded; a second decoding unit which decodes video data of a second digital broadcast and outputs second video data that is decoded; and a selection unit which selects one of the first video data and the second video data, and the first decoding unit outputs the first video data synchronous with a referential clock when the first video data is selected by the selection unit, and the first decoding unit outputs the first video data with timing delayed or accelerated by as much as an offset value with respect to timing of predetermined periodicity when the first video data is not selected by the selection unit.

摘要翻译： 根据本发明的数字广播接收装置包括：第一解码单元，其对第一数字广播的视频数据进行解码并输出被解码的第一视频数据; 第二解码单元，其对第二数字广播的视频数据进行解码并输出被解码的第二视频数据; 以及选择单元，其选择第一视频数据和第二视频数据中的一个，并且当由选择单元选择第一视频数据时，第一解码单元输出与参考时钟同步的第一视频数据，第一解码单元 当第一视频数据未被选择单元选择时，相对于预定周期的定时延迟或加速了定时的第一视频数据。