摘要:
Novel stable, non-hygroscopic 2'-deoxy-2'-methylidenecytidine dihydrate and its methods for production, and compositions with improved solubility containing same and saccharide(s).
摘要:
Novel stable, non-hygroscopic 2'-deoxy-2'-methylidenecytidine dihydrate and its methods for production, and compositions with improved solubility containing same and saccharide(s).
摘要:
Disclosed is a process for preparing a .beta.-lactam compound represented by the formula: ##STR1## wherein R.sup.1 represents a hydroxy-substituted lower alkyl group or an amino group each of which may be protected; R.sup.2 represents hydrogen atom or an ester residue; X represents a methylene group which may be substituted by a lower alkyl group, sulfur atom or a group represented by the formula: --A--CH.sub.2 -- where A represents sulfur atom, oxygen atom or methylene group; and W represents an active ester residue of hydroxyl group,or a salt thereof, which comprises the steps of treating a 1-aza-3-thia-bicycloalkane compound represented by the formula: ##STR2## wherein R.sup.1, R.sup.2 and X have the same meanings as defined above, or a salt thereof with a base in the presence of a desulfurizing agent and then reacting the resulting compound with an active esterifying agent of hydroxyl group.
摘要:
A music replay circuit is provided which includes a header analyzing unit which analyzes a header included in each of a plurality of frames in a data stream which are compressed music data and extracts bitrate information included in the header, a decoder which decodes the data stream analyzed by the header analyzing unit, a high-frequency correction unit which generates data in which high-frequency music data is interpolated, for music data decoded by the decoder, and a process setting unit which controls the process applied by the high-frequency correction unit based on the bitrate information extracted by the header analyzing unit, wherein the process setting unit control the process by the high-frequency correction unit according to the bitrate information extracted for each frame.
摘要:
A method for removing substituted or unsubstituted allyl group from .beta.-lactam compound having substituted or unsubstituted allyl group-protecting carboxyl group, which comprises treating said .beta.-lactam compound with palladium catalyst in the presence of allyl-scavenger in aqueous organic solvent, by which the substituted or unsubstituted group can be easily and effectively removed under moderate conditions so that the desired compound can be obtained in high yield at low cost.
摘要:
A process for preparing an optically active 4-mercapto-2-pyrrolidone derivative of the formula [I]: ##STR1## wherein R.sup.1 is a hydrogen atom or a protecting group and R.sup.2 is a hydrogen atom or a protecting group, which comprises subjecting racemic 4-amino-3-mercaptobutyric acid or a salt thereof to optical resolution by using 1-(trichlorophenyl)ethanesulfonic acid, followed by subjecting the product to cyclization reaction after protecting the functional groups thereof, if necessary, and further optionally removing the protecting groups therefrom. The present process is industrially advantageous than conventional processes for preparing optically active 4-mercapto-2-pyrrolidone derivatives which are useful as an intermediate for various medicines such as carbapenem antibacterial agents.
摘要:
There is disclosed an azetidinone compound of the formula [I]: ##STR1## wherein Ring B is a benzene ring which may have substituent(s), R.sup.1 is a hydroxy-substituted lower alkyl group which may have substituent(s), X is oxygen atom and the like, Y is oxygen atom and the like, and Z is a methylene group which may have substituent(s), which is useful as a synthetic intermediate of the 1.beta.-methylcarbapenem-type antibacterial agent.
摘要:
A road path searching apparatus applicable to a car navigation system is disclosed. Road map data with different level of detail for defining a predetermined area is stored previously in a memory device. First, nodes Nai and Nbj adjacent to each of the search nodes Pa and PB are detected based on map data having a high level of detail. When nodes Nai and Nbj exist on a map of a lower level of detail, a map of one lower level of detail is selected as a map to be used in the searching process. Accordingly, as following searching process is performed based on the map data of lower level of detail, required processing time is reduced.
摘要:
A synchronous pattern detection section checks coincidence between a predetermined reference synchronous pattern and a bit pattern included in a data stream. Each time a bit pattern which coincides with the reference synchronous pattern is detected, the synchronous pattern detection section extracts a frame length of a data frame corresponding to the bit pattern which is detected, and stores the extracted frame length in a storage section. Each time a bit pattern which coincides with the reference synchronous pattern is detected in the synchronous pattern detection section, a synchronization determination section determines whether or not the bit pattern detected by the synchronous pattern detection section is a correct synchronous pattern, based on a plurality of frame lengths stored in the storage section and a bit length of a data stream which is obtained after detection of the bit pattern. With this structure, a synchronous pattern included in the data stream can be detected with higher precision.
摘要:
The present invention provides a process of preparing a compound of the formula [I]: wherein X is a group of the formula: —N═ or —CH═; R1 is a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a cyano group or an amino group optionally substituted by a lower alkyl group; Ring A is a nitrogen-containing heterocyclic group; Ring B is an optionally substituted benzene ring or an optionally substituted pyridine ring; and R3 is a hydrogen atom or a lower alkyl group, or a pharmaceutically acceptable salt thereof, which is useful as an inhibitor of activated blood coagulation factor X.
摘要翻译:本发明提供制备式[I]化合物的方法:其中X是下式的基团:-N-或-CH-; R 1是氢原子,卤素原子,低级烷基,低级烷氧基,氰基或任选被低级烷基取代的氨基; 环A是含氮杂环基; 环B是任选取代的苯环或任选取代的吡啶环; R 3是氢原子或低级烷基或其药学上可接受的盐,其可用作活化凝血因子X的抑制剂。