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1.发明授权Process for an anthracycline derivative, and an anthracyclinone derivative useful for the process 失效蒽环类衍生物的方法和用于该方法的蒽环类衍生物衍生物
公开(公告)号：US4564674A
公开(公告)日：1986-01-14
申请号：US662833
申请日：1984-10-19
IPC分类号： C07F7/18 , C07H15/252 , C07H15/24
CPC分类号： C07H15/252 , C07F7/1856
摘要： A process for producing an anthracycline derivative represented by the general formula: ##STR1## where R.sup.1 is an acyl group, each of X.sup.1 and X.sup.2 is a hydrogen atom, a methoxy group, a hydroxyl group, a halogen atom or a lower alkyl group, each of Y.sup.1 and Y.sup.2 is a hydrogen atom, an alkoxy group or a hydroxyl group, and Z is a hydrogen atom or a protected hydroxyl group, which comprises reacting an anthracyclinone derivative represented by the general formula: ##STR2## where R is a hydrogen atom or a trialkylsilyl group, and X.sup.1, X.sup.2, Y.sup.1, Y.sup.2 and Z are as defined above, with a 1-acyl-sugar derivative represented by the general formula: ##STR3## where R.sup.2 is an acyl group and R.sup.1 is as defined above, in the presence of a silyl sulfonic acid derivative represented by the general formula:R.sup.5 R.sup.4 R.sup.3 SiOSO.sub.2 A (IV)where each of R.sup.3, R.sup.4 and R.sup.5 is an alkyl group and A is an alkyl group, an aryl group, a polyfluoroalkyl group or a hydrogen atom.
摘要翻译： 一种制备由以下通式表示的蒽环衍生物的方法：其中R1是酰基，其中X1和X2分别是氢原子，甲氧基，羟基，卤原子或低级 烷基，Y 1和Y 2各自为氢原子，烷氧基或羟基，Z为氢原子或被保护的羟基，其包括使由通式（II）表示的蒽环腈衍生物： ）其中R是氢原子或三烷基甲硅烷基，X 1，X 2，Y 1，Y 2和Z如上所定义，与通式如下的1-酰基 - 糖衍生物反应：其中R 2为 在通式R5R4R3SiOSO2A（IV）表示的甲硅烷基磺酸衍生物存在下，酰基和R 1如上所定义，其中R3，R4和R5各自为烷基，A为烷基，芳基 基团，多氟烷基或氢原子。
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公开(公告)号：US5231179A
公开(公告)日：1993-07-27
申请号：US684488
申请日：1991-04-12
申请人： Shiro Terashima , Yoshio Ito , Takeo Kawabata , Kunikazu Sakai , Tamejiro Hiyama , Yoshikazu Kimura , Makoto Sunagawa , Katsumi Tamoto , Akira Sasaki
发明人： Shiro Terashima , Yoshio Ito , Takeo Kawabata , Kunikazu Sakai , Tamejiro Hiyama , Yoshikazu Kimura , Makoto Sunagawa , Katsumi Tamoto , Akira Sasaki
IPC分类号： C07D205/08 , C07D233/32 , C07D263/26 , C07D263/52 , C07D263/58 , C07D403/06 , C07D413/06
CPC分类号： C07D263/52 , C07D205/08 , C07D233/32 , C07D263/26 , C07D263/58 , C07D403/06 , C07D413/06
摘要： A compound of the formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each a hydrogen atom, a lower alkyl group, an ar(lower)alkyl group or an aryl group, or R.sub.1 and R.sub.2 may be combined together to form a lower alkylene group and/or R.sub.3 and R.sub.4 are combined together to form a lower alkylene group, or R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be combined together to form an o-phenylene group, X is a halogen atom and Y is an oxygen atom or a nitrogen atom substituted with lower alkyl or aryl, which is useful as an intermediate in the synthesis of 1.beta.-methylcarbapenem compounds valuable as antibiotics.
摘要翻译： 下式的化合物：其中R 1，R 2，R 3和R 4各自为氢原子，低级烷基，芳（低级）烷基或芳基，或者R 1和R 2可以组合 一起形成低级亚烷基和/或R 3和R 4结合在一起形成低级亚烷基，或者，R 1，R 2，R 3和R 4可以组合在一起形成邻亚苯基，X是卤素原子，Y 是氧原子或被低级烷基或芳基取代的氮原子，其可用作合成作为抗生素有价值的1β-甲基碳青霉烯化合物的中间体。
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公开(公告)号：US4892961A
公开(公告)日：1990-01-09
申请号：US889830
申请日：1986-07-28
IPC分类号： C07D261/18
CPC分类号： C07D261/18 , Y02P20/55
摘要： An amino acid derivative of the formula: ##STR1## wherein R.sup.1 is a protective group for hydroxyl, which is useful as an intermediate for production of antimicrobial agent.
摘要翻译： 下式的氨基酸衍生物：其中R1是羟基的保护基，其可用作生产抗微生物剂的中间体。
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公开(公告)号：US08815990B2
公开(公告)日：2014-08-26
申请号：US13259112
申请日：2010-04-16
申请人： Yoshikazu Kimura , Tetsuya Shintaku
发明人： Yoshikazu Kimura , Tetsuya Shintaku
摘要： A stabilizer composition comprising a phenyl acrylate compound or phosphite compound, and a sugar alcohol.A thermoplastic polymer composition comprising a phenyl acrylate compound or phosphite compound, and a sugar alcohol, wherein the total weight of the phenyl acrylate compound or phosphite compound, and the sugar alcohol is 0.001 to 3 parts by weight with respect to 100 parts by weight of the thermoplastic polymer.
摘要翻译： 包含丙烯酸苯酯化合物或亚磷酸酯化合物和糖醇的稳定剂组合物。 包含苯基丙烯酸酯化合物或亚磷酸酯化合物和糖醇的热塑性聚合物组合物，其中丙烯酸苯酯化合物或亚磷酸酯化合物和糖醇的总重量相对于100重量份的 热塑性聚合物。
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公开(公告)号：US20120252943A1
公开(公告)日：2012-10-04
申请号：US13514685
申请日：2010-12-15
申请人： Yoshikazu Kimura
发明人： Yoshikazu Kimura
IPC分类号： C07F9/6571 , C08K5/52 , C08L29/02
CPC分类号： C08K5/527 , C08L23/0861 , C08L29/04
摘要： A resin composition comprising an ethylene/vinyl alcohol copolymer and a phosphite compound.A method of producing a resin composition, comprising the step of mixing an ethylene/vinyl alcohol copolymer with a phosphite compound.A molded article obtained by heat-molding the above-described resin composition.
摘要翻译： 包含乙烯/乙烯醇共聚物和亚磷酸酯化合物的树脂组合物。 一种制备树脂组合物的方法，包括将乙烯/乙烯醇共聚物与亚磷酸酯化合物混合的步骤。 通过对上述树脂组合物进行热成型而得到的成型体。
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公开(公告)号：US20060188715A1
公开(公告)日：2006-08-24
申请号：US10564054
申请日：2004-06-15
申请人： Masahiro Shoda , Yoshikazu Kimura
发明人： Masahiro Shoda , Yoshikazu Kimura
IPC分类号： D02G3/00
CPC分类号： A41G3/0083 , D01F6/92 , Y10T428/2913
摘要： Artificial hair having a look and feel that both are close in character to that of natural human hair, compared with artificial hair made from polyamide fibers, polyester fibers, acrylic fibers, etc., and which holds that character over time. By means of artificial hair composed of monofilaments containing poly(trimethylene terephthalate), in particular, by means of artificial hair composed of monofilaments containing poly(trimethylene terephthalate) having a denier of 22 to 333 dtex, a melting point of 225 to 235° C., a glass transition temperature of 45 to 80° C., the physical properties of elastic recovery, strength, stretch, and texture resemble natural human hair, and the occurrence of frizzes and gloss is kept under control.
摘要翻译： 与由聚酰胺纤维，聚酯纤维，丙烯酸纤维等制成的人造毛发相比，具有与天然人发的性质接近的人造毛发，并且随着时间的推移具有这种特性。 通过由含有聚（对苯二甲酸丙二醇酯）的单丝组成的人造毛发，特别是通过由含有22〜333dtex旦尼尔的聚（对苯二甲酸丙二醇酯）的单丝组成的人造毛，熔点为225〜235℃ 玻璃化转变温度为45〜80℃，弹性回复，强度，拉伸和质地的物理性质与天然人发相似，并保持卷曲和光泽的发生。
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公开(公告)号：US07041723B2
公开(公告)日：2006-05-09
申请号：US10350278
申请日：2003-01-23
申请人： Yoshikazu Kimura
发明人： Yoshikazu Kimura
IPC分类号： C08K3/10
摘要： The present invention provides a resin composition having excellent dispersibility, discoloration resistance and antimicrobial properties by blending a resin (A) with an antimicrobial agent (B) in which at least one kind of metal ion selected from the group consisting of silver, copper, zinc, and tin is supported on zeolite, and an antimicrobial agent (C) that includes a silver ion-containing phosphate as an active ingredient, or an antimicrobial agent (D) made of a soluble glass powder containing silver ion.
摘要翻译： 本发明提供一种通过将树脂（A）与抗微生物剂（B）混合而得到的分散性，耐变色性和抗菌性优异的树脂组合物，其中选自银，铜，锌中的至少一种金属离子 ，和负载在沸石上的锡，以及含有银离子的磷酸盐作为活性成分的抗微生物剂（C），或由含有银离子的可溶性玻璃粉末构成的抗菌剂（D）。
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8.发明授权Trifluoro methylthiomethyl benzene derivatives and process for production same 有权三氟甲基硫代甲基苯衍生物和生产方法相同公开(公告)号：US06225505B1
公开(公告)日：2001-05-01
申请号：US09463845
申请日：2000-02-01
IPC分类号： C07C31914
CPC分类号： C07C319/14 , C07C323/07 , C07C323/22 , C07C323/56 , C07C323/60
摘要： The present invention lies in a process for producing a trifluoromethylthiomethylbenzene derivative represented by the following general formula (2): (wherein R is a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group, an alkoxycarbonyl group, a cyano group, a nitro group, or a benzoyl group which may be substituted with halogen atom, alkyl group, alkoxy group, aliphatic or aromatic acyl group, nitro group, cyano group or alkoxycarbonyl group; n is an integer of 1 to 5; when n is an integer of 2 or more, a plurality of R's may be the same of each independently different), which process comprises reacting, in acetonitrile, a benzyl halide derivative represented by the following general formula (1): (wherein R and n have the same definitions as given above; and X is a halogen atom, an alkylsulfonyloxy group or an arylsulfonyloxy group which may be substituted with alkyl group or halogen atom) with thiophosgene and potassium fluoride.
摘要翻译： 本发明在于制备由以下通式（2）表示的三氟甲硫基甲基苯衍生物的方法：其中R是氢原子，卤素原子，烷基，烷氧基，烷氧基羰基，氰基， 硝基或可被卤素原子，烷基，烷氧基，脂肪族或芳香族酰基，硝基，氰基或烷氧基羰基取代的苯甲酰基，n为1〜5的整数，n为1〜5的整数， 2个以上的整数，多个R可以各自独立地不同），该方法包括在乙腈中使由以下通式（1）表示的苄基卤衍生物:(其中R和n具有相同的 定义如上所述; X为卤素原子，烷基磺酰氧基或可被烷基或卤原子取代的芳基磺酰氧基）与硫光气和氟化钾反应。
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公开(公告)号：US4575264A
公开(公告)日：1986-03-11
申请号：US634114
申请日：1984-07-24
CPC分类号： F16C33/107 , F16C17/045 , F16C17/18
摘要： A novel thrust bearing is provided in which a spiral element having a disc shape is loosely interposed between a pair of flat elements one of which is rotatable and the other of which is stationary, the spiral element having a spiral groove pattern on each of the opposite surfaces of the disc with the patterns on the respective surfaces reverse in relation to each other in their spiral direction.
摘要翻译： 提供了一种新颖的推力轴承，其中具有盘形的螺旋元件被松散地插入在一对平坦元件之间，其中一个平坦元件是可旋转的，另一个是静止的，螺旋元件在每个相对的 具有各个表面上的图案的盘的表面在其螺旋方向上相对于彼此相反。
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公开(公告)号：US20060141056A1
公开(公告)日：2006-06-29
申请号：US11349807
申请日：2006-02-08
申请人： Yoshikazu Kimura
发明人： Yoshikazu Kimura
摘要： A resin composition having excellent dispersibility, discoloration resistance and antimicrobial properties by blending a resin (A) with an antimicrobial agent (B) in which at least one kind of metal ion selected from the group consisting of silver, copper, zinc and tin is supported on zeolite, and an antimicrobial agent (C) that includes a silver ion-containing phosphate as an active ingredient, or an antimicrobial agent (D) made of a soluble glass powder containing silver ion.
摘要翻译： 通过将树脂（A）与抗菌剂（B）混合而得到的分散性，耐变色性和抗微生物性优异的树脂组合物，其中至少一种选自银，铜，锌和锡的金属离子被负载 和含有银离子的磷酸盐作为活性成分的抗微生物剂（C），或由含有银离子的可溶性玻璃粉末构成的抗微生物剂（D）。
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