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    Spacer for delivery of medications from an inhaler to children and breathing impaired patients
    1.
    发明申请
    Spacer for delivery of medications from an inhaler to children and breathing impaired patients 有权
    将吸入器药物递送给儿童和呼吸衰竭患者的间隔物

    公开(公告)号：US20050172955A1

    公开(公告)日：2005-08-11

    申请号：US10775465

    申请日：2004-02-10

    申请人： Shivshankar Sundaram ,  Balabhaskar Prabhakarpandian ,  Vinod Makhijani ,  Andrzej Przekwas

    发明人： Shivshankar Sundaram ,  Balabhaskar Prabhakarpandian ,  Vinod Makhijani ,  Andrzej Przekwas

    IPC分类号： A61M11/00 ,  A61M15/00

    CPC分类号： A61M15/0086 ,  A61M15/0016

    摘要： A spacer for delivering a medication spray from a metered dose inhaler includes a first conical body joined to a second conical body, forming a continuous spray conduit through first and second internal chambers of the respective first and second conical bodies. A mouthpiece is formed in the small diameter (proximal) end of the first conical body. A spray inlet for attachment to an MDI or similar device is formed at the large diameter (distal) end of the second conical body. A plurality of air inlets are placed downstream of the medication inlet proximate to, or in, the large diameter distal end surface of the first conical body. During use, high-pressure recirculation zones are created in the first and second chambers, near the spray inlet and the air inlets, and an air jacket is created along the inner surface of the wall of the first conical body. This forces the medication spray through the spacer into a defined, central airflow path through the spray conduit, minimizing particle deposition by contact with the walls of the spacer.

    摘要翻译： 用于从计量剂量吸入器输送药物喷雾的间隔件包括连接到第二锥形体的第一锥形体，通过相应的第一和第二锥形体的第一和第二内部腔形成连续的喷射导管。 在第一锥形体的小直径（近端）端部形成有接口。 在第二锥形体的大直径（远端）处形成用于附接到MDI或类似装置的喷雾入口。 多个空气入口被放置在药物入口的下游靠近第一锥形体的大直径远端表面或其中。 在使用期间，在第一和第二腔室中，在喷雾入口和进气口附近产生高压再循环区，沿着第一锥形体的壁的内表面形成气夹。 这迫使药物喷雾通过间隔物进入通过喷雾导管的限定的中心气流路径，通过与间隔物的壁接触使颗粒沉积最小化。

    Spacer for delivery of medications from an inhaler to children and breathing impaired patients
    2.
    发明授权
    Spacer for delivery of medications from an inhaler to children and breathing impaired patients 有权
    将吸入器药物递送给儿童和呼吸衰竭患者的间隔物

    公开(公告)号：US07107987B2

    公开(公告)日：2006-09-19

    申请号：US10775465

    申请日：2004-02-10

    申请人： Shivshankar Sundaram ,  Balabhaskar Prabhakarpandian ,  Vinod Makhijani ,  Andrzej Przekwas

    发明人： Shivshankar Sundaram ,  Balabhaskar Prabhakarpandian ,  Vinod Makhijani ,  Andrzej Przekwas

    IPC分类号： A61M11/00 ,  A61M15/00

    CPC分类号： A61M15/0086 ,  A61M15/0016

    摘要： A spacer for delivering a medication spray from an inhaler includes a first conical body joined to a second conical body, forming a continuous spray conduit through first and second internal chambers of the respective first and second conical bodies. A mouthpiece is formed in the proximal end of the first conical body. A spray inlet for attachment to the inhaler is formed at the distal end of the second conical body. A plurality of air inlets are placed downstream of the medication inlet proximate to, or in, the large diameter distal end surface of the first conical body. Recirculation zones are created in the first and second chambers, to force the medication spray into a central airflow path through the spray conduit, minimizing particle deposition by contract with the walls of the spacer.

    摘要翻译： 用于从吸入器输送药物喷雾的间隔件包括连接到第二锥形体的第一锥形体，通过相应的第一和第二锥形体的第一和第二内部腔形成连续的喷射导管。 在第一圆锥体的近端形成接口。 在第二锥形体的远端形成用于附接到吸入器的喷雾入口。 多个空气入口被放置在药物入口的下游靠近第一锥形体的大直径远端表面或其中。 在第一腔室和第二腔室中产生再循环区域，以迫使药物喷雾进入穿过喷雾导管的中心气流路径，通过与隔离物壁的收缩缩小使颗粒沉积最小化。

    Synthetic Microfluidic Microvasculature Networks
    7.
    发明申请
    Synthetic Microfluidic Microvasculature Networks 有权
    合成微流控微血管网络

    公开(公告)号：US20120330629A1

    公开(公告)日：2012-12-27

    申请号：US13332400

    申请日：2011-12-21

    申请人： Balabhaskar Prabhakarpandian ,  Shivshankar Sundaram ,  Kapil Pant

    发明人： Balabhaskar Prabhakarpandian ,  Shivshankar Sundaram ,  Kapil Pant

    IPC分类号： G06G7/50 ,  G06F17/10

    CPC分类号： G01N33/54346

    摘要： A synthetic microfluidic microvasculature network and associated methods mimic the structure, fluid flow characteristics, and physiological behavior of physiological microvasculature networks. Computational methods for simulating flow and particle adherence in synthetic and physiological microvascular systems and methods for determining parameters influencing particle adhesion and drug delivery are described with applications in the optimization of drug delivery and microvascular treatments and in describing disease mechanisms that affect the microvasculature.

    摘要翻译： 合成微流体微血管网络和相关方法模拟生理微血管网络的结构，流体流动特征和生理行为。 用于模拟合成和生理微血管系统中的流动和颗粒粘附的计算方法以及用于确定影响颗粒粘附和药物递送的参数的方法被描述，其用于优化药物递送和微血管治疗以及描述影响微血管系统的疾病机制。

    Synthetic microfluidic microvasculature network
    8.
    发明授权
    Synthetic microfluidic microvasculature network 有权
    合成微流体微血管网络

    公开(公告)号：US08175814B2

    公开(公告)日：2012-05-08

    申请号：US12428134

    申请日：2009-04-22

    申请人： Balabhaskar Prabhakarpandian ,  Shivshankar Sundaram ,  Kapil Pant

    发明人： Balabhaskar Prabhakarpandian ,  Shivshankar Sundaram ,  Kapil Pant

    IPC分类号： G01N33/48

    CPC分类号： G01N33/54346

    摘要： A synthetic microfluidic microvasculature network and associated methods mimic the structure, fluid flow characteristics, and physiological behavior of physiological microvasculature networks. Computational methods for simulating flow and particle adherence in synthetic and physiological microvascular systems and methods for determining parameters influencing particle adhesion and drug delivery are described with applications in the optimization of drug delivery and microvascular treatments and in describing disease mechanisms that affect the microvasculature.

    摘要翻译： 合成微流体微血管网络和相关方法模拟生理微血管网络的结构，流体流动特征和生理行为。 用于模拟合成和生理微血管系统中的流动和颗粒粘附的计算方法以及用于确定影响颗粒粘附和药物递送的参数的方法被描述，其用于优化药物递送和微血管治疗以及描述影响微血管系统的疾病机制。

    Synthetic microfluidic microvasculature network
    9.
    发明授权
    Synthetic microfluidic microvasculature network 有权
    合成微流体微血管网络

    公开(公告)号：US07725267B2

    公开(公告)日：2010-05-25

    申请号：US11393715

    申请日：2006-03-31

    申请人： Balabhaskar Prabhakarpandian ,  Shivshankar Sundaram ,  Kapil Pant

    发明人： Balabhaskar Prabhakarpandian ,  Shivshankar Sundaram ,  Kapil Pant

    IPC分类号： G01N33/48

    CPC分类号： G01N33/54346

    摘要： The present invention is a synthetic microfluidic microvasculature network and associated methods. The synthetic microfluidic microvasculature network mimics the structure, fluid flow characteristics, and physiological behavior of physiological microvasculature networks. Computational methods for simulating flow and particle adherence in synthetic and physiological microvascular systems and methods for determining parameters influencing particle adhesion and drug delivery are also described. The invention has many uses including the optimization of drug delivery and microvascular treatments and in describing disease mechanisms that affect the microvasculature such as inflammation, diabetes and hypertension.

    摘要翻译： 本发明是合成微流控微血管网络及其相关方法。 合成微流体微血管网络模拟生理微血管网络的结构，流体流动特性和生理行为。 还描述了用于模拟合成和生理微血管系统中的流动和颗粒粘附的计算方法以及用于确定影响颗粒粘附和药物递送的参数的方法。 本发明具有许多用途，包括优化药物递送和微血管治疗，并描述影响微血管的疾病机制，如炎症，糖尿病和高血压。