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    ELECTROSTATIC AEROSOL CONCENTRATOR
    1.
    发明申请
    ELECTROSTATIC AEROSOL CONCENTRATOR 有权
    静电空气浓缩器

    公开(公告)号：US20130192462A1

    公开(公告)日：2013-08-01

    申请号：US13566297

    申请日：2012-08-03

    Applicant: Kapil Pant ,  Shivshankar Sundaram ,  Yi Wang

    Inventor： Kapil Pant ,  Shivshankar Sundaram ,  Yi Wang

    IPC: B03C3/68

    CPC classification number: B03C3/68 ,  B03C3/025 ,  B03C3/06 ,  B03C3/41 ,  B03C3/49

    Abstract: Disclosed is an electrostatic aerosol concentrator for the concentration of aerosol particles and their collection for subsequent analysis. The concentrator comprises an airflow chamber that includes alternately energized and grounded electrode elements that work in concert to impart radial inward motion to charged aerosol particles and focusing them toward an enriched aerosol outlet. If desired, filtered air inlets may be used to provide a sheath of aerosol-free air along the chamber periphery and prevent deposition of particles onto electrode surfaces. Aerosol particles entering the airflow chamber may carry a positive or negative charge naturally, or a charge may be induced on the particles using a charging section located upstream of the aerosol inlet. Natural or induced charges on the aerosol particles may be used to selectively concentrate subpopulations of aerosol particles from a mixture of particles. For example, bacterial spores or aerosolized viruses may be selectively enriched without concentrating other aerosol particles. The particles of interest are focused and collected at an aerosol rich outlet in a small air volume, while the majority of the airflow, stripped of particles of interest, is purged to the atmosphere through an aerosol lean outlet.

    Abstract translation: 公开了一种用于浓缩气溶胶颗粒的静电气溶胶浓缩器及其收集用于随后的分析。 集中器包括气流室，其包括交替地供电和接地的电极元件，其一起工作以向带电的气溶胶颗粒进行径向向内运动并将它们聚焦到富集的气溶胶出口。 如果需要，可以使用过滤的空气入口来沿着室周边提供无气溶胶空气的护套，并防止颗粒沉积到电极表面上。 进入气流室的气溶胶颗粒可以自然携带正电荷或负电荷，或者可以使用位于气溶胶入口上游的充电部分在颗粒上诱导电荷。 气雾剂颗粒上的天然或诱导电荷可用于从颗粒混合物中选择性地浓缩气溶胶颗粒的亚群。 例如，细菌孢子或气雾化病毒可以选择性富集而不浓缩其它气溶胶颗粒。 将感兴趣的颗粒聚焦并收集在小气泡体积的气溶胶浓缩出口处，而大部分气流被汽提的感兴趣的颗粒通过气溶胶倾倒出口被吹扫到大气中。

    SYSTEM AND METHOD FOR BLOOD SEPARATION BY MICROFLUIDIC ACOUSTIC FOCUSING
    2.
    发明申请
    SYSTEM AND METHOD FOR BLOOD SEPARATION BY MICROFLUIDIC ACOUSTIC FOCUSING 有权
    通过微流体声学聚焦进行血液分离的系统和方法

    公开(公告)号：US20130048565A1

    公开(公告)日：2013-02-28

    申请号：US13598401

    申请日：2012-08-29

    Applicant: Jason O. FIERING ,  Shivshankar Sundaram

    Inventor： Jason O. FIERING ,  Shivshankar Sundaram

    IPC: A61M1/36 ,  B01J39/00 ,  B01D29/00 ,  B01D12/00 ,  B01D15/00

    CPC classification number: A61M1/3693 ,  A61M1/362 ,  B01D21/283 ,  B01D2221/10 ,  G01N33/491

    Abstract: Systems and methods for cleansing blood are disclosed herein. The methods include acoustically separating undesirable particles bound to capture particles from formed elements of whole blood. After introducing the capture particles to whole blood containing undesirable particles, the whole blood and capture particles are flowed through a microfluidic separation channel. At least one bulk acoustic transducer is attached to the microfluidic separation channel. A standing acoustic wave, imparted on the channel and its contents by the bulk acoustic transducer, drives the formed elements and undesirable particles bound to capture particles to specific aggregation axes. After aggregating the particles, the formed elements exit the separation channel through a first outlet and are returned to the patient. The undesirable particles, bound to the capture particles, exit through a second outlet and can be discarded to saved for later study.

    Abstract translation: 本文公开了用于清洗血液的系统和方法。 所述方法包括将结合到捕获颗粒的不需要的颗粒与形成的全血的元素进行声学分离。 在将捕获颗粒引入含有不需要的颗粒的全血之后，全血和捕获颗粒流过微流体分离通道。 至少一个体声换能器连接到微流体分离通道。 通过体声换能器在通道及其内容物上施加的声波驱动所形成的元件和结合以将颗粒捕获到特定聚集轴的不期望的颗粒。 在聚集颗粒之后，形成的元件通过第一出口离开分离通道并返回给患者。 与捕获颗粒结合的不需要的颗粒通过第二个出口排出，可以丢弃以保存以备后续研究。

    Microfluidic Assay for Characterization of the Leukocyte Adhesion Cascade
    4.
    发明申请
    Microfluidic Assay for Characterization of the Leukocyte Adhesion Cascade 有权
    微流控测定白细胞粘附级联的表征

    公开(公告)号：US20100112550A1

    公开(公告)日：2010-05-06

    申请号：US12612573

    申请日：2009-11-04

    Applicant: Shivshankar Sundaram

    Inventor： Shivshankar Sundaram

    IPC: C12Q1/70 ,  C12Q1/02 ,  C12M1/34

    CPC classification number: G01N33/5029 ,  G01N33/5032 ,  G01N33/5082 ,  G01N33/54366 ,  G01N33/56972

    Abstract: An apparatus and method for identifying and screening for agents affecting the leukocyte adhesion cascade (LAC) encompassing rolling, adhesion and migration comprises an optically clear, plastic microfluidic chip comprising flow channels with diameters in the range of 10-500 μm. The flow channels are coated with endothelial cells and at least a portion of the flow channels contains 1-30 μm sized openings, optionally filled with a native or synthetic extracellular matrix, that allow leukocyte migration into one or more tissue spaces.

    Abstract translation: 用于鉴定和筛选影响包含滚动，粘附和迁移的白细胞粘附级联（LAC）的试剂的装置和方法包括光学透明的塑料微流体芯片，其包含直径在10-500μm范围内的流动通道。 流动通道涂覆有内皮细胞，并且流动通道的至少一部分包含1-30μm大小的开口，任选地填充有天然或合成的细胞外基质，其允许白细胞迁移到一个或多个组织空间中。

    System and method for blood separation by microfluidic acoustic focusing
    6.
    发明授权
    System and method for blood separation by microfluidic acoustic focusing 有权

    公开(公告)号：US09731062B2

    公开(公告)日：2017-08-15

    申请号：US13598401

    申请日：2012-08-29

    Applicant: Jason O. Fiering ,  Shivshankar Sundaram

    Inventor： Jason O. Fiering ,  Shivshankar Sundaram

    IPC: A61M1/36 ,  B01J39/00 ,  B01D29/00 ,  B01D12/00 ,  B01D15/00 ,  B01D21/28 ,  G01N33/49

    CPC classification number: A61M1/3693 ,  A61M1/362 ,  B01D21/283 ,  B01D2221/10 ,  G01N33/491

    Abstract: Systems and methods for cleansing blood are disclosed herein. The methods include acoustically separating undesirable particles bound to capture particles from formed elements of whole blood. After introducing the capture particles to whole blood containing undesirable particles, the whole blood and capture particles are flowed through a microfluidic separation channel. At least one bulk acoustic transducer is attached to the microfluidic separation channel. A standing acoustic wave, imparted on the channel and its contents by the bulk acoustic transducer, drives the formed elements and undesirable particles bound to capture particles to specific aggregation axes. After aggregating the particles, the formed elements exit the separation channel through a first outlet and are returned to the patient. The undesirable particles, bound to the capture particles, exit through a second outlet and can be discarded to saved for later study.

    Thrombectomy microcatheter
    8.
    发明授权
    Thrombectomy microcatheter 有权
    血栓切除微导管

    公开(公告)号：US07842006B2

    公开(公告)日：2010-11-30

    申请号：US11561303

    申请日：2006-11-17

    Applicant: Guiren Wang ,  Shivshankar Sundaram ,  Kapil Pant ,  Jianjun Feng ,  Peter Storm

    Inventor： Guiren Wang ,  Shivshankar Sundaram ,  Kapil Pant ,  Jianjun Feng ,  Peter Storm

    IPC: A61B17/22

    CPC classification number: A61B17/2202 ,  A61B2017/00778 ,  A61B2017/22001 ,  A61B2017/22021

    Abstract: The present invention is an ultrasonic thrombectomy catheter that produces physical forces (shear rates) strong enough to emulsify obstructions such as thrombi and emboli without causing damage to arterial walls. This is accomplished by properly arranging piezoelectric transducers within a catheter and a tubular catheter head separated by a gap to generate acoustic streaming that simultaneously emulsifies the obstruction and sweeps resulting debris into a catheter lumen for removal. The open gap may be formed by supporting struts that connect the catheter to the catheter head. The design of the catheter tip allows the fabrication of catheters capable of removing partial or complete blockages from arteries and other vessels having diameters as small as 2 mm.

    Abstract translation: 本发明是一种超声波血栓切除术导管，其产生足够强的物理力​​（剪切速率）以乳化阻塞物如血栓和栓塞，而不会对动脉壁造成损伤。 这是通过将压电换能器适当地布置在导管内的管状导管头和由间隙分开的管状导管头来实现的，以产生声流，其同时乳化阻塞物并将所得碎片扫入导管腔以便移除。 开放间隙可以通过将导管连接到导管头上的支柱支撑而形成。 导管尖端的设计允许制造能够从直径小至2mm的动脉和其他容器中去除部分或完全阻塞的导管。

    Synthetic Microfluidic Microvasculature Networks
    10.
    发明申请
    Synthetic Microfluidic Microvasculature Networks 有权
    合成微流控微血管网络

    公开(公告)号：US20120330629A1

    公开(公告)日：2012-12-27

    申请号：US13332400

    申请日：2011-12-21

    Applicant: Balabhaskar Prabhakarpandian ,  Shivshankar Sundaram ,  Kapil Pant

    Inventor： Balabhaskar Prabhakarpandian ,  Shivshankar Sundaram ,  Kapil Pant

    IPC: G06G7/50 ,  G06F17/10

    CPC classification number: G01N33/54346

    Abstract: A synthetic microfluidic microvasculature network and associated methods mimic the structure, fluid flow characteristics, and physiological behavior of physiological microvasculature networks. Computational methods for simulating flow and particle adherence in synthetic and physiological microvascular systems and methods for determining parameters influencing particle adhesion and drug delivery are described with applications in the optimization of drug delivery and microvascular treatments and in describing disease mechanisms that affect the microvasculature.

    Abstract translation: 合成微流体微血管网络和相关方法模拟生理微血管网络的结构，流体流动特征和生理行为。 用于模拟合成和生理微血管系统中的流动和颗粒粘附的计算方法以及用于确定影响颗粒粘附和药物递送的参数的方法被描述，其用于优化药物递送和微血管治疗以及描述影响微血管系统的疾病机制。

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