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19 条记录 (耗时 0.029 秒)

    Method for differentiating primate embryonic stem cell into vascular cell
    2.
    发明申请
    Method for differentiating primate embryonic stem cell into vascular cell 有权
    将灵长类动物胚胎干细胞分化成血管细胞的方法

    公开(公告)号：US20050191744A1

    公开(公告)日：2005-09-01

    申请号：US11063584

    申请日：2005-02-24

    申请人： Kazuwa Nakao ,  Hiroshi Itoh ,  Jun Yamashita ,  Masakatsu Sone ,  Yasushi Kondo ,  Yutaka Suzuki

    发明人： Kazuwa Nakao ,  Hiroshi Itoh ,  Jun Yamashita ,  Masakatsu Sone ,  Yasushi Kondo ,  Yutaka Suzuki

    IPC分类号： C12N5/071 ,  C12N5/08

    CPC分类号： C12N5/069 ,  C12N2501/165 ,  C12N2506/03

    摘要： To provide a technique of the differentiation from a primate embryonic stem cell into a vascular cell, and techniques using the same. A method for differentiating a primate embryonic stem cell into a vascular cell, comprising differentiating a primate embryonic stem cell into a VEGFR-2-positive and undifferentiated primate embryonic stem cell marker-negative cell, and if need, further differentiating the resulting cell, a method of the differentiation into a vascular cell, and a vascular cell obtained by the method.

    摘要翻译： 提供从灵长类动物胚胎干细胞分化成血管细胞的技术以及使用其的技术。 一种将灵长动物胚胎干细胞分化为血管细胞的方法，其包括将灵长类动物胚胎干细胞分化为VEGFR-2阳性和未分化的灵长类动物胚胎干细胞标记物阴性细胞，如果需要，进一步分化所得细胞， 分化成血管细胞的方法和通过该方法获得的血管细胞。

    Human endothelin receptor
    5.
    发明授权
    Human endothelin receptor 失效
    人内皮素受体

    公开(公告)号：US07452970B2

    公开(公告)日：2008-11-18

    申请号：US10934973

    申请日：2004-09-03

    申请人： Hiroo Imura ,  Kazuwa Nakao ,  Shigetada Nakanishi

    发明人： Hiroo Imura ,  Kazuwa Nakao ,  Shigetada Nakanishi

    IPC分类号： C07K14/435 ,  C07K14/705 ,  C12P21/02 ,  A61K38/17

    CPC分类号： C07K14/70571 ,  C07K14/72

    摘要： DNA encoding an endothelin receptor shown in SEQ ID NO: 1 or 2 in the Sequence Listing is isolated from cDNA which is prepared from poly(A)+ RNA derived from a human placenta. In addition, an expression vector containing the DNA and a transformant containing the expression vector are obtained. An endothelin receptor is obtained by culturing this transformant. A receptor shown in SEQ ID NO: 1 is an ETA-receptor which has a high affinity for endothelins 1 and 2, especially for the endothelin 1. A receptor shown in SEQ ID NO: 2 is an ETB-receptor which has an affinity for endothelins 1, 2 and 3 with no selectivity.

    摘要翻译： 从序列表中SEQ ID NO：1或2所示的编码内皮素受体的DNA分离自由源自人胎盘的聚（A） RNA制备的cDNA。 此外，获得含有DNA的表达载体和含有表达载体的转化体。 通过培养该转化体获得内皮素受体。 SEQ ID NO：1所示的受体是对内皮素1和2具有高亲和力的ET A-A受体，特别是内皮素1。SEQ ID NO：2所示的受体是 具有对内皮素1,2和3没有选择性的亲和力的ET B受体。

    Method of treating arthritis and promoting growth of articular chondrocytes
    7.
    发明授权
    Method of treating arthritis and promoting growth of articular chondrocytes 有权
    治疗关节炎和促进关节软骨细胞生长的方法

    公开(公告)号：US07642243B2

    公开(公告)日：2010-01-05

    申请号：US10594920

    申请日：2005-03-31

    申请人： Kazuwa Nakao ,  Hidetomo Kitamura

    发明人： Kazuwa Nakao ,  Hidetomo Kitamura

    IPC分类号： A61K38/22 ,  A61K38/10 ,  C07K14/575 ,  C07K7/08

    CPC分类号： A61K38/2242

    摘要： This invention provides a new therapeutic or prophylactic agent for arthritis such as osteoarthritis. Specifically, it provides a therapeutic or prophylactic agent for arthritis such as osteoarthritis, or an agent for promoting the growth of articular chondrocyte, comprising a guanyl cyclase B (GC-B) activator as an active ingredient; or a method for inhibiting arthritis or for promoting the growth of articular chondrocyte by activating GC-B; or a method for screening an agent for promoting the growth of articular chondrocyte or an agent capable of treating arthritis using the GC-B activity as an indication.

    摘要翻译： 本发明提供了关节炎如骨关节炎的新型治疗或预防剂。 具体地说，本发明提供了关节炎如骨关节炎或促进关节软骨细胞生长的试剂的治疗或预防剂，其包含鸟苷酰环化酶B（GC-B）活化剂作为活性成分; 或通过活化GC-B抑制关节炎或促进关节软骨细胞生长的方法; 或用于筛选用于促进关节软骨细胞生长的药剂或能够使用GC-B活性治疗关节炎的药剂作为适应症的方法。

    Human endothelin receptor
    8.
    发明申请
    Human endothelin receptor 失效
    人内皮素受体

    公开(公告)号：US20080119638A1

    公开(公告)日：2008-05-22

    申请号：US10934973

    申请日：2004-09-03

    申请人： Hiroo Imura ,  Kazuwa Nakao ,  Shigetada Nakanishi

    发明人： Hiroo Imura ,  Kazuwa Nakao ,  Shigetada Nakanishi

    IPC分类号： C07K1/00

    CPC分类号： C07K14/70571 ,  C07K14/72

    摘要： DNA encoding an endothelin receptor shown in SEQ ID NO: 1 or 2 in the Sequence Listing is isolated from cDNA which is prepared from poly(A)+RNA derived from a human placenta. In addition, an expression vector containing the DNA and a transformant containing the expression vector are obtained. An endothelin receptor is obtained by culturing this transformant. A receptor shown in SEQ ID NO: 1 is an ETA-receptor which has a high affinity for endothelins 1 and 2, especially for the endothelin 1. A receptor shown in SEQ ID NO: 2 is an ETB-receptor which has an affinity for endothelins 1, 2 and 3 with no selectivity.

    摘要翻译： 从序列表中SEQ ID NO：1或2所示的编码内皮素受体的DNA分离自由源自人胎盘的聚（A） RNA制备的cDNA。 此外，获得含有DNA的表达载体和含有表达载体的转化体。 通过培养该转化体获得内皮素受体。 SEQ ID NO：1所示的受体是对内皮素1和2具有高亲和力的ET A-A受体，特别是内皮素1。SEQ ID NO：2所示的受体是 具有对内皮素1,2和3没有选择性的亲和力的ET B受体。

    Therapeutic agents for achondroplasia
    9.
    发明授权
    Therapeutic agents for achondroplasia 有权
    软骨发育的治疗剂

    公开(公告)号：US06743425B2

    公开(公告)日：2004-06-01

    申请号：US10218109

    申请日：2002-08-14

    申请人： Kazuwa Nakao

    发明人： Kazuwa Nakao

    IPC分类号： A61K3847

    CPC分类号： A61K38/2242

    摘要： The present invention aims to provide novel therapeutic agents for achondroplasia caused by mutations in FGFR3. Therapeutic agents for achondroplasia caused by the cartilage growth inhibition resulting from mutations in the gene for fibroblast growth factor receptor 3 (FGFR3), comprising a substance activating guanylyl cyclase B (GC-B) as an active ingredient are disclosed.

    摘要翻译： 本发明旨在提供由FGFR3突变引起的软骨发育不良的新型治疗剂。用于成纤维细胞生长因子受体3（FGFR3）基因突变引起的软骨生长抑制引起的软骨发育不良的治疗剂包括活化鸟苷酸环化酶B （GC-B）作为活性成分。

    Human endothelin receptor
    10.
    发明授权
    Human endothelin receptor 失效
    人内皮素受体

    公开(公告)号：US06313276B1

    公开(公告)日：2001-11-06

    申请号：US08121446

    申请日：1993-09-14

    申请人： Hiroo Imura ,  Kazuwa Nakao ,  Shigetada Nakanishi

    发明人： Hiroo Imura ,  Kazuwa Nakao ,  Shigetada Nakanishi

    IPC分类号： C07H2104

    CPC分类号： C07K14/70571 ,  C07K14/72

    摘要： DNA encoding an endothelin receptor shown in SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, or SEQ ID NO: 4. In the Sequence Listing is isolated from cDNA which is prepared from poly(A)+RNA derived from a human placenta. In addition, an expression vector containing the DNA and a transformant containing the expression vector are obtained. An endothelin receptor is obtained by culturing this transformant. A receptor shown in SEQ ID NO: 1 and SEQ ID NO: 2 is an ETA-receptor which has a high affinity for endothelins 1 and 2, especially for the endothelin 1. A receptor shown in SEQ ID NO: 3 and SEQ ID NO: 4 is an ETB-receptor which has an affinity for endothelins 1, 2 and 3 with no selectivity.

    摘要翻译： 编码SEQ ID NO：1，SEQ ID NO：2，SEQ ID NO：3或SEQ ID NO：4所示内皮素受体的DNA。序列表中分离自由poly（A）+ RNA 衍生自人胎盘。 此外，获得含有DNA的表达载体和含有表达载体的转化体。 通过培养该转化体获得内皮素受体。 SEQ ID NO：1和SEQ ID NO：2所示的受体是对内皮素1和2具有高亲和力的ETA-受体，特别是内皮素1。SEQ ID NO：3和SEQ ID NO： ：4是对内皮素1,2和3没有选择性的亲和性的ETB-受体。