公开(公告)号：US09186441B2

公开(公告)日：2015-11-17

申请号：US13259359

申请日：2010-03-16

申请人： Shoji Ochiai ,  Norifumi Tokunaga ,  Noboru Taguchi

发明人： Shoji Ochiai ,  Norifumi Tokunaga ,  Noboru Taguchi

IPC分类号： B01D29/00 ,  C08F220/10 ,  C09D133/10 ,  C09D133/08 ,  A61L33/06 ,  C08F220/26 ,  C08F220/56

CPC分类号： A61L33/064 ,  A61M1/3633 ,  B01D29/00 ,  C08F220/26 ,  C08F220/28 ,  C08F220/56 ,  C08F2220/285 ,  C09D133/08 ,  C09D133/10

摘要： A surface treating agent includes a copolymer including: a monomer (A) having a hydrophilic functional group of formula (1) or (2) below, a monomer (B) having a basic functional group, and a monomer (C) having a reactive functional group as monomer components, wherein the copolymer has a molar ratio of the monomer (A)/the monomer (B)/and the monomer (C) being between 70/15/15 and 98/1/1. (wherein each of R1 represents a hydrogen atom or a methyl group, R2 represents an alkyl group having 1 to 4 carbon atoms, n represents an integer of 2 to 4, and each of R3 and R4 independently represents a hydrogen atom or an alkyl group having 1 to 3 carbon atoms).

摘要翻译： 表面处理剂包括共聚物，其包含：具有下式（1）或（2）的亲水性官能团的单体（A），具有碱性官能团的单体（B）和具有反应性的单体（C） 官能团作为单体组分，其中共聚物具有单体（A）/单体（B）/和单体（C）的摩尔比在70/15/15至98/1/1之间。 （其中，R 1表示氢原子或甲基，R 2表示碳原子数1〜4的烷基，n表示2〜4的整数，R 3和R 4各自独立地表示氢原子或烷基 具有1至3个碳原子）。

公开(公告)号：US20120024779A1

公开(公告)日：2012-02-02

申请号：US13259359

申请日：2010-03-16

申请人： Shoji Ochiai ,  Norifumi Tokunaga ,  Noboru Taguchi

发明人： Shoji Ochiai ,  Norifumi Tokunaga ,  Noboru Taguchi

IPC分类号： B01D29/00 ,  C09D133/26 ,  C09D133/10

CPC分类号： A61L33/064 ,  A61M1/3633 ,  B01D29/00 ,  C08F220/26 ,  C08F220/28 ,  C08F220/56 ,  C08F2220/285 ,  C09D133/08 ,  C09D133/10

摘要： A surface treating agent is comprising a copolymer including: a monomer (A) having a hydrophilic functional group of formula (1) or (2) below, a monomer (B) having a basic functional group and a monomer (C) having a reactive functional group as monomer components, wherein the copolymer has a molar ratio of the monomer (A)/(B)/(C) between 70/15/15 to 98/1/1. (wherein (R1)s represent hydrogen or a methyl group, R2 represents an alkyl group having 1 to 4 carbon atoms, n represents an integer of 2 to 4, and R3 and R4 independently represent hydrogen or an alkyl group having 1 to 3 carbon atoms respectively)

摘要翻译： 表面处理剂包括共聚物，其包含：具有下式（1）或（2）的亲水性官能团的单体（A），具有碱性官能团的单体（B）和具有反应性的单体（C） 官能团作为单体组分，其中共聚物的单体（A）/（B）/（C）的摩尔比在70/15/15至98/1/1之间。 （其中（R1）表示氢或甲基，R2表示碳原子数1〜4的烷基，n表示2〜4的整数，R3和R4独立地表示氢或碳原子数1〜3的烷基 原子分别）

公开(公告)号：US06590054B2

公开(公告)日：2003-07-08

申请号：US09962591

申请日：2001-09-26

申请人： Masaru Tanaka ,  Shoji Ochiai ,  Norifumi Tokunaga ,  Yukiko Irie

发明人： Masaru Tanaka ,  Shoji Ochiai ,  Norifumi Tokunaga ,  Yukiko Irie

IPC分类号： C08F22010

CPC分类号： C08F220/28 ,  A61L33/064 ,  C08F2220/281 ,  C08L33/14 ,  C08F220/60 ,  C08F220/34

摘要： A copolymer comprising a monomer of formula (1) below and a monomer having a basic functional group copolymerizable with the monomer as monomer components, wherein molar ratio of the monomer of formula (1) to the monomer having a basic functional group is 85/15 to 99.9/0.1 and wherein the copolymer has a number based mean molecular weight of 5,000 to 500,000. The copolymer is excellent in antithrombotic activity and further in biocompatibility and can be used as a medial material having high hydrophilicity. It also can serve as an antithrombotic surface treating agent. (wherein R1 is an alkylene group having 1 to 4 carbon atoms, R2 is an alkyl group having 1 to 4 carbon atoms, and R3 represents hydrogen or a methyl group).

摘要翻译： 包含下述式（1）的单体和具有可与单体共聚的碱性官能团的单体作为单体组分的共聚物，其中式（1）的单体与具有碱性官能团的单体的摩尔比为85/15 至99.9 / 0.1，并且其中所述共聚物的数均分子量为5,000至500,000。 该共聚物的抗血栓活性优异，生物相容性更好，可以作为具有高亲水性的内侧材料使用。 也可以作为抗血栓表面处理剂（其中，R 1为碳原子数为1〜4的亚烷基，R 2为碳原子数1〜4的烷基，R 3表示氢或甲基）。

公开(公告)号：US20050148748A1

公开(公告)日：2005-07-07

申请号：US11057280

申请日：2005-02-10

申请人： Masaru Tanaka ,  Norifumi Tokunaga

发明人： Masaru Tanaka ,  Norifumi Tokunaga

IPC分类号： A61M1/02 ,  A61K35/14 ,  A61M1/36 ,  B01D39/16 ,  B01D71/40 ,  B01D71/48 ,  B01D71/54 ,  C08F8/44 ,  C08F212/14 ,  C08F220/28 ,  C08F220/34 ,  C08F220/60 ,  C08F226/06 ,  C08F20/60

CPC分类号： C08F220/28 ,  A61M1/3633 ,  A61M2202/0427 ,  A61M2202/0439 ,  C08F2220/281 ,  A61M2202/0057 ,  C08F220/34 ,  C08F220/60

摘要： A copolymer having excellent blood compatibility comprising an alkoxyalkyl (meth)acrylate and a comonomer having a basic functional group, a surface treating agent for blood filter using the same, and blood filter coated with the same on the surface thereof. The copolymer is useful as blood filter material for efficiently removing leucocytes and platelets while preventing damages of blood components at the time of blood filtration to a low level.

摘要翻译： 具有优异的血液相容性的共聚物包括（甲基）丙烯酸烷氧基烷基酯和具有碱性官能团的共聚单体，使用该共聚单体的血液过滤器的表面处理剂，以及在其表面上涂覆有它们的血液过滤器。 该共聚物可用作有效去除白细胞和血小板的血液过滤材料，同时防止血液过滤时的血液成分损伤至低水平。

公开(公告)号：US06303375B1

公开(公告)日：2001-10-16

申请号：US09338382

申请日：1999-06-23

申请人： Tetsuhiro Kimura ,  Norifumi Tokunaga ,  Yoshitaka Omura

发明人： Tetsuhiro Kimura ,  Norifumi Tokunaga ,  Yoshitaka Omura

IPC分类号： C12N500

CPC分类号： C12M25/14 ,  A61K35/12 ,  C12N5/0068 ,  C12N5/0671 ,  C12N2533/30 ,  C12N2533/78

摘要： A matrix for supporting cells such as animal cells is provided that enables cells to be supported at high efficiency and density in a short period. The matrix contains a plurality of cone shaped pores having an average diameter opening in an upstream surface of the matrix of from 500 to 1500 &mgr;m. The diameter decreases from the upstream surface to a downstream surface, and the average diameter of the cone shaped pores in the whole matrix is from 100 to 1000 &mgr;m. The matrix also contains a plurality of communicating pores that communicate with the cone shaped pores and with each other. These pores have an average diameter of from 5 to 100 &mgr;m, and the diameter decreases from a pore opening positioned near one surface of the matrix or near an interior surface of the cone shaped pores to a pore opening positioned remote from the surfaces. The matrix may also contain a plurality of column shaped pores having an average diameter of 100 to 1000 &mgr;m. A porous skin layer having an average pore size smaller than the average pore size of the communicating pores may be on the downstream surface, and the matrix may be made of polyurethane.

摘要翻译： 提供了用于支持诸如动物细胞的细胞的基质，其使细胞在短时间内以高效率和密度被支持。 该基质含有多个锥形孔，该孔具有在500至1500μm的基质的上游表面中的平均直径开口。 直径从上游表面下降到下游​​表面，整个基体中锥形孔的平均直径为100-1000μm。 该基质还包含与锥形孔和彼此连通的多个连通孔。 这些孔的平均直径为5至100μm，并且直径从位于基体的一个表面附近的孔隙或锥形孔的内表面附近的孔隙减小到远离表面的孔隙。 基质还可以含有平均直径为100-1000μm的多个柱状孔。 平均孔径小于连通孔的平均孔径的多孔表层可以在下游表面上，并且基质可以由聚氨酯制成。