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    COMPOSITIONS AND METHODS FOR PROMOTING THE GENERATION OF DEFINITIVE ENDODERM
    3.
    发明申请
    COMPOSITIONS AND METHODS FOR PROMOTING THE GENERATION OF DEFINITIVE ENDODERM 有权
    用于促进定义性内切生成的组合物和方法

    公开(公告)号：US20120088300A1

    公开(公告)日：2012-04-12

    申请号：US12679406

    申请日：2010-02-05

    申请人： Douglas A. Melton ,  Malgorzata Borowiak ,  Rene Maehr ,  Shuibing Chen ,  Weiping Tang ,  Julia L. Fox ,  Stuart L. Schreiber

    发明人： Douglas A. Melton ,  Malgorzata Borowiak ,  Rene Maehr ,  Shuibing Chen ,  Weiping Tang ,  Julia L. Fox ,  Stuart L. Schreiber

    IPC分类号： C12N5/071 ,  C07C251/86 ,  C07C251/84

    CPC分类号： C12N5/0678 ,  C12N5/0603 ,  C12N5/0606 ,  C12N2501/999 ,  C12N2506/02 ,  C12N2506/03

    摘要： Certain embodiments disclosed herein are directed to a method of producing endoderm cells, such as definitive endoderm cells by exposing stem cells such as embryonic stem cells or induced pluripotent stem (iPS) cells to an effective amount of at least one compound described herein to differentiate the stem cells into the endoderm cells such as definitive endoderm cells. Differentated endoderm cells produced by the methods disclosed herein can be differentiated into pancreatic epithelium, and other endoderm derivatives such as thymus, liver, stomach, intestine and lung. Another aspect of the present invention relates to a method of producing pancreatic progenitor cells, such as Pdx1-positive pancreatic progenitor cells by exposing endoderm cells, such as definitive endoderm cells to an effective amount of at least one compound described herein to differentiate the definitive endoderm cells into Pdx1-positive pancreatic progenitor cells. Kits and compositions comprising Pdx1-positive pancreatic progenitor produced using the methods are also described.

    摘要翻译： 本文公开的某些实施例涉及通过将干细胞如胚胎干细胞或诱导的多能干（iPS）细胞暴露于有效量的本文所述的至少一种化合物来分化本发明的内胚层细胞，例如定形内胚层细胞， 干细胞进入内胚层细胞，如定形内胚层细胞。 通过本文公开的方法产生的分化的内胚层细胞可以分化成胰腺上皮和其它内胚层衍生物如胸腺，肝，胃，肠和肺。 本发明的另一方面涉及通过将内胚层细胞如定形内胚层细胞暴露于有效量的至少一种本文所述的化合物来分化定形内胚层来产生胰腺祖细胞如Pdx1阳性胰腺祖细胞的方法 细胞进入Pdx1阳性胰腺祖细胞。 还描述了使用该方法制备的包含Pdx1阳性胰腺祖细胞的组合物和组合物。

    Compositions and methods for promoting the generation of definitive endoderm
    4.
    发明授权
    Compositions and methods for promoting the generation of definitive endoderm 有权
    用于促进确定性内胚层的产生的组成和方法

    公开(公告)号：US08507274B2

    公开(公告)日：2013-08-13

    申请号：US12679406

    申请日：2010-02-05

    申请人： Douglas A. Melton ,  Malgorzata Borowiak ,  Rene Maehr ,  Shuibing Chen ,  Weiping Tang ,  Julia L. Fox ,  Stuart L. Schreiber

    发明人： Douglas A. Melton ,  Malgorzata Borowiak ,  Rene Maehr ,  Shuibing Chen ,  Weiping Tang ,  Julia L. Fox ,  Stuart L. Schreiber

    IPC分类号： C12N5/00 ,  C12N5/02 ,  C07C61/06 ,  C07C61/16 ,  C07C405/00

    CPC分类号： C12N5/0678 ,  C12N5/0603 ,  C12N5/0606 ,  C12N2501/999 ,  C12N2506/02 ,  C12N2506/03

    摘要： Certain embodiments disclosed herein are directed to a method of producing endoderm cells, such as definitive endoderm cells by exposing stem cells such as embryonic stem cells or induced pluripotent stem (iPS) cells to an effective amount of at least one compound described herein to differentiate the stem cells into the endoderm cells such as definitive endoderm cells. Differentated endoderm cells produced by the methods disclosed herein can be differentiated into pancreatic epithelium, and other endoderm derivatives such as thymus, liver, stomach, intestine and lung. Another aspect of the present invention relates to a method of producing pancreatic progenitor cells, such as Pdx1-positive pancreatic progenitor cells by exposing endoderm cells, such as definitive endoderm cells to an effective amount of at least one compound described herein to differentiate the definitive endoderm cells into Pdx1-positive pancreatic progenitor cells. Kits and compositions comprising Pdx1-positive pancreatic progenitor produced using the methods are also described.

    摘要翻译： 本文公开的某些实施例涉及通过将干细胞如胚胎干细胞或诱导的多能干（iPS）细胞暴露于有效量的本文所述的至少一种化合物来分化本发明的内胚层细胞，例如定形内胚层细胞， 干细胞进入内胚层细胞，如定形内胚层细胞。 通过本文公开的方法产生的分化的内胚层细胞可以分化成胰腺上皮和其它内胚层衍生物如胸腺，肝，胃，肠和肺。 本发明的另一方面涉及通过将内胚层细胞如定形内胚层细胞暴露于有效量的至少一种本文所述的化合物来分化定形内胚层来产生胰腺祖细胞如Pdx1阳性胰腺祖细胞的方法 细胞进入Pdx1阳性胰腺祖细胞。 还描述了使用该方法制备的包含Pdx1阳性胰腺祖细胞的组合物和组合物。

    Compositions and methods for inducing cell dedifferentiation
    5.
    发明授权
    Compositions and methods for inducing cell dedifferentiation 有权
    用于诱导细胞去分化的组合物和方法

    公开(公告)号：US08309555B2

    公开(公告)日：2012-11-13

    申请号：US12563802

    申请日：2009-09-21

    申请人： Shuibing Chen ,  Sheng Ding ,  Peter G. Schultz

    发明人： Shuibing Chen ,  Sheng Ding ,  Peter G. Schultz

    IPC分类号： C07D473/16 ,  C07D473/24 ,  A61K31/52 ,  A61P19/08 ,  A61P19/10

    CPC分类号： C12N5/0696 ,  C07D473/16 ,  C07D473/24

    摘要： The present invention provides 2,6-disubstituted purine compounds, compositions and methods for dedifferentiating lineage committed mammalian cells into stem cells. The present invention also provides methods of inducing dedifferentiation of lineage committed mammalian cells into stem cells, which can be further differentiated into various lineage committed cells. Methods of identifying additional 2,6-disubstituted purine compounds useful for inducing dedifferentiation of lineage committed cells into stem cells are also provided.

    摘要翻译： 本发明提供2,6-二取代的嘌呤化合物，用于将分裂的哺乳动物细胞分化为干细胞的组合物和方法。 本发明还提供了诱导分泌哺乳动物细胞去干细胞到干细胞中的方法，其可进一步分化成各种谱系确定的细胞。 还提供了用于鉴定用于诱导分化为干细胞的遗传分化细胞的另外的2,6-二取代的嘌呤化合物的方法。

    Compositions and methods for inducing cell dedifferentiation
    6.
    发明授权
    Compositions and methods for inducing cell dedifferentiation 有权
    用于诱导细胞去分化的组合物和方法

    公开(公告)号：US09334481B2

    公开(公告)日：2016-05-10

    申请号：US13594524

    申请日：2012-08-24

    申请人： Shuibing Chen ,  Sheng Ding ,  Peter G. Schultz

    发明人： Shuibing Chen ,  Sheng Ding ,  Peter G. Schultz

    IPC分类号： C07D473/16 ,  C12N5/074 ,  C07D473/24

    CPC分类号： C12N5/0696 ,  C07D473/16 ,  C07D473/24

    摘要： The present invention provides compounds, compositions and methods for dedifferentiating lineage committed mammalian cells into stem cells. The present invention also provides methods of inducing dedifferentiation of lineage committed mammalian cells into stem cells, which can be further differentiated into various lineage committed cells. Methods of identifying additional compounds useful for inducing dedifferentiation of lineage committed cells into stem cells are also provided.

    摘要翻译： 本发明提供用于将分裂的哺乳动物细胞去分化为干细胞的化合物，组合物和方法。 本发明还提供了诱导分泌哺乳动物细胞去干细胞到干细胞中的方法，其可进一步分化成各种谱系确定的细胞。 还提供了鉴定另外的化合物的方法，该化合物可用于诱导谱系分化为干细胞的分化。

    COMPOSITIONS AND METHODS FOR INDUCING CELL DEDIFFERENTIATION
    9.
    发明申请
    COMPOSITIONS AND METHODS FOR INDUCING CELL DEDIFFERENTIATION 有权
    用于诱导细胞分化的组合物和方法

    公开(公告)号：US20130196989A1

    公开(公告)日：2013-08-01

    申请号：US13594524

    申请日：2012-08-24

    申请人： Shuibing Chen ,  Sheng Ding ,  Peter G. Schultz

    发明人： Shuibing Chen ,  Sheng Ding ,  Peter G. Schultz

    IPC分类号： C12N5/071 ,  C07D473/16

    CPC分类号： C12N5/0696 ,  C07D473/16 ,  C07D473/24

    摘要： The present invention provides compounds, compositions and methods for dedifferentiating lineage committed mammalian cells into stem cells. The present invention also provides methods of inducing dedifferentiation of lineage committed mammalian cells into stem cells, which can be further differentiated into various lineage committed cells. Methods of identifying additional compounds useful for inducing dedifferentiation of lineage committed cells into stem cells are also provided.

    摘要翻译： 本发明提供用于将分裂的哺乳动物细胞去分化为干细胞的化合物，组合物和方法。 本发明还提供了诱导分泌哺乳动物细胞去干细胞到干细胞中的方法，其可进一步分化成各种谱系确定的细胞。 还提供了鉴定另外的化合物的方法，该化合物可用于诱导谱系分化为干细胞的分化。

    Compositions and methods for inducing cell dedifferentiation
    10.
    发明授权
    Compositions and methods for inducing cell dedifferentiation 有权
    用于诱导细胞去分化的组合物和方法

    公开(公告)号：US07951592B2

    公开(公告)日：2011-05-31

    申请号：US10577191

    申请日：2004-11-10

    申请人： Shuibing Chen ,  Sheng Ding ,  Peter G. Schultz

    发明人： Shuibing Chen ,  Sheng Ding ,  Peter G. Schultz

    IPC分类号： C12N5/00 ,  C12N5/02 ,  C12Q1/00

    CPC分类号： C12N5/0696 ,  C07D473/16 ,  C07D473/24

    摘要： The present invention provides compounds, compositions and methods for dedifferentiating lineage committed mammalian cells into stem cells. The present invention also provides methods of inducing dedifferentiation of lineage committed mammalian cells into stem cells, which can be further differentiated into various lineage committed cells. Methods of identifying additional compounds useful for inducing dedifferentiation of lineage committed cells into stem cells are also provided.

    摘要翻译： 本发明提供用于将分裂的哺乳动物细胞去分化为干细胞的化合物，组合物和方法。 本发明还提供了诱导分泌哺乳动物细胞去干细胞到干细胞中的方法，其可进一步分化成各种谱系确定的细胞。 还提供了鉴定另外的化合物的方法，该化合物可用于诱导谱系分化为干细胞的分化。