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公开(公告)号：US20110159309A1
公开(公告)日：2011-06-30
申请号：US12972652
申请日：2010-12-20
申请人： Siyuan JIANG , Qianqian Li , Jiakuan Sun
发明人： Siyuan JIANG , Qianqian Li , Jiakuan Sun
CPC分类号： B05D7/534 , B05D2502/00 , B05D2520/00 , B05D2602/00 , C08K7/22 , C09D7/42 , C09D7/65 , C09D7/69 , C09D7/70 , Y10T428/31928
摘要： This invention relates to a multilayer coating system derived from Titanium dioxide free aqueous coating compositions. The multilayer coating system comprises at least two layers including a layer of base coating which provides good hiding function for substrates and a second layer of clear top coating which provides surface protection functions for the coating system. The base coating composition comprises an opaque (co)polymer having at least one void per (co)polymer particle. The top coating composition comprises a duller (co)polymer chosen from a multi-stage (co)polymer, a single stage crosslinked (co)polymer, and mixtures thereof.
摘要翻译： 本发明涉及一种衍生自不含二氧化钛的水性涂料组合物的多层涂料体系。 多层涂层系统包括至少两层，包括一层基底涂层，其为基底提供良好的遮盖功能，以及提供涂层系统的表面保护功能的第二层透明顶涂层。 基底涂料组合物包含对每（共）聚合物颗粒具有至少一个空隙的不透明（共）聚合物。 顶部涂料组合物包含选自多级（共）聚合物，单级交联（共）聚合物及其混合物的钝化（共）聚合物。
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公开(公告)号：US09636706B2
公开(公告)日：2017-05-02
申请号：US12972652
申请日：2010-12-20
申请人： Siyuan Jiang , Qianqian Li , Jiakuan Sun
发明人： Siyuan Jiang , Qianqian Li , Jiakuan Sun
CPC分类号： B05D7/534 , B05D2502/00 , B05D2520/00 , B05D2602/00 , C08K7/22 , C09D7/42 , C09D7/65 , C09D7/69 , C09D7/70 , Y10T428/31928
摘要： This invention relates to a multilayer coating system derived from Titanium dioxide free aqueous coating compositions. The multilayer coating system comprises at least two layers including a layer of base coating which provides good hiding function for substrates and a second layer of clear top coating which provides surface protection functions for the coating system. The base coating composition comprises an opaque (co)polymer having at least one void per (co)polymer particle. The top coating composition comprises a duller (co)polymer chosen from a multi-stage (co)polymer, a single stage crosslinked (co)polymer, and mixtures thereof.
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公开(公告)号：US08802765B2
公开(公告)日：2014-08-12
申请号：US13076508
申请日：2011-03-31
申请人： Huiling Yang , Xiangting Dong , Siyuan Jiang , Qianqian Li
发明人： Huiling Yang , Xiangting Dong , Siyuan Jiang , Qianqian Li
CPC分类号： C08K5/07 , C08K5/10 , C08K5/132 , C08K5/18 , C08K5/32 , C09D5/024 , C09D7/63 , C09D133/06 , C08L33/04
摘要： The present invention relates to an aqueous copolymer dispersion comprising an emulsion copolymer and two hydrophobic aromatic ketones, wherein the aromatic ketones are, based on the dry weight of the copolymer, from 0.1 to 3 wt % benzophenone and from 0.1 to 4 wt % a benzophenone derivative; wherein the dispersion comprises 0 or less than 0.1 wt % hydrophilic aromatic ketone. The copolymer dispersion is suitable for preparation of aqueous coating compositions which yields a relatively hard surface to provide not only short term but also long term dirt pick up resistance effects, after exposure to ultraviolet radiation.
摘要翻译： 本发明涉及包含乳液共聚物和两种疏水性芳族酮的含水共聚物分散体，其中所述芳族酮基于共聚物的干重为0.1至3重量％的二苯甲酮和0.1至4重量％的二苯甲酮 衍生物; 其中所述分散体包含0或小于0.1重量％的亲水芳族酮。 共聚物分散体适用于制备水性涂料组合物，其产生相对硬的表面，不仅在暴露于紫外线辐射之后提供短期而且长时间的防尘效果。
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公开(公告)号：US20110245390A1
公开(公告)日：2011-10-06
申请号：US13076508
申请日：2011-03-31
申请人： Huiling Yang , Xiangling Dong , Siyuan Jiang , Qianqian Li
发明人： Huiling Yang , Xiangling Dong , Siyuan Jiang , Qianqian Li
IPC分类号： C08K5/07 , C08K5/101 , C08K5/18 , C08K5/32 , C09D133/12
CPC分类号： C08K5/07 , C08K5/10 , C08K5/132 , C08K5/18 , C08K5/32 , C09D5/024 , C09D7/63 , C09D133/06 , C08L33/04
摘要： The present invention relates to an aqueous copolymer dispersion comprising an emulsion copolymer and two hydrophobic aromatic ketones, wherein the aromatic ketones are, based on the dry weight of the copolymer, from 0.1 to 3 wt % benzophenone and from 0.1 to 4 wt % a benzophenone derivative; wherein the dispersion comprises 0 or less than 0.1 wt % hydrophilic aromatic ketone. The copolymer dispersion is suitable for preparation of aqueous coating compositions which yields a relatively hard surface to provide not only short term but also long term dirt pick up resistance effects, after exposure to ultraviolet radiation.
摘要翻译： 本发明涉及包含乳液共聚物和两种疏水性芳族酮的含水共聚物分散体，其中所述芳族酮基于共聚物的干重为0.1至3重量％的二苯甲酮和0.1至4重量％的二苯甲酮 衍生物; 其中所述分散体包含0或小于0.1重量％的亲水芳族酮。 共聚物分散体适用于制备水性涂料组合物，其产生相对硬的表面，不仅在暴露于紫外线辐射之后提供短期而且长时间的防尘效果。
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公开(公告)号：US09816076B2
公开(公告)日：2017-11-14
申请号：US14113522
申请日：2012-05-02
申请人： Jianjun Wang , Qianqian Li
发明人： Jianjun Wang , Qianqian Li
IPC分类号： C12N5/074
CPC分类号： C12N5/0696 , C12N2501/115 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2506/1307
摘要： A method of generating protein-induced pluripotent stem cells by delivering bacterially expressed reprogramming proteins into nuclei of starting somatic cells using the QQ-protein transduction technique, repeating several cell reprogramming cycles for creating reprogrammed protein-induced pluripotent stem cells, moving the reprogrammed cells into a feeder-free medium for expansion, and expanding and passaging the reprogrammed cells in a whole dish for generating homogeneous piPS cells. Also provided are the piPCS cells formed using this method and uses thereof.
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6.发明授权公开(公告)号：US08722348B2
公开(公告)日：2014-05-13
申请号：US12128320
申请日：2008-05-28
申请人： Jianjun Wang , Qianqian Li
发明人： Jianjun Wang , Qianqian Li
IPC分类号： G01N33/567
CPC分类号： A61K38/00 , A61K47/48046 , A61K47/48176 , C12N15/88 , C12P21/00 , G01N33/5023 , G01N33/58 , G01N33/68 , G01N2458/15
摘要： A protein transduction method for efficiently delivery of exogenous proteins into mammalian cells is invented, which has the capability of targeting different cellular compartments and protection from degradation of the delivered proteins from cellular proteases. A composition for treat proteins has cation reagents, lipids and enhancers in a carrier. The method can be used in a number of ways including: production of large quantities of properly folded, post-translationally modified proteins using mammalian cell machinery, a in-cell fluorescence spectroscopy and imaging using small molecule fluorophores and a in-cell NMR spectroscopy using living mammalian cells. The method permits cell biology at atomic resolution that is physiologically and pathological relevant and permits protein therapy to treat human diseases. The method can also be used to deliver exogenous protein inside mammalian cells, wherein the exogenous proteins follow a similar secretion pathway as that of the endogenous protein.
摘要翻译： 发明了用于将外源蛋白有效递送到哺乳动物细胞中的蛋白质转导方法，其具有靶向不同细胞区室的能力并且防止递送的蛋白质从细胞蛋白酶降解。 用于处理蛋白质的组合物在载体中具有阳离子试剂，脂质和增强剂。 该方法可以以多种方式使用，包括：使用哺乳动物细胞机制产生大量正确折叠的翻译后修饰蛋白，使用小分子荧光团进行细胞内荧光光谱和成像，并使用细胞内核磁共振光谱 活哺乳动物细胞。 该方法允许细胞生物学在原子分辨率下与生理和病理相关，并允许蛋白质治疗来治疗人类疾病。 该方法还可用于在哺乳动物细胞内递送外源蛋白质，其中外源蛋白质遵循与内源性蛋白质相似的分泌途径。
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公开(公告)号：US20140242695A1
公开(公告)日：2014-08-28
申请号：US14113522
申请日：2012-05-02
申请人： Jianjun Wang , Qianqian Li
发明人： Jianjun Wang , Qianqian Li
IPC分类号： C12N5/074
CPC分类号： C12N5/0696 , C12N2501/115 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2506/1307
摘要： A method of generating protein-induced pluripotent stem cells by delivering bacterially expressed reprogramming proteins into nuclei of starting somatic cells using the QQ-protein transduction technique, repeating several cell reprogramming cycles for creating reprogrammed protein-induced pluripotent stem cells, moving the reprogrammed cells into a feeder-free medium for expansion, and expanding and passaging the reprogrammed cells in a whole dish for generating homogeneous piPS cells. Also provided are the piPCS cells formed using this method and uses thereof.
摘要翻译： 通过使用QQ蛋白转导技术将细菌表达的重编程蛋白递送到起始体细胞的核中产生蛋白质诱导的多能干细胞的方法，重复几个细胞重编程循环以产生重编程的蛋白质诱导的多能干细胞，将重编程细胞移动到 用于扩增的无饲养细胞培养基，并在整个培养皿中扩增和传代重编程细胞以产生均质的piPS细胞。 还提供了使用该方法形成的piPCS细胞及其用途。
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8.发明申请METHOD AND COMPOSITION FOR A PROTEIN TRANSDUCTION TECHNOLOGY AND ITS APPLICATIONS 有权蛋白质转移技术的方法和组合及其应用公开(公告)号：US20090298111A1
公开(公告)日：2009-12-03
申请号：US12128320
申请日：2008-05-28
申请人： Jianjun Wang , Qianqian Li
发明人： Jianjun Wang , Qianqian Li
CPC分类号： A61K38/00 , A61K47/48046 , A61K47/48176 , C12N15/88 , C12P21/00 , G01N33/5023 , G01N33/58 , G01N33/68 , G01N2458/15
摘要： A protein transduction method for efficiently delivery of exogenous proteins into mammalian cells is invented, which has the capability of targeting different cellular compartments and protection from degradation of the delivered proteins from cellular proteases. A composition for treat proteins has cation reagents, lipids and enhancers in a carrier. The method can be used in a number of ways including: production of large quantities of properly folded, post-translationally modified proteins using mammalian cell machinery, a in-cell fluorescence spectroscopy and imaging using small molecule fluorophores and a in-cell NMR spectroscopy using living mammalian cells. The method permits cell biology at atomic resolution that is physiologically and pathological relevant and permits protein therapy to treat human diseases. The method can also be used to deliver exogenous protein inside mammalian cells, wherein the exogenous proteins follow a similar secretion pathway as that of the endogenous protein.
摘要翻译： 发明了用于将外源蛋白有效递送到哺乳动物细胞中的蛋白质转导方法，其具有靶向不同细胞区室的能力并且防止递送的蛋白质从细胞蛋白酶降解。 用于处理蛋白质的组合物在载体中具有阳离子试剂，脂质和增强剂。 该方法可以以多种方式使用，包括：使用哺乳动物细胞机制产生大量正确折叠的翻译后修饰蛋白，使用小分子荧光团进行细胞内荧光光谱和成像，并使用细胞内核磁共振光谱 活哺乳动物细胞。 该方法允许细胞生物学在原子分辨率下与生理和病理相关，并允许蛋白质治疗来治疗人类疾病。 该方法还可用于在哺乳动物细胞内递送外源蛋白质，其中外源蛋白质遵循与内源性蛋白质相似的分泌途径。
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