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1.发明申请Composition that consists of alkanedicarboxylic acids and a pharmaceutical active ingredient 审中-公开由烷基二羧酸和药物活性成分组成的组合物公开(公告)号：US20050026982A1
公开(公告)日：2005-02-03
申请号：US10864757
申请日：2004-06-10
申请人： Soenke Johannsen , Thomas Zollner
发明人： Soenke Johannsen , Thomas Zollner
IPC分类号： A61K8/49 , A61K31/19 , A61K31/4172 , A61K31/78 , A61Q19/00
CPC分类号： A61Q19/00 , A61K8/4946 , A61K31/19 , A61K31/4172 , A61K31/78 , A61K2300/00
摘要： The invention consists of a composition that an alpha, omega-n-alkanedicarboxylic acid and an imidazole derivative with general formula whereby R is a hydrogen atom or an alkyl group, A is a saturated chain of an aliphatic hydrocarbon group, X is a hydrogen atom or an alkyl radical of a monocarboxylic or dicarboxylic aliphatic or aromatic acid. The composition is used as a pharmaceutical active ingredient, whereby the composition is used for treating psoriasis, atopic dermatitis, common acne or rosacea.
摘要翻译： 本发明包括α，ω-正烷基二羧酸和具有通式的咪唑衍生物的组合物，其中R是氢原子或烷基，A是脂族烃基的饱和链，X是氢原子 或一元羧酸或二羧酸脂族或芳族酸的烷基。 该组合物用作药物活性成分，由此该组合物用于治疗牛皮癣，特应性皮炎，常见的痤疮或红斑痤疮。
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![5-[(3,3,3-Trifluoro-2-hydroxy-1-arylpropyl)amino]-1H-quinolin-2-ones, a process for their production and their use as anti-inflammatory agents](/abs-image/US/2014/03/25/US08680117B2/abs.jpg.150x150.jpg)
2.发明授权5-[(3,3,3-Trifluoro-2-hydroxy-1-arylpropyl)amino]-1H-quinolin-2-ones, a process for their production and their use as anti-inflammatory agents 有权5 - [（3,3,3-三氟-2-羟基-1-芳基丙基）氨基] -1H-喹啉-2-酮，其制备方法及其作为抗炎剂公开(公告)号：US08680117B2
公开(公告)日：2014-03-25
申请号：US13614161
申请日：2012-09-13
申请人： Markus Berger , Hartmut Rehwinkel , Thomas Zollner , Bkkehard May , Jorma Hassfeld , Heike Schacke
发明人： Markus Berger , Hartmut Rehwinkel , Thomas Zollner , Bkkehard May , Jorma Hassfeld , Heike Schacke
IPC分类号： A61K31/04
CPC分类号： C07D215/38 , C07C45/00 , C07C45/58 , C07C45/71 , C07C49/82 , C07C49/84 , C07D303/32 , C07D405/12 , C07C47/575 , C07C47/565
摘要： The present invention relates to compounds of formula I, processes for their production and their use as anti-inflammatory agents.
摘要翻译： 本发明涉及式I化合物，其制备方法及其作为抗炎剂的用途。
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![5-[(3,3,3-trifluoro-2-hydroxy-1-arylpropyl)amino]-1H-quinolin-2-ones, a process for their production and their use as anti-inflammatory agents](/abs-image/US/2013/03/12/US08394958B2/abs.jpg.150x150.jpg)
3.发明授权5-[(3,3,3-trifluoro-2-hydroxy-1-arylpropyl)amino]-1H-quinolin-2-ones, a process for their production and their use as anti-inflammatory agents 有权5 - [（3,3,3-三氟-2-羟基-1-芳基丙基）氨基] -1H-喹啉-2-酮，其制备方法及其作为抗炎剂公开(公告)号：US08394958B2
公开(公告)日：2013-03-12
申请号：US12275392
申请日：2008-11-21
申请人： Markus Berger , Hartmut Rehwinkel , Thomas Zollner , Ekkehard May , Jorma Hassfeld , Heike Schacke
发明人： Markus Berger , Hartmut Rehwinkel , Thomas Zollner , Ekkehard May , Jorma Hassfeld , Heike Schacke
IPC分类号： C07D215/38
CPC分类号： C07D215/38 , C07C45/00 , C07C45/58 , C07C45/71 , C07C49/82 , C07C49/84 , C07D303/32 , C07D405/12 , C07C47/575 , C07C47/565
摘要： The present invention relates to compounds of formula I, processes for their production and their use as anti-inflammatory agents.
摘要翻译： 本发明涉及式I化合物，其制备方法及其作为抗炎剂的用途。
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公开(公告)号：US20120027862A1
公开(公告)日：2012-02-02
申请号：US13116791
申请日：2011-05-26
申请人： Timm SCHMIDT , Thomas Zollner , Markus Friedrich
发明人： Timm SCHMIDT , Thomas Zollner , Markus Friedrich
CPC分类号： A61K9/0014 , A61K9/06 , A61K31/20 , A61K33/24 , A61K33/26 , A61K45/06 , A61K47/02 , A61K2300/00
摘要： The present patent application relates to an azelaic acid-comprising pharmaceutical composition, preferably an azelaic acid-comprising gel, with added pigment, which composition can be used, inter alia, for treating rosacea and acne, and also to a process for its preparation.
摘要翻译： 本专利申请涉及含有壬二酸的药物组合物，优选含有壬二酸的凝胶，具有添加的颜料，该组合物尤其可用于治疗酒渣鼻和痤疮，以及其制备方法。
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5.发明申请USE OF ALKANEDICARBOXYLIC ACIDS AND RETINOIDS FOR TREATMENT OF ROSACEA AND OTHER INFLAMMATORY SKIN DISEASES 审中-公开用于治疗罗非鱼和其他炎症性皮肤病的碱金属羧酸和赖氨酸的使用公开(公告)号：US20110160306A1
公开(公告)日：2011-06-30
申请号：US12161706
申请日：2007-01-23
申请人： Thomas Zollner , Sonke Johannsen
发明人： Thomas Zollner , Sonke Johannsen
CPC分类号： A61K45/06 , A61K9/0014 , A61K31/165 , A61K31/192 , A61K31/194 , A61K31/20 , A61K31/203 , A61K31/232 , A61K31/4436
摘要： In order to make available another therapeutic possibility for rosacea the use of at least one α,ω-n-alkanedicarboxylic acid with 7 to 13 carbon atoms or its esters and at least one retinoid for producing a pharmaceutical preparation is proposed. The suggested formulation is also effective in treatment of other inflammatory skin diseases such as psoriasis, atopic dermatitis and common acne.
摘要翻译： 为了为酒渣鼻提供另一种治疗可能性，提出使用至少一种具有7至13个碳原子的α，ω-正烷烃二羧酸或其酯和至少一种类视色素用于制备药物制剂。 所提出的配方在治疗其他炎性皮肤疾病如牛皮癣，特应性皮炎和常见的痤疮方面也是有效的。
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![5-[(3,3,3-Trifluoro-2-hydroxy-1-arylpropyl)amino]-1H-quinolin-2-ones, A Process for Their Production and Their Use as Anti-inflammatory Agents](/abs-image/US/2009/05/28/US20090137564A1/abs.jpg.150x150.jpg)
6.发明申请5-[(3,3,3-Trifluoro-2-hydroxy-1-arylpropyl)amino]-1H-quinolin-2-ones, A Process for Their Production and Their Use as Anti-inflammatory Agents 有权5 - [（3,3,3-三氟-2-羟基-1-芳基丙基）氨基] -1H-喹啉-2-酮，其制备方法及其作为抗炎剂公开(公告)号：US20090137564A1
公开(公告)日：2009-05-28
申请号：US12275392
申请日：2008-11-21
申请人： Markus Berger , Hartmut Rehwinkel , Thomas Zollner , Ekkehard May , Jorna Hassfeld , Heike Schacke
发明人： Markus Berger , Hartmut Rehwinkel , Thomas Zollner , Ekkehard May , Jorna Hassfeld , Heike Schacke
IPC分类号： A61K31/551 , C07D215/227 , A61K31/4704 , C07D303/32
CPC分类号： C07D215/38 , C07C45/00 , C07C45/58 , C07C45/71 , C07C49/82 , C07C49/84 , C07D303/32 , C07D405/12 , C07C47/575 , C07C47/565
摘要： The present invention relates to compounds of formula I, processes for their production and their use as anti-inflammatory agents.
摘要翻译： 本发明涉及式I化合物，其制备方法及其作为抗炎剂的用途。
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