公开(公告)号：US09290749B2

公开(公告)日：2016-03-22

申请号：US13837996

申请日：2013-03-15

Applicant: Solazyme, Inc.

Inventor： George N. Rudenko ,  Jason Casolari ,  Scott Franklin

IPC: C12N15/82 ,  C12N5/14 ,  C12N9/18 ,  C07H21/04 ,  C12N9/16 ,  C12P7/64

CPC classification number: C12P7/6409 ,  A23L33/115 ,  A23V2002/00 ,  C10L1/02 ,  C10L2200/0476 ,  C10L2290/26 ,  C12N9/16 ,  C12P7/6463 ,  C12Y301/02014

Abstract: The invention features plant acyl-ACP thioesterase genes of the FatB class and proteins encoded by these genes. The genes are useful for constructing recombinant host cells having altered fatty acid profiles. Oleaginous microalga host cells with the new genes or previously identified FatB genes are disclosed. The microalgae cells produce triglycerides with useful fatty acid profiles.

Abstract translation: 本发明具有FatB类的植物酰基-ACP硫酯酶基因和由这些基因编码的蛋白质。 该基因可用于构建具有改变的脂肪酸谱的重组宿主细胞。 公开了具有新基因或先前鉴定的FatB基因的嗜酸微藻宿主细胞。 微藻细胞产生具有有用脂肪酸分布的甘油三酯。

公开(公告)号：US20140178950A1

公开(公告)日：2014-06-26

申请号：US14099704

申请日：2013-12-06

Applicant: Solazyme, Inc.

Inventor： Scott Franklin ,  Shane Brubaker ,  George N. Rudenko ,  Riyaz Bhat ,  Matthew Shoa-Azar ,  Aravind Somanchi ,  Aren Ewing

IPC: C12P7/64

CPC classification number: C12P7/6463 ,  C12N15/52

Abstract: Genetically engineered microbial, e.g., Chlorella protothecoides, cells producing microbial oils are useful as a food additive and a source of renewable fuels and industrial chemicals. Lipid biosynthesis genes for Auxenochlorella protethecoides are disclosed that are useful for increasing lipid production and altering fatty acid and triacylglycerol profiles in recombinant microrganisms including cells of the genus Auxenochlorella or Prototheca.

Abstract translation: 基因工程微生物，例如原型小球藻，产生微生物油的细胞可用作食品添加剂和可再生燃料和工业化学品的来源。 本发明公开了用于增加油类生物合成的脂质体生物合成基因，其可用于增加脂质生产和改变重组微生物（包括欧洲绿叶藻或原生动物）的重组微生物中的脂肪酸和三酰甘油轮廓。

公开(公告)号：US20140288320A1

公开(公告)日：2014-09-25

申请号：US14209931

申请日：2014-03-13

Applicant: Solazyme, Inc.

Inventor： George N. Rudenko ,  Jason Casolari ,  Scott Franklin

IPC: C12P7/64 ,  C12N9/16

CPC classification number: C12P7/6409 ,  C12N1/12 ,  C12N9/16 ,  C12P7/6463

Abstract: The invention features plant acyl-ACP thioesterase genes of the FatB class and proteins encoded by these genes. The genes are useful for constructing recombinant host cells having altered fatty acid profiles. Oleaginous microalga host cells with the new genes or previously identified FatB genes are disclosed. The microalgae cells produce triglycerides with useful fatty acid profiles.

Abstract translation: 本发明具有FatB类的植物酰基-ACP硫酯酶基因和由这些基因编码的蛋白质。 该基因可用于构建具有改变的脂肪酸谱的重组宿主细胞。 公开了具有新基因或先前鉴定的FatB基因的嗜酸微藻宿主细胞。 微藻细胞产生具有有用脂肪酸分布的甘油三酯。

公开(公告)号：US09328351B2

公开(公告)日：2016-05-03

申请号：US13688025

申请日：2012-11-28

Applicant: Solazyme, Inc.

Inventor： Scott Franklin ,  Shane Brubaker ,  George N. Rudenko ,  Jeffrey L. Moseley ,  Xinhua Zhao ,  Tina T. Huynh ,  Riyaz Bhat ,  Matthew Shoa-Azar ,  Trung H. Nguyen ,  Karen Espina ,  Aravind Somanchi

IPC: C12N15/79 ,  C12N15/82 ,  C07K14/405 ,  C12P7/64 ,  C12N9/00 ,  C12N9/02 ,  C12N9/16 ,  C12N9/10

CPC classification number: A61K39/0011 ,  C07K14/405 ,  C12N5/0634 ,  C12N9/00 ,  C12N9/0071 ,  C12N9/1029 ,  C12N9/16 ,  C12N15/79 ,  C12N15/8247 ,  C12P7/6445 ,  C12P7/6463 ,  C12Y114/19002 ,  C12Y114/19006 ,  C12Y203/01179 ,  C12Y301/02014 ,  Y02P20/52

Abstract: Genetically engineered microbial, e.g., Prototheca, cells provide microbial oil useful as a food additive and a source of renewable fuels and industrial chemicals.

Abstract translation: 基因工程微生物，例如Prototheca，细胞提供可用作食品添加剂的微生物油和可再生燃料和工业化学品的来源。

公开(公告)号：US20140275586A1

公开(公告)日：2014-09-18

申请号：US13837996

申请日：2013-03-15

Applicant: Solazyme, Inc.

Inventor： George N. Rudenko ,  Jason Casolari ,  Scott Franklin

IPC: C12P7/64

CPC classification number: C12P7/6409 ,  A23L33/115 ,  A23V2002/00 ,  C10L1/02 ,  C10L2200/0476 ,  C10L2290/26 ,  C12N9/16 ,  C12P7/6463 ,  C12Y301/02014

Abstract: The invention features plant acyl-ACP thioesterase genes of the FatB class and proteins encoded by these genes. The genes are useful for constructing recombinant host cells having altered fatty acid profiles. Oleaginous microalga host cells with the new genes or previously identified FatB genes are disclosed. The microalgae cells produce triglycerides with useful fatty acid profiles.