公开(公告)号：US20150125867A1

公开(公告)日：2015-05-07

申请号：US14500632

申请日：2014-09-29

申请人： SOMALOGIC, INC.

发明人： Urs Ochsner ,  Evaldas Katilius ,  Nebojsa Janjic

IPC分类号： G01N33/573

CPC分类号： G01N33/573 ,  C12N15/115 ,  C12N2310/16 ,  G01N2333/91102

摘要： The present disclosure relates generally to the field of nucleic acids and, more particularly, to aptamers capable of binding to toxins produced by Clostridium difficile; diagnostic kits and methods comprising such aptamers; and methods of making and using such aptamers.

摘要翻译： 本公开一般涉及核酸领域，更具体地涉及能够结合艰难梭菌产生的毒素的适体; 包括这种适体的诊断试剂盒和方法; 以及制备和使用这些适体的方法。

公开(公告)号：US09081010B2

公开(公告)日：2015-07-14

申请号：US14500632

申请日：2014-09-29

申请人： SomaLogic, Inc.

发明人： Urs Ochsner ,  Evaldas Katilius ,  Nebojsa Janjic

IPC分类号： C12Q1/68 ,  G01N33/573 ,  C07H21/02 ,  C07H21/04

CPC分类号： G01N33/573 ,  C12N15/115 ,  C12N2310/16 ,  G01N2333/91102

摘要： The present disclosure relates generally to the field of nucleic acids and, more particularly, to aptamers capable of binding to toxins produced by Clostridium difficile; diagnostic kits and methods comprising such aptamers; and methods of making and using such aptamers.

摘要翻译： 本公开一般涉及核酸领域，更具体地涉及能够结合艰难梭菌产生的毒素的适体; 包括这种适体的诊断试剂盒和方法; 以及制造和使用这些适体的方法。

公开(公告)号：US20210239692A1

公开(公告)日：2021-08-05

申请号：US17217006

申请日：2021-03-30

申请人： SomaLogic, Inc.

发明人： Glenn Sanders ,  Stephan Kraemer ,  Evaldas Katilius ,  EDGAR OLIVAS

IPC分类号： G01N33/543 ,  C12Q1/6811 ,  C07H21/00 ,  G01N33/53 ,  G01N33/68 ,  C12Q1/6804 ,  C12Q1/6837

摘要： The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer) where the aptamer-aptamer interactions are significantly reduced or eliminated while maintaining the aptamer-target interaction.

公开(公告)号：US20180224444A1

公开(公告)日：2018-08-09

申请号：US15827441

申请日：2017-11-30

申请人： SomaLogic, Inc.

发明人： Glenn Sanders ,  Stephan Kraemer ,  Evaldas Katilius

IPC分类号： G01N33/543 ,  G01N33/68 ,  C07H21/00 ,  G01N33/53 ,  C12Q1/6811

CPC分类号： G01N33/54393 ,  C07H21/00 ,  C12Q1/6804 ,  C12Q1/6811 ,  C12Q1/6837 ,  G01N33/5308 ,  G01N33/543 ,  G01N33/54306 ,  G01N33/68 ,  G01N33/6803 ,  G01N2570/00 ,  C12Q2525/113 ,  C12Q2525/205 ,  C12Q2561/101

摘要： The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer) where the aptamer-aptamer interactions are significantly reduced or eliminated while maintaining the aptamer-target interaction.

公开(公告)号：US20170176422A1

公开(公告)日：2017-06-22

申请号：US15454080

申请日：2017-03-09

申请人： SomaLogic, Inc.

发明人： Glenn Sanders ,  Stephan Kraemer ,  Evaldas Katilius

IPC分类号： G01N33/53 ,  C12Q1/68 ,  G01N33/68 ,  G01N33/543

CPC分类号： G01N33/54393 ,  C07H21/00 ,  C12Q1/6804 ,  C12Q1/6811 ,  C12Q1/6837 ,  G01N33/5308 ,  G01N33/543 ,  G01N33/54306 ,  G01N33/68 ,  G01N33/6803 ,  G01N2570/00 ,  C12Q2525/113 ,  C12Q2525/205 ,  C12Q2561/101

摘要： The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer) where the aptamer-aptamer interactions are significantly reduced or eliminated while maintaining the aptamer-target interaction.

公开(公告)号：US20150141259A1

公开(公告)日：2015-05-21

申请号：US14401791

申请日：2013-06-07

申请人： SomaLogic, Inc.

发明人： Glenn Sanders ,  Stephan Kraemer ,  Evaldas Katilius

IPC分类号： G01N33/543 ,  G01N33/68

CPC分类号： G01N33/54393 ,  C07H21/00 ,  C12Q1/6804 ,  C12Q1/6811 ,  C12Q1/6837 ,  G01N33/5308 ,  G01N33/543 ,  G01N33/54306 ,  G01N33/68 ,  G01N33/6803 ,  G01N2570/00 ,  C12Q2525/113 ,  C12Q2525/205 ,  C12Q2561/101

摘要： The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer) where the aptamer-aptamer interactions are significantly reduced or eliminated while maintaining the aptamer-target interaction.

摘要翻译： 本公开描述了用于检测可能存在于测试样品中的一种或多种靶分子的方法，装置，试剂和试剂盒。 所描述的方法，装置，试剂盒和试剂通过检测和定量测定样品中的非核酸靶（例如，蛋白质靶）来促进核酸（即，适体），其中适体 - 适配体相互作用显着减少或消除，同时保持适体 - 靶相互作用。

公开(公告)号：US20150031585A1

公开(公告)日：2015-01-29

申请号：US14494955

申请日：2014-09-24

申请人： SomaLogic, Inc.

发明人： Urs A. Ochsner ,  Louis S. Green ,  Larry Gold ,  Nebojsa Janjic ,  Evaldas Katilius

IPC分类号： C12Q1/68

CPC分类号： C12N15/115 ,  C12N2310/16 ,  C12N2310/334 ,  C12N2310/3341 ,  C12N2310/335

摘要： Described herein are compositions comprising a first aptamer, second aptamer and a target that are capable of forming a ternary complex, and wherein the first aptamer and the second aptamer comprise C-5 pyrimidine modification schemes that are different, and methods of making and using such compositions.

摘要翻译： 本文描述的是包含能够形成三元复合物的第一适体，第二适体和靶的组合物，其中第一适体和第二适体包含不同的C-5嘧啶修饰方案，以及制备和使用其的方法 组合物。