公开(公告)号：US10669527B2

公开(公告)日：2020-06-02

申请号：US15562576

申请日：2016-03-22

申请人： AMOREPACIFIC CORPORATION ,  SOONGSIL UNIVERSITY RESEARCH CONSORTIUM TECHNO-PARK

发明人： Dae Jin Min ,  Sung Hoon Lee ,  Hae Kwang Lee ,  Jae Hyun Jeong ,  Hee Wook Ryu ,  Hee Jin Kim

IPC分类号： C12M1/32 ,  C12N5/071 ,  C12M3/00 ,  A61K35/36 ,  A61L27/24 ,  A61L27/60 ,  C12M3/04

摘要： An artificial skin culture container according to the present invention can solve the problems of the contraction of the dermal layer of artificial skin and the detachment thereof from the culture container, which result from an interaction between collagen and fibroblasts existing in the dermal layer of artificial skin during the production of the artificial skin, by using agar and hydrophobically modifying a portion of the agar. Therefore, the use of the culture container enables to stably culture artificial skin and produce artificial skin similar to the human skin. In addition, the artificial skin culture container of the present invention comprises agar, and thus a culture solution can be supplied through a side portion as well as a lower portion of the culture container, which allows to effectively culture artificial skin.

公开(公告)号：US20160324755A1

公开(公告)日：2016-11-10

申请号：US14852241

申请日：2015-09-11

申请人： Soongsil University Research Consortium Techno-Park

发明人： Jae Hyun Jeong ,  Hee Wook Ryu ,  Yun Gon Kim ,  Hee Jin Kim

IPC分类号： A61K8/73 ,  A61K8/04 ,  C12N5/00 ,  A61Q19/00

CPC分类号： A61K8/733 ,  A23L29/256 ,  A23V2002/00 ,  A61K8/042 ,  A61K8/044 ,  A61K8/73 ,  A61Q19/00 ,  B01J13/0065 ,  C12N5/0068 ,  C12N2533/74 ,  C12N2533/76

摘要： The present invention relates to a method for preparing hydrocolloid having a diverse range of hydrophobicity, and more particularly, to a method for preparing hydrocolloid having a diverse range of hydrophobicity including preparing a hydrophobic hydrocolloid molecule by introducing a hydrophobic molecular group to a hydrocolloid molecule, and gelation by adding the hydrophobic hydrocolloid molecule to a pure hydrocolloid molecule. According to the present invention, a hydrophobic molecule is capable of being stably introduced without decomposing a hydrocolloid molecule during a synthesis process for introducing the hydrocolloid molecule, and hydrocolloid having a diverse hydrophobicity range is capable of being prepared depending on a mixing ratio.

摘要翻译： 本发明涉及一种制备具有不同范围的疏水性的水胶体的方法，更具体地说，涉及一种具有不同范围的疏水性的水胶体的方法，包括通过将疏水性分子基团导入水解胶体分子来制备疏水性水胶体分子， 并通过将疏水性水胶体分子加入到纯水胶体分子中进行凝胶化。 根据本发明，在引入水胶体分子的合成过程中疏水性分子能够稳定地引入而不分解水解胶体分子，并且能够根据混合比例制备具有多种疏水性范围的水胶体。