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公开(公告)号:US20050095610A1
公开(公告)日:2005-05-05
申请号:US10819657
申请日:2004-04-07
申请人: Sophia Kuo , Chu-an Chang , Shiaw-Min Chen , Sandra Spurgeon
发明人: Sophia Kuo , Chu-an Chang , Shiaw-Min Chen , Sandra Spurgeon
IPC分类号: C07H21/00 , C12N20060101 , C12P19/34 , C12Q1/68
CPC分类号: C07H21/00 , C12Q1/6806 , C12Q2533/101 , C12Q2525/204 , C12Q2525/151
摘要: Methods for generating nucleic acid size standards are disclosed. The methods comprise providing a template polynucleotide which comprises periodic sequences of from about 5 to about 50 contiguous nucleotides containing not more than three types of nucleotides and wherein adjacent periodic sequences are separated by a terminator complement nucleotide that differs from the not more than three types of nucleotides, and performing a primer extension reaction on the template polynucleotide in the presence of nucleoside triphosphate molecules and a 3′ terminating nucleoside triphosphate which is complementary to the terminator complement nucleotide.
摘要翻译: 公开了产生核酸尺寸标准的方法。 所述方法包括提供模板多核苷酸,其包含约5至约50个连续核苷酸的周期性序列,所述连续核苷酸含有不超过3种类型的核苷酸,并且其中相邻的周期性序列由终止子补体核苷酸分开,其不同于不超过三种类型 核苷酸,并且在核苷三磷酸分子和与终止子补体核苷酸互补的3'末端核苷三磷酸存在下对模板多核苷酸进行引物延伸反应。
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公开(公告)号:US20060078964A1
公开(公告)日:2006-04-13
申请号:US10216161
申请日:2002-08-09
申请人: Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
发明人: Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
CPC分类号: C07K14/705
摘要: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号:US20050084935A1
公开(公告)日:2005-04-21
申请号:US10897360
申请日:2004-07-21
申请人: Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
发明人: Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
IPC分类号: A61K38/00 , C07K14/47 , C07K14/705 , G01N33/50 , G01N33/574 , G01N33/68 , C12P21/02 , C07H21/04 , C12N9/00
CPC分类号: G01N33/5008 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K14/705 , C07K2319/00 , C07K2319/30 , C12N2799/026 , C12N2799/027 , G01N33/5011 , G01N33/502 , G01N33/57484 , G01N33/68 , G01N33/6845
摘要: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号:US20050079577A1
公开(公告)日:2005-04-14
申请号:US10893802
申请日:2004-07-16
申请人: Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
发明人: Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
IPC分类号: A61K38/00 , C07K14/47 , C07K14/705 , C07H21/04 , C12N9/00
CPC分类号: C07K14/47 , A61K38/00 , C07K14/4703 , C07K14/705 , C07K2319/00 , C07K2319/30 , C12N2799/026 , C12N2799/027
摘要: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号:US20050037463A1
公开(公告)日:2005-02-17
申请号:US10897359
申请日:2004-07-21
申请人: Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
发明人: Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
IPC分类号: A61K38/00 , C07K14/47 , C07K14/705 , C07H21/04 , C12N9/00
CPC分类号: C07K14/4703 , A61K38/00 , C07K14/47 , C07K14/705 , C07K2319/00 , C07K2319/30 , C12N2799/026 , C12N2799/027
摘要: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号:US20050014226A1
公开(公告)日:2005-01-20
申请号:US10918851
申请日:2004-08-13
申请人: Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Oiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
发明人: Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Oiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
IPC分类号: C07K14/47 , C07K14/705 , C07K16/18 , C07H21/04 , C12N9/00
CPC分类号: C07K16/18 , C07K14/47 , C07K14/4703 , C07K14/705 , C07K2319/00 , C07K2319/30 , C12N2799/026
摘要: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号:US20070031929A1
公开(公告)日:2007-02-08
申请号:US11536590
申请日:2006-09-28
申请人: Napoleone Ferrara , Sophia Kuo
发明人: Napoleone Ferrara , Sophia Kuo
IPC分类号: C12P21/06 , C07H21/04 , C12N5/06 , C07K14/475
CPC分类号: C07K14/52 , A61K38/00 , C07K2319/00 , C12N2799/026
摘要: The present invention involves the identification and preparation of vascular endothelial growth factor-E (VEGF-E). VEGF-E is a novel polypeptide related to vascular endothelial growth factor (VEGF) and bone morphogenetic protein 1. VEGF-E has homology to VEGF including conservation of the amino acids required for activity of VEGF. VEGF-E can be useful in wound repair, as well as in the generation and regeneration of tissue.
摘要翻译: 本发明涉及血管内皮生长因子-E(VEGF-E)的鉴定和制备。 VEGF-E是与血管内皮生长因子(VEGF)和骨形态发生蛋白1相关的新型多肽.VC-E与VEGF具有同源性,包括对VEGF活性所需氨基酸的保守性。 VEGF-E可用于伤口修复,以及组织的产生和再生。
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公开(公告)号:US20050227328A1
公开(公告)日:2005-10-13
申请号:US11129762
申请日:2005-05-13
申请人: Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
发明人: Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
IPC分类号: A61K38/00 , A61K39/395 , C07K14/47 , C07K14/705 , C07K16/28 , C12N5/10 , C12N15/12 , C12N15/62 , C12N15/63 , C07H21/04 , C07K16/18 , C12N9/00 , C12N15/09
摘要: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号:US20050124789A9
公开(公告)日:2005-06-09
申请号:US09978824
申请日:2001-10-16
申请人: Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Christopher Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Mickey Williams , William Wood
发明人: Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Christopher Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Mickey Williams , William Wood
IPC分类号: A61K31/17 , A61K38/00 , A61K38/17 , A61K38/43 , A61K39/395 , A61K48/00 , C07H21/02 , C07H21/04 , C07K14/435 , C07K14/47 , C07K14/52 , C07K14/54 , C07K14/705 , C07K16/18 , C07K16/28 , C07K16/40 , C12N5/06 , C12N9/00 , C12P21/02 , C12Q1/68 , G01N33/53 , G01N33/574 , G01N33/68
CPC分类号: C07K14/47 , A61K38/00 , A61K48/00 , C07K14/4702 , C07K14/4703 , C07K14/475 , C07K14/52 , C07K14/521 , C07K14/54 , C07K14/705 , C07K14/70503 , C07K14/70578 , C07K16/18 , C07K16/28 , C07K2317/24 , C07K2319/00 , C07K2319/30 , C12N9/00 , C12N2799/026 , C12N2799/027 , G01N33/573 , G01N33/57484 , G01N33/68 , G01N2333/99 , G01N2800/042
摘要: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号:US20080095773A1
公开(公告)日:2008-04-24
申请号:US11940770
申请日:2007-11-15
申请人: Napoleone Ferrara , Sophia Kuo
发明人: Napoleone Ferrara , Sophia Kuo
IPC分类号: A61K39/395
CPC分类号: C07K14/52 , A61K38/00 , C07K2319/00 , C12N2799/026
摘要: The present invention involves the identification and preparation of vascular endothelial growth factor-E (VEGF-E). VEGF-E is a novel polypeptide related to vascular endothelial growth factor (VEGF) and bone morphogenetic protein 1. VEGF-E has homology to VEGF including conservation of the amino acids required for activity of VEGF. VEGF-E can be useful in wound repair, as well as in the generation and regeneration of tissue.
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