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    Advanced functional biocompatible polymeric matrix containing nano-compartments
    1.
    发明授权
    Advanced functional biocompatible polymeric matrix containing nano-compartments 有权
    含有纳米隔室的高级功能生物相容性聚合物基质

    公开(公告)号：US09066885B2

    公开(公告)日：2015-06-30

    申请号：US12077173

    申请日：2008-03-17

    申请人： Srinivasa R. Raghavan ,  Gregory F. Payne ,  Chao Zhu ,  Matthew B. Dowling

    发明人： Srinivasa R. Raghavan ,  Gregory F. Payne ,  Chao Zhu ,  Matthew B. Dowling

    IPC分类号： A61P17/02 ,  A61K9/70 ,  A61K9/127 ,  A61K47/48

    CPC分类号： A61K31/722 ,  A61K9/127 ,  A61K9/1271 ,  A61K9/7007 ,  A61K47/56 ,  A61K47/61 ,  A61K47/69 ,  A61L26/0023 ,  A61L27/20 ,  A61L2300/216 ,  A61L2300/232 ,  A61L2300/418 ,  A61L2300/626 ,  A61L2400/04 ,  A61L2400/12 ,  C08L5/08

    摘要： The present invention provides a novel biomaterial which is a hybrid, self-assembling biopolymeric networked film that is functionalized through hydrophobic interactions with vesicles loaded with bioactive agents. The biomaterial compound is a polymeric network of hydrophobically modified chitosan scaffolds that is taken from solution and formed as a solid film. This solid state film is capable of hydrophobic interactions with the functionalized vesicles. The vesicles include one or more lamellar structures forming one or more nano-compartments that are capable of containing similar or alternative active moieties within. Use of the film results in a degradation of the chitosan scaffold thereby releasing the active moieties within the vesicles from the scaffold. Application of the current invention occurs through various delivery mechanisms and routes of administration as will be described herein.

    摘要翻译： 本发明提供了一种新型生物材料，其是通过与装载有生物活性剂的囊泡的疏水相互作用而官能化的混合的，自组装的生物聚合物网状膜。 生物材料化合物是从溶液中取出并形成为固体膜的疏水改性壳聚糖支架的聚合物网络。 该固态膜能够与功能化囊泡疏水相互作用。 泡囊包括形成一个或多个能够在其内含有相似或替代活性部分的纳米隔室的一个或多个层状结构。 膜的使用导致壳聚糖支架的降解，从而从支架中释放囊泡内的活性部分。 如本文所述，本发明的应用通过各种递送机制和给药途径进行。

    Advanced functional biocompatible polymeric matrix containing nano-compartments
    2.
    发明申请
    Advanced functional biocompatible polymeric matrix containing nano-compartments 有权
    含有纳米隔室的高级功能生物相容性聚合物基质

    公开(公告)号：US20080254104A1

    公开(公告)日：2008-10-16

    申请号：US12077173

    申请日：2008-03-17

    申请人： Srinivasa R. Raghavan ,  Gregory F. Payne ,  Chao Zhu ,  Matthew B. Dowling

    发明人： Srinivasa R. Raghavan ,  Gregory F. Payne ,  Chao Zhu ,  Matthew B. Dowling

    IPC分类号： A61K9/70 ,  A61P17/02

    CPC分类号： A61K31/722 ,  A61K9/127 ,  A61K9/1271 ,  A61K9/7007 ,  A61K47/56 ,  A61K47/61 ,  A61K47/69 ,  A61L26/0023 ,  A61L27/20 ,  A61L2300/216 ,  A61L2300/232 ,  A61L2300/418 ,  A61L2300/626 ,  A61L2400/04 ,  A61L2400/12 ,  C08L5/08

    摘要： The present invention provides a novel biomaterial which is a hybrid, self-assembling biopolymeric networked film that is functionalized through hydrophobic interactions with vesicles loaded with bioactive agents. The biomaterial compound is a polymeric network of hydrophobically modified chitosan scaffolds that is taken from solution and formed as a solid film. This solid state film is capable of hydrophobic interactions with the functionalized vesicles. The vesicles include one or more lamellar structures forming one or more nano-compartments that are capable of containing similar or alternative active moieties within. Use of the film results in a degradation of the chitosan scaffold thereby releasing the active moieties within the vesicles from the scaffold. Application of the current invention occurs through various delivery mechanisms and routes of administration as will be described herein.

    摘要翻译： 本发明提供了一种新型生物材料，其是通过与装载有生物活性剂的囊泡的疏水相互作用而官能化的混合的，自组装的生物聚合物网状膜。 生物材料化合物是从溶液中取出并形成为固体膜的疏水改性壳聚糖支架的聚合物网络。 该固态膜能够与功能化囊泡疏水相互作用。 泡囊包括形成一个或多个能够在其内含有相似或替代活性部分的纳米隔室的一个或多个层状结构。 膜的使用导致壳聚糖支架的降解，从而从支架中释放囊泡内的活性部分。 如本文所述，本发明的应用通过各种递送机制和给药途径进行。

    System and method for nanoparticle and nanoagglomerate fluidization
    8.
    发明授权
    System and method for nanoparticle and nanoagglomerate fluidization 失效
    纳米颗粒和纳米颗粒流化的系统和方法

    公开(公告)号：US07658340B2

    公开(公告)日：2010-02-09

    申请号：US11605176

    申请日：2006-11-28

    申请人： Robert Pfeffer ,  Caroline H. Nam ,  Rajesh N. Dave ,  Guangliang Liu ,  Jose A. Quevedo ,  Qun Yu ,  Chao Zhu

    发明人： Robert Pfeffer ,  Caroline H. Nam ,  Rajesh N. Dave ,  Guangliang Liu ,  Jose A. Quevedo ,  Qun Yu ,  Chao Zhu

    IPC分类号： B02C19/00 ,  B02C19/06

    CPC分类号： B01F13/0809 ,  B01F11/0266 ,  B01F13/0255 ,  B01J8/1872 ,  B01J8/40 ,  B01J8/42 ,  B01J19/10 ,  B01J2208/00681 ,  B82Y15/00

    摘要： With the coupling of an external field and aeration (or a flow of another gas), nanoparticles can be smoothly and vigorously fluidized. A magnetic force and/or pre-treatment may be employed with the fluidizing gas and, when coupled with a fluidizing medium, provide excellent means for achieving homogenous nanofluidization. The magnetic force interacts with non-fluidizing magnetic particles and helps to break channels as well as provide enough energy to disrupt the strong interparticle forces, thereby establishing an advantageous agglomerate size distribution. Enhanced fluidization is reflected by improved performance-related attributes. The fluidized nanoparticles may be coated, surface-treated and/or surface-modified in the fluidized state. In addition, the fluidized nanoparticles may participate in a reaction, either as a reactant or a catalyst, while in the fluidized state.

    摘要翻译： 通过外场和通气（或另一种气体的流动）的耦合，纳米颗粒可以顺利且剧烈流化。 可以与流化气体一起使用磁力和/或预处理，并且当与流化介质结合时，提供用于实现均匀纳米流化的优异手段。 磁力与非流动性磁性颗粒相互作用，有助于破坏通道，并提供足够的能量来破坏强大的颗粒间力，从而建立有利的聚集体尺寸分布。 改进的流量化反映在与性能相关的特性方面。 流化的纳米颗粒可以在流化状态下被涂覆，表面处理和/或表面改性。 此外，流化的纳米颗粒可以在流化状态下作为反应物或催化剂参与反应。

    System and method for nanoparticle and nanoagglomerate fluidization
    9.
    发明申请
    System and method for nanoparticle and nanoagglomerate fluidization 失效
    纳米颗粒和纳米颗粒流化的系统和方法

    公开(公告)号：US20070108320A1

    公开(公告)日：2007-05-17

    申请号：US11605176

    申请日：2006-11-28

    申请人： Robert Pfeffer ,  Caroline Nam ,  Rajesh Dave ,  Guangliang Liu ,  Jose Quevedo ,  Qun Yu ,  Chao Zhu

    发明人： Robert Pfeffer ,  Caroline Nam ,  Rajesh Dave ,  Guangliang Liu ,  Jose Quevedo ,  Qun Yu ,  Chao Zhu

    IPC分类号： B02C19/06

    CPC分类号： B01F13/0809 ,  B01F11/0266 ,  B01F13/0255 ,  B01J8/1872 ,  B01J8/40 ,  B01J8/42 ,  B01J19/10 ,  B01J2208/00681 ,  B82Y15/00

    摘要： With the coupling of an external field and aeration (or a flow of another gas), nanoparticles can be smoothly and vigorously fluidized. A magnetic force and/or pre-treatment may be employed with the fluidizing gas and, when coupled with a fluidizing medium, provide excellent means for achieving homogenous nanofluidization. The magnetic force interacts with non-fluidizing magnetic particles and helps to break channels as well as provide enough energy to disrupt the strong interparticle forces, thereby establishing an advantageous agglomerate size distribution. Enhanced fluidization is reflected by improved performance-related attributes. The fluidized nanoparticles may be coated, surface-treated and/or surface-modified in the fluidized state. In addition, the fluidized nanoparticles may participate in a reaction, either as a reactant or a catalyst, while in the fluidized state.

    摘要翻译： 通过外场和通气（或另一种气体的流动）的耦合，纳米颗粒可以顺利且剧烈流化。 可以与流化气体一起使用磁力和/或预处理，并且当与流化介质结合时，提供用于实现均匀纳米流化的优异手段。 磁力与非流动性磁性颗粒相互作用，有助于破坏通道，并提供足够的能量来破坏强大的颗粒间力，从而建立有利的聚集体尺寸分布。 改进的流量化反映在与性能相关的特性方面。 流化的纳米颗粒可以在流化状态下被涂覆，表面处理和/或表面改性。 此外，流化的纳米颗粒可以在流化状态下作为反应物或催化剂参与反应。

    REDUCING SPECTRUM INTERFERENCE BETWEEN WIRELESS NETWORKS
    10.
    发明申请
    REDUCING SPECTRUM INTERFERENCE BETWEEN WIRELESS NETWORKS 审中-公开

    公开(公告)号：US20120315942A1

    公开(公告)日：2012-12-13

    申请号：US13591269

    申请日：2012-08-22

    申请人： Yonghua Lin ,  Jianbin Tang ,  Jun Song Wang ,  Qing Wang ,  Rong Yan ,  Hai Zhan ,  Chao Zhu ,  Zhen Bo Zhu

    发明人： Yonghua Lin ,  Jianbin Tang ,  Jun Song Wang ,  Qing Wang ,  Rong Yan ,  Hai Zhan ,  Chao Zhu ,  Zhen Bo Zhu

    IPC分类号： H04B15/00 ,  H04W24/00 ,  H04W72/04

    CPC分类号： H04W16/14 ,  H04W72/0486 ,  H04W72/085 ,  H04W72/087 ,  H04W72/10

    摘要： A method and apparatus for reducing spectrum interference between wireless networks. This is realized by arranging at least one sub-coordinating apparatus, namely, a monitoring apparatus, in respective wireless network, and by arranging a coordinating apparatus, namely, an allocation apparatus in the whole network. Wherein, the sub-coordinating apparatus monitors the spectrum utilization situation of the wireless network where it is located, reports it to the coordinating apparatus, and requests the coordinating apparatus for spectrum resource when new spectrum resource is needed. The coordinating apparatus maintains the spectrum utilization information of each wireless network, and allocates appropriate spectrum resource to the sub-coordinating apparatus which requests spectrum resource based on the maintained information. Therefore, the interference of inter-wireless networks is reduced or even avoided through such overall management that the coordinating apparatus allocates corresponding spectrum resources to a plurality of wireless networks capable of sharing spectrum resources.