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1.发明申请Advanced functional biocompatible polymeric matrix containing nano-compartments 有权含有纳米隔室的高级功能生物相容性聚合物基质公开(公告)号：US20080254104A1
公开(公告)日：2008-10-16
申请号：US12077173
申请日：2008-03-17
CPC分类号： A61K31/722 , A61K9/127 , A61K9/1271 , A61K9/7007 , A61K47/56 , A61K47/61 , A61K47/69 , A61L26/0023 , A61L27/20 , A61L2300/216 , A61L2300/232 , A61L2300/418 , A61L2300/626 , A61L2400/04 , A61L2400/12 , C08L5/08
摘要： The present invention provides a novel biomaterial which is a hybrid, self-assembling biopolymeric networked film that is functionalized through hydrophobic interactions with vesicles loaded with bioactive agents. The biomaterial compound is a polymeric network of hydrophobically modified chitosan scaffolds that is taken from solution and formed as a solid film. This solid state film is capable of hydrophobic interactions with the functionalized vesicles. The vesicles include one or more lamellar structures forming one or more nano-compartments that are capable of containing similar or alternative active moieties within. Use of the film results in a degradation of the chitosan scaffold thereby releasing the active moieties within the vesicles from the scaffold. Application of the current invention occurs through various delivery mechanisms and routes of administration as will be described herein.
摘要翻译： 本发明提供了一种新型生物材料，其是通过与装载有生物活性剂的囊泡的疏水相互作用而官能化的混合的，自组装的生物聚合物网状膜。 生物材料化合物是从溶液中取出并形成为固体膜的疏水改性壳聚糖支架的聚合物网络。 该固态膜能够与功能化囊泡疏水相互作用。 泡囊包括形成一个或多个能够在其内含有相似或替代活性部分的纳米隔室的一个或多个层状结构。 膜的使用导致壳聚糖支架的降解，从而从支架中释放囊泡内的活性部分。 如本文所述，本发明的应用通过各种递送机制和给药途径进行。
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2.发明授权Advanced functional biocompatible polymeric matrix containing nano-compartments 有权含有纳米隔室的高级功能生物相容性聚合物基质公开(公告)号：US09066885B2
公开(公告)日：2015-06-30
申请号：US12077173
申请日：2008-03-17
CPC分类号： A61K31/722 , A61K9/127 , A61K9/1271 , A61K9/7007 , A61K47/56 , A61K47/61 , A61K47/69 , A61L26/0023 , A61L27/20 , A61L2300/216 , A61L2300/232 , A61L2300/418 , A61L2300/626 , A61L2400/04 , A61L2400/12 , C08L5/08
摘要： The present invention provides a novel biomaterial which is a hybrid, self-assembling biopolymeric networked film that is functionalized through hydrophobic interactions with vesicles loaded with bioactive agents. The biomaterial compound is a polymeric network of hydrophobically modified chitosan scaffolds that is taken from solution and formed as a solid film. This solid state film is capable of hydrophobic interactions with the functionalized vesicles. The vesicles include one or more lamellar structures forming one or more nano-compartments that are capable of containing similar or alternative active moieties within. Use of the film results in a degradation of the chitosan scaffold thereby releasing the active moieties within the vesicles from the scaffold. Application of the current invention occurs through various delivery mechanisms and routes of administration as will be described herein.
摘要翻译： 本发明提供了一种新型生物材料，其是通过与装载有生物活性剂的囊泡的疏水相互作用而官能化的混合的，自组装的生物聚合物网状膜。 生物材料化合物是从溶液中取出并形成为固体膜的疏水改性壳聚糖支架的聚合物网络。 该固态膜能够与功能化囊泡疏水相互作用。 泡囊包括形成一个或多个能够在其内含有相似或替代活性部分的纳米隔室的一个或多个层状结构。 膜的使用导致壳聚糖支架的降解，从而从支架中释放囊泡内的活性部分。 如本文所述，本发明的应用通过各种递送机制和给药途径进行。
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3.发明申请METHOD AND SYSTEM FOR CAPTURE AND USE OF INTACT VESICLES ON ELECTRODEPOSITED HYDROPHOBICALLY MODIFIED BIOPOLYMER FILMS 有权用于电沉积的疏水改性生物膜的薄膜的捕获和使用方法和系统公开(公告)号：US20120252703A1
公开(公告)日：2012-10-04
申请号：US13310579
申请日：2011-12-02
申请人： Matthew Dowling , Srinivasa R. Raghavan , Neeraja Dashaputre , Douglas Stephen English , Vishal Javvaji , Gregory F. Payne , Philip R. DeShong
发明人： Matthew Dowling , Srinivasa R. Raghavan , Neeraja Dashaputre , Douglas Stephen English , Vishal Javvaji , Gregory F. Payne , Philip R. DeShong
IPC分类号： G01N33/533 , C25D9/02 , C25D5/34 , C40B60/08
CPC分类号： A61F13/00017 , A61F13/00063 , A61L15/28 , A61L15/44 , A61L2300/104 , A61L2300/404 , A61L2300/406 , A61L2300/414 , A61L2300/626 , G01N33/5432 , G01N33/5436 , G01N33/5438 , G01N33/548 , Y10T436/11 , C08L5/08
摘要： A biosensor comprising an electrically conductive substrate coated with a modified chitosan biopolymer that has been electrodeposited on the substrate, wherein said modified chitosan biopolymer comprises at least one vesicle binding molecule. The biosensor is manufactured by a method where a modified chitosan biopolymer is electrodeposited on a substrate. The method is also used to manufacture a modified chitosan biopolymer film by electrodeposition of the chitosan on the substrate and later removing the film from the substrate after electrodeposition. The resulting film can be used in bandages to treat various types of wounds. The biosensor can also be used to detect various analytes in samples.
摘要翻译： 一种生物传感器，包括涂覆有已经电沉积在基底上的改性壳聚糖生物聚合物的导电基底，其中所述改性的壳聚糖生物聚合物包含至少一个囊泡结合分子。 通过将改性的壳聚糖生物聚合物电沉积在基材上的方法制造生物传感器。 该方法还用于通过将壳聚糖电沉积在基底上并随后在电沉积之后从基底上去除膜来制造改性的壳聚糖生物聚合物膜。 所得薄膜可用于绷带以治疗各种类型的伤口。 生物传感器也可用于检测样品中的各种分析物。
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4.发明授权Method and system for capture and use of intact vesicles on electrodeposited hydrophobically modified biopolymer films 有权在电沉积的疏水改性生物聚合物膜上捕获和使用完整囊泡的方法和系统公开(公告)号：US08858883B2
公开(公告)日：2014-10-14
申请号：US13310579
申请日：2011-12-02
申请人： Matthew Dowling , Srinivasa R. Raghavan , Neeraja Dashaputre , Douglas Stephen English , Vishal Javvaji , Gregory F. Payne , Philip R. DeShong
发明人： Matthew Dowling , Srinivasa R. Raghavan , Neeraja Dashaputre , Douglas Stephen English , Vishal Javvaji , Gregory F. Payne , Philip R. DeShong
IPC分类号： G01N15/06 , G01N33/00 , G01N33/48 , A61L15/44 , A61F13/00 , G01N33/543 , A61L15/28 , G01N33/548
CPC分类号： A61F13/00017 , A61F13/00063 , A61L15/28 , A61L15/44 , A61L2300/104 , A61L2300/404 , A61L2300/406 , A61L2300/414 , A61L2300/626 , G01N33/5432 , G01N33/5436 , G01N33/5438 , G01N33/548 , Y10T436/11 , C08L5/08
摘要： A biosensor comprising an electrically conductive substrate coated with a modified chitosan biopolymer that has been electrodeposited on the substrate, wherein said modified chitosan biopolymer comprises at least one vesicle binding molecule. The biosensor is manufactured by a method where a modified chitosan biopolymer is electrodeposited on a substrate. The method is also used to manufacture a modified chitosan biopolymer film by electrodeposition of the chitosan on the substrate and later removing the film from the substrate after electrodeposition. The resulting film can be used in bandages to treat various types of wounds. The biosensor can also be used to detect various analytes in samples.
摘要翻译： 一种生物传感器，包括涂覆有已经电沉积在基底上的改性壳聚糖生物聚合物的导电基底，其中所述改性的壳聚糖生物聚合物包含至少一个囊泡结合分子。 通过将改性的壳聚糖生物聚合物电沉积在基材上的方法制造生物传感器。 该方法还用于通过将壳聚糖电沉积在基底上并随后在电沉积之后从基底上去除膜来制造改性的壳聚糖生物聚合物膜。 所得薄膜可用于绷带以治疗各种类型的伤口。 生物传感器也可用于检测样品中的各种分析物。
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5.发明申请ELECTROADDRESSING AND IN-FILM BIOPROCESSING USING STIMULI-RESPONSIVE HYDROGEL-FORMING POLYMERS 审中-公开使用刺激性水凝胶形成聚合物进行电加工和膜内生物处理公开(公告)号：US20120103822A1
公开(公告)日：2012-05-03
申请号：US13266433
申请日：2010-04-27
申请人： Xiao-Wen Shi , Yi Liu , Gregory F. Payne , Xiaohua Yang
发明人： Xiao-Wen Shi , Yi Liu , Gregory F. Payne , Xiaohua Yang
CPC分类号： C12N11/04 , B01J2219/00576 , B01J2219/00641 , B01J2219/00644 , B01J2219/00653 , B01J2219/00725 , B01J2219/00743 , C09D105/04 , G01N33/5438
摘要： Methods for the generation of hydrogels formed by electrodeposition of an electroaddressable polymer are described. The hydrogels may contain one or more cell populations electroaddressed or electroaddressable to a location within the hydrogel and where the cells of the cell populations are entrapped by the hydrogel and are capable of expansion within the hydrogel and may be releasable from the hydrogel. Further provided are electroaddressable polysaccharide blends for the in-film expansion of a cell population, allowing probing of the cells and formation of immunocomplexes. Further provided are methods of using hydrogels containing electroaddressed or electroaddressable cell populations in in-film bioprocessing methods such as cell-based biosensing, protein-based biosensing, and in studies of cell signaling.
摘要翻译： 描述了通过电沉积聚合物电解形成的水凝胶的产生方法。 水凝胶可以含有一个或多个电解地址或电可寻址到水凝胶内的位置的细胞群，并且其中细胞群的细胞被水凝胶包埋并且能够在水凝胶内膨胀并且可以从水凝胶中释放。 还提供了用于细胞群体的膜内扩增的电可寻址多糖共混物，允许细胞的探查和免疫复合物的形成。 还提供了在膜内生物处理方法如基于细胞的生物传感，基于蛋白质的生物传感和细胞信号传导研究中使用含有电解或电可寻址细胞群的水凝胶的方法。
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公开(公告)号：US20110217785A1
公开(公告)日：2011-09-08
申请号：US13122403
申请日：2009-10-02
申请人： Yi Liu , Xiao-Wen Shi , Gregory F. Payne , W. Lee Meyer
发明人： Yi Liu , Xiao-Wen Shi , Gregory F. Payne , W. Lee Meyer
CPC分类号： G01N33/54393
摘要： A method of forming a bioelectronic device including a protein on an electrically conductive substrate, by electro-depositing aminopolysaccharide chitosan on the substrate while applying a cathodic voltage to the substrate, to form an aminopolysaccharide chitosan film thereon, applying an anodic voltage to the substrate in the presence of NaCl to activate the aminopolysaccharide chitosan film so that it is reactive with protein. The method also optionally includes reacting the aminopolysaccharide film, after activation thereof, with the protein, so that the protein assembles on and is coupled to the substrate, thereby forming a bioelectronic device. The protein can include single or multiple protein species, and including biosensing proteins. Additional methods include biosensing of electrochemically active compounds either present in a sample or generated during a biological recognition event and devices useful in such methods. The resulting devices are useful as sensors in hand-held devices, textiles, garments and the like.
摘要翻译： 在导电性基材上形成包含蛋白质的生物电子器件的方法，通过在衬底上电沉积氨基多糖壳聚糖，同时向衬底施加阴极电压，在其上形成氨基多糖壳聚糖膜，在衬底上施加阳极电压 NaCl的存在来激活氨基多糖壳聚糖膜，使其与蛋白质反应。 该方法还可选地包括使氨基多糖膜在其活化后与蛋白质反应，使得蛋白质组装在基底上并与基底结合，从而形成生物电子器件。 蛋白质可以包括单个或多个蛋白质物质，并且包括生物传感蛋白质。 另外的方法包括存在于样品中或在生物识别事件期间产生的电化学活性化合物的生物传感以及在这些方法中有用的装置。 所得到的装置可用作手持装置，纺织品，服装等中的传感器。
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7.发明授权Two step process for conversion of a weakly adsorbable compound to a strongly adsorbable compound and selective removal thereof 失效用于将弱吸附化合物转化为强吸附化合物的二步法和选择性除去
公开(公告)号：US5340483A
公开(公告)日：1994-08-23
申请号：US75283
申请日：1993-06-11
CPC分类号： C12P7/26 , B01D15/00 , C02F3/342 , C02F2101/345 , Y02W10/37 , Y10S210/909
摘要： A method for the selective separation of a particular compound from a mixture of compounds, by enzymatically converting a weakly adsorbable compound to a strongly adsorbable compound, and binding the converted compound to a material of appropriate chemical properties is described. Also described are methods for removing contaminants from wastewater streams, and from intermediate chemical process streams.
摘要翻译： 描述了通过将弱吸附化合物酶促转化为强吸附化合物，并将转化的化合物结合到具有适当化学性质的材料来选择性分离特定化合物与化合物混合物的方法。 还描述了从废水流和中间化学工艺流中除去污染物的方法。
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8.发明授权Controlled electrochemical deposition of polysaccharide films and hydrogels, and materials formed therefrom 有权多糖膜和水凝胶的控制电化学沉积及由其形成的材料公开(公告)号：US07883615B2
公开(公告)日：2011-02-08
申请号：US10541057
申请日：2004-02-11
申请人： Gregory F. Payne , Li-Qun Wu , Reza Ghodssi , William E. Bentley , Gary W. Rubloff , Hyunmin Yi , Rohan Fernandes , Tianhong Chen , David A. Small
发明人： Gregory F. Payne , Li-Qun Wu , Reza Ghodssi , William E. Bentley , Gary W. Rubloff , Hyunmin Yi , Rohan Fernandes , Tianhong Chen , David A. Small
IPC分类号： C25D9/02
CPC分类号： C25D5/022 , C09D5/4419
摘要： A method is provided for electrochemically depositing a polysaccharide mass having a selected physical state. According to an embodiment, an electrically conductive support of a substrate is contacted with an aqueous solution including a selectively insolubilizable polysaccharide, and the selectively insolubilizable polysaccharide is electrochemically deposited on the electrically conductive support while controlling deposition conditions to form the polysaccharide mass having the selected physical state, such as that of a hydrogel. Deposition may be performed in a spatially and/or temporally controlled manner.
摘要翻译： 提供了一种用于电化学沉积具有选定物理状态的多糖物质的方法。 根据一个实施方案，将基材的导电载体与包含选择性不溶性多糖的水溶液接触，并且将选择性不溶性多糖电化学沉积在导电载体上，同时控制沉积条件以形成具有选定物理性质的多糖物质 状态，例如水凝胶的状态。 沉积可以在空间和/或时间上控制的方式进行。
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公开(公告)号：US07820227B2
公开(公告)日：2010-10-26
申请号：US10581905
申请日：2004-02-20
申请人： Gregory F. Payne , Gary W. Rubloff , Hyunmin Yi , Rohan Fernandes , Li-Qun Wu , Reza Ghodssi , William E. Bentley
发明人： Gregory F. Payne , Gary W. Rubloff , Hyunmin Yi , Rohan Fernandes , Li-Qun Wu , Reza Ghodssi , William E. Bentley
IPC分类号： A61L33/00
CPC分类号： G03F7/40 , A61L31/10 , A61L31/14 , Y10T428/31504 , Y10T428/31536 , Y10T428/31971 , C08L5/08
摘要： A method for biolithographical deposition of molecules is provided. According to an embodiment of the method, a reactive layer (e.g., a polysaccharide mass) having a surface region coated with a biologically compatible resist is provided. A portion of the biologically compatible resist is selectively removed to expose an exposed portion of the reactive layer. Molecules, such as biomolecules and/or cellular species, are then conjugated to the exposed portion of the reactive layer. Also provided are materials and devices related to the method.
摘要翻译： 提供了分子生物层析沉积的方法。 根据该方法的一个实施方案，提供具有涂覆有生物相容性抗蚀剂的表面区域的反应层（例如，多糖质量）。 选择性地除去生物相容性抗蚀剂的一部分以暴露反应层的暴露部分。 分子，例如生物分子和/或细胞物质，然后与反应层的暴露部分共轭。 还提供了与该方法相关的材料和装置。
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10.发明授权Fibrous assemblies for antibody presentation, and multiplexed antigenic analysis using same 有权用于抗体呈递的纤维组件，以及使用其的多重抗原分析公开(公告)号：US08791239B2
公开(公告)日：2014-07-29
申请号：US12990981
申请日：2009-04-07
CPC分类号： A61K9/5169 , B01J19/0046 , B01J2219/00515 , B01J2219/00524 , B01J2219/00527 , B01J2219/00657 , B01J2219/00659 , B01J2219/00666 , B01J2219/00725 , C08L5/08 , G01N33/544
摘要： Biofunctionalized fibers including a fiber platform and a histidine-tagged protein and, optionally, an antibody. Chitosan is a fiber useful as the fiber platform. The fiber platform may be treated with nickel or may be directly linked to the histidine-tagged protein e.g., histidine-tagged streptococcal IgG-binding protein, protein G, protein G3T, GFP or RFP. The resulting biofunctionalized fibers can be assembled into protein fiber assemblies by a variety of biofabrication methods. The fiber assemblies, e.g., in the form of woven fabrics, are useful for (i) antigen capture; (ii) immunoanalysis, and/or (iii) multiplexed analysis. In one fabrication, each fiber of a fiber assembly presents a specific antibody, and mixing and matching of fibers, for example by weaving of fabrics from various antibody-presenting fibers, allows for multiple antigens to be captured simultaneously for multiplexed analysis.
摘要翻译： 包括纤维平台和组氨酸标记的蛋白质的生物功能化纤维和任选的抗体。 壳聚糖是用作纤维平台的纤维。 纤维平台可以用镍处理，或者可以直接连接到组氨酸标记的蛋白质，例如组氨酸标记的链球菌IgG结合蛋白，蛋白G，蛋白质G3T，GFP或RFP。 所得的生物功能化纤维可以通过各种生物制造方法组装成蛋白质纤维组件。 纤维组件，例如织造织物的形式，可用于（i）抗原捕获; （ii）免疫分析和/或（iii）多重分析。 在一个制造中，纤维组件的每个纤维呈现特异性抗体，并且纤维的混合和匹配，例如通过编织来自各种抗体呈递纤维的织物，允许同时捕获多个抗原进行多重分析。
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