公开(公告)号：US10400101B2

公开(公告)日：2019-09-03

申请号：US15602979

申请日：2017-05-23

申请人： St. Jude Medical, Atrial Fibrillation Division, Inc.

发明人： Xiaoping Guo ,  David P. Johnson ,  Richard E. Stehr

IPC分类号： C08L69/00 ,  C08G69/40 ,  C08K5/353 ,  C08L33/10 ,  C08L77/02 ,  C08L77/06 ,  C08L77/10

摘要： The invention relates to biocompatible polycarbonate/polyamide polymer compositions for use in medical and surgical devices. Additional additives, crosslinking agents, phosphites, and optionally a radiopaque filler or fillers can be used to produce the high performance compositions desired. The polymer compositions have improved melt processability along with balanced or enhanced physical and mechanical properties, especially when combined or over-extruded onto or covering other polymer layers, such as soft and/or flexible layers commonly used in medical device applications and catheter tips, for example. The ability to incorporate radiopaque compounds into these polymer compositions during melt processing offers improved methods for monitoring and visualizing medical devices when used inside the body and as well as improving the operating characteristics of the medical device components.

公开(公告)号：US20180243531A1

公开(公告)日：2018-08-30

申请号：US15963813

申请日：2018-04-26

申请人： St. Jude Medical, Atrial Fibrillation Division, Inc.

发明人： Xiaoping Guo ,  Richard E. Stehr

IPC分类号： A61M25/00 ,  B29C47/02 ,  A61M25/01 ,  B29C61/00 ,  B29D23/00 ,  B29C63/00 ,  B29K27/18 ,  B29K105/16 ,  B29L31/00

CPC分类号： A61M25/005 ,  A61M25/0009 ,  A61M25/0012 ,  A61M25/0043 ,  A61M25/0045 ,  A61M25/0108 ,  A61M2025/0059 ,  A61M2205/32 ,  B29C48/151 ,  B29C61/006 ,  B29C63/0069 ,  B29D23/001 ,  B29K2027/18 ,  B29K2105/16 ,  B29L2031/7542

摘要： A method of manufacturing a catheter shaft includes the steps of forming an inner layer of a first polymeric material, forming a plait matrix layer including a second polymeric material about the inner layer, and forming an outer layer of a third polymeric material about the plait matrix layer. The plait matrix layer includes a braided wire mesh partially or fully embedded within the second polymeric material, which is different from at least one of the first polymeric material forming the inner layer and the third polymeric material forming the outer layer. The second polymeric material has a higher yield strain and/or a lower hardness than at least the first polymeric material, and preferably both the first and the third polymeric materials. The first polymeric material and the third polymeric material may be different or the same. The catheter shaft may be formed by stepwise extrusion, co-extrusion, and/or reflow processes.

公开(公告)号：US20170312396A1

公开(公告)日：2017-11-02

申请号：US15594165

申请日：2017-05-12

申请人： St. Jude Medical, Atrial Fibrillation Division, Inc.

发明人： Xiaoping Guo ,  Richard E. Stehr

IPC分类号： A61L29/04

CPC分类号： A61L29/049 ,  A61M25/00 ,  A61M25/0021 ,  A61M2025/0048 ,  A61M2025/006 ,  A61M2025/0062 ,  C08L83/04

摘要： The invention comprises self-lubricating polymer compositions that are especially useful in medical devices and valves and gaskets of medical devices. In a preferred embodiment, the polymer compositions comprise a thermosetting or thermoplastic silicone elastomer in combination with a lubricity enhancing polyfluoropolyether fluid or hydrocarbon-based synthetic oil. In other preferred embodiments, the polymer compositions contain only biocompatible components. The improved anti-friction properties of the self-lubricating polymers can be demonstrated over a course of insertion and withdrawal cycles, where conventional polymers have changing and mostly increasing force required for each insertion and withdrawal, while the polymer compositions of the invention remain stable.

公开(公告)号：US20130338663A1

公开(公告)日：2013-12-19

申请号：US13902422

申请日：2013-05-24

申请人： St. Jude Medical, Atrial Fibrillation Division, Inc.

发明人： Hong Cao ,  Xiaoping Guo ,  Yitzhak I. Shai ,  Michael Yang ,  Kedar Ravindra Belhe ,  Saurav Paul ,  Riki Chou Thao

IPC分类号： A61B18/14

CPC分类号： A61B18/1492 ,  A61B2018/00005 ,  A61B2018/00357

摘要： An ablation catheter is provided for ablating internal tissue of a patient. The catheter includes a distal end that is adapted to be inserted into a body cavity relative to a desired location therein (e.g., within the heart). An ablation electrode is connected relative to the distal end of the catheter for providing ablation energy to patient tissue. A heat sink is provided that is in thermal contact with the ablation electrode. The heat sink, in addition to being in thermal contact with the ablation electrode, is electrically isolated from the ablation electrode. This allows the heat sink to conduct heat away from the ablation electrode without dissipating electrical energy from the electrode. In this regard, the heat sink may prevent build-up of excess heat within the electrode that may result in blood coagulation and/or tissue charring.

公开(公告)号：US20180207322A1

公开(公告)日：2018-07-26

申请号：US15903965

申请日：2018-02-23

申请人： St. Jude Medical, Atrial Fibrillation Division, Inc.

发明人： Xiaoping Guo ,  Richard E. Stehr

IPC分类号： A61L29/04 ,  A61M25/00

CPC分类号： A61L29/049 ,  A61M25/00 ,  A61M25/0021 ,  A61M2025/0048 ,  A61M2025/006 ,  A61M2025/0062 ,  C08L83/04

摘要： The invention comprises self-lubricating polymer compositions that are especially useful in medical devices and valves and gaskets of medical devices. In a preferred embodiment, the polymer compositions comprise a thermosetting or thermoplastic silicone elastomer in combination with a lubricity enhancing polyfluoropolyether fluid or hydrocarbon-based synthetic oil. In other preferred embodiments, the polymer compositions contain only biocompatible components. The improved anti-friction properties of the self-lubricating polymers can be demonstrated over a course of insertion and withdrawal cycles, where conventional polymers have changing and mostly increasing force required for each insertion and withdrawal, while the polymer compositions of the invention remain stable.

公开(公告)号：US09987463B2

公开(公告)日：2018-06-05

申请号：US15140750

申请日：2016-04-28

申请人： St. Jude Medical, Atrial Fibrillation Division, Inc.

发明人： Xiaoping Guo ,  Richard E. Stehr

IPC分类号： A61M25/00 ,  B29C61/00 ,  B29D23/00 ,  A61M25/01 ,  B29C47/02 ,  B29C63/00 ,  B29L31/00 ,  B29K27/18 ,  B29K105/16

CPC分类号： A61M25/005 ,  A61M25/0009 ,  A61M25/0012 ,  A61M25/0043 ,  A61M25/0045 ,  A61M25/0108 ,  A61M2025/0059 ,  A61M2205/32 ,  B29C47/021 ,  B29C61/006 ,  B29C63/0069 ,  B29D23/001 ,  B29K2027/18 ,  B29K2105/16 ,  B29L2031/7542

摘要： A method of manufacturing a catheter shaft includes the steps of forming an inner layer of a first polymeric material, forming a plait matrix layer including a second polymeric material about the inner layer, and forming an outer layer of a third polymeric material about the plait matrix layer. The plait matrix layer includes a braided wire mesh partially or fully embedded within the second polymeric material, which is different from at least one of the first polymeric material forming the inner layer and the third polymeric material forming the outer layer. The second polymeric material has a higher yield strain and/or a lower hardness than at least the first polymeric material, and preferably both the first and the third polymeric materials. The first polymeric material and the third polymeric material may be different or the same. The catheter shaft may be formed by stepwise extrusion, co-extrusion, and/or reflow processes.

公开(公告)号：US09931440B2

公开(公告)日：2018-04-03

申请号：US15594165

申请日：2017-05-12

申请人： St. Jude Medical, Atrial Fibrillation Division, Inc.

发明人： Xiaoping Guo ,  Richard E. Stehr

IPC分类号： A61K8/72 ,  A61L29/04 ,  A61M25/00

CPC分类号： A61L29/049 ,  A61M25/00 ,  A61M25/0021 ,  A61M2025/0048 ,  A61M2025/006 ,  A61M2025/0062 ,  C08L83/04

摘要： The invention comprises self-lubricating polymer compositions that are especially useful in medical devices and valves and gaskets of medical devices. In a preferred embodiment, the polymer compositions comprise a thermosetting or thermoplastic silicone elastomer in combination with a lubricity enhancing polyfluoropolyether fluid or hydrocarbon-based synthetic oil. In other preferred embodiments, the polymer compositions contain only biocompatible components. The improved anti-friction properties of the self-lubricating polymers can be demonstrated over a course of insertion and withdrawal cycles, where conventional polymers have changing and mostly increasing force required for each insertion and withdrawal, while the polymer compositions of the invention remain stable.

公开(公告)号：US20170321054A1

公开(公告)日：2017-11-09

申请号：US15602979

申请日：2017-05-23

申请人： St. Jude Medical, Atrial Fibrillation Division, Inc.

发明人： Xiaoping Guo ,  David P. Johnson ,  Richard E. Stehr

IPC分类号： C08L69/00 ,  C08G69/40 ,  C08L77/10 ,  C08L77/02 ,  C08L33/10 ,  C08K5/353 ,  C08L77/06

CPC分类号： C08L69/00 ,  C08G69/40 ,  C08K5/353 ,  C08L33/10 ,  C08L77/02 ,  C08L77/06 ,  C08L77/10 ,  C08L2666/20

摘要： The invention relates to biocompatible polycarbonate/polyamide polymer compositions for use in medical and surgical devices. Additional additives, crosslinking agents, phosphites, and optionally a radiopaque filler or fillers can be used to produce the high performance compositions desired. The polymer compositions have improved melt processability along with balanced or enhanced physical and mechanical properties, especially when combined or over-extruded onto or covering other polymer layers, such as soft and/or flexible layers commonly used in medical device applications and catheter tips, for example. The ability to incorporate radiopaque compounds into these polymer compositions during melt processing offers improved methods for monitoring and visualizing medical devices when used inside the body and as well as improving the operating characteristics of the medical device components

公开(公告)号：US20160317782A1

公开(公告)日：2016-11-03

申请号：US15140750

申请日：2016-04-28

申请人： St. Jude Medical, Atrial Fibrillation Division, Inc.

发明人： Xiaoping Guo ,  Richard E. Stehr

IPC分类号： A61M25/00 ,  B29C63/00 ,  B29C47/02

CPC分类号： A61M25/005 ,  A61M25/0009 ,  A61M25/0012 ,  A61M25/0043 ,  A61M25/0045 ,  A61M25/0108 ,  A61M2025/0059 ,  A61M2205/32 ,  B29C47/021 ,  B29C61/006 ,  B29C63/0069 ,  B29D23/001 ,  B29K2027/18 ,  B29K2105/16 ,  B29L2031/7542

摘要： A method of manufacturing a catheter shaft includes the steps of forming an inner layer of a first polymeric material, forming a plait matrix layer including a second polymeric material about the inner layer, and forming an outer layer of a third polymeric material about the plait matrix layer. The plait matrix layer includes a braided wire mesh partially or fully embedded within the second polymeric material, which is different from at least one of the first polymeric material forming the inner layer and the third polymeric material forming the outer layer. The second polymeric material has a higher yield strain and/or a lower hardness than at least the first polymeric material, and preferably both the first and the third polymeric materials. The first polymeric material and the third polymeric material may be different or the same. The catheter shaft may be formed by stepwise extrusion, co-extrusion, and/or reflow processes.

公开(公告)号：US11511076B2

公开(公告)日：2022-11-29

申请号：US17183640

申请日：2021-02-24

申请人： St. Jude Medical, Atrial Fibrillation Division, Inc.

发明人： Xiaoping Guo ,  Richard E. Stehr

IPC分类号： A61M25/00 ,  B29C48/151 ,  B29C61/00 ,  B29D23/00 ,  A61M25/01 ,  B29C63/00 ,  B29L31/00 ,  B29K27/18 ,  B29K105/16

摘要： A method of manufacturing a catheter shaft includes the steps of forming an inner layer of a first polymeric material, forming a plait matrix layer including a second polymeric material about the inner layer, and forming an outer layer of a third polymeric material about the plait matrix layer. The plait matrix layer includes a braided wire mesh partially or fully embedded within the second polymeric material, which is different from at least one of the first polymeric material forming the inner layer and the third polymeric material forming the outer layer. The second polymeric material has a higher yield strain and/or a lower hardness than at least the first polymeric material, and preferably both the first and the third polymeric materials. The first polymeric material and the third polymeric material may be different or the same. The catheter shaft may be formed by stepwise extrusion, co-extrusion, and/or reflow processes.