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公开(公告)号：US10213948B2
公开(公告)日：2019-02-26
申请号：US15920133
申请日：2018-03-13
IPC分类号： A61K9/16 , A61K9/20 , B29C47/00 , B29C47/40 , B29C47/60 , B29C47/80 , B29K91/00 , B29K105/00
摘要： A co-rotating twin screw extruder for forming fragments is disclosed. The extruder comprises of an intake zone for receiving one or more excipient(s) suitable for oral dosage or one or more excipient(s) suitable for oral dosage along with one or more active pharmaceutical ingredient, a melt zone for softening at least one excipient to form a viscous mass or melt and a fragmenting zone for fragmenting and cooling the viscous mass into cooled fragments and an extruder outlet for recovering the cooled fragments from the extruder.
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公开(公告)号：US20180214835A1
公开(公告)日：2018-08-02
申请号：US15747021
申请日：2016-08-01
发明人： Radhika Ghike , Vijay Kulkarni , Indu Bhushan , Himadri Sen , Babu Padmanabhan , Vinay Rao
摘要： The present disclosure relates to a process for preparing granules from an input material or a powder material. The process comprises feeding the input material for granulation in the processor using one or more powder feeders, introducing steam as a granulation activating agent in the processor, granulating the input material in presence of the steam to form granules, and optionally collecting the granules from a discharge zone of the processor, wherein feed rate of the steam into the processor is determined based on feed rate of the input material into the processor. A co-rotating twin-screw processor for preparing granules is also discl
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公开(公告)号：US20210046439A1
公开(公告)日：2021-02-18
申请号：US17007641
申请日：2020-08-31
发明人： Radhika Ghike , Vijay Kulkarni , Indu Bhushan , Himadri Sen , Babu Padmanabhan , Vinay Rao
摘要： The present disclosure relates to a process for preparing granules from an input material or a powder material. The process comprises feeding the input material for granulation in the processor using one or more powder feeders, introducing steam as a granulation activating agent in the processor, granulating the input material in presence of the steam to form granules, and optionally collecting the granules from a discharge zone of the processor, wherein feed rate of the steam into the processor is determined based on feed rate of the input material into the processor. A co-rotating twin-screw processor for preparing granules is also disclosed.
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公开(公告)号：US09956709B2
公开(公告)日：2018-05-01
申请号：US14888916
申请日：2014-05-27
IPC分类号： B29C47/00 , B29C47/40 , B29C47/60 , B29C47/80 , A61K9/16 , A61K9/20 , B29K91/00 , B29K105/00
CPC分类号： B29C47/0011 , A61K9/1617 , A61K9/1694 , A61K9/2095 , B29C47/00 , B29C47/402 , B29C47/6075 , B29C47/805 , B29C47/807 , B29K2091/00 , B29K2105/0035
摘要： A co-rotating twin screw extruder for forming fragments is disclosed. The extruder comprises of an intake zone for receiving one or more excipient(s) suitable for oral dosage or one or more excipient(s) suitable for oral dosage along with one or more active pharmaceutical ingredient, a melt zone for softening at least one excipient to form a viscous mass or melt and a fragmenting zone for fragmenting and cooling the viscous mass into cooled fragments and an extruder outlet for recovering the cooled fragments from the extruder.
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公开(公告)号：US11576855B2
公开(公告)日：2023-02-14
申请号：US17445918
申请日：2021-08-25
发明人： Babu Padmanabhan , Rakshit Shetty , Vijay Kulkarni , Himadri Sen , Indu Bhushan
IPC分类号： A61K9/46 , A61K31/546 , A61K9/16 , A61K45/06 , A61K9/00 , A61K9/20 , A61K31/198 , A61K31/616
摘要： The present disclosure concerns effervescent compositions and methods of making and using the same. In some embodiments, the disclosed effervescent compositions are formed from an input blend comprising an acid and a base by granulating the input blend in a twin-screw processor. The granules formed from the input blend can be formed by an in situ granulating agent, which can be a portion of the acid that melts during granulation. In some embodiments, the effervescent compositions can be made using a twin-screw processor comprising an intake zone for receiving an input blend comprising an acid and a base; a granulation initiation zone for melting only a portion of the acid to serve as an in situ granulating agent; a granulation completion zone for granulating the input blend; and an outlet for discharging the granules.
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公开(公告)号：US10792634B2
公开(公告)日：2020-10-06
申请号：US15747021
申请日：2016-08-01
发明人： Radhika Ghike , Vijay Kulkarni , Indu Bhushan , Himadri Sen , Babu Padmanabhan , Vinay Rao
IPC分类号： B01J2/20 , B29C48/40 , B29C48/92 , B01J2/28 , B01J2/30 , A61K9/16 , A61J3/02 , B29B9/06 , B29C48/59 , B29C48/57 , B29C48/04
摘要： A process for preparing granules is disclosed. The process comprises the steps of feeding the input material for granulation in a processor using one or more powder feeders, introducing steam as a granulation activating agent in the processor, granulating the input material in presence of the steam to form granules, and collecting the granules from a discharge zone of the processor. A co-rotating twin-screw processor for preparing granules is also disclosed.
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公开(公告)号：US20170252295A1
公开(公告)日：2017-09-07
申请号：US15512515
申请日：2015-03-26
发明人： Babu Padmanabhan , Rakshit Shetty , Vijay Kulkarni , Himadri Sen , Indu Bhushan
IPC分类号： A61K9/46 , A61K9/00 , A61K31/616 , A61K31/546 , A61K31/198 , A61K9/16 , A61K9/20
CPC分类号： A61K9/0007 , A61K9/0053 , A61K9/1611 , A61K9/1617 , A61K9/1682 , A61K9/1694 , A61K9/2009 , A61K9/2013 , A61K31/198 , A61K31/546 , A61K31/616 , A61K45/06 , A61K2300/00
摘要： The present disclosure concerns effervescent compositions and methods of making and using the same. In some embodiments, the disclosed effervescent compositions are formed from an input blend comprising an acid and a base by granulating the input blend in a twin-screw processor. The granules formed from the input blend can be formed by an in situ granulating agent, which can be a portion of the acid that melts during granulation. In some embodiments, the effervescent compositions can be made using a twin-screw processor comprising an intake zone for receiving an input blend comprising an acid and a base; a granulation initiation zone for melting only a portion of the acid to serve as an in situ granulating agent; a granulation completion zone for granulating the input blend; and an outlet for discharging the granules.
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公开(公告)号：US20180200938A1
公开(公告)日：2018-07-19
申请号：US15920133
申请日：2018-03-13
IPC分类号： B29C47/00 , B29C47/60 , A61K9/16 , A61K9/20 , B29C47/80 , B29C47/40 , B29K91/00 , B29K105/00
CPC分类号： B29C47/0011 , A61K9/1617 , A61K9/1694 , A61K9/2095 , B29C47/00 , B29C47/402 , B29C47/6075 , B29C47/805 , B29C47/807 , B29K2091/00 , B29K2105/0035
摘要： A co-rotating twin screw extruder for forming fragments is disclosed. The extruder comprises of an intake zone for receiving one or more excipient(s) suitable for oral dosage or one or more excipient(s) suitable for oral dosage along with one or more active pharmaceutical ingredient, a melt zone for softening at least one excipient to form a viscous mass or melt and a fragmenting zone for fragmenting and cooling the viscous mass into cooled fragments and an extruder outlet for recovering the cooled fragments from the extruder.
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