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    Cochlear implants containing biological cells and uses thereof
    7.
    发明授权
    Cochlear implants containing biological cells and uses thereof 有权
    含有生物细胞的耳蜗植入物及其用途

    公开(公告)号：US09265933B2

    公开(公告)日：2016-02-23

    申请号：US11518099

    申请日：2006-09-08

    申请人： Albert Edge ,  Stefan Heller

    发明人： Albert Edge ,  Stefan Heller

    IPC分类号： A61N1/05 ,  A61L27/36 ,  A61L27/38 ,  A61L27/54 ,  A61N1/36 ,  A61N1/32

    CPC分类号： A61N1/0541 ,  A61L27/3633 ,  A61L27/3834 ,  A61L27/54 ,  A61L2300/414 ,  A61L2430/14 ,  A61N1/326 ,  A61N1/36036 ,  A61N1/36121

    摘要： The present invention features devices for treating hearing loss, methods of making the devices, and methods for treating hearing loss. The devices include cochlear implants with biological cells placed at least on one or more of the electrodes of the implant. The cochlear implants then bypass dead or damaged hair cells in the cochlea by directly stimulating the auditory nerve fibers leading to the perceptions of sound. The biological cells can extend processes from the implant to the brainstem, creating a bridge that transmits electric signals from the electrode to the brainstem more efficiently than traditional cochlear implants. Methods of making the implants include applying a composition containing biological cells to an electrode of a cochlear implant, and treatment methods include implanting a cochlear implant that carries biological cells on one or more electrodes into a human who has experienced profound hearing loss (e.g., sensorineural hearing loss).

    摘要翻译： 本发明涉及用于治疗听力损失的装置，制造装置的方法以及用于治疗听力损失的方法。 所述装置包括具有放置在所述植入物的至少一个或多个电极上的生物细胞的耳蜗植入物。 耳蜗植入物然后通过直接刺激听觉神经纤维导致声音的感觉来绕过耳蜗中的死亡或损伤的毛细胞。 生物细胞可以将植入物延伸到脑干，从而形成一个将传播电信号从电极传导到脑干的桥梁，比传统的人工耳蜗更有效。 制造植入物的方法包括将含有生物细胞的组合物施用到耳蜗植入物的电极，并且治疗方法包括植入将生物细胞携带在一个或多个电极上的人类耳蜗植入物，其经历了严重的听力损失（例如感觉神经 听力损失）。