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    Dosing Device for Generating a Gas Flow with an Active Substance Finely Dispersed in the Latter
    1.
    发明申请
    Dosing Device for Generating a Gas Flow with an Active Substance Finely Dispersed in the Latter 有权
    用于在后期细分散的活性物质产生气流的配量装置

    公开(公告)号：US20120111326A1

    公开(公告)日：2012-05-10

    申请号：US13141324

    申请日：2009-12-10

    申请人： Stefan Mayer ,  Yorick Kamlag

    发明人： Stefan Mayer ,  Yorick Kamlag

    IPC分类号： A61M15/00

    CPC分类号： A61M15/0065 ,  A61M15/0025 ,  A61M2202/064

    摘要： (1) Dosing device for generating a gas flow with an active substance finely dispersed in the latter. (2) The invention relates to a dosing device for generating a gas flow with an active substance (2) finely dispersed in the latter, as a result of an underpressure applied to a mouthpiece (6) of the dosing device, with a first gas flow channel (60, 61, 62, 63, 68), and with a dosing chamber (14) that can be fitted in the area of the first gas flow channel, and with a dosing chamber release mechanism which has a separating element (54, 76, 77) that can be moved between a closed position and an open position, wherein the first gas flow channel and/or a connection between the first gas flow channel and the dosing chamber is blocked when the separating element is in the closed position, and the first gas flow channel and/or the connection between the first gas flow channel and the dosing chamber is freed when the separating element is in the open position, and with a slide guide element (53, 55) on which the separating element (54, 76, 77) is movable between the closed position and the open position and can be driven by the underpressure applied to the mouthpiece, and wherein the separating element and/or the slide guide element is provided at least in the sliding contact area with a slide element (100a, 100b, 101) that influences the sliding friction properties. This design of the separating element and/or of the slide guide element ensures that the separating element is reliably triggered after a suction stream is generated, such that the function of the dosing device can be more precisely reproduced and is more reliable.

    摘要翻译： （1）用于产生气体流的配量装置，其中活性物质分散在后者中。 （2）本发明涉及一种用于产生气体流的配量装置，其中活性物质（2）由于施加到定量给料装置的接口（6）上的负压而被精细地分散在后者中，其中第一气体 流动通道（60,61,62,63,68）以及可配合在第一气体流动通道的区域中的计量室（14）以及具有分配元件（54）的计量室释放机构 ，76,77），其可以在关闭位置和打开位置之间移动，其中当所述分离元件处于关闭位置时，所述第一气体流动通道和/或所述第一气体流动通道与所述计量室之间的连接被阻挡 ，并且当分离元件处于打开位置时，第一气体流动通道和/或第一气体流动通道和计量室之间的连接被释放，并且与滑动引导元件（53,55）分离，分离元件 （54,76,77）可在关闭位置和操作件之间移动 n位置，并且可以通过施加到接口管的负压来驱动，并且其中分离元件和/或滑动引导元件至少在滑动接触区域中被设置成影响滑动件的滑动元件（100a，100b，101） 摩擦性能。 分离元件和/或滑动引导元件的这种设计确保了在产生抽吸流之后分离元件被可靠地触发，从而可以更准确地再现计量装置的功能并且更可靠。

    Dosing device for generating a gas flow with a finely dispersed active substance
    3.
    发明授权
    Dosing device for generating a gas flow with a finely dispersed active substance 有权
    用于产生具有精细分散的活性物质的气流的给药装置

    公开(公告)号：US08833365B2

    公开(公告)日：2014-09-16

    申请号：US13141324

    申请日：2009-12-10

    申请人： Stefan Mayer ,  Yorick Kamlag

    发明人： Stefan Mayer ,  Yorick Kamlag

    IPC分类号： A61M15/00

    CPC分类号： A61M15/0065 ,  A61M15/0025 ,  A61M2202/064

    摘要： A dosing device generating a gas flow with an active substance finely dispersed, with a first gas flow channel and with a dosing chamber that can be fitted in the area of the first gas flow channel, and a dosing chamber release mechanism with a separating element. The first gas flow channel and/or a connection between the first gas flow channel and the dosing chamber is blocked when the separating element is in a closed position. The first gas flow channel and/or the connection between the first gas flow channel and the dosing chamber is freed when the separating element is in an open position. A slide guide element can be driven by the under-pressure applied to the mouthpiece. The separating element and/or the slide guide element is provided with a slide element that influences the sliding friction properties.

    摘要翻译： 产生具有细分散的活性物质的气流的计量装置，具有第一气体流动通道和可装配在第一气体流动通道的区域中的计量室，以及具有分离元件的剂量室释放机构。 当分离元件处于关闭位置时，第一气体流动通道和/或第一气体流动通道和剂量室之间的连接被阻挡。 当分离元件处于打开位置时，第一气体流动通道和/或第一气体流动通道和剂量室之间的连接被释放。 滑动引导元件可以通过施加到接口管的压力来驱动。 分离元件和/或滑动导向元件设置有影响滑动摩擦特性的滑动元件。

    Metering Device for the Inhalation of a Pulverulent Substance
    4.
    发明申请
    Metering Device for the Inhalation of a Pulverulent Substance 审中-公开
    用于吸入有毒物质的计量装置

    公开(公告)号：US20140076313A1

    公开(公告)日：2014-03-20

    申请号：US14021915

    申请日：2013-09-09

    申请人： Alfred Von Schuckmann ,  Yorick Kamlag ,  Stefan Mayer ,  Dennis Sandell

    发明人： Alfred Von Schuckmann ,  Yorick Kamlag ,  Stefan Mayer ,  Dennis Sandell

    IPC分类号： A61M15/00

    CPC分类号： A61M15/0065 ,  A61M15/0006 ,  A61M15/0025 ,  A61M15/0086 ,  A61M15/0091 ,  A61M2202/062 ,  A61M2202/064 ,  A61M2206/16

    摘要： A metering device activated by a user induced airstream for an inhalation of a medicinal substance. The device includes: a closure cap; a piston; a mouthpiece; and an annular chamber disposed upstream of the mouthpiece. A storage chamber stores the substance which can be moved out of the storage chamber when the closure cap is removed. A metering rod for removing the medicinal substance out of the storage chamber into an emptying-standby position. In the emptying-standby position, the metering chamber is closed by the piston. The piston is displaceable by airstream into an emptying-release position. In the emptying-release position, a metering chamber is released and the substance removed by the suction airstream. The metering device includes an outer cylinder which accommodates an inner cylinder.

    摘要翻译： 由用户激活的用于吸入药物的气流的计量装置。 该装置包括：封闭盖; 活塞 喉舌 以及设置在所述接口管上游的环形室。 存储室存储当去除封闭盖时能够从存储室移出的物质。 一种计量棒，用于将药物从储存室中排出到排空待机位置。 在排空待机位置，计量室由活塞封闭。 活塞可以通过气流移动到排空释放位置。 在排空释放位置，释放计量室，并通过吸入气流去除物质。 计量装置包括容纳内筒的外筒。

    Metering device for the inhalation of a pulverulent substance
    5.
    发明授权
    Metering device for the inhalation of a pulverulent substance 有权
    用于吸入粉状物质的计量装置

    公开(公告)号：US08573204B2

    公开(公告)日：2013-11-05

    申请号：US12744366

    申请日：2008-10-29

    申请人： Alfred Von Schuckmann ,  Yorick Kamlag ,  Stefan Mayer ,  Dennis Sandell

    发明人： Alfred Von Schuckmann ,  Yorick Kamlag ,  Stefan Mayer ,  Dennis Sandell

    IPC分类号： A61M15/00

    CPC分类号： A61M15/0065 ,  A61M15/0006 ,  A61M15/0025 ,  A61M15/0086 ,  A61M15/0091 ,  A61M2202/062 ,  A61M2202/064 ,  A61M2206/16

    摘要： A dosing device can be activated by a vacuum air stream of a user for the inhalation of a powder substance, particularly medicine, which is arranged in a supply chamber and which can be brought out of the same into an open emptying-ready position by a dosing chamber of a dosing rod when the mouthpiece-closure cap is removed. In particular, in order to improve dispensing, the provision of two air paths, of which one serves to open and empty the dosing chamber, and/or the second air path penetrates directly into a ring chamber in order to mix with the air flow containing the substance.

    摘要翻译： 定量给药装置可以由使用者的真空空气流激活，用于吸入粉末物质，特别是药物，其被布置在供应室中，并且可以通过以下方式将其从其排出的排空位置排出： 拆卸接口盖盖时，计量杆的计量腔。 特别地，为了改善分配，提供两个空气路径，其中一个用于打开和清空计量室，和/或第二空气通道直接穿入环形室，以便与含有 物质。

    Metering Device for the Inhalation of a Pulverulent Substance
    6.
    发明申请
    Metering Device for the Inhalation of a Pulverulent Substance 有权
    用于吸入有毒物质的计量装置

    公开(公告)号：US20100300441A1

    公开(公告)日：2010-12-02

    申请号：US12744366

    申请日：2008-10-29

    申请人： Alfred Von Schuckmann ,  Yorick Kamlag ,  Stefan Mayer ,  Dennis Sandell

    发明人： Alfred Von Schuckmann ,  Yorick Kamlag ,  Stefan Mayer ,  Dennis Sandell

    IPC分类号： A61M15/00

    CPC分类号： A61M15/0065 ,  A61M15/0006 ,  A61M15/0025 ,  A61M15/0086 ,  A61M15/0091 ,  A61M2202/062 ,  A61M2202/064 ,  A61M2206/16

    摘要： A dosing device can be activated by a vacuum air stream of a user for the inhalation of a powder substance, particularly medicine, which is arranged in a supply chamber and which can be brought out of the same into an open emptying-ready position by a dosing chamber of a dosing rod when the mouthpiece-closure cap is removed. In particular, in order to improve dispensing, the provision of two air paths, of which one serves to open and empty the dosing chamber, and/or the second air path penetrates directly into a ring chamber in order to mix with the air flow containing the substance.

    摘要翻译： 定量给药装置可以由使用者的真空空气流激活，用于吸入粉末物质，特别是药物，其被布置在供应室中，并且可以通过以下方式将其从其排出的排空位置排出： 拆卸接口盖盖时，计量杆的计量腔。 特别地，为了改善分配，提供两个空气路径，其中一个用于打开和清空计量室，和/或第二空气通道直接穿入环形室，以便与含有 物质。

    Mucoactive agents for treating a pulmonary disease
    10.
    发明授权
    Mucoactive agents for treating a pulmonary disease 失效
    用于治疗肺部疾病的粘蛋白活性剂

    公开(公告)号：US07928089B2

    公开(公告)日：2011-04-19

    申请号：US10571184

    申请日：2004-09-15

    申请人： David Morton ,  David Ganderton ,  John Staniforth ,  Yorick Kamlag

    发明人： David Morton ,  David Ganderton ,  John Staniforth ,  Yorick Kamlag

    IPC分类号： A61K31/727 ,  C08B37/10

    CPC分类号： A61K31/198 ,  A61K9/0073 ,  A61K31/727

    摘要： The present invention relates to mucoactive agents, such as heparin which are useful in the treatment of diseases where excess mucus is present in the respiratory tract, such as cystic fibrosis and chronic obstructive pulmonary disease. In particular, the invention relates to pharmaceutical compositions for administration by pulmonary inhalation. It also relates to methods for producing particles suitable for pulmonary inhalation, such as spray drying or jet milling.

    摘要翻译： 本发明涉及可用于治疗呼吸道中存在过量粘液的疾病如囊性纤维化和慢性阻塞性肺疾病的粘膜活性剂，例如肝素。 特别地，本发明涉及用于通过肺部吸入给药的药物组合物。 它还涉及用于生产适合于肺部吸入的颗粒的方法，例如喷雾干燥或喷射研磨。