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    Amphoteric liposomes, a method of formulating an amphoteric liposome and a method of loading an amphoteric liposome
    1.
    发明授权
    Amphoteric liposomes, a method of formulating an amphoteric liposome and a method of loading an amphoteric liposome 有权
    两性脂质体，配制两性脂质体的方法和加载两性脂质体的方法

    公开(公告)号：US09283186B2

    公开(公告)日：2016-03-15

    申请号：US13350137

    申请日：2012-01-13

    申请人： Steffen Panzner ,  Silke Lutz ,  Evgenios Siepi ,  Claudia Müller

    发明人： Steffen Panzner ,  Silke Lutz ,  Evgenios Siepi ,  Claudia Müller

    IPC分类号： C07D265/30 ,  A61K9/127

    CPC分类号： A61K9/127 ,  A61K9/1272 ,  A61K31/713 ,  Y02P20/582

    摘要： An amphoteric liposome composed of a mixture of lipids, said mixture comprising a cationic amphiphile, an anionic amphiphile and optionally one or more neutral amphiphiles, at least one of said cationic and anionic amphiphiles being chargeable and the respective amounts of said cationic and anionic amphiphiles being selected such there is a stoichiometric excess of positively charged cationic amphiphile at a first lower pH, a stoichiometric excess of negatively charged anionic amphiphile at a second higher pH and said mixture has an isoelectric point intermediate said first and second pHs; characterised in that said positively charged cationic and negatively charged anionic amphiphiles are adapted to form a lipid salt with one another at said isoelectric point. Also disclosed are methods of predicting the fusogenicity of an amphoteric liposome at a given pH, formulating an amphoteric liposome and loading an amphoteric liposome with a cargo moiety.

    摘要翻译： 由脂质混合物组成的两性脂质体，所述混合物包含阳离子两亲物，阴离子两亲物和任选的一个或多个中性两亲物，所述阳离子和阴离子两亲物中的至少一个是可带电的，并且相应量的所述阳离子和阴离子两亲物为 选择这样，在第二较低pH下，在第一较低pH下具有化学计量过量的带正电荷的阳离子两亲物，在第二较高pH下具有化学计量过量的带负电荷的阴离子两亲物，并且所述混合物具有介于所述第一和第二pH之间的等电点; 其特征在于所述带正电荷的阳离子和带负电荷的阴离子两亲物适于在所述等电点处彼此形成脂质盐。 还公开了在给定pH下预测两性脂质体的融合性的方法，配制两性脂质体并加载具有货物部分的两性脂质体。

    Amphoteric Liposomes, A Method Of Formulating An Amphoteric Liposome And A Method Of Loading An Amphoteric Liposome
    3.
    发明申请
    Amphoteric Liposomes, A Method Of Formulating An Amphoteric Liposome And A Method Of Loading An Amphoteric Liposome 有权
    两性脂质体，制备两性脂质体的方法和加载两性脂质体的方法

    公开(公告)号：US20120135065A1

    公开(公告)日：2012-05-31

    申请号：US13350137

    申请日：2012-01-13

    申请人： Steffen Panzner ,  Silke Lutz ,  Evgenios Siepi ,  Claudia Müller

    发明人： Steffen Panzner ,  Silke Lutz ,  Evgenios Siepi ,  Claudia Müller

    IPC分类号： A61K9/127 ,  A61K47/44 ,  A61K31/7088 ,  C07J43/00

    CPC分类号： A61K9/127 ,  A61K9/1272 ,  A61K31/713 ,  Y02P20/582

    摘要： An amphoteric liposome composed of a mixture of lipids, said mixture comprising a cationic amphiphile, an anionic amphiphile and optionally one or more neutral amphiphiles, at least one of said cationic and anionic amphiphiles being chargeable and the respective amounts of said cationic and anionic amphiphiles being selected such there is a stoichiometric excess of positively charged cationic amphiphile at a first lower pH, a stoichiometric excess of negatively charged anionic amphiphile at a second higher pH and said mixture has an isoelectric point intermediate said first and second pHs; characterised in that said positively charged cationic and negatively charged anionic amphiphiles are adapted to form a lipid salt with one another at said isoelectric point. Also disclosed are methods of predicting the fusogenicity of an amphoteric liposome at a given pH, formulating an amphoteric liposome and loading an amphoteric liposome with a cargo moiety.

    摘要翻译： 由脂质混合物组成的两性脂质体，所述混合物包含阳离子两亲物，阴离子两亲物和任选的一个或多个中性两亲物，所述阳离子和阴离子两亲物中的至少一个是可带电的，并且相应量的所述阳离子和阴离子两亲物为 选择这样，在第二较低pH下，在第一较低pH下具有化学计量过量的带正电荷的阳离子两亲物，在第二较高pH下具有化学计量过量的带负电荷的阴离子两亲物，并且所述混合物具有介于所述第一和第二pH之间的等电点; 其特征在于所述带正电荷的阳离子和带负电荷的阴离子两亲物适于在所述等电点处彼此形成脂质盐。 还公开了在给定pH下预测两性脂质体的融合性的方法，配制两性脂质体并加载具有货物部分的两性脂质体。

    Medical radioactive iodine-125 miniature radiation sources and methods of producing same
    5.
    发明授权
    Medical radioactive iodine-125 miniature radiation sources and methods of producing same 失效
    医疗放射性碘-125微型辐射源及其生产方法

    公开(公告)号：US06485406B1

    公开(公告)日：2002-11-26

    申请号：US09425158

    申请日：1999-10-21

    申请人： Jürgen Ziegler ,  Claudia Müller ,  Gunnar Mann ,  André Hess

    发明人： Jürgen Ziegler ,  Claudia Müller ,  Gunnar Mann ,  André Hess

    IPC分类号： A61N500

    CPC分类号： A61N5/1027 ,  A61N2005/1024 ,  G21G4/08

    摘要： The present invention relates to new radioactive iodine-125 miniature radiation sources (seeds) comprising a radioactive carrier matrix which consists of a porous and mechanically stable inorganic material, the pores of which contain inorganic insoluble iodide-125, and which is enclosed within a capsule made of a corrosion-resistent and body-compatible material or which is coated with such a material. The iodine seeds according to the present invention further may contain (a) usual X-ray marker(s). Another object of the present invention are methods for manufacturing said novel iodine-125 seeds.

    摘要翻译： 本发明涉及新的放射性碘-125微型辐射源（种子），其包括放射性载体基质，其由多孔和机械稳定的无机材料组成，其孔隙含有无机不溶性碘化物-125，并且其包封在胶囊内 由耐腐蚀和体相容的材料制成或涂覆有这种材料。 根据本发明的碘种子还可以含有（a）通常的X射线标记物。 本发明的另一个目的是制备所述新型碘-125种子的方法。

    Multilayer film with lamination and heat-sealable sides, and having antifogging properties
    6.
    发明授权
    Multilayer film with lamination and heat-sealable sides, and having antifogging properties 失效

    公开(公告)号：US06576348B2

    公开(公告)日：2003-06-10

    申请号：US09826187

    申请日：2001-04-04

    申请人： Holger Eggers ,  Rudi Klein ,  Claudia Müller ,  Rainer Brandt

    发明人： Holger Eggers ,  Rudi Klein ,  Claudia Müller ,  Rainer Brandt

    IPC分类号： B32B2732

    CPC分类号： B32B27/32 ,  B32B27/18 ,  B32B27/30 ,  Y10T428/1341 ,  Y10T428/1383 ,  Y10T428/2817 ,  Y10T428/31913 ,  Y10T428/31928

    摘要： A multilayer film having a lamination side and a heat-sealable side is described. The multilayer film comprises, a) an inner layer (i) ethylene/vinyl alcohol copolymer; b) a coupling agent layer (ii) and a separate coupling agent layer (ii′), said inner layer (i) being interposed between and in contact with each of said coupling agent layer (ii) and said separate coupling agent layer (ii′); c) at least one further layer (iii), said separate coupling agent layer (ii′) being interposed between and in contact with each of said inner layer (i) and said layer (iii); d) at least one layer (iv), said coupling agent layer (ii) being interposed between and in contact with each of said inner layer (i) and said layer (iv); and e) a heat-sealable layer (v), said layer (iv) being interposed between and in contact with each of said coupling agent layer (ii) and said heat-sealable layer (v). Layers (i), (ii), (ii′), (iii) and (v) of the multilayer film contain 0.1 to 3 wt. % of a sorbitan monoester, based on the total weight of said multilayer film. Layer (iii) defines the lamination side of the multilayer film, and the heat-sealable layer (v) defines the heat-sealable side of the multilayer film. Packaging materials comprising the multilayer film are also described.