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1.发明授权公开(公告)号：US11969459B2
公开(公告)日：2024-04-30
申请号：US16477878
申请日：2018-01-26
Applicant: StemRIM Inc. , OSAKA UNIVERSITY
Inventor： Katsuto Tamai , Yoshiki Sawa , Shigeru Miyagawa , Takashi Kido , Takasumi Goto , Takehiko Yamazaki
Abstract: The present inventors have found that HMGB1 fragment peptides having a particular amino acid sequence exhibit the effects of improvement of cardiac function, inhibition of cardiomyocyte hypertrophy, inhibition of myocardial fibrosis, and promotion of angiogenesis in an animal model of dilated cardiomyopathy, that the particular HMGB1 fragment peptides also exhibit the effects of improvement of cardiac function, inhibition of cardiomegaly, inhibition of cardiomyocyte hypertrophy, inhibition of myocardial fibrosis, and promotion of angiogenesis in an animal model of ischemic cardiomyopathy caused by old myocardial infarction, and that the particular HMGB1 fragment peptides exhibit the effects of inhibition of cardiomyocyte hypertrophy and inhibition of myocardial fibrosis in an animal model of hypertensive cardiomyopathy. Based on these findings, pharmaceutical compositions are provided for the prevention and/or treatment of cardiomyopathy and old myocardial infarction and chronic heart failure resulting therefrom, which comprise an HMGB1 fragment peptide having a particular amino acid sequence.
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公开(公告)号：US11298403B2
公开(公告)日：2022-04-12
申请号：US16768654
申请日：2018-11-30
Applicant: StemRIM Inc. , OSAKA UNIVERSITY
Inventor： Katsuto Tamai , Takashi Shimbo , Takehiko Yamazaki
Abstract: The present inventors discovered that an HMGB1 fragment peptide having a specific amino acid sequence exhibits an effect of suppressing weight loss and an effect of suppressing shortening of the large intestine and mucosal damage in an animal model of inflammatory bowel diseases. Based on these findings, pharmaceutical compositions for the prevention and/or treatment of inflammatory bowel diseases, which comprise the HMGB1 fragment peptide having the specific amino acid sequence are provided.
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公开(公告)号：US10550165B2
公开(公告)日：2020-02-04
申请号：US15691017
申请日：2017-08-30
Applicant: STEMRIM INC. , OSAKA UNIVERSITY
Inventor： Katsuto Tamai , Takehiko Yamazaki , Tsutomu Kanezaki , Shigeru Sakurai , Yukiko Noguchi , Mayumi Endo , Natsumi Hamabuchi , Kana Naito
Abstract: (Objective) An objective of the present invention is to provide therapeutic agents that, in association with stimulation of PDGFRα-positive cells such as bone marrow mesenchymal stem cells, promote their mobilization into blood and accumulation in a damaged tissue, and induce tissue regeneration in a living body.(Means for solution) Multiple peptides were synthesized, and the migration-promoting activity of each peptide was evaluated. As a result, the present inventors successfully identified multiple peptides that have migration-promoting activity on a PDGFRα-positive bone marrow mesenchymal stem cell line (MSC-1). Further, the present inventors confirmed that the identified peptides also have migration-promoting activity on skin fibroblasts, which are PDGFRα-positive cells.
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4.发明授权公开(公告)号：US11826401B2
公开(公告)日：2023-11-28
申请号：US16477878
申请日：2018-01-26
Applicant: StemRIM Inc. , OSAKA UNIVERSITY
Inventor： Katsuto Tamai , Yoshiki Sawa , Shigeru Miyagawa , Takashi Kido , Takasumi Goto , Takehiko Yamazaki
Abstract: The present inventors have found that HMGB1 fragment peptides having a particular amino acid sequence exhibit the effects of improvement of cardiac function, inhibition of cardiomyocyte hypertrophy, inhibition of myocardial fibrosis, and promotion of angiogenesis in an animal model of dilated cardiomyopathy, that the particular HMGB1 fragment peptides also exhibit the effects of improvement of cardiac function, inhibition of cardiomegaly, inhibition of cardiomyocyte hypertrophy, inhibition of myocardial fibrosis, and promotion of angiogenesis in an animal model of ischemic cardiomyopathy caused by old myocardial infarction, and that the particular HMGB1 fragment peptides exhibit the effects of inhibition of cardiomyocyte hypertrophy and inhibition of myocardial fibrosis in an animal model of hypertensive cardiomyopathy. Based on these findings, pharmaceutical compositions are provided for the prevention and/or treatment of cardiomyopathy and old myocardial infarction and chronic heart failure resulting therefrom, which comprise an HMGB1 fragment peptide having a particular amino acid sequence.
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Patent Agency Ranking
公开(公告)号：US11197895B2
公开(公告)日：2021-12-14
申请号：US15674835
申请日：2017-08-11
Applicant: STEMRIM INC. , OSAKA UNIVERSITY
Inventor： Katsuto Tamai , Takehiko Yamazaki , Takenao Chino , Yasufumi Kaneda
IPC: A61K35/28 , C12N5/0775 , A61K35/12
Abstract: Biologically low invasive vessels are filled with biological factors that have the activity of mobilizing specific functional cells in the body. The vessels are indwelled in the body. After specific functional cells are mobilized into the vessels, the vessels are removed from the body to collect functional cell populations mobilized to the vessels. Alternatively, the cells are directly collected from the vessels indwelled in the body.
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公开(公告)号：US09623078B2
公开(公告)日：2017-04-18
申请号：US14436906
申请日：2013-10-24
Applicant: GENOMIX CO., LTD , OSAKA UNIVERSITY
Inventor： Katsuto Tamai , Sokichi Kamata , Yasufumi Kaneda , Shigeru Miyagawa , Yoshiki Sawa , Takehiko Yamazaki
CPC classification number: A61K38/1709 , C07K14/4718
Abstract: A fragment peptide having a proper length composed of a part of an HMGB1 protein was synthesized and the peptide was confirmed to exhibit therapeutic effects on myocardial infarction.
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公开(公告)号：US20150273017A1
公开(公告)日：2015-10-01
申请号：US14436906
申请日：2013-10-24
Applicant: GENOMIX CO., LTD. , OSAKA UNIVERSITY
Inventor： Katsuto Tamai , Sokichi Kamata , Yasufumi Kaneda , Shigeru Miyagawa , Yoshiki Sawa , Takehiko Yamazaki
IPC: A61K38/17
CPC classification number: A61K38/1709 , C07K14/4718
Abstract: A fragment peptide having a proper length composed of a part of an HMGB1 protein was synthesized and the peptide was confirmed to exhibit therapeutic effects on myocardial infarction.
Abstract translation: 合成具有由HMGB1蛋白的一部分组成的适当长度的片段肽，并确认该肽对心肌梗死具有治疗效果。
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公开(公告)号：US20150274792A1
公开(公告)日：2015-10-01
申请号：US14436920
申请日：2013-10-24
Applicant: GENOMIX CO., LTD. , OSAKA UNIVERSITY
Inventor： Katsuto Tamai , Takehiko Yamazaki , Wenhao Cui
IPC: C07K14/47
Abstract: Fragment peptides having a proper length, which consists of a portion of the HMGB1 protein were synthesized, and the peptides were confirmed to show therapeutic effects on injury of the spinal cord.
Abstract translation: 合成具有适当长度的片段肽，其由HMGB1蛋白的一部分组成，并确认该肽显示对脊髓损伤的治疗效果。
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公开(公告)号：US09688733B2
公开(公告)日：2017-06-27
申请号：US14436920
申请日：2013-10-24
Applicant: GENOMIX CO., LTD , OSAKA UNIVERSITY
Inventor： Katsuto Tamai , Takehiko Yamazaki , Wenhao Cui
Abstract: Fragment peptides having a proper length, which consists of a portion of the HMGB1 protein were synthesized, and the peptides were confirmed to show therapeutic effects on injury of the spinal cord.
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