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    Method of diagnosing a clinical subtype of crohn's disease with features of ulcerative colitis
    1.
    发明授权
    Method of diagnosing a clinical subtype of crohn's disease with features of ulcerative colitis 失效
    诊断具有溃疡性结肠炎特征的克罗恩病的临床亚型的方法

    公开(公告)号：US5916748A

    公开(公告)日：1999-06-29

    申请号：US689873

    申请日：1996-08-15

    申请人： Stephan R. Targan ,  Eric A. Vasiliauskas ,  Scott E. Plevy ,  Huiying Yang ,  Jerome I. Rotter

    发明人： Stephan R. Targan ,  Eric A. Vasiliauskas ,  Scott E. Plevy ,  Huiying Yang ,  Jerome I. Rotter

    IPC分类号： C12Q1/68 ,  G01N33/569 ,  G01N33/68 ,  G01N33/564

    CPC分类号： G01N33/6893 ,  C12Q1/6883 ,  G01N33/56972 ,  C12Q2600/112 ,  C12Q2600/156 ,  G01N2800/065

    摘要： The present invention provides a method of diagnosing a clinical subtype of Crohn's disease (CD) by determining whether perinuclear anti-neutrophil antibodies (pANCA) are present in a patient with CD, where the presence of pANCA indicates the clinical subtype of CD with features of ulcerative colitis (UC). The invention also provides a method of diagnosing a clinical subtype of CD by detecting an Arg.sup.241 allele at an ICAM-1 locus in a patient with CD, where the Arg.sup.241 allele indicates a clinical subtype of CD with features of ulcerative colitis. In addition, the invention provides a method of diagnosing a pANCA-positive subtype of CD by detecting an Arg.sup.241 allele at an ICAM-1 locus in a patient with CD, where the Arg.sup.241 allele indicates the pANCA-positive subtype of CD.

    摘要翻译： 本发明提供了一种诊断克罗恩氏病（CD）的临床亚型的方法，该方法是通过确定是否存在CD患者中的核周抗中性粒细胞抗体（pANCA），其中pANCA的存在表示CD的临床亚型， 溃疡性结肠炎（UC）。 本发明还提供了通过检测患有CD的患者的ICAM-1位点处的Arg241等位基因来诊断CD的临床亚型的方法，其中Arg241等位基因表示具有溃疡性结肠炎特征的CD的临床亚型。 另外，本发明提供了通过检测患有CD的患者中ICAM-1位点处的Arg241等位基因来诊断CD的pANCA阳性亚型的方法，其中Arg241等位基因指示CD的pANCA阳性亚型。

    METHODS OF ASSESSING CROHN'S DISEASE PATIENT PHENOTYPE BY I2 SEROLOGIC RESPONSE
    2.
    发明申请
    METHODS OF ASSESSING CROHN'S DISEASE PATIENT PHENOTYPE BY I2 SEROLOGIC RESPONSE 有权
    通过I2感染反应评估冠心病患者的方法

    公开(公告)号：US20100240077A1

    公开(公告)日：2010-09-23

    申请号：US12645394

    申请日：2009-12-22

    申请人： Stephan R. Targan ,  Eric A. Vasiliauskas ,  William S. Mow ,  Huiying Yang ,  Phillip R. Fleshner ,  Jerome I. Rotter

    发明人： Stephan R. Targan ,  Eric A. Vasiliauskas ,  William S. Mow ,  Huiying Yang ,  Phillip R. Fleshner ,  Jerome I. Rotter

    IPC分类号： G01N33/53

    CPC分类号： G01N33/686 ,  C12Q1/6883 ,  C12Q2600/156 ,  G01N33/6893 ,  G01N2469/20 ,  G01N2800/065

    摘要： The invention provides a method of diagnosing or predicting susceptibility to a clinical subtype of Crohn's disease in a subject having Crohn's disease by determining the presence or absence of IgA anti-I2 antibodies in the subject, where the presence of the IgA anti-I2 antibodies indicates that the subject has a clinical subtype of Crohn's disease. In one embodiment, a method of the invention is practiced by further determining the presence or absence in the subject of a NOD2 variant, anti-Saccharomyces cerevisiae antibodies (ASCA), IgA anti-OmpC antibodies, or perinuclear anti-neutrophil cytoplasmic antibodies (pANCA). The methods of the invention can be used to diagnose or predict susceptibility to a clinical subtype of Crohn's disease, for example, a fibrostenotic subtype, a subtype characterized by the need for small bowel surgery, or a subtype characterized by the absence of features of ulcerative colitis.

    摘要翻译： 本发明提供一种诊断或预测克罗恩病临床亚型易感性的方法，其通过测定受试者中IgA抗-I2抗体的存在或不存在，其中IgA抗-I2抗体的存在表明 该受试者具有克罗恩病的临床亚型。 在一个实施方案中，通过进一步确定受试者中NOD2变体，抗酿酒酵母抗体（ASCA），IgA抗OmpC抗体或核周抗中性粒细胞胞质抗体（pANCA）的存在或不存在来实施本发明的方法 ）。 本发明的方法可以用于诊断或预测对克罗恩病的临床亚型的易感性，例如纤维狭窄亚型，特征在于需要小肠手术的亚型或特征在于不存在溃疡特征的亚型 结肠炎。

    Methods of screening for Crohn's disease using TNF microsatellite alleles
    3.
    发明授权
    Methods of screening for Crohn's disease using TNF microsatellite alleles 有权
    使用TNF微卫星等位基因筛选克罗恩病的方法

    公开(公告)号：US06534263B1

    公开(公告)日：2003-03-18

    申请号：US09419406

    申请日：1999-10-15

    申请人： Scott E. Plevy ,  Jerome I. Rotter ,  Stephan R. Targan ,  Hiroo Toyoda ,  Huiying Yang

    发明人： Scott E. Plevy ,  Jerome I. Rotter ,  Stephan R. Targan ,  Hiroo Toyoda ,  Huiying Yang

    IPC分类号： C12Q1568

    CPC分类号： C12Q1/6858 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/172

    摘要： A novel association between certain tumor necrosis factor microsatellite alleles and Crohn's disease has been discovered. In accordance with the present invention, there is provided methods for screening for Crohn's disease comprising detecting the presence or absence of nucleic acid of a subject encoding TNF microsatellite alleles associated with Crohn's disease, wherein the presence of nucleic acid encoding three or more of the alleles is indicative of Crohn's disease. Kits useful for screening for Crohn's disease are also provided which comprise nucleic acid encoding TNF microsatellite alleles associated with Crohn's disease.

    摘要翻译： 已经发现了某些肿瘤坏死因子微卫星等位基因与克罗恩病之间的关联。 根据本发明，提供了用于筛选克罗恩病的方法，包括检测编码与克罗恩病相关的TNF微卫星等位基因的受试者的核酸的存在或不存在，其中编码三个或更多个等位基因的核酸的存在 表明克罗恩病。 还提供了用于筛选克罗恩病的试剂盒，其包含编码与克罗恩病相关的TNF微卫星等位基因的核酸。

    Methods of assessing Crohn's disease patient phenotype by I2 serologic response
    4.
    发明授权
    Methods of assessing Crohn's disease patient phenotype by I2 serologic response 有权
    通过I2血清学反应评估克罗恩病患者表型的方法

    公开(公告)号：US07662569B2

    公开(公告)日：2010-02-16

    申请号：US10413501

    申请日：2003-04-11

    申请人： Stephan R. Targan ,  Eric A. Vasiliauskas ,  William S. Mow ,  Huiying Yang ,  Phillip R. Fleshner ,  Jerome I. Rotter

    发明人： Stephan R. Targan ,  Eric A. Vasiliauskas ,  William S. Mow ,  Huiying Yang ,  Phillip R. Fleshner ,  Jerome I. Rotter

    IPC分类号： G01N33/53 ,  G01N33/542 ,  G01N33/00

    CPC分类号： G01N33/686 ,  C12Q1/6883 ,  C12Q2600/156 ,  G01N33/6893 ,  G01N2469/20 ,  G01N2800/065

    摘要： The invention provides a method of diagnosing or predicting susceptibility to a clinical subtype of Crohn's disease in a subject having Crohn's disease by determining the presence or absence of IgA anti-I2 antibodies in the subject, where the presence of the IgA anti-I2 antibodies indicates that the subject has a clinical subtype of Crohn's disease. In one embodiment, a method of the invention is practiced by further determining the presence or absence in the subject of a NOD2 variant, anti-Saccharomyces cerevisiae antibodies (ASCA), IgA anti-OmpC antibodies, or perinuclear anti-neutrophil cytoplasmic antibodies (pANCA). The methods of the invention can be used to diagnose or predict susceptibility to a clinical subtype of Crohn's disease, for example, a fibrostenotic subtype, a subtype characterized by the need for small bowel surgery, or a subtype characterized by the absence of features of ulcerative colitis.

    摘要翻译： 本发明提供一种诊断或预测克罗恩病临床亚型易感性的方法，其通过测定受试者中IgA抗-I2抗体的存在或不存在，其中IgA抗-I2抗体的存在表明 该受试者具有克罗恩病的临床亚型。 在一个实施方案中，通过进一步确定受试者中NOD2变体，抗酿酒酵母抗体（ASCA），IgA抗OmpC抗体或核周抗中性粒细胞胞质抗体（pANCA）的存在或不存在来实施本发明的方法 ）。 本发明的方法可以用于诊断或预测对克罗恩病的临床亚型的易感性，例如纤维狭窄亚型，特征在于需要小肠手术的亚型或特征在于不存在溃疡特征的亚型 结肠炎。

    METHODS OF ASSESSING CROHN'S DISEASE PATIENT PHENOTYPE BY I2, OMPC AND ASCA SEROLOGIC RESPONSE
    5.
    发明申请
    METHODS OF ASSESSING CROHN'S DISEASE PATIENT PHENOTYPE BY I2, OMPC AND ASCA SEROLOGIC RESPONSE 审中-公开
    通过I2，OMPC和ASCA行为反应来评估冠心病患者的方法

    公开(公告)号：US20120208212A1

    公开(公告)日：2012-08-16

    申请号：US13312960

    申请日：2011-12-06

    申请人： Stephan R. Targan ,  Eric A. Vasiliauskas ,  William S. Mow ,  Huiying Yang ,  Phillip R. Fleshner ,  Jerome I. Rotter

    发明人： Stephan R. Targan ,  Eric A. Vasiliauskas ,  William S. Mow ,  Huiying Yang ,  Phillip R. Fleshner ,  Jerome I. Rotter

    IPC分类号： G01N33/566

    CPC分类号： G01N33/686 ,  C12Q1/6883 ,  C12Q2600/156 ,  G01N33/6893 ,  G01N2469/20 ,  G01N2800/065

    摘要： The invention provides a method of diagnosing or predicting susceptibility to a clinical subtype of Crohn's disease in a subject having Crohn's disease by determining the presence or absence of IgA anti-I2 antibodies in the subject, where the presence of the IgA anti-I2 antibodies indicates that the subject has a clinical subtype of Crohn's disease. In one embodiment, a method of the invention is practiced by further determining the presence or absence in the subject of a NOD2 variant, anti-Saccharomyces cerevisiae antibodies (ASCA), IgA anti-OmpC antibodies, or perinuclear anti-neutrophil cytoplasmic antibodies (pANCA). The methods of the invention can be used to diagnose or predict susceptibility to a clinical subtype of Crohn's disease, for example, a fibrostenotic subtype, a subtype characterized by the need for small bowel surgery, or a subtype characterized by the absence of features of ulcerative colitis.

    摘要翻译： 本发明提供一种诊断或预测克罗恩病临床亚型易感性的方法，其通过测定受试者中IgA抗-I2抗体的存在或不存在，其中IgA抗-I2抗体的存在表明 该受试者具有克罗恩病的临床亚型。 在一个实施方案中，通过进一步确定受试者中NOD2变体，抗酿酒酵母抗体（ASCA），IgA抗OmpC抗体或核周抗中性粒细胞胞质抗体（pANCA）的存在或不存在来实施本发明的方法 ）。 本发明的方法可以用于诊断或预测对克罗恩病的临床亚型的易感性，例如纤维狭窄亚型，特征在于需要小肠手术的亚型或特征在于不存在溃疡特征的亚型 结肠炎。

    Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease
    8.
    发明授权
    Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease 有权
    NOD2的突变与克罗恩病患者的纤维化疾病有关

    公开(公告)号：US07790370B2

    公开(公告)日：2010-09-07

    申请号：US10526256

    申请日：2003-07-30

    申请人： Maria T. Abreu ,  Kent D. Taylor ,  Jerome I. Rotter ,  Huiying Yang ,  Stephan R. Targan

    发明人： Maria T. Abreu ,  Kent D. Taylor ,  Jerome I. Rotter ,  Huiying Yang ,  Stephan R. Targan

    IPC分类号： C07H21/04 ,  C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/156 ,  C12Q2600/172

    摘要： The present invention provides a method of diagnosing or predicting susceptibility to a clinical subtype of Crohn's disease characterized by fibrostenosing disease by determining the presence or absence in an individual of a fibrostenosis-predisposing allele linked to a NOD2/CARD15 locus, where the presence of the fibrostenosis-predisposing allele is diagnostic of or predictive of susceptibility to the clinical subtype of Crohn's disease characterized by fibrostenosing disease. In a method of the invention, the clinical subtype of Crohn's disease can be, for example, characterized by fibrostenosing disease independent of small bowel involvement. The invention also provides a method of optimizing therapy in an individual by determining the presence or absence in the individual of a fibrostenosis-predisposing allele linked to a NOD2/CARD15 locus, diagnosing individuals in which the fibrostenosis-predisposing allele is present as having a fibrostenosing subtype of Crohn's disease, and treating the individual having a fibrostenosing subtype of Crohn's disease based on the diagnosis.

    摘要翻译： 本发明提供一种诊断或预测以特征在于纤维化疾病的克罗恩病的临床亚型的易感性的方法，其通过确定个体中存在或不存在与NOD2 / CARD15基因座连锁的纤维化狭窄等位基因，其中存在 纤维狭窄 - 易感性等位基因是以特征为纤维化疾病的克罗恩病的临床亚型的易感性的诊断或预测。 在本发明的方法中，克罗恩病的临床亚型可以是例如独立于小肠受累的纤维化疾病的特征。 本发明还提供了一种通过确定个体中存在或不存在与NOD2 / CARD15基因座连锁的纤维化狭窄等位基因来诊断个体的方法，其中存在纤维狭窄 - 倾向性等位基因的个体具有纤维化 克罗恩病的亚型，并基于诊断治疗患有克罗恩病的纤维化亚型的个体。