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1.发明申请Genetic polymorphisms sensitively predicting adverse drug reactions (adr) and drug efficacy 审中-公开遗传多态性敏感地预测不良药物反应（adr）和药物功效公开(公告)号：US20060240421A1
公开(公告)日：2006-10-26
申请号：US10524302
申请日：2003-07-28
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C07K14/705
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The invention provides diagnostic methods and kits including oligo and/or polynucleotides or derivatives, including as well antibodies determining whether a human subject is at risk of getting adverse drug reaction after statin therapy or whether the human subject is a high or low responder or a good a or bad metabolizer of statins. The invention provides further diagnostic methods and kits including antibodies determining whether a human subject is at risk for a cardiovascular disease. Still further the invention provides polymorphic sequences and other genes. The present invention further relates to isolated polynucleotides encoding a phenotype associated (PA) gene polypeptide useful in methods to identify therapeutic agents and useful for preparation of a medicament to treat cardiovascular disease or influence drug response, the polynucleotide is selected from the group comprising: SEQ ID 1-21 with allelic variation as indicated in the sequences section contained in a functional surrounding like full length cDNA for PA gene polypeptide and with or without the PA gene promoter sequence.
摘要翻译： 本发明提供了包括寡核苷酸和/或多核苷酸或衍生物的诊断方法和试剂盒，包括确定人类受试者在他汀类药物治疗后是否有获得不良药物反应风险的抗体，还是人类受试者是高反应者还是低反应者 他汀类药物或代谢物。 本发明提供了进一步的诊断方法和试剂盒，包括确定人受试者是否处于心血管疾病风险的抗体。 本发明还提供了多态序列和其他基因。 本发明还涉及编码可用于鉴定治疗剂并用于制备治疗心血管疾病或影响药物应答的药物的方法中的表型相关（PA）基因多肽的分离的多核苷酸，所述多核苷酸选自SEQ ID NO： ID 1-21具有等位基因变异，如包含在功能性周围的序列部分中所示，如PA基因多肽的全长cDNA并具有或不具有PA基因启动子序列。
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2.发明申请Genetic polymorphisms as predictive diagnostics for adverse drug reactions (adr) and drug efficacy 审中-公开遗传多态性作为药物不良反应（adr）和药物功效的预测诊断公开(公告)号：US20060204962A1
公开(公告)日：2006-09-14
申请号：US10544049
申请日：2004-01-31
申请人： Udo Stropp , Stephan Schwers , Harald Kallabis , Gerd Schmitz
发明人： Udo Stropp , Stephan Schwers , Harald Kallabis , Gerd Schmitz
CPC分类号： C07K14/4702 , A61K38/00 , C07K14/7156 , C07K14/8132 , C12Q1/6876 , C12Q2600/156
摘要： The invention provides diagnostic methods and kits including oligo and/or polynucleotides or derivatives, including as well antibodies determining whether a human subject is at risk of getting adverse drug reaction after statin therapy or whether the human subject is a high or low responder or a good a or bad metabolizer of statins. The invention provides further diagnostic methods and kits including antibodies determining whether a human subject is at risk for a cardiovascular disease. Still further the invention provides polymorphic sequences and other genes.
摘要翻译： 本发明提供了包括寡核苷酸和/或多核苷酸或衍生物的诊断方法和试剂盒，包括确定人类受试者在他汀类药物治疗后是否有获得不良药物反应风险的抗体，还是人类受试者是高反应者还是低反应者 他汀类药物或代谢物。 本发明提供了进一步的诊断方法和试剂盒，包括确定人受试者是否处于心血管疾病风险的抗体。 本发明还提供了多态序列和其他基因。
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公开(公告)号：US20090208945A1
公开(公告)日：2009-08-20
申请号：US12097961
申请日：2006-12-19
申请人： Stephan Schwers , Udo Stropp , Harald Kallabis , Andreas Schuppert , Rolf Burghaus , Christian Von Torne , Gerd Schmitz
发明人： Stephan Schwers , Udo Stropp , Harald Kallabis , Andreas Schuppert , Rolf Burghaus , Christian Von Torne , Gerd Schmitz
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/42 , C12Q1/50 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172 , G01N33/92
摘要： The invention provides diagnostic methods and kits including oligo and/or polynucleotides or derivatives, including as well antibodies determining whether a human subject is at risk of getting adverse drug reaction after statin therapy. Still further the invention provides polymorphic sequences and other genes. The present invention further relates to isolated polynucleotides encoding a SADR gene polypeptide useful in methods to identify therapeutic agents and useful for preparation of a medicament to treat statin induced adverse drug reactions (SADR), the polynucleotide is selected from the group comprising: SEQ ID 1-35 with allelic variation as indicated in the sequences section contained in a functional surrounding like full length cDNA for SADR gene polypeptide and with or without the SADR gene promoter sequence.
摘要翻译： 本发明提供了包括寡核苷酸和/或多核苷酸或衍生物的诊断方法和试剂盒，包括确定人类受试者在他汀类药物治疗后是否存在药物反应不利的风险的抗体。 本发明还提供了多态序列和其他基因。 本发明还涉及编码SADR基因多肽的分离的多核苷酸，其用于鉴定治疗剂并可用于制备治疗他汀类药物诱导的不良药物反应（SADR）的药物的方法中，所述多核苷酸选自SEQ ID No.1 -35具有等位基因变异，如包含在功能性周围的序列部分中所示，如SADR基因多肽的全长cDNA并具有或不具有SADR基因启动子序列。
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4.发明申请Genetic Polymorphisms As Predictive Diagnostics For Adverse Drug Reactions (ADR) And Drug Efficacy 审中-公开遗传多态性作为不良药物反应（ADR）和药物功效的预测诊断公开(公告)号：US20090208967A1
公开(公告)日：2009-08-20
申请号：US12424803
申请日：2009-04-16
申请人： Udo Stropp , Stephan Schwers , Harald Kallabis , Gerd Schmitz
发明人： Udo Stropp , Stephan Schwers , Harald Kallabis , Gerd Schmitz
IPC分类号： C12Q1/68
CPC分类号： C07K14/4702 , A61K38/00 , C07K14/7156 , C07K14/8132 , C12Q1/6876 , C12Q2600/156
摘要： The invention provides diagnostic methods and kits including oligo and/or polynucleotides or derivatives, including as well antibodies determining whether a human subject is at risk of getting adverse drug reaction after statin therapy or whether the human subject is a high or low responder or a good a or bad metabolizer of statins. The invention provides further diagnostic methods and kits including antibodies determining whether a human subject is at risk for a cardiovascular disease. Still further the invention provides polymorphic sequences and other genes.
摘要翻译： 本发明提供了包括寡核苷酸和/或多核苷酸或衍生物的诊断方法和试剂盒，包括确定人类受试者在他汀类药物治疗后是否有获得不良药物反应风险的抗体，还是人类受试者是高反应者还是低反应者 他汀类药物或代谢物。 本发明提供了进一步的诊断方法和试剂盒，包括确定人受试者是否处于心血管疾病风险的抗体。 本发明还提供了多态序列和其他基因。
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公开(公告)号：US07915985B2
公开(公告)日：2011-03-29
申请号：US12271562
申请日：2008-11-14
申请人： Gerd Schmitz , Volker Lang , Wolfgang Kremers , Lothar Winzen
发明人： Gerd Schmitz , Volker Lang , Wolfgang Kremers , Lothar Winzen
摘要： A switching device for direct-current applications includes a housing having a first wall and a second wall, a plurality of receiving areas for respective mutually substantially parallel current paths disposed in the housing. Each of the current paths has a respective stationary switching contact element and a respective movable switching contact element, the movable switching element being actuatable into a closed position and into an open position so as to form a respective air break, the respective movable switching contact elements being actuatable simultaneously. The switching device includes a plurality of arc-quenching devices associated with the current paths and disposed next to each other, and at least one magnet. The at least one magnet is configured to generate a magnetic field so as to generate a deflection force on the arcs so as to deflect the respective arcs toward at least one of the respective arc-quenching devices.
摘要翻译： 用于直流应用的开关装置包括具有第一壁和第二壁的壳体，用于设置在壳体中的各个相互基本平行的电流路径的多个接收区域。 每个电流路径具有相应的固定开关接触元件和相应的可移动开关触点元件，可移动开关元件可致动到关闭位置并进入打开位置以形成相应的空气断路，各个可移动开关触点元件 可同时启动。 切换装置包括与电流路径相关联并彼此相邻布置的多个灭弧装置和至少一个磁体。 所述至少一个磁体被配置为产生磁场，以便在所述电弧上产生偏转力，以便使各个弧朝着相应的灭弧装置中的至少一个偏转。
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公开(公告)号：US5959001A
公开(公告)日：1999-09-28
申请号：US859961
申请日：1997-05-21
申请人： Klaus Walz , Gerd Schmitz , Michael Kressner , Udo Herrmann , Josef Leitermann
发明人： Klaus Walz , Gerd Schmitz , Michael Kressner , Udo Herrmann , Josef Leitermann
CPC分类号： C09B67/006 , C08K3/04 , C08K5/0041
摘要： Pigment preparations comprising at leasta) 5 to 80% by weight, based on the preparation, of pigment,b) a paste-making agent which is liquid at 20.degree. C. under normal pressure,c) an amine and/or salt thereof with an average molecular weight, determined as the number-average, of M.sub.n .ltoreq.500 g/mol andd) a homo- and/or copolymer of ethylenically unsaturated monomers or comonomers having an average molecular weight, determined as the number-average, of M.sub.n =10,000-100,000,are suitable for pigmenting organic macromolecular material, in particular polyurethane foams.
摘要翻译： 颜料制剂包含至少a）5-80重量％，基于制备的颜料，b）在常压下在20℃下液体的糊剂，c）其胺和/或其盐 平均分子量确定为+ E，ovs M + EE n = 500g / mol，d）具有平均分子量的烯属不饱和单体或共聚单体的均聚物和/或共聚物 确定为+ E，ovs M + EE n = 10,000-100,000的数均值，适用于着色有机高分子材料，特别是聚氨酯泡沫。
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7.发明授权Process for the preparation of polysuccinimide, polyaspartic acid and their salts 失效聚琥珀酰亚胺，聚天冬氨酸及其盐的制备方法
公开(公告)号：US5468838A
公开(公告)日：1995-11-21
申请号：US209716
申请日：1994-03-14
申请人： Gunther Boehmke , Gerd Schmitz
发明人： Gunther Boehmke , Gerd Schmitz
CPC分类号： B01F17/005 , C08G73/1092 , C11D3/3719
摘要： Polysuccinimide, polyaspartic acid and their salts are prepared by reaction of maleic anhydride and ammonia, polycondensation of the resulting product in the presence of a solubilizing agent and, if appropriate, hydrolysis.
摘要翻译： 聚琥珀酰亚胺，聚天冬氨酸及其盐通过马来酸酐和氨的反应制备，所得产物在增溶剂存在下进行缩聚，如果合适的话，水解。
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公开(公告)号：US06671157B1
公开(公告)日：2003-12-30
申请号：US10048047
申请日：2002-01-24
申请人： Wolfgang Meid , Wilhelm Melchert , Gerd Schmitz
发明人： Wolfgang Meid , Wilhelm Melchert , Gerd Schmitz
IPC分类号： H01H4700
CPC分类号： H01H9/563
摘要： The invention relates to a method for effecting an electronic drive control of a drive coil of a protection system using an electronic device which comprises a microcontroller. The aim of the invention is to increase the serviceable life of a protection system. To this end, the invention uses a randomly selected and constantly changing delay time (tx) that occurs after a time (t2, t3) at which the supply voltage is established on the electronic device.
摘要翻译： 本发明涉及一种利用包括微控制器的电子装置对保护系统的驱动线圈进行电子驱动控制的方法。 本发明的目的是提高保护系统的使用寿命。 为此，本发明使用在电子设备上建立电源电压的时间（t2，t3）之后发生的随机选择且不断变化的延迟时间（tx）。
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公开(公告)号：US4415010A
公开(公告)日：1983-11-15
申请号：US313175
申请日：1981-10-20
申请人： Gerd Schmitz
发明人： Gerd Schmitz
摘要： The projectile weaving machine is provided with a retractor apparatus at the braking device in which an elastically yielding and damping body is disposed to absorb impact forces and damp vibrations. The elastically yielding and damping body is located between the stop surface of the retractor and a fulcrum between the retractor and a lever for moving the retractor within the apparatus. In some embodiments, the body is positioned between two parts of the retractor while in other embodiments, the body may be disposed between the retractor and the moving means or may be incorporated in the retractor itself.
摘要翻译： 抛丸编织机在制动装置处设有牵开器装置，其中设置弹性屈服和阻尼体以吸收冲击力并减轻振动。 弹性收缩和阻尼体位于牵开器的止动表面和牵开器与杠杆之间的支点之间，用于使牵开器在装置内移动。 在一些实施例中，主体定位在牵开器的两个部分之间，而在其他实施例中，主体可以设置在牵开器和移动装置之间，或者可以并入到牵开器本身中。
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公开(公告)号：US20090127230A1
公开(公告)日：2009-05-21
申请号：US12271672
申请日：2008-11-14
申请人： Gerd Schmitz , Volker Lang , Wolfgang Kremers , Lothar Winzen
发明人： Gerd Schmitz , Volker Lang , Wolfgang Kremers , Lothar Winzen
IPC分类号： H01H9/42
CPC分类号： H01H9/40 , H01H33/596
摘要： A switching device for direct-current applications including a housing, and at least three current paths. Each current path includes a respective movable switching contact element, a respective stationary switching contact element, and a respective air break between the respective movable and stationary contact elements. Each movable switching contact element is movable into a closed position and into an open position. The switching device includes a quenching capacitor connected in parallel to the respective at least one air break of a first of the current paths and configured to at least one of prevent the formation of an arc and quench an arc formed therealong. The quenching capacitor is not coupled to a second of the current paths. The second current path is couplable in series to the first current path.
摘要翻译： 一种用于直流应用的开关装置，包括壳体和至少三个电流路径。 每个电流路径包括相应的可移动开关触点元件，相应的固定开关触点元件以及相应的可移动和固定触点元件之间的相应空气断路。 每个可移动开关触点元件可移动到关闭位置并进入打开位置。 开关装置包括与第一电流路径的相应的至少一个空气断路并联连接的淬火电容器，并且被配置为防止形成电弧并骤冷其形成的电弧中的至少一个。 淬灭电容器不耦合到第二电流路径。 第二电流路径与第一电流路径串联耦合。
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