公开(公告)号：US07617048B2

公开(公告)日：2009-11-10

申请号：US10533778

申请日：2003-05-02

申请人： Stephan Simon ,  Brad Ignaczak ,  Robert Lyons

发明人： Stephan Simon ,  Brad Ignaczak ,  Robert Lyons

IPC分类号： B60Q11/00

CPC分类号： G08G1/161 ,  B60R21/0134 ,  G01S13/726 ,  G01S13/931 ,  G01S2013/9342 ,  G01S2013/9346 ,  G01S2013/9353 ,  G01S2013/9357 ,  G08G1/166

摘要： A method for determining an accident risk of a first object with at least one second object is proposed, a collision probability and a hazard probability of the at least one second object being determined in a predefined region around the first object, the collision probability and the hazard probability being determined as a function of motions and object classes of the first and the at least one second object. The accident risk is then determined as a function of the collision probability and the hazard probability.

摘要翻译： 提出了一种用于确定具有至少一个第二对象的第一对象的事故风险的方法，所述至少一个第二对象的碰撞概率和危险概率在所述第一对象周围的预定区域中确定，所述冲突概率和 危险概率被确定为第一和第二对象的运动和对象类别的函数。 然后将事故风险确定为碰撞概率和危险概率的函数。

公开(公告)号：US20060041381A1

公开(公告)日：2006-02-23

申请号：US10533778

申请日：2003-05-02

申请人： Stephan Simon ,  Brad Ignaczak ,  Robert Lyons

发明人： Stephan Simon ,  Brad Ignaczak ,  Robert Lyons

IPC分类号： G08G1/16

CPC分类号： G08G1/161 ,  B60R21/0134 ,  G01S13/726 ,  G01S13/931 ,  G01S2013/9342 ,  G01S2013/9346 ,  G01S2013/9353 ,  G01S2013/9357 ,  G08G1/166

摘要： A method for determining an accident risk of a first object with at least one second object is proposed, a collision probability and a hazard probability of the at least one second object being determined in a predefined region around the first object, the collision probability and the hazard probability being determined as a function of motions and object classes of the first and the at least one second object. The accident risk is then determined as a function of the collision probability and the hazard probability.

摘要翻译： 提出了一种用于确定具有至少一个第二对象的第一对象的事故风险的方法，所述至少一个第二对象的碰撞概率和危险概率在所述第一对象周围的预定区域中确定，所述冲突概率和 危险概率被确定为第一和第二对象的运动和对象类别的函数。 然后将事故风险确定为碰撞概率和危险概率的函数。

公开(公告)号：US20070227255A1

公开(公告)日：2007-10-04

申请号：US11698296

申请日：2007-01-25

申请人： Neil Goldfine ,  Vladimir Zilberstein ,  David Grundy ,  Andrew Washabaugh ,  Darrell Schlicker ,  Ian Shay ,  Robert Lyons ,  Christopher Craven ,  Christopher Root ,  Mark Windoloski ,  Volker Weiss

发明人： Neil Goldfine ,  Vladimir Zilberstein ,  David Grundy ,  Andrew Washabaugh ,  Darrell Schlicker ,  Ian Shay ,  Robert Lyons ,  Christopher Craven ,  Christopher Root ,  Mark Windoloski ,  Volker Weiss

IPC分类号： G01L1/12

CPC分类号： G01N27/902 ,  G01N27/023 ,  G01N27/24 ,  G01N27/904 ,  G01N27/9046 ,  G01N27/9053

摘要： Observability of damage precursor, damage and usage states, or event occurrence may be enhanced by modifying component materials to include self-monitoring materials or by processing test material to alter the surface properties. The properties of the self monitoring materials, such as magnetic permeability or electrical conductivity, are monitored with electromagnetic sensors and provide greater property variations with component condition than the original component material. Processing includes shot peening or laser welding.

公开(公告)号：US20070077436A1

公开(公告)日：2007-04-05

申请号：US11634285

申请日：2006-12-04

申请人： Basil Naji ,  John Cottier ,  Robert Lyons

发明人： Basil Naji ,  John Cottier ,  Robert Lyons

IPC分类号： B32B9/04

CPC分类号： B28B1/522 ,  B28B7/46 ,  C04B18/08 ,  C04B28/02 ,  C04B2111/00482 ,  C04B2111/00612 ,  E04C2/06 ,  E04F13/02 ,  E04F15/12 ,  Y02W30/92 ,  Y10S106/01 ,  Y10T428/249932 ,  Y10T428/249968 ,  Y10T428/249972 ,  Y10T428/249986 ,  Y10T428/25 ,  Y10T428/265 ,  Y10T428/31504 ,  Y10T428/31667 ,  Y10T442/10 ,  C04B20/008

摘要： The Abstract of the Disclosure filed herewith has replaced the previous Abstract of the Disclosure that begins with the words, “A composite product comprising a substrate layer” with the following paragraph: An exemplary composite product and method of manufacturing is provided. In one embodiment, the method includes dewatering a first slurry through a dewatering belt to form a first substrate layer, applying a first functional layer onto at least a portion of the first substrate layer, and dewatering a second slurry through the dewatering belt to form a second substrate layer. A first side of the second substrate layer may be overlayed onto the first functional layer, and the layers may be cured, and the layers bonded.

摘要翻译： 本文提交的披露摘要已经取代了以下开始于“包含基底层的复合产品”的以前的摘要摘要：提供了一种示例性的复合产品和制造方法。 在一个实施方案中，所述方法包括通过脱水带将第一浆料脱水以形成第一基材层，将第一功能层施加到第一基材层的至少一部分上，以及通过脱水带将第二浆料脱水形成 第二基板层。 第二衬底层的第一侧可以覆盖在第一功能层上，并且可以使层固化，并且层粘合。

公开(公告)号：US20060141049A1

公开(公告)日：2006-06-29

申请号：US11354415

申请日：2006-02-14

申请人： Robert Lyons ,  James Chang ,  John Trogden ,  Scott Whitcup

发明人： Robert Lyons ,  James Chang ,  John Trogden ,  Scott Whitcup

IPC分类号： A61K31/728 ,  A61K31/695 ,  A61K9/14

CPC分类号： A61K9/0048 ,  A61K31/56 ,  A61K31/573 ,  A61K47/36

摘要： Triamcinolone compositions, and methods of using such compositions, useful for injection into the vitreous of human eyes are provided. Such compositions can include triamcinolone particles present in a therapeutically effective amount, a viscosity inducing component, and an aqueous carrier component. The compositions have viscosities of at least about 10 cps or about 100 cps at a shear rate of 0.1/second. In a preferred embodiment, the viscosity is in the range of from about 80,000 cps to about 300,000 cps. The compositions advantageously suspend the triamcinolone particles for prolonged periods of time.

摘要翻译： 提供曲安奈德组合物，以及使用这些组合物的方法，其用于注射到人眼的玻璃体中。 这样的组合物可以包括以治疗有效量存在的曲安奈德颗粒，粘度诱导组分和水性载体组分。 组合物在0.1 /秒的剪切速率下具有至少约10cps或约100cps的粘度。 在优选的实施方案中，粘度在约80,000cps至约300,000cps的范围内。 组合物有利地将曲安奈德颗粒悬浮较长时间。

公开(公告)号：US20050250737A1

公开(公告)日：2005-11-10

申请号：US11091977

申请日：2005-03-28

申请人： Patrick Hughes ,  Laurent Delahaye ,  Michele Boix ,  James Chang ,  Robert Lyons

发明人： Patrick Hughes ,  Laurent Delahaye ,  Michele Boix ,  James Chang ,  Robert Lyons

IPC分类号： A61K9/00 ,  A61K31/573 ,  A61K31/724 ,  A61K47/36

CPC分类号： A61K9/0048 ,  A61K31/573 ,  A61K47/36 ,  A61K47/40

摘要： Pharmaceutical compositions suitable for administration into the interior of an eye of a person or animal are described. The present compositions include one or more components which are effective in providing a reduced toxicity relative to existing intraocular ophthalmic compositions. The present compositions include one or more therapeutic agents in amounts effective in providing a desired therapeutic effect when placed in an eye, and one or more retinal friendly excipients that have a reduced toxicity relative to benzyl alcohol or polysorbate 80. In certain compositions, the excipient component of the compositions comprises one or more cyclodextrins or cyclodextrin derivatives. Methods of using the compositions to treat ocular conditions are also described.

摘要翻译： 描述适于施用于人或动物的眼睛内部的药物组合物。 本发明组合物包括一种或多种有效提供相对于现有眼内眼用组合物的毒性降低的成分。 本发明的组合物包含一种或多种治疗剂，其用量在置于眼中时可提供所需的治疗效果，以及一种或多种视黄醛友好的赋形剂，其相对于苯甲醇或聚山梨酸酯80具有降低的毒性。在某些组合物中，赋形剂 组合物的组分包含一种或多种环糊精或环糊精衍生物。 还描述了使用组合物治疗眼睛病症的方法。

公开(公告)号：US20050004074A1

公开(公告)日：2005-01-06

申请号：US10613097

申请日：2003-07-01

申请人： Robert Lyons ,  James Chang

发明人： Robert Lyons ,  James Chang

IPC分类号： A61K9/00 ,  A61K31/557 ,  A61K31/724

CPC分类号： A61K9/0048 ,  A61K31/557 ,  A61K31/724

摘要： This invention relates to a method of reducing an irritating or adverse side effect associated with the topical use of an active ophthalmic drug comprising incorporating an effective amount of a cyclodextrin or cyclodextrin derivative into a formulation to complex the active drug such that the concentration of the free active drug is reduced below a tolerable threshold, and incorporating an effective amount of a viscosity increasing agent in said formulation such that the bioavailability of said drug is high enough to be therapeutically effective, wherein the cyclodextrin or cyclodextrin derivative is not required to solubilize the active drug. Another aspect of this invention relates to topical ophthalmic formulations comprising an active drug, a cyclodextrin or cyclodextrin derivative, and a viscosity-enhancing agent, in effective amounts as stated above.

公开(公告)号：US08928316B2

公开(公告)日：2015-01-06

申请号：US13297933

申请日：2011-11-16

申请人： Neil J. Goldfine ,  Andrew P. Washabaugh ,  Robert Lyons ,  Zachary Thomas ,  David A. Jablonski ,  Christopher Martin

发明人： Neil J. Goldfine ,  Andrew P. Washabaugh ,  Robert Lyons ,  Zachary Thomas ,  David A. Jablonski ,  Christopher Martin

IPC分类号： G01R33/12 ,  G01N27/82 ,  G01R33/10 ,  G01R33/00

CPC分类号： G01N27/90 ,  G01N27/72 ,  G01N27/9046 ,  G01R33/0064 ,  G01R33/0094 ,  G01R33/093 ,  G01R33/10

摘要： Methods and apparatus for characterizing composite materials for manufacturing quality assurance (QA), periodic inspection during the useful life, or for forensic analysis/material testing. System are provided that relate eddy-current sensor responses to the fiber layup of a composite structure, the presence of impact damage on a composite structure with or without a metal liner, volumetric stress within the composite, fiber tow density, and other NDE inspection requirements. Also provided are systems that determine electromagnetic material properties and material dimensions of composite materials from capacitive sensor inspection measurements. These properties are related to the presence of buried defects in non-conductive composite materials, moisture ingress, aging of the material due to service or environmental/thermal exposure, or changes in manufacturing quality.

摘要翻译： 表征用于制造质量保证（QA）的复合材料，使用寿命期间的定期检查或法医分析/材料测试的方法和装置。 提供了将涡电流传感器响应与复合结构的纤维叠层相关联的系统，在具有或不具有金属衬垫的复合结构上的冲击损伤的存在，复合材料内的体积应力，纤维丝束密度和其他NDE检查要求 。 还提供了从电容传感器检查测量确定复合材料的电磁材料性质和材料尺寸的系统。 这些性质与非导电复合材料中存在的掩埋缺陷有关，水分进入，由于使用或环境/热暴露引起的材料老化或制造质量的变化。

公开(公告)号：US08153245B2

公开(公告)日：2012-04-10

申请号：US12691505

申请日：2010-01-21

申请人： Basil Naji ,  John Sydney Cottier ,  Robert Lyons

发明人： Basil Naji ,  John Sydney Cottier ,  Robert Lyons

IPC分类号： B32B9/00 ,  C04B37/00

CPC分类号： B28B1/522 ,  B28B7/46 ,  C04B18/08 ,  C04B28/02 ,  C04B2111/00482 ,  C04B2111/00612 ,  E04C2/06 ,  E04F13/02 ,  E04F15/12 ,  Y02W30/92 ,  Y10S106/01 ,  Y10T428/249932 ,  Y10T428/249968 ,  Y10T428/249972 ,  Y10T428/249986 ,  Y10T428/25 ,  Y10T428/265 ,  Y10T428/31504 ,  Y10T428/31667 ,  Y10T442/10 ,  C04B20/008

摘要： An exemplary composite product and method of manufacturing is provided. In one embodiment, the method includes dewatering a first slurry through a dewatering belt to form a first substrate layer, applying a first functional layer onto at least a portion of the first substrate layer, and dewatering a second slurry through the dewatering belt to form a second substrate layer. A first side of the second substrate layer may be overlayed onto the first functional layer, and the layers may be cured, and the layers bonded.

摘要翻译： 提供了一种示例性的复合产品和制造方法。 在一个实施方案中，所述方法包括通过脱水带将第一浆料脱水以形成第一基材层，将第一功能层施加到第一基材层的至少一部分上，以及通过脱水带将第二浆料脱水形成 第二基板层。 第二衬底层的第一侧可以覆盖在第一功能层上，并且可以使层固化，并且层粘合。

公开(公告)号：US20080044476A1

公开(公告)日：2008-02-21

申请号：US11828561

申请日：2007-07-26

申请人： Robert Lyons ,  Michael Robinson ,  John Trogden ,  Scott Whitcup

发明人： Robert Lyons ,  Michael Robinson ,  John Trogden ,  Scott Whitcup

IPC分类号： A61K9/14 ,  A61K31/56 ,  A61K31/715 ,  A61P29/00 ,  A61P19/02 ,  A61K9/00

CPC分类号： A61K9/0019 ,  A61K9/0048 ,  A61K31/56 ,  A61K31/573 ,  A61K31/58 ,  A61K31/715 ,  A61K47/02 ,  A61K47/34 ,  A61K47/36 ,  A61K47/40

摘要： Viscous formulations and methods of using such compositions, useful for intramuscular and intra-articular injection are provided to treat peripheral conditions. Such compositions can include triamcinolone particles present in a therapeutically effective amount, a viscosity inducing component, and an aqueous carrier component. The compositions have viscosities of at least about 10 cps or about 100 cps at a shear rate of 0.1/second. In a preferred embodiment, the viscosity is in the range of from about 80,000 cps to about 300,000 cps. In a most preferred embodiment, the viscosity is in the range of from about 140,000 cps to about 280,000 cps at a shear rate of 0.1/second at 25° C. The compositions advantageously suspend the triamcinolone particles for prolonged periods of time.

摘要翻译： 提供使用这种组合物的粘性制剂和方法，其可用于肌肉内和关节内注射以治疗外周病症。 这样的组合物可以包括以治疗有效量存在的曲安奈德颗粒，粘度诱导组分和水性载体组分。 组合物在0.1 /秒的剪切速率下具有至少约10cps或约100cps的粘度。 在优选的实施方案中，粘度在约80,000cps至约300,000cps的范围内。 在最优选的实施方案中，粘度在25℃下以0.1 /秒的剪切速率在约140,000cps至约280,000cps的范围内。组合物有利地将曲安奈德颗粒悬浮较长时间。