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1.发明申请Administration of agents mimicking dopachrome tautomerase (TRP-2) activity for protecting hair follicle melanocytes 有权给予模仿多巴肼互变异构酶（TRP-2）活性以保护毛囊黑素细胞的药剂公开(公告)号：US20050186233A1
公开(公告)日：2005-08-25
申请号：US11009153
申请日：2004-12-13
申请人： Stephane Commo , Olivier Gaillard , Bruno Bernard
发明人： Stephane Commo , Olivier Gaillard , Bruno Bernard
摘要： Agents mimicking DOPAchrome tautomerase activity are administered, notably topically applied, to protect and/or regenerate the melanocytes of hair follicles, to promote the cyclic renewal of the follicular pigmentation unit, to prevent and/or limit and/or arrest the development of canities, and to maintain the natural pigmentation of gray or white head hair and/or body hair.
摘要翻译： 施用模仿DOPAchrome互变异构酶活性的试剂，特别是局部应用，以保护和/或再生毛囊的黑素细胞，促进滤泡色素沉着单位的循环更新，以预防和/或限制和/或阻止囊泡的发育， 并保持灰色或白色头发和/或身体毛发的天然色素沉着。
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2.发明授权Administration of agents mimicking DOPAchrome tautomerase (TRP-2) activity for protecting hair follicle melanocytes 有权给予模仿DOPAchrome互变异构酶（TRP-2）活性以保护毛囊黑素细胞的药剂公开(公告)号：US07585514B2
公开(公告)日：2009-09-08
申请号：US11009153
申请日：2004-12-13
申请人： Stephane Commo , Olivier Gaillard , Bruno Bernard
发明人： Stephane Commo , Olivier Gaillard , Bruno Bernard
IPC分类号： A61K8/02
摘要： Agents mimicking DOPAchrome tautomerase activity are administered, notably topically applied, to protect and/or regenerate the melanocytes of hair follicles, to promote the cyclic renewal of the follicular pigmentation unit, to prevent and/or limit and/or arrest the development of canities, and to maintain the natural pigmentation of gray or white head hair and/or body hair.
摘要翻译： 施用模仿DOPAchrome互变异构酶活性的试剂，特别是局部应用，以保护和/或再生毛囊的黑素细胞，促进滤泡色素沉着单位的循环更新，以预防和/或限制和/或阻止囊泡的发育， 并保持灰色或白色头发和/或身体毛发的天然色素沉着。
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3.发明申请Administration of agents inducing DOPAchrome tautomerase (TRP-2) expression for protecting hair follicle melanocytes 审中-公开诱导诱导DOPAchrome互变异构酶（TRP-2）表达以保护毛囊黑素细胞的药剂的给药公开(公告)号：US20050208086A1
公开(公告)日：2005-09-22
申请号：US11009364
申请日：2004-12-13
申请人： Stephane Commo , Bruno Bernard
发明人： Stephane Commo , Bruno Bernard
IPC分类号： A61K8/34 , A61K8/42 , A61K8/63 , A61K8/64 , A61K31/7048 , A61Q5/00 , A61Q5/06 , A61Q5/10 , A61Q7/00 , A61K7/135
CPC分类号： A61Q5/065 , A61K8/34 , A61K8/42 , A61K8/63 , A61K8/64 , A61K31/7048 , A61K2800/70 , A61Q5/00 , A61Q5/10 , A61Q7/00
摘要： Agents inducing the expression of DOPAchrome tautomerase are administered, notably topically applied, to protect and/or regenerate the melanocytes of hair follicles, to promote the cyclic renewal of the follicular pigmentation unit, to prevent and/or limit and/or arrest the development of canities, and to maintain the natural pigmentation of gray or white head hair and/or body hair.
摘要翻译： 诱导诱导DOPAchrome互变异构酶表达的药剂，特别是局部施用，以保护和/或再生毛囊的黑素细胞，促进滤泡色素沉着单位的循环更新，以预防和/或限制和/或阻止 并保持灰色或白色头发和/或身体毛发的天然色素沉着。
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4.发明申请ADMINISTRATION OF AGENTS MIMICKING DOPACHROME TAUTOMERASE (TRP-2) ACTIVITY FOR PROTECTING HAIR FOLLICLE MELANOCYTES 有权用于保护头发微生物蛋白的药剂的治疗药物DOPACHROME TAUTOMERASE（TRP-2）活性公开(公告)号：US20100074929A1
公开(公告)日：2010-03-25
申请号：US12541398
申请日：2009-08-14
申请人： Stephane Commo , Olivier Gaillard , Bruno Bernard
发明人： Stephane Commo , Olivier Gaillard , Bruno Bernard
摘要： Agents mimicking DOPAchrome tautomerase activity are administered, notably topically applied, to protect and/or regenerate the melanocytes of hair follicles, to promote the cyclic renewal of the follicular pigmentation unit, to prevent and/or limit and/or arrest the development of canities, and to maintain the natural pigmentation of gray or white head hair and/or body hair.
摘要翻译： 施用模仿DOPAchrome互变异构酶活性的试剂，特别是局部应用，以保护和/或再生毛囊的黑素细胞，促进滤泡色素沉着单位的循环更新，以预防和/或限制和/或阻止囊泡的发育， 并保持灰色或白色头发和/或身体毛发的天然色素沉着。
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公开(公告)号：US20090275033A1
公开(公告)日：2009-11-05
申请号：US12387138
申请日：2009-04-28
CPC分类号： C07K14/4747 , A61K8/64 , A61Q5/00
摘要： The present invention concerns the use of a polypeptide comprising a sequence having at least 90% identity with all or part of BNIPXLβ, for cosmetic or therapeutic applications, in the treatment or prevention of premature canities in humans, said portion comprising at least 30 amino acids, as well as the use, for the same purpose, of a molecule comprising a RNAi sequence having at least 90% identity with all or part of the cDNA sequence of BNIPXLβ, said part comprising at least 18 nucleotides.The invention also concerns methods for screening molecules modulating the expression of a gene coding for BNIPXL-beta and molecules modulating the activity of the BNIPXL-beta polypeptide, in order to identify an agent for use for cosmetic or therapeutic purposes in the field of pigmentation. The invention also encompasses various uses of molecules which may be identified by these methods.
摘要翻译： 本发明涉及包含与全部或部分BNIPXLβ具有至少90％同一性的序列用于化妆品或治疗应用的多肽在治疗或预防人类早衰症中的用途，所述部分包含至少30个氨基酸 以及用于相同目的的包含与BNIPXLβ的全部或部分cDNA序列具有至少90％同一性的RNAi序列的分子，所述部分包含至少18个核苷酸。 本发明还涉及用于筛选调节编码BNIPXL-β的基因的表达的调节分子和调节BNIPXL-β多肽的活性的分子的方法，以鉴定在色素沉着领域中用于化妆品或治疗目的的药剂。 本发明还包括可以通过这些方法鉴定的分子的各种用途。
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6.发明申请Administration of agents inducing dopachrome tautomerase (TRP-2) expression for protecting hair follicle melanocytes 审中-公开施用诱导多巴肼互变异构酶（TRP-2）表达以保护毛囊黑素细胞的药剂公开(公告)号：US20090118203A1
公开(公告)日：2009-05-07
申请号：US12076753
申请日：2008-03-21
申请人： Stephane Commo , Bruno Bernard
发明人： Stephane Commo , Bruno Bernard
IPC分类号： A61K31/704 , A61K31/7088 , A61K31/352 , C12Q1/48
CPC分类号： A61Q5/065 , A61K8/34 , A61K8/42 , A61K8/63 , A61K8/64 , A61K31/7048 , A61K2800/70 , A61Q5/00 , A61Q5/10 , A61Q7/00
摘要： Agents inducing the expression of DOPAchrome tautomerase are administered, notably topically applied, to protect and/or regenerate the melanocytes of hair follicles, to promote the cyclic renewal of the follicular pigmentation unit, to prevent and/or limit and/or arrest the development of canities, and to maintain the natural pigmentation of gray or white head hair and/or body hair.
摘要翻译： 诱导诱导DOPAchrome互变异构酶表达的药剂，特别是局部施用，以保护和/或再生毛囊的黑素细胞，促进滤泡色素沉着单位的循环更新，以预防和/或限制和/或阻止 并保持灰色或白色头发和/或身体毛发的天然色素沉着。
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公开(公告)号：US6113889A
公开(公告)日：2000-09-05
申请号：US233062
申请日：1999-01-20
CPC分类号： G01N33/5088 , Y10S514/88
摘要： The invention concerns a procedure for testing a potentially-active substance used in the hair-care field, this procedure being characterized by the fact that a fragment of at least one hair follicle without dermal papilla is isolated, this fragment being taken from beneath the point of attachment of the sebaceous gland and excluding the portion of the hair shaft located above the point of attachment of the sebaceous gland; that this fragment is incubated in a suitable culture medium for a sufficient period; that this fragment is placed in contact with a potentially-active hair-care substance; that a marker of the activity of said tested substance is quantitatively determined; and that the results of this determination are assessed as they compare to a control.
摘要翻译： 本发明涉及一种用于测试头发护理领域中使用的潜在活性物质的方法，该方法的特征在于，至少一种没有真皮乳头的毛囊的片段被分离，该片段从点下面 皮脂腺附着并排除位于皮脂腺附着点之上的毛发部分; 将该片段在合适的培养基中培养足够的时间; 该片段与潜在活性的护发物质接触; 定量测定所述被测物质的活性的标记物; 并且与其对照相比，评估该测定的结果。
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8.发明授权Administration of agents mimicking dopachrome tautomerase (TRP-2) activity for protecting hair follicle melanocytes 有权给予模仿多巴肼互变异构酶（TRP-2）活性以保护毛囊黑素细胞的药剂公开(公告)号：US08445004B2
公开(公告)日：2013-05-21
申请号：US12541398
申请日：2009-08-14
申请人： Stephane Commo , Olivier Gaillard , Bruno Bernard
发明人： Stephane Commo , Olivier Gaillard , Bruno Bernard
IPC分类号： A61K8/02
摘要： Agents mimicking DOPAchrome tautomerase activity are administered, notably topically applied, to protect and/or regenerate the melanocytes of hair follicles, to promote the cyclic renewal of the follicular pigmentation unit, to prevent and/or limit and/or arrest the development of canities, and to maintain the natural pigmentation of gray or white head hair and/or body hair.
摘要翻译： 施用模仿DOPAchrome互变异构酶活性的试剂，特别是局部应用，以保护和/或再生毛囊的黑素细胞，促进滤泡色素沉着单位的循环更新，以预防和/或限制和/或阻止囊泡的发育， 并保持灰色或白色头发和/或身体毛发的天然色素沉着。
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公开(公告)号：US5891426A
公开(公告)日：1999-04-06
申请号：US800457
申请日：1997-02-18
CPC分类号： G01N33/5088 , Y10S514/88
摘要： The invention concerns a procedure for testing a potentially-active substance used in the hair-care field, this procedure being characterized by the fact that a fragment of at least one hair follicle without dermal papilla is isolated, this fragment being taken from beneath the point of attachment of the sebaceous gland and excluding the portion of the hair shaft located above the point of attachment of the sebaceous gland; that this fragment is incubated in a suitable culture medium for a sufficient period; that this fragment is placed in contact with a potentially-active hair-care substance; that a marker of the activity of said tested substance is quantitatively determined; and that the results of this determination are assessed as they compare to a control.
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10.发明申请Administration of coumarin, butylated hydroxyanisole and ethoxyquine for the treatment of canities 失效管理香豆素，丁基化羟基苯甲醚和乙氧基喹啉治疗阴茎公开(公告)号：US20080026018A1
公开(公告)日：2008-01-31
申请号：US11812571
申请日：2007-06-20
申请人： Stephane Commo
发明人： Stephane Commo
CPC分类号： A61K8/498 , A61K8/347 , A61K8/4926 , A61Q5/00 , A61Q5/065 , H01L2924/0002 , H01L2924/00
摘要： At least one compound selected from among coumarin and/or derivative thereof, butylated hydroxyanisole, ethoxyquine and mixtures thereof, and admixtures thereof with other active agents selected from among active agents for combating desquamative conditions of the scalp, plant extracts having propigmenting activity and active agents that slow hair loss and/or promote hair regrowth, are useful for preventing and/or limiting and/or stopping the development of canities.
摘要翻译： 选自香豆素和/或其衍生物中的至少一种化合物，丁基化羟基茴香醚，乙氧基喹啉及其混合物，以及与其它活性剂的混合物，所述活性剂选自用于防治头皮脱屑条件的活性剂，具有辅助活性的植物提取物和活性剂 减缓脱发和/或促进头发再生长，对于预防和/或限制和/或阻止发展神经系统是有用的。
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