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    Multifunctional medical articles
    5.
    发明申请
    Multifunctional medical articles 有权
    多功能医疗用品

    公开(公告)号：US20070003588A1

    公开(公告)日：2007-01-04

    申请号：US11295836

    申请日：2005-12-06

    申请人： Joseph Chinn ,  Sean Stucke ,  Stephen Chudzik

    发明人： Joseph Chinn ,  Sean Stucke ,  Stephen Chudzik

    IPC分类号： A61F2/06

    CPC分类号： A61L29/085 ,  A61L27/34 ,  A61L31/10 ,  A61L33/0011

    摘要： The invention provides medical articles that include more than one biocompatibility-promoting function. In one aspect, the invention provides a medical articles that include a polymeric matrix including more than one biocompatible agent, wherein each biocompatible agent is provided at a distinct portion of the medical article surface. Methods of making medical articles, as well as methods of using the same, are also described.

    摘要翻译： 本发明提供包括多于一种生物相容性促进功能的医疗制品。 在一个方面，本发明提供了包括包含多于一种生物相容剂的聚合物基质的医疗制品，其中每个生物相容性试剂提供在医疗用品表面的不同部分。 还描述了制造医疗用品的方法及其使用方法。

    Crosslinkable macromers
    6.
    发明申请
    Crosslinkable macromers 有权

    公开(公告)号：US20060240072A1

    公开(公告)日：2006-10-26

    申请号：US11475438

    申请日：2006-06-27

    申请人： Stephen Chudzik ,  Joseph Chinn

    发明人： Stephen Chudzik ,  Joseph Chinn

    IPC分类号： A61F2/00

    CPC分类号： A61L27/34 ,  A61L29/085 ,  A61L31/10 ,  Y10S623/92 ,  Y10S623/926

    摘要： A crosslinkable macromer system and related methods of preparing the system and using the system in the form of a crosslinked matrix between a tissue site and an implant article such as a tissue implant or on the porous surface of a prosthetic device. The macromer system includes two or more polymer-pendent polymerizable groups and one or more multifunctional initiator groups. The polymerizable groups and the initiator group(s), when polymer-pendent, can be pendent on the same or different polymeric backbones. The macromer system provides advantages over the use of polymerizable macromers and separate, low molecular weight initiators, including advantages with respect to such properties as nontoxicity, efficiency, and solubility. A macromer system of the invention can be used as an interface between the tissue site and implant article in a manner sufficient to permit tissue growth through the crosslinked matrix and between the tissue site and implant. In a preferred embodiment, polymers with pendent polymerizable groups, for use in the macromer system, are prepared by reacting a polysaccharide polymer with a reactive moiety in an organic, polar solvent such as formamide.