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1.发明申请Regional delivery of therapeutic agents for the treatment of vascular diseases 审中-公开用于治疗血管疾病的治疗剂的区域递送公开(公告)号：US20080146489A1
公开(公告)日：2008-06-19
申请号：US11639512
申请日：2006-12-15
申请人： Stephen D. Pacetti , Paul M. Consigny , Ronald W. Heil , Florian Niklas Ludwig , Dariush Davalian , Li Zhao , Irina Astafieva , Jinping Wan , Fozan El-Nounou , Katsuyuki Murase , Syed F.A. Hossainy , Rachel Bright , Jeffrey Ellis
发明人： Stephen D. Pacetti , Paul M. Consigny , Ronald W. Heil , Florian Niklas Ludwig , Dariush Davalian , Li Zhao , Irina Astafieva , Jinping Wan , Fozan El-Nounou , Katsuyuki Murase , Syed F.A. Hossainy , Rachel Bright , Jeffrey Ellis
CPC分类号： A61M25/1002 , A61F2/82 , A61F2250/0067 , A61K31/27 , A61K31/44 , A61K31/56 , A61K31/66 , A61K38/1709 , A61L29/08 , A61L29/16 , A61L31/08 , A61L31/16 , A61L2300/112 , A61L2300/216 , A61L2300/252 , A61L2300/40 , A61L2300/41 , A61L2300/416 , A61L2300/606 , A61L2300/62 , A61M25/10 , A61M37/0015 , A61M2025/105 , A61M2025/1086 , A61M2037/0023 , A61M2037/0061 , A61M2210/12
摘要： The present invention relates to the regional delivery of therapeutic agents for the treatment of vascular diseases wherein regional delivery refers to delivery of a therapeutically effective amount of the therapeutic agent to an area of the vessel that includes not only afflicted tissue but non-afflicted tissue at the periphery of the afflicted tissue as well.
摘要翻译： 本发明涉及用于治疗血管疾病的治疗剂的区域递送，其中区域递送是指将治疗有效量的治疗剂递送至血管的区域，该区域不仅包括受到损伤的组织而且包括非折磨组织 受影响组织的外围也是如此。
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2.发明授权公开(公告)号：US08735344B2
公开(公告)日：2014-05-27
申请号：US13177476
申请日：2011-07-06
申请人： Katsuyuki Murase , Li Zhao , Irina Astafieva , Paul M. Consigny , Stephen D. Pacetti , Dariush Davalian , Syed Fayaiz Ahmed Hossainy , Florian N. Ludwig , Jinping Wan , John Stankus , Rachel Bright
发明人： Katsuyuki Murase , Li Zhao , Irina Astafieva , Paul M. Consigny , Stephen D. Pacetti , Dariush Davalian , Syed Fayaiz Ahmed Hossainy , Florian N. Ludwig , Jinping Wan , John Stankus , Rachel Bright
CPC分类号： C07K14/775 , A61K38/00
摘要： A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (Apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (Apo A-I) synthetic peptide, or combination of an Apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various Apo A-I mimetic peptides, or endogenous Apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous Apo A-I.
摘要翻译： 一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将包含持续释放载体和载脂蛋白A-I（Apo A-I）合成模拟肽的组合物引入所述特定区域的血管壁中，其中所述肽具有使所述肽在反向胆固醇转运中有效的性质。 一种包含载体载脂蛋白AI（Apo AI）合成肽或Apo AI合成模拟肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸 序列的顺序与各种Apo AI模拟肽或内源性Apo AI类似物的顺序相反，或内源Apo AI的螺旋1和螺旋9的嵌合体。
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3.发明授权公开(公告)号：US07985728B1
公开(公告)日：2011-07-26
申请号：US11858862
申请日：2007-09-20
申请人： Katsuyuki Murase , Li Zhao , Irina Astafieva , Paul M. Consigny , Stephen D. Pacetti , Dariush Davalian , Syed Fayaiz Ahmed Hossainy , Florian N. Ludwig , Jinping Wan , John Stankus , Rachel Bright
发明人： Katsuyuki Murase , Li Zhao , Irina Astafieva , Paul M. Consigny , Stephen D. Pacetti , Dariush Davalian , Syed Fayaiz Ahmed Hossainy , Florian N. Ludwig , Jinping Wan , John Stankus , Rachel Bright
CPC分类号： C07K14/775 , A61K38/00
摘要： A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (Apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (Apo A-I) synthetic peptide, or combination of an Apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various Apo A-I mimetic peptides, or endogenous Apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous Apo A-I.
摘要翻译： 一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将包含持续释放载体和载脂蛋白A-I（Apo A-I）合成模拟肽的组合物引入所述特定区域的血管壁中，其中所述肽具有使所述肽在反向胆固醇转运中有效的性质。 一种包含载体载脂蛋白AI（Apo AI）合成肽或Apo AI合成模拟肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸 序列的顺序与各种Apo AI模拟肽或内源性Apo AI类似物的顺序相反，或内源Apo AI的螺旋1和螺旋9的嵌合体。
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公开(公告)号：US20110293706A1
公开(公告)日：2011-12-01
申请号：US13184406
申请日：2011-07-15
CPC分类号： A61K9/5031 , A61K9/0004 , A61K9/0019 , A61K9/5115 , A61K9/5138 , A61K38/446 , A61K41/0052 , A61K47/6923 , A61K47/6925 , A61K47/6929 , A61K47/6931 , A61L31/16 , A61L2300/00 , A61L2400/06 , A61L2400/12 , B01J13/02 , B22F1/025 , B82Y5/00 , Y10S977/773 , Y10S977/906 , Y10T428/2991 , Y10T428/2998
摘要： Nano-constructscomprising nanoshells and methods of using the nano-constructs for treating or ameliorating a medical condition are provided.
摘要翻译： 提供纳米结构的纳米壳和使用纳米结构物治疗或改善医学病症的方法。
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公开(公告)号：US20070292495A1
公开(公告)日：2007-12-20
申请号：US11454813
申请日：2006-06-15
CPC分类号： A61K9/5115 , A61K9/0009 , A61K9/127 , A61K41/0019 , A61K41/0028
摘要： Nano-constructs comprising nanoshells and methods of using the nano-constructs for treating or ameliorating a medical condition are provided.
摘要翻译： 提供包含纳米壳的纳米构建体和使用纳米构建体治疗或改善医学状况的方法。
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公开(公告)号：US20070298257A1
公开(公告)日：2007-12-27
申请号：US11473822
申请日：2006-06-23
CPC分类号： A61K9/5031 , A61K9/0004 , A61K9/0019 , A61K9/5115 , A61K9/5138 , A61K38/446 , A61K41/0052 , A61K47/6923 , A61K47/6925 , A61K47/6929 , A61K47/6931 , A61L31/16 , A61L2300/00 , A61L2400/06 , A61L2400/12 , B01J13/02 , B22F1/025 , B82Y5/00 , Y10S977/773 , Y10S977/906 , Y10T428/2991 , Y10T428/2998
摘要： Nano-constructs comprising nanoshells and methods of using the nano-constructs for treating or ameliorating a medical condition are provided.
摘要翻译： 提供包含纳米壳的纳米构建体和使用纳米构建体治疗或改善医学状况的方法。
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公开(公告)号：US08293367B2
公开(公告)日：2012-10-23
申请号：US13184406
申请日：2011-07-15
IPC分类号： B32B5/16
CPC分类号： A61K9/5031 , A61K9/0004 , A61K9/0019 , A61K9/5115 , A61K9/5138 , A61K38/446 , A61K41/0052 , A61K47/6923 , A61K47/6925 , A61K47/6929 , A61K47/6931 , A61L31/16 , A61L2300/00 , A61L2400/06 , A61L2400/12 , B01J13/02 , B22F1/025 , B82Y5/00 , Y10S977/773 , Y10S977/906 , Y10T428/2991 , Y10T428/2998
摘要： Nano-constructscomprising nanoshells and methods of using the nano-constructs for treating or ameliorating a medical condition are provided.
摘要翻译： 提供纳米结构的纳米壳和使用纳米结构物治疗或改善医学病症的方法。
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公开(公告)号：US08017237B2
公开(公告)日：2011-09-13
申请号：US11473822
申请日：2006-06-23
IPC分类号： B32B5/16
CPC分类号： A61K9/5031 , A61K9/0004 , A61K9/0019 , A61K9/5115 , A61K9/5138 , A61K38/446 , A61K41/0052 , A61K47/6923 , A61K47/6925 , A61K47/6929 , A61K47/6931 , A61L31/16 , A61L2300/00 , A61L2400/06 , A61L2400/12 , B01J13/02 , B22F1/025 , B82Y5/00 , Y10S977/773 , Y10S977/906 , Y10T428/2991 , Y10T428/2998
摘要： Nano-constructs comprising nanoshells and methods of using the nano-constructs for treating or ameliorating a medical condition are provided.
摘要翻译： 提供包含纳米壳的纳米构建体和使用纳米构建体治疗或改善医学状况的方法。
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9.发明申请POLYMERS CONTAINING POLY(HYDROXYALKANOATES) AND AGENTS FOR USE WITH MEDICAL ARTICLES AND METHODS OF FABRICATING THE SAME 有权含有聚（羟基甘草酸酯）的聚合物和用于医药制品的试剂及其制备方法公开(公告)号：US20110274733A1
公开(公告)日：2011-11-10
申请号：US13183966
申请日：2011-07-15
IPC分类号： A61K9/00 , C08G12/26 , A61K31/765 , C08G69/26
CPC分类号： C08G63/912 , C08B37/0072 , C08B37/0075 , C08G63/06 , C08G63/664 , C08L1/08 , C08L1/286 , C08L5/02 , C08L5/08 , C08L5/10 , C08L25/18 , C08L33/26 , C08L39/06 , C08L67/04 , C08L71/02 , C08L77/12 , C09D101/286 , C09D105/02 , C09D105/08 , C09D105/10 , C09D167/04 , C08L2666/04 , C08L2666/26 , C08L2666/20 , C08L2666/06 , C08L2666/22
摘要： Embodiments of the present invention provides medical devices comprising poly(hydroxyalkanoates) and agents.
摘要翻译： 本发明的实施方案提供包含聚（羟基链烷酸酯）和试剂的医疗装置。
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10.发明授权Polymers containing poly(hydroxyalkanoates) and agents for use with medical articles and methods of fabricating the same 有权含有聚（羟基链烷酸酯）的聚合物和用于医疗制品的试剂及其制造方法公开(公告)号：US08007775B2
公开(公告)日：2011-08-30
申请号：US11027955
申请日：2004-12-30
IPC分类号： A61K31/765
CPC分类号： C08G63/912 , C08B37/0072 , C08B37/0075 , C08G63/06 , C08G63/664 , C08L1/08 , C08L1/286 , C08L5/02 , C08L5/08 , C08L5/10 , C08L25/18 , C08L33/26 , C08L39/06 , C08L67/04 , C08L71/02 , C08L77/12 , C09D101/286 , C09D105/02 , C09D105/08 , C09D105/10 , C09D167/04 , C08L2666/04 , C08L2666/26 , C08L2666/20 , C08L2666/06 , C08L2666/22
摘要： Polymers containing poly(hydroxyalkanoates) and agents for use with medical articles and methods of fabricating the same are disclosed. The medical article generally comprises an implantable substrate having a coating, and the coating contains a poly(hydroxyalkanoate).
摘要翻译： 公开了含有聚（羟基链烷酸酯）的聚合物和用于医疗制品的试剂及其制造方法。 医疗制品通常包括具有涂层的可植入基底，并且该涂层含有聚（羟基链烷酸酯）。
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