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    High humidity crimping process
    5.
    发明授权
    High humidity crimping process 有权
    高湿度压接工艺

    公开(公告)号：US08020273B2

    公开(公告)日：2011-09-20

    申请号：US12692529

    申请日：2010-01-22

    申请人： Stephen Dirk Pacetti

    发明人： Stephen Dirk Pacetti

    IPC分类号： B23P11/00 ,  B23P25/00 ,  A61F2/82

    CPC分类号： A61F2/958 ,  A61F2/06 ,  A61F2/07 ,  A61F2/82 ,  A61F2002/9522 ,  A61F2240/001 ,  A61L31/022 ,  A61L31/048 ,  A61L31/16 ,  A61L2300/416 ,  A61L2420/06 ,  B05C11/00 ,  B21D39/048 ,  Y10T29/49863 ,  Y10T29/49865 ,  Y10T29/49925 ,  Y10T29/49927 ,  Y10T29/53996

    摘要： A method of producing a stent-balloon assembly is disclosed which includes providing a stent having a polymeric component; exposing the stent to a relative humidity of 20% to 100%; and crimping the stent on a balloon of a catheter assembly. The polymeric component could be at least part of the material from which the stent is made or could be a constituent of a coating for the stent, such as a drug delivery coating. In lieu of or in addition to the application of humidity, a plasticizing agent can be applied to the polymeric component. A crimping device is also disclosed which allows the stent to be exposed to humidity during the crimping process.

    摘要翻译： 公开了一种制造支架 - 球囊组件的方法，其包括提供具有聚合物组分的支架; 将支架暴露于20％至100％的相对湿度; 并将支架卷曲在导管组件的气球上。 聚合物组分可以是制造支架的材料的至少一部分，或者可以是用于支架的涂层的成分，例如药物递送涂层。 除了施加湿度之外，还可以将增塑剂施加到聚合物组分上。 还公开了压接装置，其允许支架在压接过程期间暴露于湿度。

    Blends of poly(ester amide) polymers
    7.
    发明授权
    Blends of poly(ester amide) polymers 有权
    聚（酯酰胺）聚合物的共混物

    公开(公告)号：US07520891B2

    公开(公告)日：2009-04-21

    申请号：US12056197

    申请日：2008-03-26

    申请人： Jessica R. DesNoyer ,  Stephen Dirk Pacetti ,  Lothar W. Kleiner

    发明人： Jessica R. DesNoyer ,  Stephen Dirk Pacetti ,  Lothar W. Kleiner

    IPC分类号： A61L27/34 ,  A61L29/08 ,  C08L77/12

    CPC分类号： A61L31/10 ,  A61L31/16 ,  A61L2300/606 ,  C08L77/12 ,  C08L2666/14

    摘要： Provided herein is a poly(ester amide) (PEA) polymer blend and a polymeric coating containing the PEA polymer blend. The PEA polymer blend has a Tg above the Tg of poly(ester amide benzyl ester) (PEA-Bz) or the Tg of poly(ester amide TEMPO). The PEA polymer blend can form a coating on an implantable device, one example of which is a stent. The coating can optionally include a biobeneficial material and/or optionally with a bioactive agent. The implantable device can be used to treat or prevent a disorder such as one of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.

    摘要翻译： 本文提供了聚（酯酰胺）（PEA）聚合物共混物和含有PEA聚合物共混物的聚合物涂层。 PEA聚合物共混物的Tg高于聚（酯酰胺苄酯）（PEA-Bz）的Tg或聚（酯酰胺TEMPO）的Tg。 PEA聚合物共混物可以在可植入装置上形成涂层，其一个实例是支架。 涂层可任选地包括生物有益材料和/或任选地含有生物活性剂。 可植入装置可用于治疗或预防动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔之一，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍 导管阻塞，输尿管阻塞，肿瘤阻塞及其组合。

    Poly(ester amide) filler blends for modulation of coating properties
    10.
    发明授权
    Poly(ester amide) filler blends for modulation of coating properties 有权
    用于调节涂层性能的聚（酯酰胺）填料混合物

    公开(公告)号：US07390497B2

    公开(公告)日：2008-06-24

    申请号：US10976551

    申请日：2004-10-29

    申请人： Jessica Renee DesNoyer ,  Stephen Dirk Pacetti ,  Syed Faiyaz Shmed Hossainy ,  Lothar Kleiner ,  Yiwen Tang ,  Gina Zhang

    发明人： Jessica Renee DesNoyer ,  Stephen Dirk Pacetti ,  Syed Faiyaz Shmed Hossainy ,  Lothar Kleiner ,  Yiwen Tang ,  Gina Zhang

    IPC分类号： A61K31/00 ,  A61L31/10 ,  A61L27/34 ,  A61L29/08 ,  C08G63/02

    CPC分类号： C09D177/12 ,  A61L31/06 ,  A61L31/10 ,  Y10S623/90 ,  Y10T428/31725 ,  Y10T428/31786 ,  C08L77/12

    摘要： Provided herein is a PEA polymer blend and coatings or implantable devices formed therefrom. The PEA polymer blend is formed of a PEA polymer and a material capable of hydrogen bonding with the PEA. The PEA polymer blend can form a coating on an implantable device, one example of which is a stent. The coating can optionally include a biobeneficial material and/or optionally with a bioactive agent. The implantable device can be used to treat or prevent a disorder such as one of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.

    摘要翻译： 本文提供了由其形成的PEA聚合物共混物和涂层或可植入装置。 PEA聚合物共混物由PEA聚合物和能够与PEA氢键合的材料形成。 PEA聚合物共混物可以在可植入装置上形成涂层，其一个实例是支架。 涂层可任选地包括生物有益材料和/或任选地含有生物活性剂。 可植入装置可用于治疗或预防动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔之一，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍 导管阻塞，输尿管阻塞，肿瘤阻塞及其组合。