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1.发明申请ANIMAL PRODUCT FREE SYSTEM AND PROCESS FOR PURIFYING A BOTULINUM TOXIN 有权动物产品免费系统和净化BOTULINUM TOXIN的方法公开(公告)号：US20120149089A1
公开(公告)日：2012-06-14
申请号：US12098896
申请日：2008-04-07
申请人： Hui Xiang , Mingjiang Luo , Ping Wang , Stephen Donovan
发明人： Hui Xiang , Mingjiang Luo , Ping Wang , Stephen Donovan
IPC分类号： C12N9/52
CPC分类号： C12N9/52 , C07K14/33 , C12N1/20 , C12N9/6489 , C12P21/02 , C12Y304/24069
摘要： Chromatographic processes and systems for purifying a botulinum toxin from an APF fermentation medium.
摘要翻译： 用于从APF发酵培养基中纯化肉毒毒素的色谱法和系统。
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2.发明授权公开(公告)号：US07354740B2
公开(公告)日：2008-04-08
申请号：US11072673
申请日：2005-03-03
申请人： Hui Xiang , Mingjiang Luo , Ping Wang , Stephen Donovan
发明人： Hui Xiang , Mingjiang Luo , Ping Wang , Stephen Donovan
CPC分类号： C12N9/52 , C07K14/33 , C12N1/20 , C12N9/6489 , C12P21/02 , C12Y304/24069
摘要： Chromatographic processes and systems for purifying a botulinum toxin from an APF fermentation medium.
摘要翻译： 用于从APF发酵培养基中纯化肉毒杆菌毒素的色谱法和系统。
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公开(公告)号：US20070111288A1
公开(公告)日：2007-05-17
申请号：US11609449
申请日：2006-12-12
申请人： Ping Wang , Stephen Donovan
发明人： Ping Wang , Stephen Donovan
CPC分类号： C12N1/20 , C07K14/33 , C12N9/6489 , C12P21/02 , C12Y304/24069 , Y10S435/842
摘要： Animal product free (APF) media and processes for the culture and fermentation of botulinum toxin producing Clostridium botulinum bacteria. The botulinum toxin obtained can be used for formulating and compounding botulinum toxin pharmaceutical compositions. The APF media can contain significantly reduced levels of meat or dairy by-products and use non-animal based products instead of the animal-derived products. Preferably, the APF media used are substantially free or free of animal derived products.
摘要翻译： 不含动物产品（APF）的培养基和产生肉毒杆菌毒素的肉毒杆菌的培养和发酵过程。 获得的肉毒杆菌毒素可用于配制和配制肉毒杆菌毒素药物组合物。 APF媒体可以显着降低肉类或乳制品副产品的含量，并使用非动物产品，而不是动物衍生产品。 优选地，所用的APF介质基本上是游离的或没有动物衍生的产品。
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4.发明申请Media for clostridium bacterium and processes for obtaining a clostridial toxin 有权梭菌细菌的培养基和获得梭菌毒素的方法公开(公告)号：US20050238668A1
公开(公告)日：2005-10-27
申请号：US11072050
申请日：2005-03-03
申请人： Ping Wang , Stephen Donovan
发明人： Ping Wang , Stephen Donovan
CPC分类号： C12N1/20 , C07K14/33 , C12N9/6489 , C12P21/02 , C12Y304/24069 , Y10S435/842
摘要： Animal product free (APF) media and processes for the culture and fermentation of botulinum toxin producing Clostridium botulinum bacteria. The botulinum toxin obtained can be used for formulating and compounding botulinum toxin pharmaceutical compositions. The APF media can contain significantly reduced levels of meat or dairy by-products and use non-animal based products instead of the animal-derived products. Preferably, the APF media used are substantially free or free of animal derived products.
摘要翻译： 不含动物产品（APF）的培养基和产生肉毒杆菌毒素的肉毒杆菌的培养和发酵过程。 获得的肉毒杆菌毒素可用于配制和配制肉毒杆菌毒素药物组合物。 APF媒体可以显着降低肉类或乳制品副产品的含量，并使用非动物产品，而不是动物产品。 优选地，所用的APF介质基本上是游离的或没有动物衍生的产品。
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公开(公告)号：US07560251B2
公开(公告)日：2009-07-14
申请号：US11609449
申请日：2006-12-12
申请人： Ping Wang , Stephen Donovan
发明人： Ping Wang , Stephen Donovan
CPC分类号： C12N1/20 , C07K14/33 , C12N9/6489 , C12P21/02 , C12Y304/24069 , Y10S435/842
摘要： Animal product free (APF) media and processes for the culture and fermentation of botulinum toxin producing Clostridium botulinum bacteria. The botulinum toxin obtained can be used for formulating and compounding botulinum toxin pharmaceutical compositions. The APF media can contain significantly reduced levels of meat or dairy by-products and use non-animal based products instead of the animal-derived products. Preferably, the APF media used are substantially free or free of animal derived products.
摘要翻译： 不含动物产品（APF）的培养基和产生肉毒杆菌毒素的肉毒杆菌的培养和发酵过程。 获得的肉毒杆菌毒素可用于配制和配制肉毒杆菌毒素药物组合物。 APF媒体可以显着降低肉类或乳制品副产品的含量，并使用非动物产品，而不是动物产品。 优选地，所用的APF介质基本上是游离的或没有动物衍生的产品。
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6.发明授权Media for clostridium bacterium and processes for obtaining a clostridial toxin 有权梭菌细菌的培养基和获得梭菌毒素的方法公开(公告)号：US07160699B2
公开(公告)日：2007-01-09
申请号：US11072050
申请日：2005-03-03
申请人： Ping Wang , Stephen Donovan
发明人： Ping Wang , Stephen Donovan
CPC分类号： C12N1/20 , C07K14/33 , C12N9/6489 , C12P21/02 , C12Y304/24069 , Y10S435/842
摘要： Animal product free (APF) media and processes for the culture and fermentation of botulinum toxin producing Clostridium botulinum bacteria. The botulinum toxin obtained can be used for formulating and compounding botulinum toxin pharmaceutical compositions. The APF media can contain significantly reduced levels of meat or dairy by-products and use non-animal based products instead of the animal-derived products. Preferably, the APF media used are substantially free or free of animal derived products.
摘要翻译： 不含动物产品（APF）的培养基和产生肉毒杆菌毒素的肉毒杆菌的培养和发酵过程。 获得的肉毒杆菌毒素可用于配制和配制肉毒杆菌毒素药物组合物。 APF媒体可以显着降低肉类或乳制品副产品的含量，并使用非动物产品，而不是动物产品。 优选地，所用的APF介质基本上是游离的或没有动物衍生的产品。
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7.发明授权公开(公告)号：US08409828B2
公开(公告)日：2013-04-02
申请号：US12098896
申请日：2008-04-07
申请人： Hui Xiang , Mingjiang Luo , Ping Wang , Stephen Donovan
发明人： Hui Xiang , Mingjiang Luo , Ping Wang , Stephen Donovan
CPC分类号： C12N9/52 , C07K14/33 , C12N1/20 , C12N9/6489 , C12P21/02 , C12Y304/24069
摘要： Chromatographic processes and systems for purifying a botulinum toxin from an APF fermentation medium.
摘要翻译： 用于从APF发酵培养基中纯化肉毒毒素的色谱法和系统。
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8.发明申请公开(公告)号：US20050238669A1
公开(公告)日：2005-10-27
申请号：US11072673
申请日：2005-03-03
申请人： Hui Xiang , Mingjiang Luo , Ping Wang , Stephen Donovan
发明人： Hui Xiang , Mingjiang Luo , Ping Wang , Stephen Donovan
CPC分类号： C12N9/52 , C07K14/33 , C12N1/20 , C12N9/6489 , C12P21/02 , C12Y304/24069
摘要： Chromatographic processes and systems for purifying a botulinum toxin from an APF fermentation medium.
摘要翻译： 用于从APF发酵培养基中纯化肉毒毒素的色谱法和系统。
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9.发明授权Media for clostridium bacterium and processes for obtaining a clostridial toxin 有权梭菌细菌的培养基和获得梭菌毒素的方法公开(公告)号：US08012716B2
公开(公告)日：2011-09-06
申请号：US12501376
申请日：2009-07-10
申请人： Stephen Donovan , Ping Wang
发明人： Stephen Donovan , Ping Wang
CPC分类号： C12N1/20 , C07K14/33 , C12N9/6489 , C12P21/02 , C12Y304/24069 , Y10S435/842
摘要： Animal product free (APF) media and processes for the culture and fermentation of botulinum toxin producing Clostridium botulinum bacteria. The botulinum toxin obtained can be used for formulating and compounding botulinum toxin pharmaceutical compositions. The APF media can contain significantly reduced levels of meat or dairy by-products and use non-animal based products instead of the animal-derived products. Preferably, the APF media used are substantially free or free of animal derived products.
摘要翻译： 不含动物产品（APF）的培养基和产生肉毒杆菌毒素的肉毒杆菌的培养和发酵过程。 获得的肉毒杆菌毒素可用于配制和配制肉毒杆菌毒素药物组合物。 APF媒体可以显着降低肉类或乳制品副产品的含量，并使用非动物产品，而不是动物产品。 优选地，所用的APF介质基本上是游离的或没有动物衍生的产品。
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公开(公告)号：US08119563B2
公开(公告)日：2012-02-21
申请号：US10595298
申请日：2004-10-04
申请人： George Theodoridis , David Rosen , Shunxiang Zhang , Walter H. Yeager , Robert N. Henrie, II , Syed Z. Ahmed , Hongbin Men , Stephen Donovan
发明人： George Theodoridis , David Rosen , Shunxiang Zhang , Walter H. Yeager , Robert N. Henrie, II , Syed Z. Ahmed , Hongbin Men , Stephen Donovan
IPC分类号： A01N43/22 , C07D211/06
CPC分类号： C07D211/48 , A01N43/40 , A01N43/54 , A01N43/58 , A01N43/713 , A01N43/90 , A01N47/06 , A01N47/20 , A01N47/22 , C07D211/94 , C07D401/10 , C07D401/12 , C07D451/02 , C07D471/10
摘要： N-substituted azacycle derivative compounds represented by formula (I): wherein m, q, r, t and u are independently selected from 0 or 1; and p is 0, 1, 2, or 3; and A, B, D, X, Y, R, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 are fully described herein. The compounds being particularly useful in compositions comprising an insecticidally effective amount of at least one compound of formula I, and an insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.
摘要翻译： 由式（I）表示的N-取代的azacycle衍生物化合物：其中m，q，r，t和u独立地选自0或1; 且p为0,1,2或3; 并且A，B，D，X，Y，R，R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9，R 10和R 11在本文中被完整描述。 还公开了特别可用于包含杀虫有效量的至少一种式I化合物和杀虫相容载体的化合物; 以及控制昆虫的方法，包括将所述组合物施用于存在昆虫或预期存在的场所。
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