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    Disposable cartridge for producing gas-enriched fluids
    1.
    发明授权
    Disposable cartridge for producing gas-enriched fluids 有权
    用于生产富含气体的流体的一次性筒

    公开(公告)号：US07820102B2

    公开(公告)日：2010-10-26

    申请号：US10402463

    申请日：2003-03-28

    申请人： Stephen E. Myrick ,  Gregory P. Watson ,  William R. Patterson ,  Paul J. Zalesky

    发明人： Stephen E. Myrick ,  Gregory P. Watson ,  William R. Patterson ,  Paul J. Zalesky

    IPC分类号： A61M1/00 ,  A61M37/00

    CPC分类号： A61M1/3621 ,  A61M1/32 ,  A61M1/3626 ,  A61M2202/0208 ,  A61M2202/0476 ,  B01F3/04758

    摘要： A device generates a gas-enriched physiologic fluid and combines it with a bodily fluid to create a gas-enriched bodily fluid. The device may take the form of a disposable cartridge. The cartridge may include a fluid supply chamber for delivering physiologic fluid under pressure to an atomizer. The atomizer delivers fluid droplets into a gas-pressurized atomization chamber to enrich the physiologic fluid with the gas. The gas-enriched physiologic fluid is delivered to a mixing chamber in the cartridge where the gas-enriched physiologic fluid is mixed with a bodily fluid, such as blood, to create a gas-enriched bodily fluid.

    摘要翻译： 装置产生气体富集的生理流体并将其与体液结合以产生富含气体的体液。 该装置可以采取一次性盒式的形式。 药筒可以包括用于将生理液体在压力下输送到雾化器的流体供应室。 雾化器将流体液滴输送到气体加压的雾化室中以与气体一起富集生理液体。 将气体富集的生理液体输送到药筒中的混合室，其中富含气体的生理液体与诸如血液的体液混合，以产生富含气体的体液。

    Method for blood oxygenation
    6.
    发明授权
    Method for blood oxygenation 失效

    公开(公告)号：US06596235B2

    公开(公告)日：2003-07-22

    申请号：US09778433

    申请日：2001-02-07

    申请人： Vincent Divino, Jr. ,  Paul J. Zalesky ,  William R. Patterson

    发明人： Vincent Divino, Jr. ,  Paul J. Zalesky ,  William R. Patterson

    IPC分类号： A61M136

    CPC分类号： A61M1/1698 ,  A61M1/3613 ,  A61M2202/0476 ,  B01F3/04758

    摘要： An apparatus and method for blood oxygenation is provided, advantageously comprising an extracorporeal circuit for the preparation and delivery of hyperoxic or hyperbaric blood. In one embodiment, an apparatus for gas-supersaturating fluids, e.g., physiologic saline, includes a chamber having a first inlet to receive the fluid; a second inlet to receive a gas, e.g., oxygen, from a gas supply that maintains pressure within the chamber at a predetermined level, advantageously about 600 p.s.i.; and an outlet advantageously coupled to a capillary assembly. An atomizer nozzle coupled to the first inlet advantageously creates within the chamber fine droplets of fluid into which gas diffuses to create the gas-supersaturated fluid, which collects within the chamber below the atomizer nozzle for removal via the outlet. The removed gas-supersaturated fluid mixes with blood provided by a blood pump, the mixing occurring within a liquid-to-liquid oxygenation assembly including a pressurizable chamber having inlets for the gas-supersaturated fluid and blood, the inlets advantageously arranged to create a vortical or cyclonic fluid flow within the chamber to promote mixing. The mixed fluid exits the chamber via an outlet for delivery to a patient (e.g., sub-selective delivery) or other site via a catheter, infusion guidewire, or other interventional fluid delivery device, the mixed fluid advantageously comprising blood having increased oxygen levels, i.e., oxygenated blood. Alternately, the blood may be provided by the pump to a high pressure hollow fiber or other type membrane oxygenator within which oxygen, advantageously provided at a pressure greater than atmospheric, diffuses across the membrane(s) and into the blood to form oxygenated blood, again for delivery to a patient or other site. Advantageously, the oxygenated blood is delivered at a target pO2 greater than about 760 mm Hg and is delivered from the liquid-to-liquid oxygenation assembly or membrane oxygenator via a fluid conduit having an approximate pressure drop greater than the target pO2.

    Method of blood oxygenation
    8.
    发明授权
    Method of blood oxygenation 失效
    血氧合法

    公开(公告)号：US06855291B2

    公开(公告)日：2005-02-15

    申请号：US10384301

    申请日：2003-03-07

    申请人： William R. Patterson ,  Stephen E. Myrick ,  Vincent Divino, Jr. ,  Jeffrey L. Creech ,  Mark S. Buhr

    发明人： William R. Patterson ,  Stephen E. Myrick ,  Vincent Divino, Jr. ,  Jeffrey L. Creech ,  Mark S. Buhr

    IPC分类号： A61M1/16 ,  A61M1/36 ,  A61M1/14 ,  A61M37/00

    CPC分类号： A61M1/1698 ,  A61M1/3613 ,  A61M2202/0476 ,  B01F3/04758 ,  Y10S128/03 ,  Y10S261/28

    摘要： An apparatus and method for blood oxygenation are provided. The apparatus includes a chamber having a first inlet to receive a gas-supersaturating fluid, e.g., physiologic saline; a second inlet to receive a gas, e.g., oxygen, from a gas supply; and an outlet coupled to a capillary assembly. An atomizer nozzle coupled to the first inlet creates within the chamber fine droplets of fluid into which the gas diffuses to create the gas-supersaturated fluid, which is removed via the outlet. The removed gas-supersaturated fluid mixes with blood within a liquid-to-liquid oxygenation assembly to form oxygenated blood for delivery to a patient. Alternately, the blood may be provided by the pump to a high pressure hollow fiber or other type membrane oxygenator within which oxygen diffuses across the membranes(s) and into the blood to form oxygenated blood, again for delivery to a patient or other site.

    摘要翻译： 提供了一种用于血氧的装置和方法。 该装置包括具有第一入口以容纳气体过饱和流体例如生理盐水的室; 用于接收来自气体供应源的气体例如氧的第二入口; 和连接到毛细管组件的出口。 联接到第一入口的雾化喷嘴在室内形成细小的液体，气体扩散到其中，以产生气体过饱和流体，其通过出口被去除。 去除的气体过饱和流体与液体至液体氧合装置内的血液混合以形成用于输送给患者的含氧血液。 或者，血液可以由泵提供给高压中空纤维或其他类型的膜氧合器，其中氧气扩散通过膜并进入血液以形成含氧血液，再次输送到患者或其他部位。