公开(公告)号：US20100099182A1

公开(公告)日：2010-04-22

申请号：US12638435

申请日：2009-12-15

申请人： Stephen James Russell ,  John Morris

发明人： Stephen James Russell ,  John Morris

IPC分类号： C12N5/071 ,  C12N15/74

CPC分类号： C07K14/705

摘要： A novel strategy for monitoring the location of a transgene in a mammal is disclosed. A sodium iodide symporter is genetically fused to either the N-terminus or C-terminus of the product of a transgene through a linker peptide which bears the recognition sequence of a host cell protease. Expression of the transgene confers the activity of the sodium iodide symporter (NIS) to a host cell which expresses the transgene. Subsequent administration of labeled iodine results in transport of the labeled iodine into the cell bearing the NIS, which can then be localized and measured using standard imaging techniques. The system is particularly useful for monitoring the location of therapeutic transgenes and tissue-specific distribution of the therapeutic gene product.

摘要翻译： 公开了一种监测哺乳动物转基因位置的新颖策略。 碘化钠同向转运体通过承载宿主细胞蛋白酶识别序列的接头肽与转基因产物的N末端或C末端融合。 转基因的表达赋予碘化钠对映体（NIS）对表达转基因的宿主细胞的活性。 随后给予标记的碘导致标记的碘转运到携带NIS的细胞中，然后可以使用标准成像技术进行定位和测量。 该系统特别可用于监测治疗转基因的位置和治疗性基因产物的组织特异性分布。

公开(公告)号：US06586411B1

公开(公告)日：2003-07-01

申请号：US09640198

申请日：2000-08-16

申请人： Stephen James Russell ,  John Morris

发明人： Stephen James Russell ,  John Morris

IPC分类号： A61K3170

CPC分类号： C07K14/705

摘要： A novel strategy for monitoring the location of a transgene in a mammal is disclosed. A sodium iodide symporter is genetically fused to either the N-terminus or C-terminus of the product of a transgene through a linker peptide which bears the recognition sequence of a host cell protease. Expression of the transgene confers the activity of the sodium iodide symporter (NIS) to a host cell which expresses the transgene. Subsequent administration of labeled iodine results in transport of the labeled iodine into the cell bearing the NIS, which can then be localized and measured using standard imaging techniques. The system is particularly useful for monitoring the location of therapeutic transgenes and tissue-specific distribution of the therapeutic gene product.

摘要翻译： 公开了一种监测哺乳动物转基因位置的新颖策略。 碘化钠同向转运体通过承载宿主细胞蛋白酶识别序列的接头肽与转基因产物的N末端或C末端融合。 转基因的表达赋予碘化钠对映体（NIS）对表达转基因的宿主细胞的活性。 随后给予标记的碘导致标记的碘转运到携带NIS的细胞中，然后可以使用标准成像技术进行定位和测量。 该系统特别可用于监测治疗转基因的位置和治疗性基因产物的组织特异性分布。

公开(公告)号：US07645865B2

公开(公告)日：2010-01-12

申请号：US10428868

申请日：2003-05-01

申请人： Stephen James Russell ,  John Morris

发明人： Stephen James Russell ,  John Morris

IPC分类号： C07H21/02

CPC分类号： C07K14/705

摘要： A novel strategy for monitoring the location of a transgene in a mammal is disclosed. A sodium iodide symporter is genetically fused to either the N-terminus or C-terminus of the product of a transgene through a linker peptide which bears the recognition sequence of a host cell protease. Expression of the transgene confers the activity of the sodium iodide symporter (NIS)to a host cell which expresses the transgene. Subsequent administration of labeled iodine results in transport of the labeled iodine into the cell bearing the NIS, which can then be localized and measured using standard imaging techniques. The system is particularly useful for monitoring the location of therapeutic transgenes and tissue-specific distribution of the therapeutic gene product.

摘要翻译： 公开了一种监测哺乳动物转基因位置的新颖策略。 碘化钠同向转运体通过承载宿主细胞蛋白酶识别序列的接头肽与转基因产物的N末端或C末端融合。 转基因的表达赋予碘化钠对映体（NIS）对表达转基因的宿主细胞的活性。 随后给予标记的碘导致标记的碘转运到携带NIS的细胞中，然后可以使用标准成像技术进行定位和测量。 该系统特别可用于监测治疗转基因的位置和治疗性基因产物的组织特异性分布。

公开(公告)号：US10435281B1

公开(公告)日：2019-10-08

申请号：US15590007

申请日：2017-05-08

申请人： John Morris

发明人： John Morris

IPC分类号： B66F9/12 ,  E02F3/34 ,  E02F3/04 ,  B66F9/00 ,  E02F3/00

摘要： A Multi-Armed Lifting Accessory is disclosed herein which is compact and transportable in various deployments. The Multi-Armed Lifting Accessory is advantageous and useful as it has hingedly connected loading and support arms attached to a main lifter body. The supporting arms are spring loaded allowing the Multi-Armed Lifting Accessory to stably engage with irregular shaped objects such as barge lid or a skidsteer loader and allows for flexible engagement and balanced lifting operations.

公开(公告)号：US20160077345A1

公开(公告)日：2016-03-17

申请号：US14489370

申请日：2014-09-17

申请人： Michael Bohan ,  John Morris ,  Yuenkeen Cheong ,  Errol M. Tazbaz ,  Rod G. Fleck

发明人： Michael Bohan ,  John Morris ,  Yuenkeen Cheong ,  Errol M. Tazbaz ,  Rod G. Fleck

IPC分类号： G02B27/02 ,  G02B5/23 ,  G02B26/02 ,  G02C7/16 ,  G02C7/10

CPC分类号： G02C7/101 ,  G02B5/23 ,  G02B26/02 ,  G02B27/0172 ,  G02B2027/0178 ,  G02C7/16

摘要： A monocular display device of a head mounted monocular display is adjustably positioned in front of a display eye of a user. The monocular display device displays information in a first field of view of the display eye. An occluding device is adjustably positioned in front of a non-display eye of the user. The occluding device blocks a second field of view of the non-display eye, the blocking being regulated to block at least a part of the second field of view that corresponds to the first field of view containing the displayed information.

摘要翻译： 头戴式单眼显示器的单目显示装置可调节地定位在用户的显示眼睛的前方。 单眼显示装置在显示眼睛的第一视野中显示信息。 闭塞装置被可调节地定位在用户的非显示眼睛的前方。 闭塞装置阻挡非显示眼睛的第二视野，阻挡被调节以阻挡与包含所显示的信息的第一视野相对应的第二视野的至少一部分。

公开(公告)号：US08598216B1

公开(公告)日：2013-12-03

申请号：US13328043

申请日：2011-12-16

申请人： Maurizio Acquasaliente ,  Didier Houllemare ,  Geoff Zhang ,  Pulla Singam ,  John Morris ,  Kennan Marsh ,  Martin Babcock ,  John Pavlina ,  Yi Shi ,  Yuchuan Gong

发明人： Maurizio Acquasaliente ,  Didier Houllemare ,  Geoff Zhang ,  Pulla Singam ,  John Morris ,  Kennan Marsh ,  Martin Babcock ,  John Pavlina ,  Yi Shi ,  Yuchuan Gong

IPC分类号： A61K31/426 ,  A61K31/41

CPC分类号： C07D277/18

摘要： The invention relates to ritonavir bis-hydrochloride, processes for the preparation of the ritonavir bis-hydrochloride, pharmaceutical compositions containing the ritonavir bis-hydrochloride and made from it, and methods of using the ritonavir bis-hydrochloride to inhibit HIV protease or enhance the pharmacokinetics of compounds which are metabolized by cytochrome P450 3A4.

摘要翻译： 本发明涉及利托那韦双盐酸盐，制备利托那韦双盐酸盐的方法，含有利托那韦双盐酸盐并由其制备的药物组合物，以及使用利托那韦双盐酸盐抑制HIV蛋白酶或增强药代动力学的方法 的化合物，其被细胞色素P450 3A4代谢。

公开(公告)号：US08363866B2

公开(公告)日：2013-01-29

申请号：US12322258

申请日：2009-01-30

申请人： Shree Jaisimha ,  Mohammed Reza Kanji ,  Li Lian Lay ,  John Morris ,  James P. Reefe

发明人： Shree Jaisimha ,  Mohammed Reza Kanji ,  Li Lian Lay ,  John Morris ,  James P. Reefe

IPC分类号： H04R5/02

CPC分类号： H04R5/04 ,  B60K2350/901 ,  G06F3/16 ,  H04R1/1041 ,  H04R2499/13 ,  H04S7/30 ,  H04S2400/13 ,  H04S2420/01

摘要： A method of operating an audio system having first and second sources includes outputting a first audio signal from the first source on first and second speakers. In response to a listener input, the first audio signal and a second audio signal from the second source are output simultaneously on the first and second speakers. The first signal is output from each of the first and second speakers such that the first signal is perceived by a listener to originate from a first direction toward the listener. The second signal is output from each of the first and second speakers such that the second signal is perceived by the listener to originate from a second direction toward the listener. The second direction is offset at least ninety degrees from the first direction.

摘要翻译： 一种操作具有第一和第二源的音频系统的方法包括在第一和第二扬声器上从第一源输出第一音频信号。 响应于收听者输入，来自第二源的第一音频信号和第二音频信号在第一和第二扬声器上同时输出。 第一信号从第一和第二扬声器的每一个输出，使得第一信号被听者感知为从朝向收听者的第一方向发起。 从第一和第二扬声器中的每一个输出第二信号，使得第二信号被收听者感知为从朝向收听者的第二方向发起。 第二方向与第一方向偏移至少九十度。

公开(公告)号：US20100250304A1

公开(公告)日：2010-09-30

申请号：US12415128

申请日：2009-03-31

申请人： Justin Whitaker ,  John Morris

发明人： Justin Whitaker ,  John Morris

IPC分类号： G06Q10/00 ,  G06F3/048

CPC分类号： G06Q10/06393 ,  G06Q10/06316 ,  G06Q10/0633 ,  G06Q10/0637 ,  G06Q10/06375 ,  G06Q10/0639 ,  G06Q10/06395 ,  G06Q10/10

摘要： Process studies are performed to determine improvements to processes, such as manufacturing or service related processes. One or more instances of a process may be captured (e.g., recorded) and annotated. A user is enabled to interact with a recording included in the process instance of a process being performed. The user is enabled to apply a process step tag selected from a plurality of process steps to a section of the recording. The user may be enabled to interact with the recording to apply an attribute value selected from a list of attribute values to the process instance. The user may be enabled to interact with the recording to apply discovery information to the process instance. Annotation information associated with the process instance is generated that includes the process step tag, any applied attribute values, and any applied discovery information.

摘要翻译： 执行过程研究以确定对过程的改进，例如制造或服务相关过程。 可以捕获（例如记录）和注释一个或多个进程的实例。 用户能够与正在执行的进程的流程实例中包括的记录进行交互。 用户能够将从多个处理步骤选择的处理步骤标签应用到记录的一部分。 可以使用户能够与记录交互以将从属性值列表中选择的属性值应用于流程实例。 可以使用户能够与记录交互以将发现信息应用于流程实例。 生成与流程实例相关联的注释信息，其中包括流程步骤标签，任何应用的属性值以及任何应用的发现信息。

公开(公告)号：US20070067575A1

公开(公告)日：2007-03-22

申请号：US11470710

申请日：2006-09-07

申请人： John Morris ,  Bhashyam Ramesh

发明人： John Morris ,  Bhashyam Ramesh

IPC分类号： G06F12/00

CPC分类号： G06F12/0888 ,  G06F12/0866 ,  G06F12/121

摘要： A technique for use in managing a data cache involves receiving one or more data objects to be written to a storage device. A temperature value is assigned to the one or more data objects before storing the data objects in the data cache. The temperature value assigned to the one or more data objects is compared with a threshold value. A copy of the one or more data objects is stored in the data cache if the assigned temperature value exceeds the threshold value.

摘要翻译： 用于管理数据高速缓存的技术包括接收要写入存储设备的一个或多个数据对象。 在将数据对象存储在数据高速缓存中之前，将温度值分配给一个或多个数据对象。 分配给一个或多个数据对象的温度值与阈值进行比较。 如果分配的温度值超过阈值，则一个或多个数据对象的副本被存储在数据高速缓存中。

公开(公告)号：US20070055706A1

公开(公告)日：2007-03-08

申请号：US11470373

申请日：2006-09-06

申请人： John Morris

发明人： John Morris

IPC分类号： G06F17/30

CPC分类号： G06F3/0611 ,  G06F3/065 ,  G06F3/0689 ,  G06F2201/84

摘要： A technique for use in performing snap imaging of a plurality of data objects and associated metadata involves placing the plurality of data objects in a consistent state. While the data objects are in a consistent state, a copy is created of the metadata associated with the plurality of data objects. The data objects are then taken out of the consistent state. The temperature value associated with one or more of the data objects is/are compared with a threshold value. A copy is created of at least some of the data objects for which the associated temperature value exceeds the threshold value.

摘要翻译： 用于对多个数据对象和相关元数据执行快照成像的技术涉及将所述多个数据对象置于一致状态。 当数据对象处于一致状态时，创建与多个数据对象相关联的元数据的副本。 然后将数据对象从一致状态中取出。 将与一个或多个数据对象相关联的温度值与阈值进行比较。 创建一个副本，其中至少一些对应的温度值超过阈值的数据对象。