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公开(公告)号：US06797716B2
公开(公告)日：2004-09-28
申请号：US10406181
申请日：2003-04-03
申请人： John F. Gerster , Kyle J. Lindstrom , Stephen L. Crooks , Philip D. Heppner , Gregory J. Marszalek , Peter V. Maye , Bryon A. Merrill , John W. Mickelson , Michael J. Rice
发明人： John F. Gerster , Kyle J. Lindstrom , Stephen L. Crooks , Philip D. Heppner , Gregory J. Marszalek , Peter V. Maye , Bryon A. Merrill , John W. Mickelson , Michael J. Rice
IPC分类号： A61K31437
CPC分类号： C07D471/04 , A61K31/4745 , A61K45/06 , C07D471/14 , A61K2300/00
摘要： Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.
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公开(公告)号：US06780873B2
公开(公告)日：2004-08-24
申请号：US10352604
申请日：2003-01-28
IPC分类号： A61K314745
CPC分类号： C07D471/04 , A61K31/4745
摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain urea, thiourea, acylurea, or sulfonylurea functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
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公开(公告)号：US06451810B1
公开(公告)日：2002-09-17
申请号：US09589580
申请日：2000-06-07
申请人： Patrick L. Coleman , Stephen L. Crooks , Kyle J. Lindstrom , Bryon A. Merrill , Michael J. Rice
发明人： Patrick L. Coleman , Stephen L. Crooks , Kyle J. Lindstrom , Bryon A. Merrill , Michael J. Rice
IPC分类号： A01N4342
CPC分类号： C07D471/04 , A61K31/4745
摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
摘要翻译： 在1位含有酰胺官能团的咪唑并喹啉和四氢咪唑并喹啉化合物可用作免疫应答调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。
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公开(公告)号：US07038051B2
公开(公告)日：2006-05-02
申请号：US11188418
申请日：2005-07-25
申请人： John F. Gerster , Kyle J. Lindstrom , Stephen L. Crooks , Philip D. Heppner , Gregory J. Marszalek , Peter V. Maye , Bryon A. Merrill , John W. Mickelson , Michael J. Rice
发明人： John F. Gerster , Kyle J. Lindstrom , Stephen L. Crooks , Philip D. Heppner , Gregory J. Marszalek , Peter V. Maye , Bryon A. Merrill , John W. Mickelson , Michael J. Rice
IPC分类号： C07D471/12 , C07D471/00
CPC分类号： C07D471/04 , A61K31/4745 , A61K45/06 , C07D471/14 , A61K2300/00
摘要： Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.
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公开(公告)号：US07393859B2
公开(公告)日：2008-07-01
申请号：US10848893
申请日：2004-05-19
申请人： Patrick L. Coleman , Stephen L. Crooks , George W. Griesgraber , Kyle J. Lindstrom , Bryon A. Merrill , Michael J. Rice
发明人： Patrick L. Coleman , Stephen L. Crooks , George W. Griesgraber , Kyle J. Lindstrom , Bryon A. Merrill , Michael J. Rice
IPC分类号： A61K31/437 , C07D471/02
CPC分类号： C07D471/04 , A61K31/4745
摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
摘要翻译： 在1位含有酰胺官能团的咪唑并喹啉和四氢咪唑并喹啉化合物可用作免疫应答调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。
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公开(公告)号：US07157453B2
公开(公告)日：2007-01-02
申请号：US11038434
申请日：2005-01-20
申请人： Stephen L. Crooks , Michael J. Rice
发明人： Stephen L. Crooks , Michael J. Rice
IPC分类号： A61K31/5377 , A61K31/437 , C07D413/14 , C07D471/02
CPC分类号： C07D471/04 , A61K31/4745 , Y02A50/409
摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain urea, thiourea, acylurea, or sulfonylurea functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
摘要翻译： 在1位含有尿素，硫脲，酰基脲或磺酰脲官能团的咪唑并喹啉和四氢咪唑并喹啉化合物可用作免疫应答调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。
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公开(公告)号：US06784188B2
公开(公告)日：2004-08-31
申请号：US10370800
申请日：2003-02-20
申请人： Stephen L. Crooks , George W. Griesgraber , Kyle J. Lindstrom , Bryon A. Merrill , Michael J. Rice
发明人： Stephen L. Crooks , George W. Griesgraber , Kyle J. Lindstrom , Bryon A. Merrill , Michael J. Rice
IPC分类号： A61K314745
CPC分类号： C07D471/04 , A61K31/4745 , Y02A50/409
摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain urea, thiourea, acylurea, or sulfonylurea functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
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公开(公告)号：US06756382B2
公开(公告)日：2004-06-29
申请号：US10027218
申请日：2001-12-21
申请人： Patrick L. Coleman , Stephen L. Crooks , George W. Griesgraber , Kyle J. Lindstrom , Bryon A. Merrill , Michael J. Rice
发明人： Patrick L. Coleman , Stephen L. Crooks , George W. Griesgraber , Kyle J. Lindstrom , Bryon A. Merrill , Michael J. Rice
IPC分类号： A61K3144
CPC分类号： C07D471/04 , A61K31/4745
摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
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公开(公告)号：US06541485B1
公开(公告)日：2003-04-01
申请号：US09589236
申请日：2000-06-07
IPC分类号： A61K314745
CPC分类号： C07D471/04 , A61K31/4745
摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain urea, thiourea, acylurea, or sulfonylurea functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
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公开(公告)号：US06514985B1
公开(公告)日：2003-02-04
申请号：US09706990
申请日：2000-11-06
申请人： John F. Gerster , Kyle J. Lindstrom , Stephen L. Crooks , Philip D. Heppner , Gregory J. Marszalek , Peter V. Maye , Bryon A. Merrill , John W. Mickelson , Michael J. Rice
发明人： John F. Gerster , Kyle J. Lindstrom , Stephen L. Crooks , Philip D. Heppner , Gregory J. Marszalek , Peter V. Maye , Bryon A. Merrill , John W. Mickelson , Michael J. Rice
IPC分类号： A61K314353
CPC分类号： C07D471/04 , A61K31/4745 , A61K45/06 , C07D471/14 , A61K2300/00
摘要： Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.
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